Detailed information for compound 27709

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 286.364 | Formula: C15H26O5
  • H donors: 1 H acceptors: 1 LogP: 2.14 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[C@@H]1CCC[C@H]2[C@]31OO[C@@](O[C@@H]3OC)([C@@H](C2)C)C
  • InChi: 1S/C15H26O5/c1-10-9-12-6-4-5-11(7-8-16)15(12)13(17-3)18-14(10,2)19-20-15/h10-13,16H,4-9H2,1-3H3/t10-,11+,12-,13+,14-,15+/m1/s1
  • InChiKey: BZBGKPOOTLXLKR-DXUDUQDWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi orphan nuclear receptor NR2E1 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0323186 0.0305705 0.0305705
Trichomonas vaginalis glucosylceramidase, putative 0.156217 0.231826 0.556113
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0280931 0.0237068 0.0263334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0323186 0.0305705 0.0305705
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.270134 0.416868 0.416868
Brugia malayi Glycosyl hydrolases family 31 protein 0.15133 0.223887 0.223887
Trichomonas vaginalis glucosylceramidase, putative 0.196973 0.298028 0.714921
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Trypanosoma cruzi hypothetical protein, conserved 0.15133 0.223887 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0323186 0.0305705 0.0305705
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0308811 0.0282355 0.0677325
Trichomonas vaginalis glucosylceramidase, putative 0.156217 0.231826 0.556113
Trichomonas vaginalis glucosylceramidase, putative 0.270134 0.416868 1
Echinococcus granulosus neutral alpha glucosidase AB 0.15133 0.223887 0.223639
Schistosoma mansoni nuclear hormone receptor 0.0152452 0.00283712 0.00315146
Loa Loa (eye worm) hypothetical protein 0.0208685 0.0119715 0.0119715
Echinococcus granulosus adam 17 protease 0.0351711 0.0352039 0.0348955
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0152452 0.00283712 0.00251833
Brugia malayi Matrixin family protein 0.0208685 0.0119715 0.0119715
Schistosoma mansoni alpha-glucosidase 0.567722 0.900257 1
Trichomonas vaginalis alpha-glucosidase, putative 0.15133 0.223887 0.537069
Trypanosoma cruzi hypothetical protein, conserved 0.15133 0.223887 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.15133 0.223887 0.223887
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0664275 0.0859754 0.265074
Loa Loa (eye worm) hypothetical protein 0.0170734 0.00580684 0.00580684
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0280931 0.0237068 0.0263334
Brugia malayi steroid hormone receptor 0.22713 0.347014 0.347014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0170734 0.00580684 0.005489
Schistosoma mansoni pyruvate dehydrogenase 0.0913046 0.126385 0.140387
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0152452 0.00283712 0.00251833
Echinococcus multilocularis ceramide glucosyltransferase 0.23883 0.366019 0.365816
Echinococcus granulosus ecdysone induced protein 78C 0.0323186 0.0305705 0.0302605
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0280931 0.0237068 0.0233947
Schistosoma mansoni pyruvate dehydrogenase 0.0964952 0.134816 0.149753
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0323186 0.0305705 0.0302605
Brugia malayi manba-prov protein 0.0221626 0.0140735 0.0140735
Brugia malayi Glycosyl hydrolases family 31 protein 0.629127 1 1
Mycobacterium ulcerans alpha-L-fucosidase 0.208509 0.316767 0.736085
Onchocerca volvulus Glucosylceramidase homolog 0.156217 0.231826 0.394354
Trypanosoma brucei Peptide deformylase 2 0.104612 0.148 0.595603
Echinococcus granulosus lysosomal alpha glucosidase 0.629127 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.210056 0.31928 0.319063
Trichomonas vaginalis glucosylceramidase, putative 0.270134 0.416868 1
Trichomonas vaginalis glucosylceramidase, putative 0.156217 0.231826 0.556113
Loa Loa (eye worm) hypothetical protein 0.0323186 0.0305705 0.0305705
Schistosoma mansoni ceramide glucosyltransferase 0.23883 0.366019 0.406571
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0313592 0.029012 0.0322263
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0136953 0.000319596 0.000319596
Brugia malayi nuclear hormone receptor family member odr-7 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) hypothetical protein 0.0170734 0.00580684 0.00580684
