Detailed information for compound 31461

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.96 | Formula: C23H29ClN5O4-
  • H donors: 4 H acceptors: 5 LogP: 2.37 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCNCCn1nc2c3c1ccc(c3c(=O)c1c2c(O)ccc1O)N(CCN(C)C)C.[Cl-]
  • InChi: 1S/C23H29N5O4.ClH/c1-26(2)11-12-27(3)14-4-5-15-18-19(14)23(32)21-17(31)7-6-16(30)20(21)22(18)25-28(15)10-8-24-9-13-29;/h4-7,24,29-31H,8-13H2,1-3H3;1H/p-1
  • InChiKey: FVYHMFFCPFHGQS-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cysteine protease 0.0035 0.0028 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0034 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Brugia malayi Cathepsin L-like precursor 0.0035 0.0028 0.0108
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.042 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.025 0.025
Brugia malayi AKH receptor 0.0037 0.0034 0.0129
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0034 0.0129
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0117 0.0353 0.0353
Echinococcus multilocularis serotonin receptor 0.0037 0.0034 0.0034
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0014 0.0014
Echinococcus granulosus g protein coupled receptor 0.0037 0.0034 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0353 0.1148
Echinococcus granulosus fmrfamide receptor 0.0037 0.0034 0.011
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.011
Echinococcus multilocularis somatostatin receptor 0.0037 0.0034 0.0034
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0132 0.0402
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0034 0.011
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Echinococcus multilocularis serotonin receptor 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0037 0.0034 0.0406
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0034 0.0034
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0034 0.0034
Echinococcus multilocularis fibrillin 1 0.0073 0.018 0.018
Echinococcus multilocularis prostaglandin H2 D isomerase 0.04 0.1476 0.1476
Echinococcus granulosus hypothetical protein 0.0037 0.0034 0.011
Brugia malayi Serotonin receptor 0.0037 0.0034 0.0129
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0034 0.0129
Brugia malayi larval opioid receptor 0.0037 0.0034 0.0129
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0052 0.0198
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0034 0.011
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0000000049743 0.000000016152
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0034 0.011
Schistosoma mansoni hypothetical protein 0.0173 0.0573 0.186
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0052 0.5
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0052 0.0293
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0028 0.0028
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.008 0.0206 0.0667
Brugia malayi hypothetical protein 0.0032 0.0014 0.0055
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0034 0.0034
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0032 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0584
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni myosin xvIII 0.0037 0.0034 0.011
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0034 0.0129
Leishmania major cathepsin L-like protease 0.0035 0.0028 0.0001
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0034 0.011
Echinococcus granulosus glycoprotein Antigen 5 0.0032 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0584
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0034 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) fibroinase 0.0035 0.0028 0.0092
Schistosoma mansoni amine GPCR 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Toxoplasma gondii PAN domain-containing protein 0.0084 0.0222 0.0438
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Echinococcus granulosus microtubule associated protein 2 0.0701 0.2667 0.866
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0052 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Brugia malayi Dopamine receptor protein 2 0.0037 0.0034 0.0129
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0034 0.0129
Echinococcus granulosus glutathione S transferase 0.0091 0.0248 0.0806
Echinococcus multilocularis glutathione S transferase 0.0091 0.0248 0.0248
Brugia malayi Trypsin family protein 0.0032 0.0014 0.0055
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0117 0.0353 0.1148
Giardia lamblia Kinase, AGC AKT 0.069 0.2625 1
Schistosoma mansoni atypical protein kinase C 0.0117 0.0353 0.1148
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0034 0.011
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0014 0.0046
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni hypothetical protein 0.0072 0.0176 0.0572
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Brugia malayi Hr1 repeat family protein 0.0117 0.0353 0.1346
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0032 0.0014 0.0046
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0034 0.011
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0087 0.15
