TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 569.515 | Formula: C31H23NO10
H donors: 6 H acceptors: 9 LogP: 4.38 Rotable bonds: 9
Rule of 5 violations (Lipinski): 3
SMILES: Oc1ccc(cc1)C(=O)N[C@H]1[C@@H](OC(=O)c2cc(O)c(c(c2)O)C(=O)c2c(O)cccc2C(=O)O)Cc2c1cccc2
InChi: 1S/C31H23NO10/c33-18-10-8-15(9-11-18)29(38)32-27-19-5-2-1-4-16(19)14-24(27)42-31(41)17-12-22(35)26(23(36)13-17)28(37)25-20(30(39)40)6-3-7-21(25)34/h1-13,24,27,33-36H,14H2,(H,32,38)(H,39,40)/t24-,27+/m0/s1
InChiKey: NNVINYYJNCKGRA-RPLLCQBOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase C, gamma	Starlite/ChEMBL	No references
Homo sapiens	protein kinase C, epsilon	Starlite/ChEMBL	No references
Homo sapiens	protein kinase C, eta	Starlite/ChEMBL	No references
Homo sapiens	protein kinase C, delta	Starlite/ChEMBL	No references
Homo sapiens	protein kinase C, alpha	Starlite/ChEMBL	No references
Homo sapiens	protein kinase C, beta	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Onchocerca volvulus		Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Schistosoma japonicum	Protein kinase C epsilon type, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	ko:K06068 novel protein kinase C, putative	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129314	All targets in OG5_129314
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132502	All targets in OG5_132502
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus granulosus	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	protein kinase C II.	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus granulosus	serine:threonine protein kinase N2	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus multilocularis	protein kinase c epsilon type	Get druggable targets OG5_129314	All targets in OG5_129314
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Entamoeba histolytica	PH domain containing protein kinase, putative	Get druggable targets OG5_129314	All targets in OG5_129314

