TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.925 | Formula: C23H27ClN2O3
H donors: 2 H acceptors: 3 LogP: 5.15 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC1CC(C)CN(C1)c1ccc(cc1C(=O)NCCc1ccc(cc1)C(=O)O)Cl
InChi: 1S/C23H27ClN2O3/c1-15-11-16(2)14-26(13-15)21-8-7-19(24)12-20(21)22(27)25-10-9-17-3-5-18(6-4-17)23(28)29/h3-8,12,15-16H,9-11,13-14H2,1-2H3,(H,25,27)(H,28,29)
InChiKey: VYVITXCBCOLLKT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0186	0.0165
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.0219
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0019	0.0031	0.0014
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.2208	0.7315	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0122	0.0138
Onchocerca volvulus		0.003	0.0067	0.5
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2208	0.7315	0.7309
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0211	0.0671	0.0892
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2208	0.7315	0.7309
Schistosoma mansoni	DNA helicase recq5	0.0019	0.0031	0.0014
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0031	0.0014
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0067	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0089	0.0093
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0021	0.0029
Trypanosoma cruzi	hexose transporter, putative	0.003	0.0067	0.0046
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0122	0.0207
Onchocerca volvulus		0.003	0.0067	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Plasmodium falciparum	hexose transporter	0.0211	0.0671	0.0892
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.1397	0.4615	0.6299
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Toxoplasma gondii	sugar transporter ST3	0.003	0.0067	0.0091
Brugia malayi	Sugar transporter family protein	0.0211	0.0671	0.0892
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0019	0.0031	0.0013
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.003	0.0067	0.0211
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0729	0.2393	0.2377
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.3015	1	1
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0186	0.0165
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.003	0.0067	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0211	0.0671	0.0856
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0181	0.0219
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0729	0.2393	0.2377
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0811	0.2668	0.3604
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0186	0.0188
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.003	0.0067	0.0063
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.0219
Leishmania major	glucose transporter, lmgt3	0.0066	0.0186	0.0165
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.003	0.0067	0.0046
Loa Loa (eye worm)	RecQ helicase	0.0046	0.012	0.0204
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0066	0.0186	0.0165
Trypanosoma cruzi	hexose transporter	0.0066	0.0186	0.0165
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Entamoeba histolytica	hypothetical protein	0.0036	0.0089	0.0122
Entamoeba histolytica	hypothetical protein	0.0036	0.0089	0.0122
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.2208	0.7315	0.5
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0186	0.0165
Onchocerca volvulus		0.003	0.0067	0.5
Entamoeba histolytica	recQ family helicase, putative	0.0024	0.0049	0.0068
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Onchocerca volvulus		0.003	0.0067	0.5
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0122	0.0138
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.1479	0.4889	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0211	0.0671	0.0892
Toxoplasma gondii	facilitative glucose transporter GT1	0.0211	0.0671	0.0918
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0186	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0067	0.0024
Schistosoma mansoni	sugar transporter	0.003	0.0067	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1397	0.4615	0.6284
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.2208	0.7315	1
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.2208	0.7315	1
Brugia malayi	major facilitator superfamily protein	0.003	0.0067	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0729	0.2393	0.2377
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0186	0.0165
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0211	0.0671	0.0892
Echinococcus granulosus	synaptic vesicle 2 protein	0.003	0.0067	0.0063
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0019	0.0031	0.0014
Schistosoma mansoni	hypothetical protein	0.0036	0.0089	0.0093
Onchocerca volvulus		0.003	0.0067	0.5
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.154	0.5093	0.695
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0126
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2208	0.7315	0.7309
Onchocerca volvulus		0.003	0.0067	0.5
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Echinococcus multilocularis	solute carrier family 22	0.003	0.0067	0.0063
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0019	0.0031	0.002
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0729	0.2393	0.2377
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0122	0.0138
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0136	0.0235
Giardia lamblia	Sugar-proton symporter	0.003	0.0067	0.0049
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	myo-inositol transporter, putative	0.003	0.0067	0.0024
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Onchocerca volvulus		0.003	0.0067	0.5
Onchocerca volvulus	Putative transporter	0.003	0.0067	0.5
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.2208	0.7315	1
Onchocerca volvulus		0.003	0.0067	0.5
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2208	0.7315	1
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0186	0.0188
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0021	0.0029
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0089	0.0093
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0729	0.2393	0.2377
Leishmania major	myo-inositol/proton symporter (MIT)	0.003	0.0067	0.0046