Loa Loa (eye worm) AGC/PKN protein kinase 0.0117 0.0353 0.1148
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0117 0.0353 0.1148
Onchocerca volvulus 0.0037 0.0034 0.0406
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0353 0.1148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Onchocerca volvulus 0.0037 0.0034 0.0406
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.0034 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0034 0.011
Entamoeba histolytica hypothetical protein 0.0072 0.0176 0.455
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Echinococcus multilocularis glutathione S transferase 0.031 0.1116 0.1116
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0034 0.011
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0034 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0034 0.011
Echinococcus granulosus glutathione S transferase Mu 1 0.0091 0.0248 0.0806
Schistosoma mansoni neuropeptide receptor 0.0037 0.0034 0.011
Toxoplasma gondii PAN domain-containing protein 0.0084 0.0222 0.0438
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0034 0.0034
Brugia malayi Protein kinase domain containing protein 0.0117 0.0353 0.1346
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Echinococcus granulosus allatostatin A receptor 0.0037 0.0034 0.011
Brugia malayi latrophilin 2 splice variant baaae 0.0173 0.0573 0.2182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Entamoeba histolytica protein kinase, putative 0.0117 0.0353 1
Brugia malayi protein kinase C II. 0.0117 0.0353 0.1346
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0084 0.0222 0.2669
Loa Loa (eye worm) hypothetical protein 0.0252 0.0889 0.2888
Toxoplasma gondii calcium binding egf domain-containing protein 0.0073 0.018 0.0356
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Echinococcus granulosus dna polymerase eta 0.005 0.0087 0.0282
Brugia malayi Melatonin receptor type 1A 0.0037 0.0034 0.0129
Loa Loa (eye worm) hypothetical protein 0.0084 0.0222 0.072
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0132 1
Onchocerca volvulus 0.0037 0.0034 0.0406
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0073 0.018 0.0584
Echinococcus granulosus prostaglandin H2 D isomerase 0.04 0.1476 0.4791
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0034 0.0034
Echinococcus granulosus Protein kinase C brain isozyme 0.0117 0.0353 0.1148
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Entamoeba histolytica protein kinase, putative 0.0117 0.0353 1
Echinococcus multilocularis glutathione S transferase 0.007 0.0166 0.0166
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0028 0.0108
Onchocerca volvulus 0.0035 0.0028 0.0341
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Entamoeba histolytica hypothetical protein 0.0072 0.0176 0.455
Echinococcus granulosus glutathione s transferase mu 0.0091 0.0248 0.0806
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0034 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.042 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0034 0.0034
Brugia malayi notch-like transmembrane receptor 0.0028 0.0000000049743 0.000000018948
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0117 0.0353 0.1148
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0034 0.011
Echinococcus granulosus neuropeptide receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0034 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0034 0.0034
Brugia malayi Calcium binding EGF domain containing protein 0.0073 0.018 0.0685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.025 0.0813
Toxoplasma gondii PAN domain-containing protein 0.0084 0.0222 0.0438
Brugia malayi G protein-coupled receptor 0.0037 0.0034 0.0129
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0132 0.0261
Leishmania major DNA polymerase eta, putative 0.005 0.0087 0.0226
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0052 0.1069
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0028 0.0055
Echinococcus multilocularis protein kinase c iota type 0.0117 0.0353 0.0353
Brugia malayi Glutathione S-transferase 4 0.007 0.0166 0.0633
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0034 0.011
Schistosoma mansoni serine/threonine kinase 0.0117 0.0353 0.1148
Brugia malayi hypothetical protein 0.0122 0.0372 0.1416
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0028 0.0341
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0117 0.0353 0.1148
Brugia malayi Cathepsin L-like precursor 0.0035 0.0028 0.0108
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0805 0.308 1
Onchocerca volvulus 0.0037 0.0034 0.0406
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Onchocerca volvulus 0.0037 0.0034 0.0406
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Loa Loa (eye worm) hypothetical protein 0.0148 0.0478 0.1551
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0034 0.011
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0028 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0034 0.011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0034 0.0034
