Detailed information for compound 257059

Basic information

Technical information
  • TDR Targets ID: 257059
  • Name: 4-[2-[[5-chloro-2-(3-methylpiperidin-1-yl)ben zoyl]amino]ethyl]benzoic acid
  • MW: 400.899 | Formula: C22H25ClN2O3
  • H donors: 2 H acceptors: 3 LogP: 4.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCN(C1)c1ccc(cc1C(=O)NCCc1ccc(cc1)C(=O)O)Cl
  • InChi: 1S/C22H25ClN2O3/c1-15-3-2-12-25(14-15)20-9-8-18(23)13-19(20)21(26)24-11-10-16-4-6-17(7-5-16)22(27)28/h4-9,13,15H,2-3,10-12,14H2,1H3,(H,24,26)(H,27,28)
  • InChiKey: KFVXXANBQKERJF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-[2-[[5-chloro-2-(3-methyl-1-piperidyl)benzoyl]amino]ethyl]benzoic acid
  • 4-[2-[[[5-chloro-2-(3-methyl-1-piperidinyl)phenyl]-oxomethyl]amino]ethyl]benzoic acid
  • 4-[2-[[5-chloro-2-(3-methylpiperidin-1-yl)phenyl]carbonylamino]ethyl]benzoic acid
  • 4-[2-[[5-chloro-2-(3-methylpiperidino)benzoyl]amino]ethyl]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sugar transporter 0.003 0.0067 0.0063
Brugia malayi RNA binding protein 0.0064 0.0181 0.0219
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0811 0.2668 0.3629
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0031 0.0014
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0087 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.037 0.0716
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0067 0.0063
Brugia malayi Sugar transporter family protein 0.003 0.0067 0.0063
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1479 0.4889 1
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.037 0.0716
Brugia malayi MH2 domain containing protein 0.0121 0.037 0.0478
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0031 0.0042
Toxoplasma gondii sugar transporter ST2 0.003 0.0067 0.0091
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0031 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.002
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0181 0.0219
Onchocerca volvulus 0.003 0.0067 0.5
Schistosoma mansoni glucose transport protein 0.0211 0.0671 0.0892
Leishmania major glucose transporter, lmgt3 0.0066 0.0186 0.0165
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2208 0.7315 0.7309
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0181 0.0219
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0031 0.002
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2208 0.7315 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0136 0.0235
Loa Loa (eye worm) hypothetical protein 0.0139 0.0432 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0067 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0181 0.0329
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 0.7309
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0811 0.2668 0.3604
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2208 0.7315 0.7309
Loa Loa (eye worm) sugar transporter 0.0211 0.0671 0.1336
Schistosoma mansoni glucose transport protein 0.0211 0.0671 0.0892
Echinococcus multilocularis General substrate transporter 0.0182 0.0573 0.0756
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Echinococcus granulosus solute carrier family 22 0.003 0.0067 0.0063
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0067 0.0024
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0071 0.0069
Onchocerca volvulus 0.003 0.0067 0.5
Echinococcus granulosus solute carrier family 22 0.003 0.0067 0.0063
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0186 0.0188
Loa Loa (eye worm) sugar transporter 0.003 0.0067 0.0094
Brugia malayi TAR-binding protein 0.0064 0.0181 0.0219
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0136 0.0235
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0031 0.0014
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0083 0.0084
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0067 0.0094
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0031 0.0042
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.012 0.0098
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2208 0.7315 0.7309
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0021 0.0029
Schistosoma mansoni glucose transporter 0.003 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Echinococcus granulosus General substrate transporter 0.0182 0.0573 0.0756
Brugia malayi hypothetical protein 0.003 0.0067 0.0063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0181 0.0219
Onchocerca volvulus 0.003 0.0067 0.5
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0067 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.007 0.0095
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2208 0.7315 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.2208 0.7315 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Brugia malayi major facilitator superfamily protein 0.003 0.0067 0.0063
Entamoeba histolytica hypothetical protein 0.0036 0.0089 0.0122
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0049 0.0028
Echinococcus granulosus tar DNA binding protein 0.0064 0.0181 0.0219
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0089 0.0093
Onchocerca volvulus 0.003 0.0067 0.5
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0186 0.0165
Trypanosoma brucei glucose transporter 2A 0.0066 0.0186 0.0165
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.0671 0.0892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0122 0.0138
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0729 0.2393 0.2377
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0089 0.0093
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0729 0.2393 0.2377
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0181 0.0329
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.2208 0.7315 0.7309
Onchocerca volvulus 0.003 0.0067 0.5
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2208 0.7315 1
Schistosoma mansoni DNA helicase recq5 0.0019 0.0031 0.0014
