Detailed information for compound 323133

Basic information

Technical information
  • TDR Targets ID: 323133
  • Name: 2-(2-bromophenyl)benzo[h][3,1]benzoxazin-4-on e
  • MW: 352.182 | Formula: C18H10BrNO2
  • H donors: 0 H acceptors: 1 LogP: 4.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccccc1c1oc(=O)c2c(n1)c1ccccc1cc2
  • InChi: 1S/C18H10BrNO2/c19-15-8-4-3-7-13(15)17-20-16-12-6-2-1-5-11(12)9-10-14(16)18(21)22-17/h1-10H
  • InChiKey: MTOMDFSLQNFJDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-bromophenyl)-4-benzo[h][3,1]benzoxazinone
  • 4H-Naphth[1,2-d][1,3]oxazin-4-one, 2-(2-bromophenyl)-
  • AIDS-219671
  • AIDS219671

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0139 0.1671 0.1661
Onchocerca volvulus 0.0139 0.1671 0.1789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0139 0.1671 0.1789
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.02 0.0253
Entamoeba histolytica glutamine synthetase, putative 0.0191 0.2371 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.1336 0.1427
Loa Loa (eye worm) norepinephrine transporter 0.0069 0.0729 0.0773
Onchocerca volvulus 0.0139 0.1671 0.1789
Toxoplasma gondii glutamine synthetase, type I, putative 0.0488 0.6359 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0705 0.9284 0.9284
Brugia malayi putative neuropeptide receptor 0.0139 0.1671 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0705 0.9284 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0139 0.1671 0.1661
Onchocerca volvulus 0.0139 0.1671 0.1789
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.0525 0.0552
Brugia malayi neuropeptide F receptor 0.0139 0.1671 0.1789
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.02 0.0253
Echinococcus granulosus neuropeptide FF receptor 2 0.0139 0.1671 0.1661
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0091 0.102 0.1009
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0139 0.1671 0.1789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.0058 0.0091
Schistosoma mansoni myosin xvIII 0.0139 0.1671 0.1661
Echinococcus multilocularis nuclear receptor nhr 48 0.0333 0.4272 0.4264
Loa Loa (eye worm) hypothetical protein 0.0373 0.4808 0.5172
Onchocerca volvulus 0.0139 0.1671 0.1789
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0133 0.0111
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0705 0.9284 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0191 0.0234
Brugia malayi nuclear receptor RXR 0.0373 0.4808 0.5172
Loa Loa (eye worm) CYP4Cod1 0.0018 0.004 0.003
Loa Loa (eye worm) hypothetical protein 0.0373 0.4808 0.5172
Echinococcus granulosus somatostatin receptor 0.0139 0.1671 0.1661
Trypanosoma brucei glutamine synthetase, putative 0.0758 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0705 0.9284 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0139 0.1671 0.1789
Schistosoma mansoni neuropeptide receptor 0.0139 0.1671 0.1661
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0333 0.4272 0.4593
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Echinococcus multilocularis neuropeptide receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0225 0.0315
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0056 0.0555 0.0517
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0705 0.9284 1
Loa Loa (eye worm) calcium channel 0.0091 0.102 0.1087
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Onchocerca volvulus Neuropeptide F receptor homolog 0.0139 0.1671 0.1789
Schistosoma mansoni amine GPCR 0.0139 0.1671 0.1661
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0333 0.4272 0.4264
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0069 0.0729 0.0773
Schistosoma mansoni amine GPCR 0.0139 0.1671 0.1661
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0705 0.9284 0.9284
Brugia malayi sulfakinin receptor protein 0.0139 0.1671 0.1789
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0705 0.9284 0.9284
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0705 0.9284 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Schistosoma mansoni thyroid hormone receptor 0.0705 0.9284 0.9284
Brugia malayi Nuclear hormone receptor E75 0.0333 0.4272 0.4593
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.004 0.0337 0.0324
Echinococcus multilocularis g protein coupled receptor 0.0139 0.1671 0.1661
Schistosoma mansoni hypothetical protein 0.0078 0.0848 0.0837
Schistosoma mansoni steroid hormone receptor ad4bp 0.0705 0.9284 0.9284
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0139 0.1671 0.1789
Echinococcus multilocularis neuropeptide Y receptor 0.0139 0.1671 0.1661
Schistosoma mansoni voltage-gated cation channel 0.0091 0.102 0.1009
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.0225 0.0293