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0206 0.0206
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Trichomonas vaginalis glutaminyl-tRNA synthetase, putative 0.007 0.0166 0.1715
Brugia malayi Protein kinase domain containing protein 0.0117 0.0353 0.1346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0008 0.0025
Brugia malayi sulfakinin receptor protein 0.0037 0.0034 0.0129
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0353 0.1148
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.069 0.2625 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Toxoplasma gondii hypothetical protein 0.0084 0.0222 0.0438
Schistosoma mansoni hypothetical protein 0.008 0.0206 0.0667
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0028 0.0000000049743 0.000000059833
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Brugia malayi hypothetical protein 0.0072 0.0176 0.0671
Echinococcus multilocularis sex peptide receptor 0.0037 0.0034 0.0034
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0034 0.0034
Echinococcus granulosus sex peptide receptor 0.0037 0.0034 0.011
Plasmodium vivax vivapain-2 0.0035 0.0028 0.014
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0034 0.011
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.0034 0.011
Brugia malayi Latrophilin receptor protein 2 0.008 0.0206 0.0783
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0028 0.0028
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0034 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Brugia malayi G-protein coupled receptor 0.0037 0.0034 0.0129
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni neuropeptide receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0046
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0117 0.0353 0.1148
Echinococcus granulosus muscleblind protein 0.0148 0.0478 0.1551
Trypanosoma brucei rac serine-threonine kinase, putative 0.0117 0.0353 0.8195
Loa Loa (eye worm) hypothetical protein 0.0122 0.0372 0.1207
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0028 0.0092
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0034 0.0034
Toxoplasma gondii calcium binding egf domain-containing protein 0.0073 0.018 0.0356
Onchocerca volvulus 0.0037 0.0034 0.0406
Echinococcus granulosus GPCR family 2 0.008 0.0206 0.0667
Leishmania major cathepsin L-like protease 0.0134 0.042 0.1509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0008 0.0025
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0032 0.0014 0.0014
Brugia malayi Protein kinase domain containing protein 0.0117 0.0353 0.1346
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0034 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0034 0.0034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0176 0.0572
Brugia malayi Cathepsin L-like precursor 0.0035 0.0028 0.0108
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0014 0.0046
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) PAN domain-containing protein 0.0084 0.0222 0.072
Onchocerca volvulus 0.0032 0.0014 0.0172
Trypanosoma brucei DNA polymerase eta, putative 0.005 0.0087 0.0947
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0014 0.0046
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0034 0.0034
Brugia malayi Trypsin family protein 0.0032 0.0014 0.0055
Entamoeba histolytica hypothetical protein 0.0072 0.0176 0.455
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Onchocerca volvulus 0.003 0.0008 0.0093
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0206 0.0783
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0034 0.011
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.0034 0.0034
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0034 0.011
Echinococcus granulosus Mastin 0.0032 0.0014 0.0046
Brugia malayi ORL1-like opioid receptor 0.0037 0.0034 0.0129
Onchocerca volvulus Arrow homolog 0.0073 0.018 0.2164
Brugia malayi Cathepsin L-like precursor 0.0035 0.0028 0.0108
Onchocerca volvulus 0.0084 0.0222 0.2669
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0132 0.043
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Onchocerca volvulus 0.0037 0.0034 0.0406
Echinococcus multilocularis microtubule associated protein 2 0.0701 0.2667 0.2667
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.025 0.0813
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0034 0.011
Schistosoma mansoni DNA polymerase eta 0.005 0.0087 0.0282
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0034 0.011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0014 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0046
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0034 0.0129
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0034 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0008 0.0008
Echinococcus granulosus serotonin receptor 0.0037 0.0034 0.011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0052 0.0168
Echinococcus multilocularis glutathione S-transferase 0.0091 0.0248 0.0248
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0831 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0034 0.011