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Schistosoma mansoni sugar transporter 0.003 0.0067 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0136 0.0157
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.012 0.0136
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.2208 0.7315 1
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.2208 0.7315 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Entamoeba histolytica hypothetical protein 0.0036 0.0089 0.0122
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Echinococcus multilocularis solute carrier family 22 0.003 0.0067 0.0063
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2208 0.7315 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0122 0.0138
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.0671 0.0892
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0067 0.0063
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.2208 0.7315 0.5
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0186 0.0188
Leishmania major glucose transporter, lmgt2 0.0066 0.0186 0.0165
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2208 0.7315 1
Trypanosoma brucei glucose transporter, putative 0.0066 0.0186 0.0165
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0031 0.0014
Echinococcus granulosus solute carrier family 22 0.003 0.0067 0.0063
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0729 0.2393 0.2377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0122 0.0138
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0089 0.0093
Plasmodium falciparum hexose transporter 0.0211 0.0671 0.0892
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.0671 0.0892
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.2208 0.7315 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0067 0.0024
Echinococcus granulosus solute carrier family 22 0.003 0.0067 0.0063
Schistosoma mansoni hypothetical protein 0.0036 0.0089 0.0093
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Trypanosoma cruzi glucose transporter, putative 0.003 0.0067 0.0046
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Brugia malayi Sugar transporter family protein 0.0211 0.0671 0.0892
Schistosoma mansoni hypothetical protein 0.0034 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0088 0.0092
Trypanosoma brucei glucose transporter, putative 0.0066 0.0186 0.0165
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0122 0.0138
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0067 0.0063
Schistosoma mansoni hypothetical protein 0.0211 0.0671 0.0892
Echinococcus multilocularis solute carrier family 22 0.003 0.0067 0.0063
Onchocerca volvulus 0.003 0.0067 0.5
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0067 0.0024
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1397 0.4615 0.6284
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Entamoeba histolytica hypothetical protein 0.0036 0.0089 0.0122
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0729 0.2393 0.3253
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1397 0.4615 0.6284
Trichomonas vaginalis glucose transporter, putative 0.003 0.0067 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0122 0.0138
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.2208 0.7315 1
Schistosoma mansoni DNA helicase recq1 0.0019 0.0031 0.0014
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0067 0.0211
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0067 0.0094
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Toxoplasma gondii sugar transporter ST1 0.003 0.0067 0.0091
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 0.7309
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.2208 0.7315 1
Trypanosoma brucei glucose transporter, putative 0.0066 0.0186 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0067 0.0024
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0211 0.0671 0.0892
Onchocerca volvulus 0.003 0.0067 0.5
Onchocerca volvulus 0.003 0.0067 0.5
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1397 0.4615 0.9437
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.3015 1 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0049 0.0028
Giardia lamblia Sugar-proton symporter 0.003 0.0067 0.0049
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.0671 0.0892
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0049 0.0068
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0668 0.219 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0122 0.0138
Loa Loa (eye worm) RNA binding protein 0.0064 0.0181 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0186 0.0188
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.2208 0.7315 0.7309
Loa Loa (eye worm) RecQ helicase 0.0046 0.012 0.0204
Plasmodium vivax sugar transporter, putative 0.003 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.1397 0.4615 0.9437
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0186 0.0188
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0181 0.0219
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0186 0.0165
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0729 0.2393 0.2377
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0729 0.2393 0.2377
Onchocerca volvulus 0.003 0.0067 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.3015 1 1
Onchocerca volvulus 0.003 0.0067 0.5
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2208 0.7315 0.7309
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0668 0.219 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0067 0.0063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2208 0.7315 0.7309
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1397 0.4615 0.9437
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0031 0.0013
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0067 0.0211
Onchocerca volvulus 0.003 0.0067 0.5