Onchocerca volvulus 0.37272 0.583504 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.629127 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.629127 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.15133 0.223887 0.537069
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0152452 0.00283712 0.00315146
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0323186 0.0305705 0.0305705
Plasmodium vivax peptide deformylase, putative 0.274155 0.423399 0.5
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) nuclear hormone receptor 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) matrixin family protein 0.0462853 0.0532574 0.0532574
Brugia malayi Matrixin family protein 0.0208685 0.0119715 0.0119715
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.017263 0.0061147 0.00679217
Schistosoma mansoni pyruvate dehydrogenase 0.0913046 0.126385 0.140387
Plasmodium falciparum peptide deformylase 0.274155 0.423399 0.5
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0176597 0.00675913 0.00675913
Echinococcus multilocularis thyroid hormone receptor alpha 0.0323186 0.0305705 0.0302605
Brugia malayi Nuclear hormone receptor-like 1 0.0170734 0.00580684 0.00580684
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0323186 0.0305705 0.0305705
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0214758 0.0129579 0.0126423
Trichomonas vaginalis alpha-glucosidase, putative 0.0664275 0.0859754 0.206241
Brugia malayi Nuclear hormone receptor-like 1 0.0323186 0.0305705 0.0305705
Trichomonas vaginalis conserved hypothetical protein 0.0556428 0.0684573 0.164218
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Brugia malayi Hemopexin family protein 0.0295897 0.0261378 0.0261378
Loa Loa (eye worm) nuclear receptor NHR-67 0.0152452 0.00283712 0.00283712
Trichomonas vaginalis beta-mannosidase, putative 0.0158205 0.00377164 0.00904756
Schistosoma mansoni nuclear receptor nhr-48 0.0152452 0.00283712 0.00315146
Echinococcus granulosus nuclear receptor nhr 48 0.0152452 0.00283712 0.00251833
Loa Loa (eye worm) hypothetical protein 0.0170734 0.00580684 0.00580684
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.127832 0.185718 0.804914
Schistosoma mansoni alpha-l-fucosidase 0.0998308 0.140234 0.155771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0323186 0.0305705 0.0305705
Loa Loa (eye worm) hypothetical protein 0.0208685 0.0119715 0.0119715
Brugia malayi nuclear receptor NHR-88 0.0323186 0.0305705 0.0305705
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0170734 0.00580684 0.00580684
Loa Loa (eye worm) ceramide glucosyltransferase 0.23883 0.366019 0.366019
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.075875 0.101322 0.101034
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0664275 0.0859754 0.206241
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0323186 0.0305705 0.0302605
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0308811 0.0282355 0.0677325
Trichomonas vaginalis alpha-glucosidase, putative 0.15133 0.223887 0.537069
Trypanosoma cruzi Peptide deformylase 2, putative 0.104612 0.148 0.595603
Trichomonas vaginalis sucrase-isomaltase, putative 0.127832 0.185718 0.445508
Schistosoma mansoni ceramide glucosyltransferase 0.23883 0.366019 0.406571
Brugia malayi photoreceptor-specific nuclear receptor 0.0323186 0.0305705 0.0305705
Loa Loa (eye worm) hypothetical protein 0.0323186 0.0305705 0.0305705
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.104612 0.148 0.595603
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0964952 0.134816 0.13454
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0214758 0.0129579 0.0126423
Brugia malayi Matrixin family protein 0.0504582 0.0600357 0.0600357
Echinococcus multilocularis adam 17 protease 0.0313592 0.029012 0.0287015
Echinococcus multilocularis nuclear receptor nhr 48 0.0152452 0.00283712 0.00251833
Giardia lamblia Ceramide glucosyltransferase 0.108677 0.154604 1
Trypanosoma brucei Polypeptide deformylase 1 0.104612 0.148 0.595603
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0176597 0.00675913 0.00675913
Loa Loa (eye worm) hypothetical protein 0.0964952 0.134816 0.134816