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0191 0.0152
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0082 0.0069
Echinococcus granulosus 7TM GPCR rhodopsin 0.0139 0.1671 0.1661
Echinococcus multilocularis somatostatin receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0373 0.4808 0.4802
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.02 0.0202
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Brugia malayi G protein-coupled receptor F59B2.13 0.0139 0.1671 0.1789
Echinococcus multilocularis sex peptide receptor 0.0139 0.1671 0.1661
Trypanosoma cruzi glutamine synthetase, putative 0.0758 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0395 0.0413
Loa Loa (eye worm) hypothetical protein 0.0051 0.0475 0.0499
Echinococcus granulosus ecdysone induced protein 78C 0.0705 0.9284 0.9284
Brugia malayi nuclear receptor NHR-88 0.0333 0.4272 0.4593
Brugia malayi Nuclear hormone receptor-like 1 0.0373 0.4808 0.5172
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0191 0.0234
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0021 0.0076 0.0068
Onchocerca volvulus 0.0139 0.1671 0.1789
Schistosoma mansoni nuclear receptor 0.0333 0.4272 0.4264
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0333 0.4272 0.4593
Schistosoma mansoni biogenic amine (5HT) receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0139 0.1671 0.1661
Brugia malayi Dopamine receptor 0.0139 0.1671 0.1789
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0191 0.0234
Brugia malayi G protein-coupled receptor 0.0139 0.1671 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0705 0.9284 1
Brugia malayi GnHR receptor homolog 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus multilocularis G protein coupled receptor 139 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0705 0.9284 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0139 0.1671 0.1661
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Mycobacterium ulcerans hypothetical protein 0.0191 0.2371 0.3689
Schistosoma mansoni biogenic amine (5HT) receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.004 0.003
Trichomonas vaginalis glutamine synthetase, putative 0.0191 0.2371 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0013 0.002
Schistosoma mansoni coup transcription factor 0.0705 0.9284 0.9284
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0139 0.1671 0.1661
Echinococcus multilocularis fmrfamide receptor 0.0139 0.1671 0.1661
Echinococcus granulosus fmrfamide receptor 0.0139 0.1671 0.1661
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0373 0.4808 0.4802
Echinococcus multilocularis neuropeptides capa receptor 0.0139 0.1671 0.1661
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.02 0.0218
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0121 0.0092
Brugia malayi nuclear hormone receptor family member nhr-6 0.0333 0.4272 0.4593
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Brugia malayi photoreceptor-specific nuclear receptor 0.0705 0.9284 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0139 0.1671 0.1661
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0139 0.1671 0.1661
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.1336 0.1427
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.1336 0.1427
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0044 0.0034
Echinococcus multilocularis serotonin receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis fmrfamide receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) G-protein coupled receptor 0.0139 0.1671 0.1789
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0139 0.1671 0.1661
Echinococcus granulosus tachykinin peptides receptor 99D 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0283 0.0271
Loa Loa (eye worm) hypothetical protein 0.0176 0.2168 0.2325
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0091 0.102 0.1009
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Echinococcus granulosus orexin receptor type 2 0.0139 0.1671 0.1661
Echinococcus granulosus Nuclear hormone receptor HR96 0.0333 0.4272 0.4264
Onchocerca volvulus 0.0333 0.4272 0.4593
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0139 0.1671 0.1661
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0082 0.0128
Brugia malayi hypothetical protein 0.0176 0.2168 0.2325
Echinococcus granulosus nuclear receptor nhr 48 0.0333 0.4272 0.4264
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0191 0.2371 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0395 0.0383
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0133 0.0146
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0091 0.102 0.1009
