Detailed information for compound 305810

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.376 | Formula: C16H19Cl2N3O4S2
  • H donors: 3 H acceptors: 4 LogP: 3.52 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CCNS(=O)(=O)NS(=O)(=O)NCCc1ccc(cc1)Cl
  • InChi: 1S/C16H19Cl2N3O4S2/c17-15-5-1-13(2-6-15)9-11-19-26(22,23)21-27(24,25)20-12-10-14-3-7-16(18)8-4-14/h1-8,19-21H,9-12H2
  • InChiKey: SLUOFEUMUOFKIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.1094
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0153
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0073 0.1427
Loa Loa (eye worm) glutaminase 2 0.0279 0.0452 0.886
Echinococcus granulosus cpg binding protein 0.0065 0.0098 0.1447
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0017 0.0246
Brugia malayi MH2 domain containing protein 0.0008 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0025
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.0083
Schistosoma mansoni hypothetical protein 0.0341 0.0555 0.8157
Schistosoma mansoni helicase 0.0069 0.0104 0.1529
Echinococcus granulosus flap endonuclease 1 0.0027 0.0035 0.051
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0017 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0115
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.0024 0.0088
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi MH1 domain containing protein 0.0008 0.0005 0.0006
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0331
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0023 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0005 0.0066
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.003 0.0108
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.0083
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0051 0.0756
Echinococcus granulosus smad 0.0008 0.0005 0.0066
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0343
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0011
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0006 0.0001 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0085
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0001 0.0003
Echinococcus multilocularis smad 0.0008 0.0005 0.0066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0115
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.0083
Trichomonas vaginalis glutaminase, putative 0.0279 0.0452 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0127
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0115
Loa Loa (eye worm) glutaminase 0.0279 0.0452 0.886
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0256
Brugia malayi polybromodomain protein 0.0006 0.0001 0.0002
Brugia malayi MH2 domain containing protein 0.0008 0.0005 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0115
Echinococcus multilocularis polybromo 1 0.0006 0.0001 0.0019
Schistosoma mansoni importin beta-1 0.0029 0.0039 0.0579
Onchocerca volvulus 0.0039 0.0056 0.0055
Echinococcus granulosus BRK domain containing protein 0.0012 0.001 0.0153
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0023 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0154
Echinococcus multilocularis muscleblind protein 0.0152 0.0243 0.3566
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0005 0.0066
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0192 0.3768
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0051 0.0756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0011
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0343
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0023 0.0517
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0096 0.1878
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.0498
Echinococcus granulosus disco interacting protein 2 0.0039 0.0056 0.0819
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0115
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0035 0.051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0115
Plasmodium vivax hypothetical protein, conserved 0.0006 0.0001 0.0002
Echinococcus granulosus dna polymerase eta 0.002 0.0023 0.0343
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1655 0.2725 1
Echinococcus granulosus Chromo domain 0.0012 0.001 0.0153
Trypanosoma brucei telomerase reverse transcriptase 0.1655 0.2725 1
Leishmania major DNA polymerase eta, putative 0.0006 0.0001 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0115
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0115
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0035 0.0127
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0082
Loa Loa (eye worm) hypothetical protein 0.0152 0.0243 0.476
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0051 0.0756
Onchocerca volvulus 0.001 0.0008 0.0007
Brugia malayi MH2 domain containing protein 0.0122 0.0192 0.0264
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.05 0.1834
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0011
Brugia malayi Importin beta-1 subunit 0.0029 0.0039 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.051 1
Echinococcus granulosus geminin 0.0341 0.0555 0.8157
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0066
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0017 0.0328
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0035 0.0127
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0023 0.0086
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0115
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0498
Echinococcus granulosus GPCR family 2 0.0016 0.0017 0.0246
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0079
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.05 0.1832
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0023 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0005 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0001 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0062 0.0226
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0005 0.0066
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0006 0.0001 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.0331
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0078 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.05 0.1832
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0115
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0035 0.0768
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.068 1
Echinococcus multilocularis disco interacting protein 2 0.0039 0.0056 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi RNA, U transporter 1 0.0084 0.0129 0.0178
Echinococcus granulosus importin subunit beta 1 0.0029 0.0039 0.0579
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0232 0.085
Brugia malayi SNF2 family N-terminal domain containing protein 0.0006 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0115
Plasmodium vivax helicase, putative 0.0006 0.0001 0.0002
Echinococcus multilocularis Smad4 0.0008 0.0005 0.0066
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0005 0.0089
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.05 0.1834
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0246
Echinococcus granulosus dna polymerase kappa 0.002 0.0023 0.0343
Brugia malayi Smad1 0.0008 0.0005 0.0006
Echinococcus multilocularis BRK domain 0.0012 0.001 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0001 0.0003
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0115
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0023 0.0343
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0355 0.0577 1