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0170734 0.00580684 0.0064502
Onchocerca volvulus Matrilysin homolog 0.0208685 0.0119715 0.0157307
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0323186 0.0305705 0.0339575
Brugia malayi Nuclear hormone receptor E75 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0323186 0.0305705 0.0305705
Schistosoma mansoni coup transcription factor 0.0323186 0.0305705 0.0339575
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0323186 0.0305705 0.0305705
Loa Loa (eye worm) DR-78 0.0152452 0.00283712 0.00283712
Onchocerca volvulus 0.147193 0.217167 0.36911
Echinococcus granulosus fucosidase alpha L 1 tissue 0.208509 0.316767 0.316549
Loa Loa (eye worm) alpha-L-fucosidase 0.0998308 0.140234 0.140234
Brugia malayi nuclear receptor RXR 0.0170734 0.00580684 0.00580684
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0323186 0.0305705 0.0302605
Entamoeba histolytica beta-galactosidase, putative 0.0334802 0.0324573 0.021578
Echinococcus multilocularis bile acid beta glucosidase 0.14914 0.22033 0.22008
Onchocerca volvulus Bile acid receptor homolog 0.0466167 0.0537957 0.0877587
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0136953 0.000319596 0.000355006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0323186 0.0305705 0.0302605
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0323186 0.0305705 0.0305705
Schistosoma mansoni zinc finger protein 0.0152452 0.00283712 0.00315146
Schistosoma mansoni hypothetical protein 0.0402301 0.0434215 0.0482324
Mycobacterium ulcerans peptide deformylase 0.274155 0.423399 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0254168 0.0193595 0.0193595
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.15133 0.223887 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0323186 0.0305705 0.0305705
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0280931 0.0237068 0.0263334
Chlamydia trachomatis peptide deformylase 0.274155 0.423399 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0323186 0.0305705 0.0302605
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0308811 0.0282355 0.0113305
Schistosoma mansoni alpha-glucosidase 0.567722 0.900257 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.15133 0.223887 0.537069
Schistosoma mansoni bile acid beta-glucosidase-related 0.14914 0.22033 0.244741
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) matrix metalloproteinase 0.0208685 0.0119715 0.0119715
Onchocerca volvulus 0.0208685 0.0119715 0.0157307
Loa Loa (eye worm) steroid hormone receptor 0.22713 0.347014 0.347014
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0358048 0.0362332 0.0313402
Schistosoma mansoni beta-mannosidase 0.0158205 0.00377164 0.00418951
Schistosoma mansoni hypothetical protein 0.07424 0.0986657 0.109597
Schistosoma mansoni nuclear receptor 0.0152452 0.00283712 0.00315146
Loa Loa (eye worm) hypothetical protein 0.0169055 0.00553402 0.00553402
Trichomonas vaginalis glucosylceramidase, putative 0.196973 0.298028 0.714921
Loa Loa (eye worm) hypothetical protein 0.090091 0.124413 0.124413
Trichomonas vaginalis glycoside hydrolase, putative 0.112223 0.160364 0.384687
Brugia malayi nuclear hormone receptor family member nhr-6 0.0152452 0.00283712 0.00283712
Brugia malayi Alpha-L-fucosidase family protein 0.0998308 0.140234 0.140234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0323186 0.0305705 0.0305705
Echinococcus granulosus bile acid beta glucosidase 0.14914 0.22033 0.22008
Trichomonas vaginalis glucosylceramidase, putative 0.270134 0.416868 1
Trichomonas vaginalis glucosylceramidase, putative 0.156217 0.231826 0.556113
Brugia malayi Beta-glucuronidase precursor 0.0221626 0.0140735 0.0140735
Schistosoma mansoni nuclear hormone receptor 0.0152452 0.00283712 0.00315146
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0280931 0.0237068 0.0233947
Echinococcus granulosus Nuclear hormone receptor HR96 0.0152452 0.00283712 0.00251833
Trichomonas vaginalis glucosylceramidase, putative 0.270134 0.416868 1
Brugia malayi nuclear receptor NHR-67 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) hypothetical protein 0.0170734 0.00580684 0.00580684
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0323186 0.0305705 0.0302605