Brugia malayi hypothetical protein 0.0373 0.4808 0.5172
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0705 0.9284 0.9284
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus granulosus serotonin transporter 0.0069 0.0729 0.0717
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0333 0.4272 0.4264
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0825 0.0876
Echinococcus multilocularis g protein coupled receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis glutamine synthetase 0.0758 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0333 0.4272 0.4264
Loa Loa (eye worm) hypothetical protein 0.0705 0.9284 1
Echinococcus multilocularis neuropeptide s receptor 0.0139 0.1671 0.1661
Schistosoma mansoni glutamine synthetase bacteria 0.0191 0.2371 0.2361
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0758 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0044 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0705 0.9284 0.9284
Echinococcus granulosus neuropeptides capa receptor 0.0139 0.1671 0.1661
Mycobacterium ulcerans thioesterase 0.0025 0.0133 0.0146
Echinococcus multilocularis Tolloid protein 1 0.0021 0.0076 0.0064
Loa Loa (eye worm) hypothetical protein 0.0705 0.9284 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.032 0.0331
Brugia malayi nuclear hormone receptor 0.0333 0.4272 0.4593
Echinococcus granulosus g protein coupled receptor 0.0139 0.1671 0.1661
Brugia malayi tailless protein 0.0333 0.4272 0.4593
Echinococcus granulosus Tolloid protein 1 0.0021 0.0076 0.0064
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni growth hormone secretagogue receptor 0.0139 0.1671 0.1661
Mycobacterium ulcerans glutamine synthetase 0.0488 0.6359 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.02 0.0253
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0091 0.102 0.1009
Brugia malayi G-protein coupled receptor 0.0139 0.1671 0.1789
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0139 0.1671 0.1661
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.02 0.0276
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0091 0.102 0.1009
Echinococcus granulosus 7tm_1 domain containing protein 0.0139 0.1671 0.1661
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0705 0.9284 1
Schistosoma mansoni neuropeptide F-like receptor 0.0139 0.1671 0.1661
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0488 0.6359 1
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0848 0.0902
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0139 0.1671 0.1661
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0705 0.9284 0.9284
Onchocerca volvulus 0.0139 0.1671 0.1789
Brugia malayi Nuclear hormone receptor-like 1 0.0373 0.4808 0.5172
Entamoeba histolytica glutamine synthetase, putative 0.0191 0.2371 0.5
Onchocerca volvulus 0.0139 0.1671 0.1789
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0139 0.1671 0.1661
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0139 0.1671 0.1661
Schistosoma mansoni hypothetical protein 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.0225 0.0315
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0705 0.9284 1
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Brugia malayi glutamine synthetase 0.0271 0.3437 0.3693
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Brugia malayi conserved hypotetical protein 0.0333 0.4272 0.4593
Brugia malayi nuclear receptor RXR 0.0333 0.4272 0.4593
Onchocerca volvulus 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus multilocularis voltage dependent calcium channel 0.0091 0.102 0.1009
Loa Loa (eye worm) nuclear hormone receptor 0.0333 0.4272 0.4593
Loa Loa (eye worm) G-protein coupled receptor 0.0139 0.1671 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0705 0.9284 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0091 0.102 0.1009
Loa Loa (eye worm) nuclear receptor NHR-67 0.0333 0.4272 0.4593
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.0562 0.0593
Loa Loa (eye worm) fatty acid synthase 0.003 0.0195 0.0196
Echinococcus granulosus neuropeptide receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0705 0.9284 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0121 0.0128
Brugia malayi ecdysone receptor 0.0333 0.4272 0.4593
Echinococcus multilocularis g protein coupled receptor 0.0139 0.1671 0.1661
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0283 0.0271
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0139 0.1671 0.1661
Echinococcus granulosus allatostatin A receptor 0.0139 0.1671 0.1661
Schistosoma mansoni hypothetical protein 0.0036 0.0283 0.0271
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.02 0.0276
Loa Loa (eye worm) voltage-dependent calcium channel 0.0021 0.0082 0.0074