Echinococcus granulosus Smad4 0.0008 0.0005 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0082
Schistosoma mansoni flap endonuclease-1 0.0024 0.003 0.0448
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0064
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0035 0.0681
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0066 0.1294
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0115
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0115
Echinococcus multilocularis dna polymerase kappa 0.002 0.0023 0.0343
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0032
Giardia lamblia DINP protein human, muc B family 0.002 0.0023 0.0082
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0127
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0023 0.0458
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0042
Schistosoma mansoni polybromo-1 0.0006 0.0001 0.0019
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.0024 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0498
Trichomonas vaginalis lymphoid specific helicase, putative 0.0012 0.0011 0.0253
Echinococcus multilocularis Chromo domain 0.0012 0.001 0.0153
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0023 0.0079
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0115
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0008 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0023 0.0079
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0003 0.0042
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0011 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0039 0.0145
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0039 0.0579
Brugia malayi polk-prov protein 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.1427
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0001 0.0003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0023 0.0479
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0232 0.0847
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0011
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0101 0.0158 0.2731
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0115
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0115
Leishmania major DNA polymerase kappa, putative 0.0006 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0153
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0442
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0115
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0066
Giardia lamblia Telomerase catalytic subunit 0.1655 0.2725 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0011
Schistosoma mansoni Smad4 0.0008 0.0005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0021
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0011
Echinococcus granulosus helicase 0.0006 0.0001 0.001
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0458
Loa Loa (eye worm) BRM protein 0.0035 0.0049 0.0968
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0115
Mycobacterium ulcerans hypothetical protein 0.0162 0.0259 0.5726
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Giardia lamblia DNA repair protein RAD52 0.0355 0.0577 0.2114
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0259 1
Echinococcus multilocularis global transcription activator snf2l2 0.0069 0.0104 0.1529
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0039 0.0145
Toxoplasma gondii hypothetical protein 0.005 0.0073 0.0268
Brugia malayi SET domain containing protein 0.0007 0.0002 0.0003
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0232 0.085
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0039 0.0145
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0023 0.021
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0001 0.0003
Trichomonas vaginalis importin beta-1, putative 0.0024 0.003 0.0669
Brugia malayi Flap endonuclease-1 0.0027 0.0035 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.0024 0.0354
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0256
Schistosoma mansoni hypothetical protein 0.0006 0.0001 0.001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0064
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0017 0.0064
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0008 0.0031
Loa Loa (eye worm) Smad1 0.0008 0.0005 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0086
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0115
Schistosoma mansoni hypothetical protein 0.0037 0.0051 0.0756
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0066 0.097
Schistosoma mansoni hypothetical protein 0.0034 0.0047 0.0688
Toxoplasma gondii exonuclease III APE 0.0019 0.0023 0.0083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0093 0.1374
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0066 0.097
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0192 0.3768
Entamoeba histolytica hypothetical protein 0.0037 0.0051 0.0892
Echinococcus granulosus muscleblind protein 0.0152 0.0243 0.3566
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0331
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.001 0.0014
Brugia malayi BRM protein 0.0069 0.0104 0.0143
Echinococcus multilocularis muscleblind protein 1 0.0152 0.0243 0.3566
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0023 0.5
Brugia malayi Disco-interacting protein 2 homolog 0.0039 0.0056 0.0077
Schistosoma mansoni glutaminase 0.0279 0.0452 0.6638
Leishmania major DNA polymerase eta, putative 0.002 0.0023 0.0086
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0115
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0017 0.0246
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0066
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0008 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0073 0.01
Brugia malayi MH1 domain containing protein 0.0008 0.0005 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0066 0.097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0328
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0005 0.0066
Brugia malayi hypothetical protein 0.0037 0.0051 0.0071
Schistosoma mansoni smad 0.0008 0.0005 0.0066
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0017 0.0023
Leishmania major DNA damage repair protein, putative 0.0006 0.0001 0.0003
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0035 0.0602
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0035 0.0124
Echinococcus granulosus polybromo 1 0.0006 0.0001 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0115
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0001 0.0003
Schistosoma mansoni cpg binding protein 0.0065 0.0098 0.1447
Loa Loa (eye worm) BRM protein 0.0044 0.0063 0.1238
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Brugia malayi glutaminase DH11.1 0.0279 0.0452 0.0621
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0083
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0124
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0023 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.0498
Schistosoma mansoni hypothetical protein 0.0314 0.051 0.7492
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0011
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0153
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0115
Plasmodium falciparum Snf2-related CBP activator, putative 0.0006 0.0001 0.0002
Echinococcus granulosus Helicase SANT associated DNA binding 0.0006 0.0001 0.001
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0524