Echinococcus multilocularis lysosomal alpha glucosidase 0.629127 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0323186 0.0305705 0.0305705
Schistosoma mansoni retinoic acid receptor RXR 0.0323186 0.0305705 0.0339575
Brugia malayi hypothetical protein 0.0152452 0.00283712 0.00283712
Schistosoma mansoni nuclear receptor 0.0152452 0.00283712 0.00315146
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0409954 0.0446647 0.052435
Loa Loa (eye worm) matrixin family protein 0.0504582 0.0600357 0.0600357
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0308811 0.0282355 0.0282355
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0152452 0.00283712 0.00251833
Trichomonas vaginalis maltase-glucoamylase, putative 0.15133 0.223887 0.537069
Loa Loa (eye worm) hypothetical protein 0.0254168 0.0193595 0.0193595
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0323186 0.0305705 0.0302605
Loa Loa (eye worm) hypothetical protein 0.0466167 0.0537957 0.0537957
Brugia malayi Matrixin family protein 0.0208685 0.0119715 0.0119715
Echinococcus granulosus non lysosomal glucosylceramidase 0.14914 0.22033 0.22008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.138966 0.203803 0.203803
Brugia malayi Matrixin family protein 0.0208685 0.0119715 0.0119715
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0664275 0.0859754 0.295116
Loa Loa (eye worm) hypothetical protein 0.0323186 0.0305705 0.0305705
Echinococcus granulosus Nuclear hormone receptor HR96 0.0152452 0.00283712 0.00251833
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0664275 0.0859754 0.143177
Trypanosoma brucei glycosyl hydrolase-like protein 0.0664275 0.0859754 0.265074
Leishmania major polypeptide deformylase-like protein, putative 0.104612 0.148 0.595603
Trichomonas vaginalis alpha-glucosidase, putative 0.0664275 0.0859754 0.206241
Schistosoma mansoni hypothetical protein 0.0223061 0.0143066 0.0158917
Trichomonas vaginalis set domain proteins, putative 0.147193 0.217167 0.520949
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Schistosoma mansoni steroid hormone receptor ad4bp 0.0323186 0.0305705 0.0339575
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Trichomonas vaginalis glucosylceramidase, putative 0.156217 0.231826 0.556113
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0323186 0.0305705 0.0339575
Brugia malayi kinase, mitochondrial precursor 0.0964952 0.134816 0.134816
Trypanosoma brucei glucosidase, putative 0.15133 0.223887 1
Loa Loa (eye worm) hypothetical protein 0.100575 0.141444 0.141444
Brugia malayi hypothetical protein 0.0170734 0.00580684 0.00580684
Echinococcus multilocularis neutral alpha glucosidase AB 0.15133 0.223887 0.223639
Loa Loa (eye worm) hypothetical protein 0.0323186 0.0305705 0.0305705
Trypanosoma cruzi Peptide deformylase 2, putative 0.104612 0.148 0.595603
Loa Loa (eye worm) hypothetical protein 0.0664275 0.0859754 0.0859754
Loa Loa (eye worm) hypothetical protein 0.0323186 0.0305705 0.0305705
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0152452 0.00283712 0.00251833
Brugia malayi nuclear receptor RXR 0.0152452 0.00283712 0.00283712
Echinococcus granulosus glycogen debranching enzyme 0.0308811 0.0282355 0.0279248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0323186 0.0305705 0.0305705
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0152452 0.00283712 0.00251833
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0280931 0.0237068 0.0233947
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0152452 0.00283712 0.00251833
Brugia malayi nuclear hormone receptor 0.0152452 0.00283712 0.00283712
Trichomonas vaginalis alpha-glucosidase, putative 0.0664275 0.0859754 0.206241
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0964952 0.134816 0.13454
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0152452 0.00283712 0.00315146
Loa Loa (eye worm) hypothetical protein 0.0308811 0.0282355 0.0282355
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.15133 0.223887 0.537069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0323186 0.0305705 0.0305705
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0323186 0.0305705 0.0305705
Schistosoma mansoni thyroid hormone receptor 0.0323186 0.0305705 0.0339575