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0121 0.0128
Schistosoma mansoni hypothetical protein 0.0036 0.0283 0.0271
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0139 0.1671 0.1661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0705 0.9284 1
Echinococcus granulosus tm gpcr rhodopsin 0.0139 0.1671 0.1661
Brugia malayi ecdysteroid receptor 0.0705 0.9284 1
Echinococcus multilocularis FTZ F1 alpha 0.0705 0.9284 0.9284
Brugia malayi ORL1-like opioid receptor 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0488 0.6359 1
Mycobacterium ulcerans polyketide synthase Pks9 0.002 0.0063 0.0036
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0139 0.1671 0.1789
Schistosoma mansoni nuclear receptor nhr-48 0.0333 0.4272 0.4264
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0373 0.4808 0.5172
Loa Loa (eye worm) hypothetical protein 0.0373 0.4808 0.5172
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0373 0.4808 0.4802
Onchocerca volvulus 0.0052 0.05 0.0525
Echinococcus multilocularis GPCR, family 2 0.0036 0.0283 0.0271
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni neuropeptide f receptor 76f 0.0139 0.1671 0.1661
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0044 0.0031
Schistosoma mansoni adenoreceptor 0.0139 0.1671 0.1661
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.0225 0.0258
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0333 0.4272 0.4264
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0002
Schistosoma mansoni amine GPCR 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0373 0.4808 0.5172
Onchocerca volvulus 0.0139 0.1671 0.1789
Echinococcus multilocularis allatostatin A receptor 0.0139 0.1671 0.1661
Onchocerca volvulus 0.0139 0.1671 0.1789
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0091 0.102 0.1009
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0333 0.4272 0.4593
Brugia malayi RNA binding protein 0.0076 0.0825 0.0876
Echinococcus granulosus tm gpcr rhodopsin 0.0139 0.1671 0.1661
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0333 0.4272 0.4264
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0225 0.0293
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0173 0.0174
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0333 0.4272 0.4264
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0705 0.9284 1
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0825 0.0813
Leishmania major glutamine synthetase, putative 0.0758 1 1
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0488 0.6359 1
Brugia malayi nuclear receptor NHR-88 0.0705 0.9284 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0086 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0705 0.9284 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0825 0.0813
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.04 0.057
Schistosoma mansoni neuropeptide receptor 0.0139 0.1671 0.1661
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni neuropeptide receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0283 0.0292
Loa Loa (eye worm) hypothetical protein 0.0032 0.0229 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0825 0.0813
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0825 0.0813
Brugia malayi Steroid receptor seven-up type 2 0.0705 0.9284 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Brugia malayi nuclear receptor NHR-67 0.0333 0.4272 0.4593
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0044 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.0139 0.1671 0.1661
Schistosoma mansoni retinoic acid receptor RXR 0.0705 0.9284 0.9284
Onchocerca volvulus 0.0069 0.0729 0.0773
Schistosoma mansoni glutamine synthetase bacteria 0.0191 0.2371 0.2361
Schistosoma mansoni nuclear hormone receptor 0.0333 0.4272 0.4264
Onchocerca volvulus 0.0139 0.1671 0.1789
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0091 0.102 0.1009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0705 0.9284 0.9284
Loa Loa (eye worm) hypothetical protein 0.0069 0.0729 0.0773
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0139 0.1671 0.1661
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0333 0.4272 0.4593
Schistosoma mansoni opsin-like receptor 0.0139 0.1671 0.1661
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0029 0.0191 0.0193
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.02 0.0218
Echinococcus granulosus peptide allatostatin:somatostatin 0.0139 0.1671 0.1661
Schistosoma mansoni hypothetical protein 0.0139 0.1671 0.1661
Brugia malayi Tachykinin-like peptides receptor 99D 0.0139 0.1671 0.1789
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0084 0.0131