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0034 0.011
Onchocerca volvulus 0.0084 0.0222 0.2669
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0805 0.308 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) ctsf protein 0.0035 0.0028 0.0092
Toxoplasma gondii PAN/Apple domain-containing protein 0.0084 0.0222 0.0438
Brugia malayi glutathione transferase 0.0091 0.0248 0.0946
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni histamine h1 receptor 0.0037 0.0034 0.011
Onchocerca volvulus Huntingtin homolog 0.0122 0.0372 0.4471
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0252 0.0889 0.2888
Onchocerca volvulus 0.0084 0.0222 0.2669
Loa Loa (eye worm) hypothetical protein 0.0084 0.0222 0.072
Entamoeba histolytica protein kinase, putative 0.0117 0.0353 1
Leishmania major cathepsin L-like protease 0.0035 0.0028 0.0001
Brugia malayi Trypsin-like protease protein 5 0.0032 0.0014 0.0055
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0028 0.0028
Onchocerca volvulus 0.0037 0.0034 0.0406
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0034 0.011
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0073 0.018 0.0584
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0034 0.0034
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0052 0.0724
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0132 1
Onchocerca volvulus 0.0037 0.0034 0.0406
Toxoplasma gondii PAN domain-containing protein 0.1305 0.506 1
Schistosoma mansoni egf-like domain protein 0.0073 0.018 0.0584
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0034 0.011
Onchocerca volvulus 0.0037 0.0034 0.0406
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0034 0.011
Brugia malayi Pre-SET motif family protein 0.003 0.0008 0.003
Trypanosoma cruzi major cysteine proteinase, putative 0.0105 0.0306 0.7101
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni neuropeptide receptor 0.0037 0.0034 0.011
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.04 0.1476 0.4791
Onchocerca volvulus 0.0035 0.0028 0.0341
Onchocerca volvulus 0.0032 0.0014 0.0172
Echinococcus granulosus g protein coupled receptor 0.0037 0.0034 0.011
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.042 1
Onchocerca volvulus 0.0084 0.0222 0.2669
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0000000049743 0.0000000049743
Onchocerca volvulus 0.0037 0.0034 0.0406
Schistosoma mansoni amine GPCR 0.0037 0.0034 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0052 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0132 1
Onchocerca volvulus 0.0032 0.0014 0.0172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0084 0.0222 0.072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Echinococcus granulosus cathepsin l1 0.0035 0.0028 0.0092
Toxoplasma gondii microneme protein, putative 0.0084 0.0222 0.0438
Plasmodium vivax glutathione S-transferase, putative 0.04 0.1476 1
Echinococcus multilocularis glutathione S transferase 0.0091 0.0248 0.0248
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0034 0.0406
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0034 0.011
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0034 0.0034
Toxoplasma gondii microneme protein MIC17B 0.0084 0.0222 0.0438
Brugia malayi neuropeptide F receptor 0.0037 0.0034 0.0129
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0252 0.0889 0.3388
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0176 0.0572
Onchocerca volvulus 0.0035 0.0028 0.0341
Onchocerca volvulus 0.0032 0.0014 0.0172
Echinococcus granulosus orexin receptor type 2 0.0037 0.0034 0.011
Onchocerca volvulus 0.0035 0.0028 0.0341
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0034 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Schistosoma mansoni microtubule-associated protein tau 0.0701 0.2667 0.866
Onchocerca volvulus 0.0037 0.0034 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.025 0.0813
Toxoplasma gondii hypothetical protein 0.0084 0.0222 0.0438
Schistosoma mansoni GST class-mu 0.0091 0.0248 0.0806
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0034 0.0034
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0584
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni biogenic amine receptor 0.0037 0.0034 0.011
Echinococcus multilocularis cysteine protease 0.0035 0.0028 0.0028
Schistosoma mansoni amine GPCR 0.0037 0.0034 0.011
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0034 0.0034
Echinococcus multilocularis serine:threonine protein kinase N2 0.0117 0.0353 0.0353
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0034 0.011
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0176 0.0176
Echinococcus granulosus glutathione S transferase 0.031 0.1116 0.3625
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0584
Schistosoma mansoni amine GPCR 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0117 0.0353 0.1148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0034 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0028 0.0092
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0008 0.0008
Onchocerca volvulus 0.0084 0.0222 0.2669
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0032 0.0014 0.0055
