Detailed information for compound 256346

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.354 | Formula: C20H18O5
  • H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1(C)C[C@H](c2ccc(cc2)O)c2c(O1)c1ccccc1oc2=O
  • InChi: 1S/C20H18O5/c1-20(23-2)11-15(12-7-9-13(21)10-8-12)17-18(25-20)14-5-3-4-6-16(14)24-19(17)22/h3-10,15,21H,11H2,1-2H3/t15-,20?/m1/s1
  • InChiKey: ADZNYMHOFIXDFZ-IWPPFLRJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Onchocerca volvulus 0.0037 0.0042 0.0397
Schistosoma mansoni hypothetical protein 0.0168 0.0555 0.652
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0174 0.0576 0.8837
Loa Loa (eye worm) hypothetical protein 0.005 0.0092 0.0358
Brugia malayi Serotonin receptor 0.0037 0.0042 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Schistosoma mansoni survival motor neuron protein 0.0097 0.0277 0.3251
Loa Loa (eye worm) glutathione reductase 0.0076 0.0195 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0042 0.0042
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0035 0.0032 0.0536
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0042 0.0492
Trypanosoma cruzi hypothetical protein, conserved 0.0902 0.343 1
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0075
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0042 0.0042
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.018 0.0601 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0032 0.0536
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0042 0.0066
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.018 0.0601 0.0601
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.018 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0032 0.0536
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0032 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0035 0.0032 0.0536
Treponema pallidum NADH oxidase 0.0026 0 0.5
Echinococcus granulosus serine protein kinase ATM 0.0101 0.0294 0.0294
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.018 0.0601 1
Plasmodium vivax thioredoxin reductase, putative 0.0076 0.0195 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.018 0.0601 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0032 0.001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.018 0.0601 0.1751
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.018 0.0601 0.1751
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0035 0.0032 0.0536
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Schistosoma mansoni opsin-like receptor 0.0037 0.0042 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0 0.5
Onchocerca volvulus 0.0097 0.0277 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0277 0.1573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0032 0.0183
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0042 0.0042
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0036 0.0036
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0042 0.0042
Brugia malayi glutathione reductase 0.0076 0.0195 0.1107
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0042 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Plasmodium vivax hypothetical protein 0.0035 0.0032 0.1653
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0042 0.0042
Onchocerca volvulus 0.0037 0.0042 0.0397
Echinococcus multilocularis serotonin receptor 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Plasmodium falciparum thioredoxin reductase 0.0076 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Schistosoma mansoni hypothetical protein 0.0168 0.0555 0.652
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0391 0.4598
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0032 0.0183
Echinococcus multilocularis 0.0035 0.0032 0.0032
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.1759 0.1759
Leishmania major phosphatidylinositol 3-related kinase, putative 0.018 0.0601 0.1684
Schistosoma mansoni opsin-like receptor 0.0037 0.0042 0.0492
Schistosoma mansoni biogenic amine receptor 0.0037 0.0042 0.0492
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0391 0.2087
Onchocerca volvulus 0.0037 0.0042 0.0397
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.001
Toxoplasma gondii FATC domain-containing protein 0.0101 0.0294 0.489
Toxoplasma gondii target of rapamycin (TOR), putative 0.018 0.0601 1
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0042 0.0042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0042 0.0066
Schistosoma mansoni histamine h1 receptor 0.0037 0.0042 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0035 0.0032 0.0032
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0042 0.0042
Echinococcus multilocularis sex peptide receptor 0.0037 0.0042 0.0042
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0035 0.0032 0.0536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Onchocerca volvulus 0.0037 0.0042 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0032 0.0536
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0067 0.0158 0.0461
Trypanosoma cruzi trypanothione reductase, putative 0.0076 0.0195 0.0568
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0035 0.0032 0.1653
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0035 0.0032 0.0536
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.018 0.0601 0.1751
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0035 0.0032 0.0536
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0035 0.0032 0.0032
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0042 0.0042
Schistosoma mansoni adenoreceptor 0.0037 0.0042 0.0492
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0042 0.0066
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0294 0.489
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0035 0.0032 0.0032
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0391 0.2224
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0042 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0042 0.0492
Brugia malayi RE15519p 0.0037 0.0042 0.0238
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0042 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Leishmania major phosphatidylinositol 4-kinase, putative 0.0035 0.0032 0.009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0035 0.0032 0.0378
Onchocerca volvulus 0.0037 0.0042 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0042 0.0492
Brugia malayi TAR-binding protein 0.0126 0.0391 0.2224
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0042 0.0238
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Loa Loa (eye worm) thioredoxin reductase 0.0076 0.0195 0.095
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0174 0.0576 0.8777
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0101 0.0294 0.0294
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0042 0.0066