Mycobacterium ulcerans polyketide synthase 0.0032 0.0225 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0705 0.9284 1
Brugia malayi Cytochrome P450 family protein 0.0018 0.004 0.003
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Echinococcus granulosus GPCR family 2 0.0036 0.0283 0.0271
Onchocerca volvulus 0.0176 0.2168 0.2325
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0191 0.0152
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0044 0.0031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0705 0.9284 0.9284
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0044 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0705 0.9284 0.9284
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0139 0.1671 0.1789
Plasmodium vivax glutamine synthetase, putative 0.0488 0.6359 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0395 0.0383
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.0225 0.0354
Loa Loa (eye worm) serotonin transporter b 0.0069 0.0729 0.0773
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0139 0.1671 0.1661
Echinococcus granulosus alpha 1A adrenergic receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0188 0.0256
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0091 0.102 0.1009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0705 0.9284 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0044 0.0031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0069 0.0729 0.0773
Loa Loa (eye worm) hypothetical protein 0.0705 0.9284 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.0225 0.0258
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.002 0.0063 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0044 0.0031
Echinococcus granulosus serotonin receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0705 0.9284 0.9284
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0044 0.0004
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Echinococcus multilocularis serotonin transporter 0.0069 0.0729 0.0717
Loa Loa (eye worm) steroid hormone receptor 0.0705 0.9284 1
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0447 0.0435
Onchocerca volvulus Bile acid receptor homolog 0.0705 0.9284 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0139 0.1671 0.1789
Schistosoma mansoni amine GPCR 0.0139 0.1671 0.1661
Loa Loa (eye worm) Gln-2 protein 0.0488 0.6359 0.6845
Brugia malayi hypothetical protein 0.0333 0.4272 0.4593
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0283 0.0292
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0705 0.9284 1
Brugia malayi isocitrate dehydrogenase 0.0018 0.0044 0.0034
Schistosoma mansoni RAR-like nuclear receptor 0.0705 0.9284 0.9284
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0705 0.9284 1
Loa Loa (eye worm) hypothetical protein 0.0705 0.9284 1
Loa Loa (eye worm) neuropeptide F receptor 0.0139 0.1671 0.1789
Brugia malayi nuclear hormone receptor 0.0705 0.9284 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Echinococcus granulosus sex peptide receptor 0.0139 0.1671 0.1661
Schistosoma mansoni thyroid hormone receptor 0.0705 0.9284 0.9284
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0705 0.9284 0.9284
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0044 0.0004
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Brugia malayi hypothetical protein 0.0019 0.0051 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0074
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.0126 0.0159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Schistosoma mansoni amine GPCR 0.0139 0.1671 0.1661
Onchocerca volvulus 0.0139 0.1671 0.1789
Brugia malayi RE15519p 0.0139 0.1671 0.1789
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.04 0.0535
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0069 0.0729 0.0717
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0139 0.1671 0.1661
Plasmodium falciparum glutamine synthetase, putative 0.0488 0.6359 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.04 0.0591
Schistosoma mansoni biogenic amine receptor 0.0139 0.1671 0.1661
Echinococcus granulosus G protein coupled receptor 139 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0705 0.9284 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0139 0.1671 0.1661
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0825 0.0813
Schistosoma mansoni hypothetical protein 0.0139 0.1671 0.1661
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0825 0.0876
Schistosoma mansoni sodium/chloride dependent transporter 0.0069 0.0729 0.0717
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.04 0.0591
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0705 0.9284 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni histamine h1 receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0705 0.9284 0.9284