Echinococcus granulosus serine:threonine protein kinase N2 0.0117 0.0353 0.1148
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0206 0.0667
Schistosoma mansoni hypothetical protein 0.008 0.0206 0.0667
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0034 0.0129
Loa Loa (eye worm) hypothetical protein 0.0084 0.0222 0.072
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0353 0.1148
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0117 0.0353 0.0353
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0034 0.0406
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0028 0.0092
Brugia malayi p70 ribosomal S6 kinase beta 0.0117 0.0353 0.1346
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0034 0.0034
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Loa Loa (eye worm) PAN domain-containing protein 0.0084 0.0222 0.072
Schistosoma mansoni hypothetical protein 0.0032 0.0014 0.0046
Onchocerca volvulus 0.0084 0.0222 0.2669
Schistosoma mansoni ap endonuclease 0.0041 0.0052 0.0168
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Toxoplasma gondii PAN domain-containing protein 0.1305 0.506 1
Brugia malayi Cathepsin L-like precursor 0.0035 0.0028 0.0108
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0132 1
Schistosoma mansoni hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Toxoplasma gondii PAN domain-containing protein 0.0084 0.0222 0.0438
Schistosoma mansoni biogenic amine receptor 0.0037 0.0034 0.011
Echinococcus granulosus glutathione S transferase 0.007 0.0166 0.0539
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0034 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Onchocerca volvulus 0.0037 0.0034 0.0406
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0034 0.011
Leishmania major cathepsin L-like protease 0.0134 0.042 0.1509
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0028 0.0092
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0117 0.0353 0.1148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni opsin-like receptor 0.0037 0.0034 0.011
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0073 0.018 0.0685
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0034 0.011
Brugia malayi G-protein coupled receptor 0.0037 0.0034 0.0129
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0008 0.0015
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0034 0.011
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0034 0.011
Schistosoma mansoni adenoreceptor 0.0037 0.0034 0.011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.025 0.0813
Echinococcus granulosus transmembrane protease serine 3 0.0032 0.0014 0.0046
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0034 0.0034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0206 0.0667
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0025
Onchocerca volvulus Huntingtin homolog 0.0122 0.0372 0.4471
Plasmodium falciparum glutathione S-transferase 0.0091 0.0248 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0805 0.308 0.308
Brugia malayi EGF-like domain containing protein 0.0028 0.0000000049743 0.000000018948
Onchocerca volvulus 0.0035 0.0028 0.0341
Schistosoma mansoni opsin-like receptor 0.0037 0.0034 0.011
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Brugia malayi RE15519p 0.0037 0.0034 0.0129
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) trypsin family protein 0.0032 0.0014 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0034 0.0034
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0034 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0034 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0008 0.0025
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0052 0.0293
Brugia malayi putative neuropeptide receptor 0.0037 0.0034 0.0129
Echinococcus granulosus Tolloid protein 1 0.0073 0.018 0.0584
Echinococcus multilocularis glutathione S transferase 0.007 0.0166 0.0166
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.025 0.0813
Echinococcus granulosus NDR protein kinase 0.0117 0.0353 0.1148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0173 0.0573 0.186
Leishmania major cathepsin L-like protease 0.0134 0.042 0.1509
Entamoeba histolytica protein kinase, putative 0.0117 0.0353 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0073 0.018 0.0584
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0034 0.011
Onchocerca volvulus Neurogenic locus notch homolog 0.0028 0.0000000049743 0.000000059833
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0353 0.1148
Onchocerca volvulus 0.0037 0.0034 0.0406
Onchocerca volvulus 0.0084 0.0222 0.2669
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0034 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0052 0.0092
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0034 0.0034
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0014 0.0046
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0028 0.0092
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0282
Loa Loa (eye worm) AGC/AKT protein kinase 0.0117 0.0353 0.1148