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0101 0.0294 0.0294
Brugia malayi Dopamine receptor protein 2 0.0037 0.0042 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0391 0.2087
Echinococcus granulosus g protein coupled receptor 0.0037 0.0042 0.0042
Schistosoma mansoni opsin-like receptor 0.0037 0.0042 0.0492
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0035 0.0032 0.1653
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0036 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.0501 0.1861 0.1861
Echinococcus granulosus thioredoxin glutathione reductase 0.0077 0.0199 0.0199
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.018 0.0601 0.7059
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0158 0.2636
Onchocerca volvulus 0.0037 0.0042 0.0397
Brugia malayi GnHR receptor homolog 0.0037 0.0042 0.0238
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0078 0.0204 0.0204
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0035 0.0032 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0036 0.0429
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0035 0.0032 0.0094
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0035 0.0032 0.0378
Echinococcus granulosus tar DNA binding protein 0.0126 0.0391 0.0391
Schistosoma mansoni myosin xvIII 0.0037 0.0042 0.0492
Onchocerca volvulus 0.0037 0.0042 0.0397
Schistosoma mansoni neuropeptide receptor 0.0037 0.0042 0.0492
Echinococcus granulosus orexin receptor type 2 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus granulosus sex peptide receptor 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0391 0.0391
Brugia malayi ORL1-like opioid receptor 0.0037 0.0042 0.0238
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0032 0.001
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0042 0.0066
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0042 0.0397
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0032 0.1653
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0042 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0174 0.0576 0.8837
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0042 0.0042
Brugia malayi G protein-coupled receptor 0.0037 0.0042 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0391 0.4598
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0158 0.2636
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0042 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0294 0.489
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0035 0.0032 0.0536
Onchocerca volvulus 0.0037 0.0042 0.0397
Loa Loa (eye worm) phosphatidylinositol 3 0.018 0.0601 0.3298
Loa Loa (eye worm) hypothetical protein 0.0113 0.0339 0.1785
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.018 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0035 0.0032 0.0536
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0101 0.0294 0.0856
Entamoeba histolytica hypothetical protein 0.0101 0.0294 0.4601
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0032 0.0183
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.018 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Loa Loa (eye worm) RNA binding protein 0.0126 0.0391 0.2087
Leishmania major phosphatidylinositol kinase, putative 0.0035 0.0032 0.009
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0042 0.0238
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0075
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0042 0.0042
Brugia malayi Melatonin receptor type 1A 0.0037 0.0042 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0042 0.0042
Schistosoma mansoni amine GPCR 0.0037 0.0042 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0294 0.489
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0092 0.0358
Echinococcus multilocularis serine protein kinase ATM 0.0101 0.0294 0.0294
Schistosoma mansoni neuropeptide receptor 0.0037 0.0042 0.0492
Brugia malayi hypothetical protein 0.0476 0.1759 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0035 0.0032 0.1653
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Loa Loa (eye worm) phosphatidylinositol 3 0.018 0.0601 0.3298
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0035 0.0032 0.0536
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0042 0.0492
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0032 0.0183
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0042 0.0492
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0042 0.0492
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0035 0.0032 0.0536
Brugia malayi FAT domain containing protein 0.0078 0.0204 0.1158
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0042 0.0042
Mycobacterium tuberculosis Probable oxidoreductase 0.0193 0.0652 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0391 0.4598
Schistosoma mansoni hypothetical protein 0.0035 0.0032 0.0378
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0042 0.0042
Echinococcus granulosus allatostatin A receptor 0.0037 0.0042 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0042 0.0492
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0035 0.0032 0.0183
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0042 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0032 0.0183
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0042 0.0238
Echinococcus multilocularis serotonin receptor 0.0037 0.0042 0.0042
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0042 0.0492
Echinococcus granulosus g protein coupled receptor 0.0037 0.0042 0.0042
Leishmania major hypothetical protein, conserved 0.0937 0.3566 1
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0042 0.0492
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0042 0.0042
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0076 0.0195 0.2985
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0042 0.0066
Leishmania major trypanothione reductase 0.0076 0.0195 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0035 0.0032 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0042 0.0492
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0113 0.0339 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Onchocerca volvulus 0.0037 0.0042 0.0397
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0035 0.0032 0.0094
Onchocerca volvulus 0.0037 0.0042 0.0397
Mycobacterium tuberculosis Probable reductase 0.0174 0.0576 0.8837
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0042 0.0397
Brugia malayi Thioredoxin reductase 0.0076 0.0195 0.1107
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0042 0.0492
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0035 0.0032 0.0032
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Leishmania major hypothetical protein, unknown function 0.0035 0.0032 0.009