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0925	0.4792	1
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0092	0.0117	0.024
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0925	0.4792	0.9828
Echinococcus granulosus	protein kinase C gamma type	0.0215	0.0809	0.1659
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0496	0.2382	0.4885
Loa Loa (eye worm)	hypothetical protein	0.011	0.0221	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0241	0.0957	0.161
Trypanosoma cruzi	hypothetical protein, conserved	0.0454	0.2151	0.331
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0768	0.3909	0.8066
Brugia malayi	Protein kinase c protein 2	0.0197	0.0711	0.0711
Loa Loa (eye worm)	matrixin family protein	0.0087	0.009	0.009
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.0117	0.024
Schistosoma mansoni	peptidylglycine monooxygenase	0.0499	0.2404	0.493
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0496	0.2382	0.2382
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0454	0.2151	0.331
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0768	0.3909	0.8016
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0098	0.0154	0.0315
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.4044
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0241	0.0957	0.2405
Loa Loa (eye worm)	hypothetical protein	0.0212	0.0794	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1711	0.1711
Echinococcus multilocularis	protein kinase c epsilon type	0.0284	0.1198	0.2457
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.331
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0376	0.1711	0.1711
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0768	0.3909	0.8183
Echinococcus multilocularis	protein kinase c iota type	0.011	0.0221	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0538	0.0538
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0241	0.0957	0.161
Giardia lamblia	Rab geranylgeranyltransferase	0.0241	0.0957	0.1449
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0454	0.2151	0.4411
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0241	0.0957	0.0957
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.011	0.0221	0.0221
Echinococcus granulosus	protein kinase c epsilon type	0.0284	0.1198	0.2457
Onchocerca volvulus		0.0454	0.2151	1
Loa Loa (eye worm)	fli-1 protein	0.0215	0.0807	0.0807
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0496	0.2382	0.4885
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0454	0.2151	0.4411
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0126	0.0308	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0957	0.0957
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0925	0.4792	1
Loa Loa (eye worm)	hypothetical protein	0.0499	0.2404	0.2404
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1161	0.1161
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.0117	0.024
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0768	0.3909	1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0126	0.0308	0.0189
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0278	0.1161	0.1161
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1161	0.1161
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0768	0.3909	0.3909
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0284	0.1198	0.1198
Schistosoma mansoni	serine/threonine protein kinase	0.0261	0.1065	0.2183
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0768	0.3909	0.3909
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0376	0.1711	0.3509
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0925	0.4792	1
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1711	0.1711
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0925	0.4792	0.4792
Echinococcus granulosus	endothelin converting enzyme 1	0.0376	0.1711	0.3509
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Trypanosoma brucei	hypothetical protein, conserved	0.0454	0.2151	0.331
Echinococcus multilocularis	sterol regulatory element binding protein	0.011	0.0221	0.0454
Toxoplasma gondii	hypothetical protein	0.0471	0.2245	0.5719
Brugia malayi	Matrixin family protein	0.0087	0.009	0.009
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Schistosoma mansoni	ets-related	0.0215	0.0807	0.1655
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1161	0.1161
Echinococcus granulosus	protein kinase c iota type	0.011	0.0221	0.0453
Giardia lamblia	Rab geranylgeranyltransferase	0.0454	0.2151	0.411
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0496	0.2382	0.4323
Echinococcus multilocularis	serine threonine protein kinase	0.0215	0.0809	0.1659
Brugia malayi	CHE-14 protein	0.011	0.0221	0.0221
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0092	0.0117	0.0117
Echinococcus granulosus	sterol regulatory element binding protein	0.011	0.0221	0.0454
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Schistosoma mansoni	atypical protein kinase C	0.011	0.0221	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0268	0.1104	0.1104
Schistosoma mansoni	neprilysin-2 (M13 family)	0.019	0.0667	0.1368
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0268	0.1104	0.2265
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0925	0.4792	0.9828
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0957	0.0957
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0231	0.09	0.1845
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0278	0.1161	0.1161
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0768	0.3909	0.7695
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0261	0.1065	0.2183
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.019	0.0667	0.1368
Brugia malayi	Fli-1 protein	0.0215	0.0807	0.0807
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0454	0.2151	0.4411
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0152	0.0455	0.0455
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0768	0.3909	0.8066
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.331
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0496	0.2382	0.4726
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0454	0.2151	0.4411
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1161	0.1161
Echinococcus multilocularis	protein dispatched 1	0.011	0.0221	0.0454
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0925	0.4792	0.4792
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0246	0.0983	0.0983
Echinococcus granulosus	Protein patched homolog 1	0.011	0.0221	0.0454
Toxoplasma gondii	peptidase family M13 protein	0.0376	0.1711	0.4345
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0768	0.3909	0.8183
Echinococcus multilocularis	RNA directed DNA polymerase	0.0143	0.0405	0.083
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0768	0.3909	0.8016
Onchocerca volvulus		0.0167	0.0538	0.2323
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0538	0.0538
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0499	0.2404	0.493
Brugia malayi	peptidase family M13 containing protein	0.0092	0.0117	0.0117
Schistosoma mansoni	hypothetical protein	0.0098	0.0154	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1711	0.1711
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0092	0.0117	0.024
Echinococcus granulosus	Niemann Pick C1 protein	0.011	0.0221	0.0454
Schistosoma mansoni	serine/threonine protein kinase	0.0261	0.1065	0.2183
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0126	0.0308	0.0189
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0268	0.1104	0.0408
Trypanosoma cruzi	lanosterol synthase, putative	0.0885	0.4564	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0648	0.0648
Mycobacterium ulcerans	zinc metalloprotease	0.0376	0.1711	1
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0241	0.0957	0.196
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0454	0.2151	0.4462
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0499	0.2404	0.2404
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0925	0.4792	0.9828
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0768	0.3909	0.8016
Schistosoma mansoni	endothelin-converting enzyme-related	0.0092	0.0117	0.024
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0241	0.0957	0.1963
Echinococcus granulosus	RNA directed DNA polymerase	0.0143	0.0405	0.083
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0925	0.4792	1
Mycobacterium leprae	probable zinc metalloprotease	0.0376	0.1711	0.5
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0526	0.2555	0.5309
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0768	0.3909	0.8183
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.094	0.4876	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.4221
Schistosoma mansoni	serine/threonine protein kinase	0.0284	0.1198	0.2457
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.011	0.0221	0.0454
Echinococcus multilocularis	endothelin converting enzyme 1	0.0376	0.1711	0.3509
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.013	0.0335	0.0687
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0768	0.3909	0.8066
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0496	0.2382	0.4885
Echinococcus granulosus	serine:threonine protein kinase N2	0.0168	0.0546	0.1119
Leishmania major	lanosterol synthase, putative	0.0643	0.321	0.7633
Brugia malayi	Peptidase family M13 containing protein	0.0376	0.1711	0.1711
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0768	0.3909	0.8066
Leishmania major	farnesyltransferase beta subunit	0.0768	0.3909	1
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.094	0.4876	1
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0454	0.2151	0.4411
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0143	0.0405	0.083
Loa Loa (eye worm)	hypothetical protein	0.094	0.4876	0.4876
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.094	0.4876	0.4876
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0925	0.4792	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.019	0.0667	0.1368
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0268	0.1104	0.0408
Loa Loa (eye worm)	matrixin family protein	0.008	0.005	0.005
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0925	0.4792	1
Brugia malayi	protein kinase C II.	0.0284	0.1198	0.1198
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0268	0.1104	0.0408
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0241	0.0957	0.1963
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0405	0.0405
Giardia lamblia	Rab geranylgeranyltransferase	0.0925	0.4792	1
Onchocerca volvulus		0.0186	0.0648	0.2845
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0268	0.1104	0.1104
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0454	0.2151	0.2151
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0454	0.2151	0.378
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0241	0.0957	0.2405
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.0117	0.024
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0268	0.1104	0.2265
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Giardia lamblia	Prenyltransferase	0.0768	0.3909	0.8029
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0268	0.1104	0.0498
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0454	0.2151	0.331
Echinococcus multilocularis	protein patched	0.011	0.0221	0.0454
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0268	0.1104	0.2265
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0768	0.3909	0.8066
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0768	0.3909	0.8147
Schistosoma mansoni	neprilysin	0.0098	0.0154	0.0315
Schistosoma mansoni	patched 1	0.011	0.0221	0.0454
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0454	0.2151	0.3112
Loa Loa (eye worm)	hypothetical protein	0.0284	0.1198	0.1198
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0454	0.2151	0.331
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.019	0.0667	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0925	0.4792	0.4792
Echinococcus granulosus	tm gpcr rhodopsin	0.0508	0.2452	0.5029
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.013	0.0335	0.0687
Toxoplasma gondii	hypothetical protein	0.0454	0.2151	0.5477
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0508	0.2452	0.5029
Trypanosoma brucei	lanosterol synthase	0.0885	0.4564	1
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.1854	1	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.066	0.066
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0496	0.2382	0.2382
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0768	0.3909	0.7919
Loa Loa (eye worm)	hypothetical protein	0.0231	0.09	0.09
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0885	0.4564	1
Trypanosoma cruzi	lanosterol synthase, putative	0.0885	0.4564	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0454	0.2151	0.2151
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0768	0.3909	0.8066
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.094	0.4876	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0253	0.1025	0.1025
Plasmodium vivax	geranylgeranyltransferase, putative	0.0241	0.0957	0.196
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0241	0.0957	0.0969
Echinococcus multilocularis	Niemann Pick C1 protein	0.011	0.0221	0.0454
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.019	0.0667	0.1368
Trypanosoma cruzi	hypothetical protein, conserved	0.0454	0.2151	0.331
Echinococcus granulosus	Protein kinase C brain isozyme	0.0261	0.1065	0.2183
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0496	0.2382	0.4885
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0471	0.2245	0.4427
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0454	0.2151	0.331