Echinococcus multilocularis solute carrier family 22 0.003 0.0067 0.0063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0186 0.0165
Trypanosoma brucei glucose transporter 1E 0.0066 0.0186 0.0165
Schistosoma mansoni glucose transport protein 0.0211 0.0671 0.0892
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0186 0.0165
Onchocerca volvulus 0.003 0.0067 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.0671 0.0892
Echinococcus multilocularis solute carrier family 22 0.003 0.0067 0.0063
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 0.7309
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.2208 0.7315 1
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1479 0.4889 1
Brugia malayi hypothetical protein 0.0036 0.0089 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0186 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0186 0.0188
Trypanosoma brucei glucose transporter, putative 0.0066 0.0186 0.0165
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0181 0.0219
Onchocerca volvulus 0.003 0.0067 0.5
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0102 0.0111
Toxoplasma gondii sugar transporter ST3 0.003 0.0067 0.0091
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Giardia lamblia Hexose transporter 0.003 0.0067 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0122 0.0138
Trypanosoma brucei glucose transporter, putative 0.0066 0.0186 0.0165
Brugia malayi hypothetical protein 0.003 0.0067 0.0063
Echinococcus granulosus bloom syndrome protein 0.0046 0.012 0.0136
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Schistosoma mansoni sugar transporter 0.003 0.0067 0.0063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0186 0.0165
Leishmania major hypothetical protein, conserved 0.003 0.0067 0.0046
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1397 0.4615 0.6299
Toxoplasma gondii facilitative glucose transporter GT1 0.0211 0.0671 0.0918
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.012 0.0098
Brugia malayi Sugar transporter family protein 0.003 0.0067 0.0063
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0181 0.0219
Onchocerca volvulus Putative transporter 0.003 0.0067 0.5
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1397 0.4615 0.6299
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.3015 1 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0083 0.0126
Echinococcus multilocularis bloom syndrome protein 0.0046 0.012 0.0136
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0031 0.0014
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.154 0.5093 0.695
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.2208 0.7315 0.5
Trypanosoma cruzi hexose transporter 0.0066 0.0186 0.0165
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0067 0.0046
Trypanosoma brucei glucose transporter, putative 0.0066 0.0186 0.0165
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Onchocerca volvulus 0.003 0.0067 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0067 0.0024
Onchocerca volvulus 0.003 0.0067 0.5
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0067 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0136 0.0157
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.0671 0.0892
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.2208 0.7315 1
Trypanosoma brucei sugar transporter, putative 0.003 0.0067 0.0046
Trypanosoma cruzi sugar transporter, putative 0.003 0.0067 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0067 0.0063
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0067 0.0091
Schistosoma mansoni sugar transporter 0.003 0.0067 0.0063
Trypanosoma cruzi hexose transporter, putative 0.003 0.0067 0.0046
Entamoeba histolytica hypothetical protein 0.0036 0.0089 0.0122
Trypanosoma brucei glucose transporter, putative 0.0066 0.0186 0.0165
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0021 0.0029
Plasmodium vivax hexose transporter 0.0211 0.0671 0.0892
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0067 0.0063
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.0671 0.0892
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0122 0.0207
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.2208 0.7315 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0186 0.0165
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0067 0.0063
Brugia malayi hypothetical protein 0.003 0.0067 0.0063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.2208 0.7315 0.7309
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.2208 0.7315 1
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0186 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0122 0.0138
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0067 0.0063
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 0.7309
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0031 0.0014
Trichomonas vaginalis sugar transporter, putative 0.003 0.0067 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0049 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0181 0.0219
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Brugia malayi major facilitator superfamily protein 0.003 0.0067 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.0671 0.0856
Trypanosoma brucei glucose transporter, putative 0.0066 0.0186 0.0165
Leishmania major glucose transporter, lmgt1 0.0066 0.0186 0.0165
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.2208 0.7315 1
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0186 0.0165
Loa Loa (eye worm) hypothetical protein 0.003 0.0067 0.0094
Onchocerca volvulus 0.003 0.0067 0.5

Activities

Activity type Activity value Assay description Source Reference
Delta BG (functional) = -22 % Maximum % decrease of blood glucose (deltaBG) was observed within 4 hour after administration orally at 1 mg/kg dose to fasted adult female rats versus a control group ChEMBL. 9857091

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.