Giardia lamblia Phosphatidylinositol 4-kinase 0.0035 0.0032 0.0536
Schistosoma mansoni fkbp-rapamycin associated protein 0.0101 0.0294 0.3452
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0042 0.0066
Giardia lamblia GTOR 0.018 0.0601 1
Schistosoma mansoni hypothetical protein 0.0037 0.0042 0.0492
Schistosoma mansoni hypothetical protein 0.0097 0.0277 0.3251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Leishmania major phosphatidylinositol kinase related protein, putative 0.0035 0.0032 0.009
Echinococcus granulosus neuropeptide s receptor 0.0501 0.1861 0.1861
Toxoplasma gondii thioredoxin reductase 0.0076 0.0195 0.3241
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0035 0.0032 0.1653
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.0294 0.167
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0042 0.0042
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0035 0.0032 0.0032
Brugia malayi AKH receptor 0.0037 0.0042 0.0238
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0035 0.0032 0.0536
Echinococcus granulosus somatostatin receptor 0.0037 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0032 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0294 0.489
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0032 0.0493
Echinococcus multilocularis neuropeptide receptor A26 0.0501 0.1861 0.1861
Schistosoma mansoni neuropeptide receptor 0.0037 0.0042 0.0492
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0042 0.0066
Loa Loa (eye worm) hypothetical protein 0.0067 0.0158 0.074
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0035 0.0032 0.0094
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0035 0.0032 0.0378
Brugia malayi larval opioid receptor 0.0037 0.0042 0.0238
Trypanosoma brucei trypanothione reductase 0.0076 0.0195 0.3241
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0042 0.0042
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0092 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0032 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Brugia malayi Dopamine receptor protein 1 0.0037 0.0042 0.0238
Echinococcus multilocularis Zinc finger, PHD finger 0.0035 0.0032 0.0032
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0101 0.0294 0.489
Schistosoma mansoni biogenic amine receptor 0.0037 0.0042 0.0492
Echinococcus granulosus neuropeptide receptor 0.0037 0.0042 0.0042
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0032 0.1653
Onchocerca volvulus 0.0037 0.0042 0.0397
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.258 1 1
Schistosoma mansoni amine GPCR 0.0037 0.0042 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0042 0.0042
Brugia malayi G-protein coupled receptor 0.0037 0.0042 0.0238
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0042 0.0042
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0035 0.0032 0.1653
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0032 0.1653
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0042 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0294 0.489
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.018 0.0601 0.7059
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0391 0.4598
Echinococcus granulosus fmrfamide receptor 0.0037 0.0042 0.0042
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0035 0.0032 0.0094
Onchocerca volvulus 0.0037 0.0042 0.0397
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0035 0.0032 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0032 0.0536
Brugia malayi neuropeptide F receptor 0.0037 0.0042 0.0238
Brugia malayi Dopamine receptor 0.0037 0.0042 0.0238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0042 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0032 0.0183
Onchocerca volvulus 0.0037 0.0042 0.0397
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0042 0.0042
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.1759 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0294 0.489
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0032 0.0536
Loa Loa (eye worm) hypothetical protein 0.0101 0.0294 0.1523
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0 0.5
Onchocerca volvulus 0.0037 0.0042 0.0397
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0042 0.0492
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0035 0.0032 0.001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0035 0.0032 0.0536
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0042 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Brugia malayi G-protein coupled receptor 0.0037 0.0042 0.0238
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0035 0.0032 0.0094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0042 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0042 0.0042
Brugia malayi hypothetical protein 0.0036 0.0036 0.0207
Leishmania major phosphatidylinositol 3-kinase, putative 0.018 0.0601 0.1684
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.018 0.0601 0.1684
Schistosoma mansoni biogenic amine receptor 0.0037 0.0042 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Onchocerca volvulus 0.0037 0.0042 0.0397
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0037 0.0042 0.0492
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.018 0.0601 0.1684
Echinococcus multilocularis geminin 0.0168 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0101 0.0294 0.3452
Leishmania major phosphatidylinositol 3-kinase, putative 0.0035 0.0032 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0035 0.0032 0.0094
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Plasmodium falciparum glutathione reductase 0.0076 0.0195 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.018 0.0601 0.1751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0339 0.5645
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.018 0.0601 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0035 0.0032 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0092 0.0525
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.0294 0.167
Schistosoma mansoni amine GPCR 0.0037 0.0042 0.0492
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0042 0.0042
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0042 0.0042
Echinococcus multilocularis thioredoxin glutathione reductase 0.0077 0.0199 0.0199
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0035 0.0032 0.0536
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0035 0.0032 0.0536
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.018 0.0601 0.3414
Plasmodium vivax glutathione reductase, putative 0.0076 0.0195 1
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0042 0.0066
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0042 0.0238
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Schistosoma mansoni amine GPCR 0.0037 0.0042 0.0492