Leishmania major	glucose transporter, lmgt1	0.0066	0.0186	0.0165
Echinococcus granulosus	solute carrier family 22	0.003	0.0067	0.0063
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.0219
Toxoplasma gondii	sugar transporter ST1	0.003	0.0067	0.0091
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.1397	0.4615	0.6299
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0186	0.0165
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0181	0.0219
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2208	0.7315	0.7309
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0067	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.2208	0.7315	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0089	0.0093
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	sugar transport protein, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Schistosoma mansoni	blooms syndrome DNA helicase	0.0036	0.0088	0.0092
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.0219
Onchocerca volvulus		0.003	0.0067	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0122	0.0138
Echinococcus granulosus	solute carrier family 22	0.003	0.0067	0.0063
Echinococcus multilocularis	bloom syndrome protein	0.0046	0.012	0.0136
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0668	0.219	1
Trypanosoma cruzi	glucose transporter, putative	0.003	0.0067	0.0046
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0186	0.0165
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0211	0.0671	0.0892
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0024	0.0049	0.0028
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0186	0.0165
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0031	0.0042
Echinococcus granulosus	solute carrier family 22	0.003	0.0067	0.0063
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.037	0.0716
Entamoeba histolytica	hypothetical protein	0.0036	0.0089	0.0122
Trypanosoma cruzi	sugar transporter, putative	0.003	0.0067	0.0046
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0668	0.219	0.5
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Schistosoma mansoni	glucose transport protein	0.0211	0.0671	0.0892
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Brugia malayi	hypothetical protein	0.003	0.0067	0.0063
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0067	0.0024
Echinococcus multilocularis	synaptic vesicle 2 protein	0.003	0.0067	0.0063
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0811	0.2668	0.3629
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Loa Loa (eye worm)	hypothetical protein	0.1397	0.4615	0.9437
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0181	0.0219
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.004	0.0102	0.0111
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0122	0.0138
Trypanosoma brucei	glucose transporter 2A	0.0066	0.0186	0.0165
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.2208	0.7315	0.7309
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0186	0.0165
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0729	0.2393	0.3253
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0067	0.0063
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.2208	0.7315	1
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.2208	0.7315	1
Echinococcus multilocularis	solute carrier family 22	0.003	0.0067	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0031	0.007	0.0095
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0087	0.0066
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.1397	0.4615	0.9437
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	0.7309
Trichomonas vaginalis	DNA helicase recq, putative	0.0046	0.012	0.0098
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.003	0.0067	0.0063
Echinococcus multilocularis	solute carrier family 22	0.003	0.0067	0.0063
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	0.7309
Schistosoma mansoni	DNA helicase recq1	0.0019	0.0031	0.0014
Trypanosoma brucei	glucose transporter 1E	0.0066	0.0186	0.0165
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.037	0.0716
Trichomonas vaginalis	glucose transporter, putative	0.0066	0.0186	0.0188
Entamoeba histolytica	hypothetical protein	0.0036	0.0089	0.0122
Schistosoma mansoni	sugar transporter	0.003	0.0067	0.0063
Onchocerca volvulus		0.003	0.0067	0.5
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0067	0.0063
Loa Loa (eye worm)	sugar transporter	0.0211	0.0671	0.1336
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0122	0.0138
Plasmodium vivax	sugar transporter, putative	0.003	0.0067	0.0063
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trypanosoma brucei	sugar transporter, putative	0.003	0.0067	0.0046
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0211	0.0671	0.0892
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.2208	0.7315	1
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0181	0.0329
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.1397	0.4615	0.9437
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trichomonas vaginalis	glucose transporter, putative	0.003	0.0067	0.0024
Brugia malayi	MH2 domain containing protein	0.0121	0.037	0.0478
Brugia malayi	hypothetical protein	0.003	0.0067	0.0063
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0211	0.0671	0.0892
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.1479	0.4889	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0186	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0186	0.0188
Toxoplasma gondii	sugar transporter ST2	0.003	0.0067	0.0091
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2208	0.7315	1
Echinococcus multilocularis	solute carrier family 22	0.003	0.0067	0.0063
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Brugia malayi	hypothetical protein	0.003	0.0067	0.0063
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0024	0.0049	0.0028
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0186	0.0165
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0136	0.0157
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.3015	1	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0067	0.0094
Brugia malayi	major facilitator superfamily protein	0.003	0.0067	0.0063
