Detailed information for compound 28879

Basic information

Technical information
  • TDR Targets ID: 28879
  • Name: 3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methy l]-6-hydroxy-2-methoxybenzamide
  • MW: 306.4 | Formula: C17H26N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.12 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCC[C@H]1CNC(=O)c1c(O)ccc(c1OC)CC
  • InChi: 1S/C17H26N2O3/c1-4-12-8-9-14(20)15(16(12)22-3)17(21)18-11-13-7-6-10-19(13)5-2/h8-9,13,20H,4-7,10-11H2,1-3H3,(H,18,21)/t13-/m0/s1
  • InChiKey: OQXGPPSRXAKOOA-ZDUSSCGKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-6-hydroxy-2-methoxy-benzamide
  • 3-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-6-hydroxy-2-methoxybenzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D2 receptor   444 aa 440 aa 30.0 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Loa Loa (eye worm) hypothetical protein Dopamine D2 receptor   444 aa 433 aa 21.2 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D2 receptor   444 aa 432 aa 30.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0043 0.0031
Brugia malayi Thioredoxin reductase 0.0047 0.0088 0.0088
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0029 0.0027
Schistosoma mansoni glutamate receptor NMDA 0.0034 0.0055 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0119 0.0119
Echinococcus multilocularis glutamate receptor 2 0.0021 0.0024 0.0022
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0022 0.0018
Schistosoma mansoni survival motor neuron protein 0.0047 0.0089 0.0089
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.0055 0.0053
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0029 0.0027
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0018 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0012 0.0015
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni hypothetical protein 0.0335 0.0806 0.0806
Onchocerca volvulus 0.0023 0.0029 0.0008
Brugia malayi Glutamate receptor 2 precursor 0.0034 0.0055 0.0055
Loa Loa (eye worm) solute carrier family 6 member 4 0.0059 0.0117 0.0105
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0029 0.0029
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0022 0.0158
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0029 0.0017
Schistosoma mansoni ap endonuclease 0.0037 0.0063 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0018 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0696 0.6028
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0023 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0029 0.0029
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0548 0.0546
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0696 0.6028
Onchocerca volvulus 0.0023 0.0029 0.0008
Brugia malayi Abnormal catecholamine distribution protein 1 0.0187 0.0438 0.0438
Schistosoma mansoni neuropeptide receptor 0.0023 0.0029 0.0029
Onchocerca volvulus 0.0023 0.0029 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.012 0.0108
Echinococcus multilocularis vesicular acetylcholine transporter 0.4019 1 1
Schistosoma mansoni hypothetical protein 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0029 0.0027
Schistosoma mansoni opsin-like receptor 0.0023 0.0029 0.0029
Onchocerca volvulus 0.0023 0.0029 0.0008
Schistosoma mansoni biogenic amine receptor 0.0023 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0119 0.0119
Echinococcus granulosus sex peptide receptor 0.0023 0.0029 0.0027
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.002 0.0022 0.0022
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0029 0.0027
Brugia malayi Dopamine receptor 0.0023 0.0029 0.0029
Schistosoma mansoni amine GPCR 0.0023 0.0029 0.0029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0018 0.0016
Treponema pallidum sodium- and chloride- dependent transporter 0.0059 0.0117 0.1544
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0029 0.0029
Brugia malayi Dopamine receptor protein 1 0.0023 0.0029 0.0029
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.0055 0.0053
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0029 0.0027
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0029 0.0027
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0269 0.4096
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0063 0.0457
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0029 0.0027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0063 0.0096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0063 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.002 0.0022 1
Schistosoma mansoni histamine h1 receptor 0.0023 0.0029 0.0029
Brugia malayi putative neuropeptide receptor 0.0023 0.0029 0.0029
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0055 0.0053
Schistosoma mansoni hypothetical protein 0.0023 0.0029 0.0029
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0034 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni amine GPCR 0.0023 0.0029 0.0029
Leishmania major UDP-galactopyranose mutase 0.002 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) serotonin transporter b 0.0059 0.0117 0.0105
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0034 0.0055 0.0053
Schistosoma mansoni opsin-like receptor 0.0023 0.0029 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0018 0.0102
Brugia malayi SWIRM domain containing protein 0.002 0.0022 0.0022
Onchocerca volvulus 0.0023 0.0029 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Giardia lamblia PHD finger protein 15 0.0029 0.0043 0.0462
Brugia malayi ORL1-like opioid receptor 0.0023 0.0029 0.0029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0029 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Echinococcus granulosus orexin receptor type 2 0.0023 0.0029 0.0027
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0548 0.0546
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0058 0.0058
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0231 0.0548 0.0537