Brugia malayi sulfakinin receptor protein 0.0037 0.0042 0.0238
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0042 0.0042
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0174 0.0576 0.8837
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0042 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0101 0.0294 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0035 0.0032 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0294 0.489
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0035 0.0032 0.0094
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0042 0.0042
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0042 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0042 0.0042
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0042 0.0492
Echinococcus granulosus serotonin receptor 0.0037 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0037 0.0042 0.0492
Echinococcus multilocularis neuropeptide s receptor 0.0501 0.1861 0.1861
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0042 0.0042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0174 0.0576 0.8837
Trypanosoma brucei target of rapamycin kinase 3, putative 0.018 0.0601 1
Echinococcus granulosus geminin 0.0168 0.0555 0.0555
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0042 0.0042
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0042 0.0066
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.018 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0035 0.0032 0.0536
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0294 0.489
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0042 0.0042
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0035 0.0032 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0042 0.0042
Brugia malayi RNA binding protein 0.0126 0.0391 0.2224
Brugia malayi neuropeptide F receptor 0.0037 0.0042 0.0238
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0042 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.003 0.0173
Loa Loa (eye worm) hypothetical protein 0.0078 0.0204 0.1002
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Entamoeba histolytica protein kinase rad3, putative 0.0101 0.0294 0.4601
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0391 0.4598
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0101 0.0294 0.0856
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0193 0.0652 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0042 0.0492
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0035 0.0032 0.0094
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0042 0.0042
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0035 0.0032 0.009
Onchocerca volvulus 0.0037 0.0042 0.0397
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus multilocularis somatostatin receptor 0.0037 0.0042 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.018 0.0601 0.3414
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0429
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0035 0.0032 0.0536
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0035 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.001
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0035 0.0032 0.0032
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0193 0.0652 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0035 0.0032 0.0536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Schistosoma mansoni neuropeptide receptor 0.0037 0.0042 0.0492
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0042 0.0042
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0035 0.0032 0.0094
Loa Loa (eye worm) phosphatidylinositol kinase 0.0035 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Schistosoma mansoni amine GPCR 0.0037 0.0042 0.0492
Echinococcus granulosus neuropeptide receptor 0.0037 0.0042 0.0042
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0035 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0034 0.003 0.0358
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0174 0.0576 0.8837
Brugia malayi Serotonin receptor 0.0037 0.0042 0.0238
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0113 0.0339 0.5645
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0032 0.001
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0035 0.0032 0.0094
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.018 0.0601 1
Schistosoma mansoni hypothetical protein 0.0078 0.0204 0.2394
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.018 0.0601 0.1684
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0042 0.0238
Echinococcus granulosus g protein coupled receptor 0.0037 0.0042 0.0042
Brugia malayi putative neuropeptide receptor 0.0037 0.0042 0.0238
Entamoeba histolytica hypothetical protein 0.0036 0.0036 0.0075
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0035 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.0339 0.5645
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0193 0.0652 1
Trypanosoma cruzi target of rapamycin kinase 3 0.018 0.0601 0.1751
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0204 0.3391
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0078 0.0204 0.0204
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0035 0.0032 0.0536
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0035 0.0032 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.018 0.0601 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0066
Giardia lamblia Hypothetical protein 0.0035 0.0032 0.0536
Loa Loa (eye worm) hypothetical protein 0.0476 0.1759 1
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0042 0.0042
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0042 0.0492
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0042 0.0042
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0042 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Schistosoma mansoni hypothetical protein 0.0037 0.0042 0.0492
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0035 0.0032 0.0536
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0042 0.0042
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0035 0.0032 0.0378
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0035 0.0032 0.0536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0042 0.0492
Echinococcus granulosus hypothetical protein 0.0037 0.0042 0.0042
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0042 0.0042
Brugia malayi hypothetical protein 0.0037 0.0042 0.0238
Onchocerca volvulus 0.0037 0.0042 0.0397

Activities

Activity type Activity value Assay description Source Reference
RPF (ADMET) = 76.2 pM nM-1 Rate of metabolism in liver microsomes (BNF treated rats) ChEMBL. 3981543

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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