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.270134 0.416868 0.416868
Schistosoma mansoni thyroid hormone receptor 0.0323186 0.0305705 0.0339575
Echinococcus multilocularis glycogen debranching enzyme 0.0308811 0.0282355 0.0279248
Onchocerca volvulus Protein ultraspiracle homolog 0.0323186 0.0305705 0.0477612
Trichomonas vaginalis alpha-glucosidase, putative 0.15133 0.223887 0.537069
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0150669 0.00254751 0.00254751
Onchocerca volvulus Matrix metalloproteinase homolog 0.0462853 0.0532574 0.0868317
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0152452 0.00283712 0.00283712
Trichomonas vaginalis glucosylceramidase, putative 0.270134 0.416868 1
Trichomonas vaginalis glucosylceramidase, putative 0.270134 0.416868 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0401168 0.0432376 0.10372
Schistosoma mansoni RAR-like nuclear receptor 0.0323186 0.0305705 0.0339575
Treponema pallidum polypeptide deformylase (def) 0.274155 0.423399 0.5
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0208685 0.0119715 0.0132978
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.274155 0.423399 1
Onchocerca volvulus Matrilysin homolog 0.0462853 0.0532574 0.0868317
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0170734 0.00580684 0.0064502
Loa Loa (eye worm) hypothetical protein 0.0208685 0.0119715 0.0119715
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0323186 0.0305705 0.0305705
Leishmania major glycosyl hydrolase-like protein 0.0664275 0.0859754 0.265074
Echinococcus granulosus FTZ F1 alpha 0.0323186 0.0305705 0.0302605
Echinococcus multilocularis ecdysone induced protein 78C 0.0323186 0.0305705 0.0302605
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0323186 0.0305705 0.0305705
Brugia malayi Nuclear hormone receptor E75 0.0152452 0.00283712 0.00283712
Trichomonas vaginalis beta-galactosidase, putative 0.0556428 0.0684573 0.164218
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.208509 0.316767 0.316549
Brugia malayi Glycosyl hydrolases family 31 protein 0.0664275 0.0859754 0.0859754
Trichomonas vaginalis alpha-glucosidase, putative 0.0664275 0.0859754 0.206241
Brugia malayi tailless protein 0.0152452 0.00283712 0.00283712
Loa Loa (eye worm) hypothetical protein 0.0323186 0.0305705 0.0305705
Trichomonas vaginalis glucosylceramidase, putative 0.156217 0.231826 0.556113
Brugia malayi Steroid receptor seven-up type 2 0.0323186 0.0305705 0.0305705
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.274155 0.423399 1
Brugia malayi ecdysteroid receptor 0.0466167 0.0537957 0.0537957
Schistosoma mansoni nuclear hormone receptor 0.0323186 0.0305705 0.0339575
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Toxoplasma gondii hypothetical protein 0.274155 0.423399 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0964952 0.134816 0.13454
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Brugia malayi Ceramide glucosyltransferase 0.23883 0.366019 0.366019
Trypanosoma brucei developmentally regulated phosphoprotein 0.0964952 0.134816 0.525345
Brugia malayi ecdysone receptor 0.0152452 0.00283712 0.00283712
Echinococcus granulosus ceramide glucosyltransferase 0.23883 0.366019 0.365816
Trichomonas vaginalis maltase-glucoamylase, putative 0.0664275 0.0859754 0.206241
Leishmania major alpha glucosidase II subunit, putative 0.15133 0.223887 1
Brugia malayi Nuclear hormone receptor-like 1 0.0170734 0.00580684 0.00580684
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0323186 0.0305705 0.0302605
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0323186 0.0305705 0.0339575
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.274155 0.423399 0.5
Loa Loa (eye worm) hypothetical protein 0.0152452 0.00283712 0.00283712
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0664275 0.0859754 0.265074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0323186 0.0305705 0.0477612
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0323186 0.0305705 0.0339575
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0323186 0.0305705 0.0339575
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0323186 0.0305705 0.0302605