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.05 uM	Inhibition of protein kinase C beta II	ChEMBL.	No reference
IC50 (binding)	= 0.05 uM	Inhibition of protein kinase C gamma	ChEMBL.	No reference
IC50 (binding)	= 0.05 uM	Inhibition of protein kinase C delta	ChEMBL.	No reference
IC50 (binding)	< 0.05 uM	Inhibition of protein kinase C eta	ChEMBL.	No reference
IC50 (binding)	= 0.05 uM	Inhibition of protein kinase C beta II	ChEMBL.	No reference
IC50 (binding)	= 0.05 uM	Inhibition of protein kinase C gamma	ChEMBL.	No reference
IC50 (binding)	= 0.05 uM	Inhibition of protein kinase C delta	ChEMBL.	No reference
IC50 (binding)	< 0.05 uM	Inhibition of protein kinase C eta	ChEMBL.	No reference
IC50 (binding)	= 0.06 uM	Inhibition of protein kinase C beta 1	ChEMBL.	No reference
IC50 (binding)	= 0.06 uM	Inhibition of protein kinase C beta 1	ChEMBL.	No reference
IC50 (binding)	= 0.29 uM	Inhibition of protein kinase C alpha	ChEMBL.	No reference
IC50 (binding)	= 0.29 uM	Inhibition of protein kinase C alpha	ChEMBL.	No reference
IC50 (binding)	= 1.9 uM	Inhibition of protein kinase C epsilon	ChEMBL.	No reference
IC50 (binding)	= 1.9 uM	Inhibition of protein kinase C epsilon	ChEMBL.	No reference
IC50 (binding)	= 50 uM	Inhibition of cAMP-dependent protein kinase (PKA)	ChEMBL.	No reference
IC50 (binding)	= 50 uM	Inhibition of cAMP-dependent protein kinase (PKA)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL367127

Bibliographic References

No literature references available for this target.

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Detailed information for compound 311020