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.0024 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0049
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0154
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0017 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Echinococcus multilocularis helicase 0.0006 0.0001 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0062 0.0226
Brugia malayi Telomerase reverse transcriptase 0.4404 0.7266 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0066 0.097
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0017 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1655 0.2725 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0154
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0152 0.0243 0.476
Brugia malayi Muscleblind-like protein 0.0152 0.0243 0.0334
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0001 0.0003
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.0007
Leishmania major telomerase reverse transcriptase, putative 0.1655 0.2725 1
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0246
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.0024 0.0088
Schistosoma mansoni cpg binding protein 0.0063 0.0096 0.1407
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0085
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.0153
Entamoeba histolytica hypothetical protein 0.0037 0.0051 0.0892
Entamoeba histolytica hypothetical protein 0.0101 0.0158 0.2731
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0062 0.0229
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0918
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0331
Plasmodium vivax importin-beta 2, putative 0.0029 0.0039 0.0145
Loa Loa (eye worm) helicase DNA-binding protein 0.0012 0.001 0.0204
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0023 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Leishmania major importin beta-1 subunit, putative 0.0024 0.003 0.0111
Brugia malayi CXXC zinc finger family protein 0.0063 0.0096 0.0132
Echinococcus multilocularis geminin 0.0341 0.0555 0.8157
Echinococcus multilocularis dna polymerase eta 0.002 0.0023 0.0343
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0017 0.0064
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.0024 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0773
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0073 0.01
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0017 0.0342
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0256
Brugia malayi isocitrate dehydrogenase 0.0016 0.0017 0.0024
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0154
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0669
Plasmodium falciparum importin beta, putative 0.0029 0.0039 0.0145
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0001 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0066 0.0091
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0042
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.001 0.0153
Toxoplasma gondii hypothetical protein 0.0086 0.0133 0.049
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0023 0.0086
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0039 0.0056 0.0819
Echinococcus granulosus dnaJ subfamily B 0.0417 0.068 1
Trypanosoma brucei unspecified product 0.002 0.0023 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus granulosus snurportin 1 0.0314 0.051 0.7492
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0017 0.0256
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0062 0.0226
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0001 0.0013
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.0024 0.0354
Mycobacterium ulcerans glutaminase 0.0279 0.0452 1
Entamoeba histolytica hypothetical protein 0.0037 0.0051 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0011
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0113
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0064
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0115
Echinococcus granulosus global transcription activator snf2l2 0.0069 0.0104 0.1529
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0003 0.0042
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0047 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0066 0.097
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0115
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0005 0.0089
Plasmodium vivax telomerase reverse transcriptase, putative 0.1655 0.2725 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0085 0.0314
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0115
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0153
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0017 0.0061
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0003 0.0042
Leishmania major DNA polymerase kappa, putative 0.002 0.0023 0.0086
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0017 0.0256
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0001 0.0003
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.0024 0.0418
Schistosoma mansoni hypothetical protein 0.0341 0.0555 0.8157
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0031
Schistosoma mansoni hypothetical protein 0.0014 0.0013 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0066 0.097
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0001 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0066 0.097
Trichomonas vaginalis helicase, putative 0.0007 0.0002 0.0039
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.0024 0.0088
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0086 0.0133 0.049
Schistosoma mansoni DNA polymerase eta 0.002 0.0023 0.0343
Toxoplasma gondii RNA-directed DNA polymerase 0.1655 0.2725 1
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0037 0.0051 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0154
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0023 0.0244
Schistosoma mansoni cpg binding protein 0.0065 0.0098 0.1447
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0017 0.0246
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0006 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0023 0.0244
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0017 0.0246
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0011
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0023 0.0405
Schistosoma mansoni hypothetical protein 0.0417 0.068 1
Leishmania major modification methylase-like protein 0.002 0.0024 0.0088
Echinococcus multilocularis GPCR, family 2 0.0016 0.0017 0.0246
Plasmodium falciparum flap endonuclease 1 0.0027 0.0035 0.0127
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0154
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0246
Echinococcus multilocularis snurportin 1 0.0314 0.051 0.7492
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0082
Onchocerca volvulus 0.0063 0.0096 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Echinococcus multilocularis cpg binding protein 0.0065 0.0098 0.1447
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0669
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0086
Plasmodium falciparum telomerase reverse transcriptase 0.1655 0.2725 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 62 % Percent inhibition of slow reacting substance of anaphylaxis (SRS-A) induced contractions of isolated guinea pig ileum at 20 uM concentration. ChEMBL. 7120283

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.