Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.3233 | 0.3607 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.528 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.528 | 1 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.3233 | 0.3607 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.3224 | 0.3579 | 0.2235 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.3224 | 0.3579 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.528 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.528 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.528 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.2632 | 0.1731 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.528 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.528 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3281 | 0.3759 | 0.2452 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.2078 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.528 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.528 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.528 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.3224 | 0.3579 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.2632 | 0.1731 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3233 | 0.3607 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.528 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9.6 nM | In vitro binding affinity towards serotonin transporter in rat cerebral cortical homogenates by [3H]-paroxetine displacement. | ChEMBL. | 8558525 |
Ki (binding) | = 9.6 nM | In vitro binding affinity towards serotonin transporter in rat cerebral cortical homogenates by [3H]-paroxetine displacement. | ChEMBL. | 8558525 |
Ki (binding) | = 15.1 nM | In vitro binding affinity towards dopamine transporter in rat striatal membranes by [3H]-GBR-12,395 displacement. | ChEMBL. | 8558525 |
Ki (binding) | = 15.1 nM | In vitro binding affinity towards dopamine transporter in rat striatal membranes by [3H]-GBR-12,395 displacement. | ChEMBL. | 8558525 |
Ki (binding) | > 5000 nM | In vitro binding affinity towards Norepinephrine transporter rat cerebral cortical homogenates by [3H]-nisoxetine displacement. | ChEMBL. | 8558525 |
Ki (binding) | > 5000 nM | In vitro binding affinity towards Norepinephrine transporter rat cerebral cortical homogenates by [3H]-nisoxetine displacement. | ChEMBL. | 8558525 |
Selectivity (binding) | = 0.636 | Selectivity for Dopamine and Serotonin transporters | ChEMBL. | 8558525 |
Selectivity (binding) | > 330 | Selectivity for Dopamine and Norepinephrine transporters | ChEMBL. | 8558525 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.