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni myosin xvIII 0.0023 0.0029 0.0029
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0239 0.3619
Leishmania major trypanothione reductase 0.0047 0.0088 0.0142
Schistosoma mansoni biogenic amine receptor 0.0023 0.0029 0.0029
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.0696 1
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0029 0.0027
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0029 0.0027
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0029 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0063 0.0758
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.1005 0.0993
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0018 0.0027
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0029 0.0017
Schistosoma mansoni adenoreceptor 0.0023 0.0029 0.0029
Echinococcus granulosus g protein coupled receptor 0.0023 0.0029 0.0027
Echinococcus multilocularis serotonin transporter 0.0059 0.0117 0.0115
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0029 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Onchocerca volvulus 0.0023 0.0029 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0063 0.5075
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0029 0.0029
Schistosoma mansoni neuropeptide receptor 0.0023 0.0029 0.0029
Brugia malayi Dopamine receptor protein 2 0.0023 0.0029 0.0029
Echinococcus granulosus serotonin receptor 0.0023 0.0029 0.0027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0591 0.0579
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0119 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Brugia malayi G protein-coupled receptor 0.0023 0.0029 0.0029
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0034 0.0055 0.0053
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.4019 1 1
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.002 0.0022 0.1295
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0029 0.0027
Echinococcus granulosus peregrin 0.0029 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0059 0.0117 0.0105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.0158
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0029 0.0017
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0029 0.0027
Brugia malayi neuropeptide F receptor 0.0023 0.0029 0.0029
Mycobacterium ulcerans protoporphyrinogen oxidase 0.002 0.0022 0.0147
Schistosoma mansoni hypothetical protein 0.0023 0.0029 0.0029
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0012 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0055 0.0055
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0029 0.0029
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0029 0.0027
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0029 0.0027
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0269 0.4096
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0029 0.0029
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0029 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0029 0.0027
Toxoplasma gondii exonuclease III APE 0.0037 0.0063 0.5094
Schistosoma mansoni hypothetical protein 0.0029 0.0043 0.0043
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Plasmodium vivax hypothetical protein, conserved 0.002 0.0022 0.1365
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0012 0.0015
Schistosoma mansoni biogenic amine receptor 0.0023 0.0029 0.0029
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0012 0.0015
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0022 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0029 0.0027
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0029 0.0027
Schistosoma mansoni ap endonuclease 0.0037 0.0063 0.0063
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0058 0.0046
Echinococcus granulosus dna polymerase eta 0.0019 0.0018 0.0016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.0055 0.0053
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0029 0.0027
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0029 0.0027
Echinococcus granulosus synaptic vesicular amine transporter 0.0187 0.0438 0.0436
Brugia malayi hypothetical protein 0.002 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0029 0.0017
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0022 0.0018
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0018 0.0018
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0187 0.0438 0.0426
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0063 0.0758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Onchocerca volvulus 0.0023 0.0029 0.0008
Echinococcus granulosus serotonin transporter 0.0059 0.0117 0.0115
Schistosoma mansoni neuropeptide receptor 0.0023 0.0029 0.0029
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.4019 1 1
Echinococcus granulosus neuropeptide receptor 0.0023 0.0029 0.0027
Onchocerca volvulus 0.0471 0.1147 0.1128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Plasmodium falciparum glutathione reductase 0.0047 0.0088 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0159 0.0159
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.0055 0.0053
Echinococcus granulosus glutamate NMDA receptor subunit 0.0034 0.0055 0.0053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0018 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0009
Toxoplasma gondii thioredoxin reductase 0.0047 0.0088 0.7288
Echinococcus granulosus geminin 0.0335 0.0806 0.0804
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0012 0.0485
Onchocerca volvulus 0.0059 0.0117 0.0096
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.0055 0.0053
Plasmodium vivax glutathione reductase, putative 0.0047 0.0088 0.7278
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0063 0.0826
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0029 0.0029
Brugia malayi neuropeptide F receptor 0.0023 0.0029 0.0029
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Mycobacterium tuberculosis Probable reductase 0.0107 0.0239 0.3619