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0139 0.1671 0.1661
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0705 0.9284 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0705 0.9284 0.9284
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0139 0.1671 0.1789
Onchocerca volvulus 0.0333 0.4272 0.4593
Onchocerca volvulus 0.0139 0.1671 0.1789
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) solute carrier family 6 member 4 0.0069 0.0729 0.0773
Onchocerca volvulus Protein ultraspiracle homolog 0.0705 0.9284 1
Schistosoma mansoni nuclear hormone receptor 0.0333 0.4272 0.4264
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.02 0.0276
Loa Loa (eye worm) hypothetical protein 0.0069 0.0729 0.0773
Brugia malayi Cytochrome P450 family protein 0.0018 0.004 0.003
Echinococcus granulosus biogenic amine 5HT receptor 0.0139 0.1671 0.1661
Brugia malayi AKH receptor 0.0139 0.1671 0.1789
Brugia malayi G-protein coupled receptor 0.0139 0.1671 0.1789
Schistosoma mansoni biogenic amine receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0395 0.0413
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0373 0.4808 0.4802
Loa Loa (eye worm) hypothetical protein 0.0021 0.0076 0.0068
Echinococcus multilocularis thyroid hormone receptor alpha 0.0705 0.9284 0.9284
Loa Loa (eye worm) melatonin receptor type 1A 0.0139 0.1671 0.1789
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0191 0.0301
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0139 0.1671 0.1661
Brugia malayi Serotonin receptor 0.0139 0.1671 0.1789
Echinococcus granulosus neuropeptide receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis neuropeptides capa receptor 0.0139 0.1671 0.1661
Brugia malayi TAR-binding protein 0.0076 0.0825 0.0876
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0044 0.0031
Brugia malayi hypothetical protein 0.0373 0.4808 0.5172
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0825 0.0813
Echinococcus multilocularis dro:myosuppressin receptor 0.0139 0.1671 0.1661
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0173 0.0234
Treponema pallidum sodium- and chloride- dependent transporter 0.0069 0.0729 0.5
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0091 0.102 0.1087
Echinococcus granulosus neuropeptide Y receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis g-protein coupled receptor 0.0139 0.1671 0.1661
Brugia malayi Melatonin receptor type 1A 0.0139 0.1671 0.1789
Schistosoma mansoni biogenic amine receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis sodium channel protein 0.004 0.0337 0.0324
Echinococcus multilocularis ecdysone induced protein 78C 0.0705 0.9284 0.9284
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0283 0.0292
Brugia malayi hypothetical protein 0.0029 0.0191 0.0193
Echinococcus granulosus biogenic amine 5HT receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0825 0.0876
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0705 0.9284 0.9284
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0044 0.0029
Brugia malayi putative neuropeptide receptor NPR1 0.0139 0.1671 0.1789
Loa Loa (eye worm) RNA binding protein 0.0076 0.0825 0.0876
Loa Loa (eye worm) TYRA-2 protein 0.0139 0.1671 0.1789
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Mycobacterium ulcerans polyketide synthase 0.003 0.02 0.0253
Brugia malayi follicle stimulating hormone receptor 0.0139 0.1671 0.1789
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0114 0.1336 0.1427
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0705 0.9284 0.9284
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0139 0.1671 0.1661
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.0191 0.2371 0.3703
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0333 0.4272 0.4264
Echinococcus granulosus neuropeptide receptor A26 0.0139 0.1671 0.1661
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0447 0.0435
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.02 0.0253
Loa Loa (eye worm) hypothetical protein 0.0078 0.0848 0.0902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Onchocerca volvulus 0.0028 0.0173 0.0174
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0044 0.0069
Trypanosoma cruzi glutamine synthetase, putative 0.0758 1 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus granulosus neuropeptides capa receptor 0.0139 0.1671 0.1661
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0825 0.0813
Echinococcus multilocularis voltage dependent calcium channel 0.0091 0.102 0.1009
Echinococcus granulosus dro:myosuppressin receptor 0.0139 0.1671 0.1661