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0152452 0.00283712 0.00251833
Brugia malayi nuclear receptor NHR-88 0.0152452 0.00283712 0.00283712
Trichomonas vaginalis alpha-glucosidase, putative 0.15133 0.223887 0.537069
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0170734 0.00580684 0.005489
Onchocerca volvulus 0.0323186 0.0305705 0.0477612
Trichomonas vaginalis conserved hypothetical protein 0.0158143 0.00376149 0.00902323
Brugia malayi nuclear hormone receptor 0.0323186 0.0305705 0.0305705
Schistosoma mansoni hypothetical protein 0.0295897 0.0261378 0.0290336
Loa Loa (eye worm) hypothetical protein 0.0170734 0.00580684 0.00580684
Brugia malayi Pre-SET motif family protein 0.138966 0.203803 0.203803
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.075875 0.101322 0.101034
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0401168 0.0432376 0.10372
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0323186 0.0305705 0.0302605
Brugia malayi hypothetical protein 0.0170734 0.00580684 0.00580684
Schistosoma mansoni bile acid beta-glucosidase-related 0.14914 0.22033 0.244741
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.15133 0.223887 0.500836
Trichomonas vaginalis alpha-glucosidase, putative 0.0664275 0.0859754 0.206241
Brugia malayi conserved hypotetical protein 0.0152452 0.00283712 0.00283712
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0323186 0.0305705 0.0302605
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.23883 0.366019 0.625456
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0323186 0.0305705 0.0305705
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0664275 0.0859754 0.206241
Schistosoma mansoni alpha glucosidase 0.15133 0.223887 0.248692
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0323186 0.0305705 0.0302605
Loa Loa (eye worm) beta-glucuronidase 0.0221626 0.0140735 0.0140735
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0964952 0.134816 0.525345
Leishmania major developmentally regulated phosphoprotein-like protein 0.0964952 0.134816 0.525345
Brugia malayi hypothetical protein 0.0152452 0.00283712 0.00283712
Trichomonas vaginalis glucosylceramidase, putative 0.156217 0.231826 0.556113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0323186 0.0305705 0.0339575
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0323186 0.0305705 0.0302605
Loa Loa (eye worm) hypothetical protein 0.0323186 0.0305705 0.0305705
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.104612 0.148 0.595603
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0280931 0.0237068 0.0263334
Onchocerca volvulus 0.0295897 0.0261378 0.0401274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0323186 0.0305705 0.0302605
Echinococcus multilocularis non lysosomal glucosylceramidase 0.14914 0.22033 0.22008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0323186 0.0305705 0.0305705
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0323186 0.0305705 0.0305705

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.2 ng ml-1 In vitro inhibitory activity of the compoound against Chloroquine-sensitive P. falciparum (NF54), determined by measuring the incorporation of [3H]-hypoxanthine. ChEMBL. 7608890
IC50 (functional) = 2.2 ng ml-1 In vitro inhibitory activity of the compoound against Chloroquine-sensitive P. falciparum (NF54), determined by measuring the incorporation of [3H]-hypoxanthine. ChEMBL. 7608890
IC50 (functional) > 500 ng ml-1 In vitro antimalarial activity against W-2 Indochina clone of Plasmodium falciparum ChEMBL. 8176702
IC50 (functional) > 500 ng ml-1 In vitro antimalarial activity against D-6 African clone of Plasmodium falciparum ChEMBL. 8176702
IC50 (functional) > 500 ng ml-1 In vitro antimalarial activity against W-2 Indochina clone of Plasmodium falciparum ChEMBL. 8176702
IC50 (functional) > 500 ng ml-1 In vitro antimalarial activity against D-6 African clone of Plasmodium falciparum ChEMBL. 8176702
Log RA (functional) = -1.8 Antimalarial activity of the compound was determined against chloroquine-resistant, mefloquine-sensitive Plasmodium falciparum W-2 clone ChEMBL. 11784134

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 7608890

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.