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0029 0.0017
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0029 0.0027
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0029 0.0017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0239 0.3619
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0029 0.0029
Onchocerca volvulus 0.0023 0.0029 0.0008
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0029 0.0027
Echinococcus granulosus glutamate receptor 2 0.0034 0.0055 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0696 0.6028
Brugia malayi jmjC domain containing protein 0.0095 0.0208 0.0208
Onchocerca volvulus 0.0023 0.0029 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0018 0.0018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0696 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0029 0.0029
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0088 0.0076
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0029 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Echinococcus multilocularis 0.002 0.0022 0.002
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0591 0.0591
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0009
Plasmodium falciparum thioredoxin reductase 0.0047 0.0088 1
Loa Loa (eye worm) hypothetical protein 0.2177 0.5403 0.5397
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Leishmania major DNA polymerase kappa, putative 0.0019 0.0018 0.0012
Echinococcus multilocularis synaptic vesicular amine transporter 0.0187 0.0438 0.0436
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0119 0.0119
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0029 0.0029
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0029 0.0027
Trichomonas vaginalis set domain proteins, putative 0.0471 0.1147 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Schistosoma mansoni glutamate receptor NMDA 0.0034 0.0055 0.0055
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0012 0.0012
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0012 0.0012
Brugia malayi GnHR receptor homolog 0.0023 0.0029 0.0029
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0063 0.6758
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0009
Onchocerca volvulus 0.0023 0.0029 0.0008
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0029 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0696 0.6028
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0002
Echinococcus multilocularis dna polymerase eta 0.0019 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0029 0.0027
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Loa Loa (eye worm) RecQ helicase 0.0021 0.0023 0.0011
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0043 0.0043
Echinococcus granulosus g protein coupled receptor 0.0023 0.0029 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0018 0.0094
Schistosoma mansoni amine oxidase 0.002 0.0022 0.0022
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0063 0.0764
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0029 0.0017
Brugia malayi PHD-finger family protein 0.0029 0.0043 0.0043
Onchocerca volvulus 0.0059 0.0119 0.0098
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0029 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0018 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0119 0.0117
Schistosoma mansoni amine GPCR 0.0023 0.0029 0.0029
Schistosoma mansoni vesicular amine transporter 0.0187 0.0438 0.0438
Echinococcus granulosus jumonji domain containing protein 0.004 0.0072 0.007
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Brugia malayi sulfakinin receptor protein 0.0023 0.0029 0.0029
Loa Loa (eye worm) glutathione reductase 0.0047 0.0088 0.0076
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0208 0.0206
Echinococcus granulosus glutamate receptor 2 0.0021 0.0024 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0696 0.6028
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0088 0.0086
Echinococcus granulosus somatostatin receptor 0.0023 0.0029 0.0027
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.0055 0.0053
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0088 0.0086
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0239 0.3619
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0072 0.007
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0023 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0029 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0063 0.067
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0029 0.0027
Plasmodium vivax SET domain protein, putative 0.0059 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0119 0.0107
Onchocerca volvulus 0.0047 0.0089 0.0067
Brugia malayi Bromodomain containing protein 0.0029 0.0043 0.0043
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0029 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0029 0.0027
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0029 0.0029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0058 0.0058
Schistosoma mansoni DNA polymerase eta 0.0019 0.0018 0.0018
Echinococcus granulosus g protein coupled receptor 0.0023 0.0029 0.0027
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0029 0.0029
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0018 0.0006
Loa Loa (eye worm) norepinephrine transporter 0.0059 0.0117 0.0105
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0088 0.7278
Brugia malayi G-protein coupled receptor 0.0023 0.0029 0.0029
Echinococcus granulosus fmrfamide receptor 0.0023 0.0029 0.0027
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Onchocerca volvulus Alhambra homolog 0.0029 0.0043 0.0022
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0018 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0063 0.0063
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0029 0.0029
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0018 0.0102
Toxoplasma gondii histone lysine-specific demethylase 0.002 0.0022 0.1397