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Schistosoma mansoni	hypothetical protein	0.0211	0.0671	0.0892
Toxoplasma gondii	transporter, major facilitator family protein	0.003	0.0067	0.0091
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0186	0.0165
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.003	0.0067	0.0211
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0181	0.0219
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2208	0.7315	0.7309
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.2208	0.7315	0.7309
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Echinococcus granulosus	General substrate transporter	0.0182	0.0573	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0432	0.0844
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Echinococcus multilocularis	General substrate transporter	0.0182	0.0573	0.0756
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0211	0.0671	0.0892
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Loa Loa (eye worm)	hypothetical protein	0.005	0.0136	0.0235
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0181	0.0329
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0136	0.0157
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.2208	0.7315	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0031	0.0042
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0186	0.0165
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0186	0.0188
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0186	0.0165
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0067	0.0063
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0031	0.0071	0.0069
Brugia malayi	hypothetical protein	0.0036	0.0089	0.0093
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2208	0.7315	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0083	0.0084
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	0.7309
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Onchocerca volvulus		0.003	0.0067	0.5
Schistosoma mansoni	glucose transport protein	0.0211	0.0671	0.0892
Schistosoma mansoni	hypothetical protein	0.0034	0.0083	0.0084
Loa Loa (eye worm)	sugar transporter	0.003	0.0067	0.0094
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	0.7309
Onchocerca volvulus		0.003	0.0067	0.5
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.1397	0.4615	0.6284
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0122	0.0138
Onchocerca volvulus		0.003	0.0067	0.5
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.2208	0.7315	1
Schistosoma mansoni	sugar transporter	0.003	0.0067	0.0063
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0211	0.0671	0.0892
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0024	0.0049	0.0028
Echinococcus granulosus	bloom syndrome protein	0.0046	0.012	0.0136
Brugia malayi	Sugar transporter family protein	0.003	0.0067	0.0063
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0186	0.0188
Echinococcus granulosus	Sugar transporter ERD6 protein	0.003	0.0067	0.0063
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0019	0.0031	0.0014
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0122	0.0138
Schistosoma mansoni	sugar transporter	0.003	0.0067	0.0063
Onchocerca volvulus		0.003	0.0067	0.5
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.3015	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0181	0.0329
Schistosoma mansoni	glucose transporter	0.003	0.0067	0.0063
Echinococcus granulosus	solute carrier family 22	0.003	0.0067	0.0063
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.2208	0.7315	1
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.2208	0.7315	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0046	0.012	0.0098
Trichomonas vaginalis	glucose transporter, putative	0.0066	0.0186	0.0188
Brugia malayi	RNA binding protein	0.0064	0.0181	0.0219
Onchocerca volvulus		0.003	0.0067	0.5
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.2208	0.7315	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0031	0.0014
Leishmania major	hypothetical protein, conserved	0.003	0.0067	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0067	0.0024
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Giardia lamblia	Hexose transporter	0.003	0.0067	0.0049
Leishmania major	glucose transporter, lmgt2	0.0066	0.0186	0.0165
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0019	0.0031	0.0014
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Brugia malayi	Bloom's syndrome protein homolog	0.0046	0.012	0.0136
Plasmodium vivax	hexose transporter	0.0211	0.0671	0.0892
Schistosoma mansoni	glucose transport protein	0.0211	0.0671	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0031	0.002
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Onchocerca volvulus		0.003	0.0067	0.5
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.2208	0.7315	1
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0067	0.0024
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0067	0.0094
Loa Loa (eye worm)	hypothetical protein	0.003	0.0067	0.0094
Brugia malayi	TAR-binding protein	0.0064	0.0181	0.0219
Brugia malayi	Sugar transporter family protein	0.003	0.0067	0.0063
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.2208	0.7315	0.7309

Activities

Activity type	Activity value	Assay description	Source	Reference
Delta BG (functional)	= -44 %	Maximum % decrease of blood glucose (deltaBG) was observed within 4 hour after administration orally at 1 mg/kg dose to fasted adult female rats versus a control group	ChEMBL.	9857091
Delta BG (functional)	= -29 %	Maximum % decrease of blood glucose (deltaBG) of the compound was observed within 4 hour after administration orally at 0.5 mg/kg dose to fasted adult female rats versus a control group	ChEMBL.	9857091
Delta BG (functional)	= -11 %	Maximum % decrease of blood glucose (deltaBG) was observed within 4 hour after administration orally at 1 mg/kg dose to fasted adult female rats versus a control group	ChEMBL.	9857091
ED50 (functional)	= 0.33 mg kg-1	Half-maximal effective dose of the compound was measured on rat blood glucose after administrating of the compound at 4 hr	ChEMBL.	9857091

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL148593

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 256500