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0028 0.0341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0092
Echinococcus granulosus g protein coupled receptor 0.0037 0.0034 0.011
Toxoplasma gondii microneme protein MIC17A 0.0084 0.0222 0.0438
Onchocerca volvulus 0.007 0.0166 0.1997
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0003 0.0011
Schistosoma mansoni opsin-like receptor 0.0037 0.0034 0.011
Schistosoma mansoni hypothetical protein 0.0032 0.0014 0.0046
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0034 0.0034
Echinococcus multilocularis Mastin 0.0032 0.0014 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0034 0.011
Leishmania major cathepsin L-like protease 0.0035 0.0028 0.0001
Loa Loa (eye worm) hypothetical protein 0.0084 0.0222 0.072
Echinococcus granulosus laminin 0.0073 0.018 0.0584
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0052 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.0478 0.1551
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0717 0.2328
Onchocerca volvulus 0.0084 0.0222 0.2669
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0014 0.0046
Brugia malayi Serotonin receptor 0.0037 0.0034 0.0129
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Onchocerca volvulus 0.0084 0.0222 0.2669
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0034 0.011
Loa Loa (eye worm) PAN domain-containing protein 0.0084 0.0222 0.072
Brugia malayi GnHR receptor homolog 0.0037 0.0034 0.0129
Echinococcus multilocularis laminin 0.0073 0.018 0.018
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.0087 0.033
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0034 0.011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0034 0.011
Schistosoma mansoni ap endonuclease 0.0041 0.0052 0.0168
Schistosoma mansoni hypothetical protein 0.008 0.0206 0.0667
Echinococcus granulosus somatostatin receptor 0.0037 0.0034 0.011
Echinococcus multilocularis serine:threonine protein kinase 38 0.0117 0.0353 0.0353
Onchocerca volvulus 0.0032 0.0014 0.0172
Schistosoma mansoni biogenic amine receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.007 0.0166 0.0539
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0034 0.011
Echinococcus granulosus protein kinase C gamma type 0.0117 0.0353 0.1148
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0034 0.011
Echinococcus multilocularis serine threonine protein kinase 0.0117 0.0353 0.0353
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0034 0.011
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Echinococcus granulosus protein kinase c epsilon type 0.0117 0.0353 0.1148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Leishmania major cathepsin L-like protease 0.0035 0.0028 0.0001
Brugia malayi ribosomal protein S6 kinase alpha 3 0.069 0.2625 1
Echinococcus granulosus enteropeptidase 0.0032 0.0014 0.0046
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0034 0.0129
Onchocerca volvulus 0.0035 0.0028 0.0341
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0034 0.0129
Brugia malayi Fibulin-1 precursor 0.0073 0.018 0.0685
Brugia malayi Muscleblind-like protein 0.0148 0.0478 0.1819
Loa Loa (eye worm) hypothetical protein 0.0073 0.018 0.0584
Echinococcus multilocularis muscleblind protein 0.0148 0.0478 0.0478
Echinococcus multilocularis glutathione s transferase mu 0.0091 0.0248 0.0248
Brugia malayi Trypsin family protein 0.0032 0.0014 0.0055
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0132 0.043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.025 0.025
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0073 0.018 0.0584
Echinococcus granulosus protein kinase c iota type 0.0117 0.0353 0.1148
Loa Loa (eye worm) hypothetical protein 0.0091 0.0248 0.0806
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0034 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0034 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Onchocerca volvulus 0.0238 0.0831 1
Brugia malayi Trypsin family protein 0.0032 0.0014 0.0055
Loa Loa (eye worm) hypothetical protein 0.0084 0.0222 0.072
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Loa Loa (eye worm) PAN domain-containing protein 0.0084 0.0222 0.072
Schistosoma mansoni amine GPCR 0.0037 0.0034 0.011
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0032 0.0014 0.0046
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0034 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0034 0.011
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0353 0.4048
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0034 0.0034
Brugia malayi neuropeptide F receptor 0.0037 0.0034 0.0129
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0115 0.0343 0.3923
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Echinococcus multilocularis dna polymerase eta 0.005 0.0087 0.0087
Echinococcus multilocularis enteropeptidase 0.0032 0.0014 0.0014
Echinococcus multilocularis glycoprotein Antigen 5 0.0032 0.0014 0.0014
Onchocerca volvulus 0.0035 0.0028 0.0341
Onchocerca volvulus 0.0037 0.0034 0.0406
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0028 0.0341
Toxoplasma gondii microneme protein MIC17C 0.0084 0.0222 0.0438