Brugia malayi AKH receptor 0.0023 0.0029 0.0029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0063 0.0111
Onchocerca volvulus 0.0023 0.0029 0.0008
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0029 0.0029
Echinococcus granulosus allatostatin A receptor 0.0023 0.0029 0.0027
Mycobacterium ulcerans monoamine oxidase 0.002 0.0022 0.0147
Echinococcus granulosus vesicular acetylcholine transporter 0.4019 1 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.002 0.0022 0.1397
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0029 0.0027
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0043 0.3309
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0029 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0119 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0018 0.0012
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.005 0.0095 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni sodium/chloride dependent transporter 0.0059 0.0117 0.0117
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0022 0.002
Brugia malayi amine oxidase, flavin-containing family protein 0.002 0.0022 0.0022
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0239 0.7158
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0029 0.0027
Brugia malayi RE15519p 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0012 0.052
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0088 0.0142
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0325 0.4621
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0114 0.0112
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0029 0.0027
Brugia malayi Pre-SET motif family protein 0.0414 0.1005 0.1005
Schistosoma mansoni hypothetical protein 0.0335 0.0806 0.0806
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.002 0.0022 0.1365
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0058 0.0057
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0023 0.0029 0.0029
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0043 0.0041
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0239 0.3619
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0006
Brugia malayi Melatonin receptor type 1A 0.0023 0.0029 0.0029
Loa Loa (eye worm) glutamate receptor 1 0.0034 0.0055 0.0042
Plasmodium vivax protoporphyrinogen oxidase, putative 0.002 0.0022 0.1365
Schistosoma mansoni neuropeptide receptor 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus multilocularis somatostatin receptor 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0117 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0009
Brugia malayi Glutamate receptor 1 precursor 0.0034 0.0055 0.0055
Echinococcus granulosus dna polymerase kappa 0.0019 0.0018 0.0016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0528 0.1288 0.1286
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0029 0.0027
Brugia malayi hypothetical protein 0.0231 0.0548 0.0548
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0063 0.0096
Onchocerca volvulus 0.0023 0.0029 0.0008
Mycobacterium ulcerans oxidoreductase 0.002 0.0022 0.0147
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Mycobacterium ulcerans dehydrogenase 0.002 0.0022 0.0147
Loa Loa (eye worm) hypothetical protein 0.0059 0.0117 0.0105
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0043 0.3309
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0012 0.0015
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0029 0.0027
Echinococcus multilocularis serotonin receptor 0.0023 0.0029 0.0027
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.0696 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0325 0.4994
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0063 0.0062
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Loa Loa (eye worm) glutamate receptor 2 0.0034 0.0055 0.0042
Echinococcus granulosus hypothetical protein 0.0023 0.0029 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0696 0.6028
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0018 0.0027
Schistosoma mansoni amine oxidase 0.002 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0119 0.0119
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0029 0.0027
Echinococcus multilocularis protoporphyrinogen oxidase 0.002 0.0022 0.002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0018 0.0016
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0288 0.069 1
Schistosoma mansoni opsin-like receptor 0.0023 0.0029 0.0029
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0063 0.0062
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0018 0.0018
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0029 0.0017
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0018 0.0012
Schistosoma mansoni ATP-binding cassette transporter 0.0034 0.0055 0.0055
Schistosoma mansoni amine GPCR 0.0023 0.0029 0.0029
Leishmania major C-8 sterol isomerase-like protein 0.2177 0.5403 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Onchocerca volvulus 0.0023 0.0029 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0696 0.6028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0269 0.4096
Leishmania major DNA polymerase eta, putative 0.0019 0.0018 0.0012
Plasmodium vivax hypothetical protein, conserved 0.002 0.0022 0.1365
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0023 0.0021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0088 0.1223
Brugia malayi G-protein coupled receptor 0.0023 0.0029 0.0029
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Plasmodium falciparum phd finger protein, putative 0.0029 0.0043 0.4121
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0055 0.0055
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0029 0.0029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0063 0.0096
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0029 0.0029
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0119 0.0117
Echinococcus multilocularis lysine specific histone demethylase 1A 0.002 0.0022 0.002
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0029 0.0027