Toxoplasma gondii cathepsin CPL 0.0035 0.0028 0.0056
Brugia malayi Dopamine receptor protein 1 0.0037 0.0034 0.0129
Leishmania major cathepsin L-like protease 0.0035 0.0028 0.0001
Plasmodium vivax vivapain-2 0.0035 0.0028 0.014
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0034 0.011
Brugia malayi hypothetical protein 0.0037 0.0034 0.0129
Echinococcus granulosus neuropeptide receptor 0.0037 0.0034 0.011
Toxoplasma gondii exonuclease III APE 0.0041 0.0052 0.0102
Echinococcus multilocularis serine:threonine protein kinase N2 0.0117 0.0353 0.0353
Toxoplasma gondii subtilisin SUB12 0.0084 0.0222 0.0438
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0052 0.061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0028 0.0000000049743 0.000000016152
Brugia malayi Dopamine receptor 0.0037 0.0034 0.0129
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0122 0.0374 0.8825
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Schistosoma mansoni neuropeptide receptor 0.0037 0.0034 0.011
Onchocerca volvulus 0.0032 0.0014 0.0172
Schistosoma mansoni serine/threonine protein kinase 0.0805 0.308 1
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0034 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0052 0.03
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Echinococcus multilocularis transmembrane protease serine 3 0.0032 0.0014 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0132 0.043
Trypanosoma cruzi cruzipain precursor, putative 0.0134 0.042 1
Loa Loa (eye worm) PAN domain-containing protein 0.0084 0.0222 0.072
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.025 0.0813
Toxoplasma gondii microneme protein MIC4 0.0084 0.0222 0.0438
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0034 0.0034
Onchocerca volvulus 0.0084 0.0222 0.2669
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0028 0.0092
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0117 0.0353 0.0353
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Loa Loa (eye worm) AGC/NDR protein kinase 0.0117 0.0353 0.1148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0206 0.0667
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0052 0.0198
Echinococcus multilocularis protein kinase c epsilon type 0.0117 0.0353 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0117 0.0353 0.1148
Entamoeba histolytica hypothetical protein 0.0072 0.0176 0.455
Brugia malayi PAN domain containing protein 0.0084 0.0222 0.0845
Leishmania major cysteine peptidase A (CPA) 0.0035 0.0028 0.0001
Echinococcus multilocularis GPCR, family 2 0.008 0.0206 0.0206
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0052 0.3181
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.0667
Onchocerca volvulus 0.0037 0.0034 0.0406
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0028 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0008 0.0025
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0034 0.011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0252 0.0889 0.3388
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0034 0.0034
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0084 0.0222 0.0438
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0052 0.061
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0034 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0034 0.011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0034 0.0129
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0046
Echinococcus multilocularis glutathione S transferase 0.0091 0.0248 0.0248
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.025 0.0954
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.0122 0.0372 0.1207
Echinococcus multilocularis Tolloid protein 1 0.0073 0.018 0.018
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0034 0.011
Echinococcus multilocularis cysteine protease 0.0035 0.0028 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0008 0.0025
Brugia malayi Pre-SET motif family protein 0.0209 0.0717 0.2731
Brugia malayi Cathepsin L-like precursor 0.0035 0.0028 0.0108
Loa Loa (eye worm) hypothetical protein 0.0037 0.0034 0.011
Toxoplasma gondii AGC kinase 0.0117 0.0353 0.0698
Schistosoma mansoni cercarial elastase (S01 family) 0.0032 0.0014 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0222 0.072
Schistosoma mansoni glutathione-S-transferase 0.0091 0.0248 0.0806
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.042 1
Echinococcus granulosus neuropeptide s receptor 0.0037 0.0034 0.011

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 4.9 Activity against P388 leukemia cells in mice, by intraperitoneal dosing and net log tumor cell kill was reported ChEMBL. 3806589
Dose (functional) = 12.5 mg kg-1 Optimal dose per injection in mg/kg required to inhibit growth of P388 leukemia cells in mice ChEMBL. 3806589
IC50 (functional) = 6.3 M Tested in vitro against murine L1210 leukemia. ChEMBL. 3806589
T/C (functional) = 188 % Inhibition of P388 leukemia cells in mice, measured as percent treated to the control values with the number of 30 day survivors ChEMBL. 3806589

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.