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0029 0.0027
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0001 0.0001
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0029 0.0029
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0029 0.0027
Schistosoma mansoni hypothetical protein 0.0047 0.0089 0.0089
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0208 0.0206
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0043 0.3284
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0063 0.0051
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0239 0.3619
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0055 0.0055
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0288 0.069 1
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0029 0.0027
Onchocerca volvulus 0.0023 0.0029 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0528 0.1288 0.1286
Brugia malayi glutathione reductase 0.0047 0.0088 0.0088
Giardia lamblia DINP protein human, muc B family 0.0019 0.0018 0.0094
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0012 0.052
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0058 0.0057
Trypanosoma brucei C-8 sterol isomerase, putative 0.2177 0.5403 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus multilocularis serotonin receptor 0.0023 0.0029 0.0027
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0059 0.0117 0.0117
Onchocerca volvulus 0.0023 0.0029 0.0008
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0018 0.0056
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0055 0.0055
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.0696 1
Onchocerca volvulus 0.0023 0.0029 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0029 0.0027
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.1112 0.2747 0.2738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0018 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0268 0.064 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0269 0.8143
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0029 0.0027
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0029 0.0027
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0055 0.0053
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0029 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0018 0.0094
Echinococcus granulosus neuropeptide receptor 0.0023 0.0029 0.0027
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0029 0.0027
Schistosoma mansoni Lysine-specific histone demethylase 1 0.002 0.0022 0.0022
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2177 0.5403 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0029 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.0696 0.6028
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Brugia malayi Serotonin receptor 0.0023 0.0029 0.0029
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0012 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0018 0.0027
Brugia malayi hypothetical protein 0.0023 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0018 0.0016
Brugia malayi ERG2 and Sigma1 receptor like protein 0.2177 0.5403 0.5403
Echinococcus granulosus bloom syndrome protein 0.0021 0.0023 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0029 0.0027
Echinococcus multilocularis geminin 0.0335 0.0806 0.0804
Brugia malayi Serotonin receptor 0.0023 0.0029 0.0029
Trypanosoma brucei unspecified product 0.0019 0.0018 0.0027
Trypanosoma brucei trypanothione reductase 0.0047 0.0088 0.0157
Plasmodium falciparum protoporphyrinogen oxidase 0.002 0.0022 0.1295
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0059 0.0117 0.0117
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Onchocerca volvulus 0.0023 0.0029 0.0008
Echinococcus multilocularis sex peptide receptor 0.0023 0.0029 0.0027
Brugia malayi jmjC domain containing protein 0.0035 0.0058 0.0058
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0043 0.0041
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni amine GPCR 0.0023 0.0029 0.0029
Brugia malayi larval opioid receptor 0.0023 0.0029 0.0029
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0063 0.0457
Echinococcus multilocularis peregrin 0.0029 0.0043 0.0041
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0029 0.0008
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0029 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0029 0.0027
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Schistosoma mansoni vesicular acetylcholine transporter 0.4019 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0017 0.066
Brugia malayi Pre-SET motif family protein 0.0059 0.0119 0.0119
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0023 0.0029 0.0017
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0029 0.0027
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0012 0.0012
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0022 0.1295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0029 0.0029
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0029 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0029 0.0027

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.47 uM kg-1 Compound was evaluated in vivo for antagonist activity against apomorphine induced behavioral syndrome such as Hyperactivity in rat after intraperitoneal administration; activity value ranges from 0.45-0.49 ChEMBL. 4040977
ED50 (functional) = 0.79 uM kg-1 Compound was evaluated in vivo its antagonist activity against apomorphine induced behavioral syndrome such as Stereotypy in rat after intraperitoneal administration; activity value ranges from 0.56-0.95 ChEMBL. 4040977
IC50 (binding) = 0.123 uM In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane ChEMBL. 4040977
IC50 (binding) = 0.123 uM In vitro binding affinity at Dopamine receptor D2 in rat by displacing [3H]- spiperone from rat striatal membrane ChEMBL. 4040977

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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