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0139 0.1671 0.1661
Onchocerca volvulus 0.0139 0.1671 0.1789
Brugia malayi steroid hormone receptor 0.0705 0.9284 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0139 0.1671 0.1661
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0139 0.1671 0.1789
Schistosoma mansoni opsin-like receptor 0.0139 0.1671 0.1661
Brugia malayi hypothetical protein 0.0333 0.4272 0.4593
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0002
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0139 0.1671 0.1789
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0173 0.0174
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0139 0.1671 0.1661
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0056 0.0555 0.0517
Schistosoma mansoni hypothetical protein 0.0036 0.0283 0.0271
Onchocerca volvulus 0.0139 0.1671 0.1789
Echinococcus multilocularis serotonin receptor 0.0139 0.1671 0.1661
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0044 0.0004
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0013 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0191 0.0152
Schistosoma mansoni nuclear receptor 0.0333 0.4272 0.4264
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0044 0.0034
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Brugia malayi larval opioid receptor 0.0139 0.1671 0.1789
Schistosoma mansoni hypothetical protein 0.0139 0.1671 0.1661
Brugia malayi nuclear hormone receptor family member odr-7 0.0333 0.4272 0.4593
Schistosoma mansoni hypothetical protein 0.0036 0.0283 0.0271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Brugia malayi Serotonin receptor 0.0139 0.1671 0.1789
Brugia malayi Nuclear hormone receptor E75 0.0333 0.4272 0.4593
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Toxoplasma gondii hypothetical protein 0.0016 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Echinococcus granulosus hypothetical protein 0.0139 0.1671 0.1661
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.0225 0.0258
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0021 0.0076 0.0064
Echinococcus granulosus g protein coupled receptor 0.0139 0.1671 0.1661
Onchocerca volvulus 0.0139 0.1671 0.1789
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0705 0.9284 0.9284
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0139 0.1671 0.1789
Echinococcus granulosus g protein coupled receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0191 0.2371 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0044 0.0031
Schistosoma mansoni neuropeptide F-like receptor 0.0139 0.1671 0.1661
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0333 0.4272 0.4264
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0283 0.0271
Schistosoma mansoni alpha-1 adrenergic receptor 0.0139 0.1671 0.1661
Echinococcus granulosus g-protein coupled receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0139 0.1671 0.1661
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0133 0.0169
Onchocerca volvulus 0.0705 0.9284 1
Schistosoma mansoni opsin-like receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) DR-78 0.0333 0.4272 0.4593
Echinococcus multilocularis neuropeptide FF receptor 2 0.0139 0.1671 0.1661
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0139 0.1671 0.1661
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0333 0.4272 0.4264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0139 0.1671 0.1661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0705 0.9284 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.004 0.003
Echinococcus multilocularis neuropeptide Y receptor 0.0139 0.1671 0.1661
Schistosoma mansoni zinc finger protein 0.0333 0.4272 0.4264
Echinococcus granulosus Nuclear hormone receptor HR96 0.0333 0.4272 0.4264
Brugia malayi hypothetical protein 0.0139 0.1671 0.1789
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0044 0.0031
Brugia malayi Dopamine receptor protein 1 0.0139 0.1671 0.1789
Loa Loa (eye worm) neuropeptide F receptor 0.0139 0.1671 0.1789
Echinococcus granulosus thyroid hormone receptor alpha 0.0333 0.4272 0.4264
Echinococcus granulosus neuropeptide Y receptor 0.0139 0.1671 0.1661
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0139 0.1671 0.1661
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.0225 0.0315
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0283 0.0271
Loa Loa (eye worm) hypothetical protein 0.0333 0.4272 0.4593
Echinococcus granulosus FTZ F1 alpha 0.0705 0.9284 0.9284
Echinococcus granulosus neuropeptide s receptor 0.0139 0.1671 0.1661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0705 0.9284 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.1671 0.1661
Brugia malayi Dopamine receptor protein 2 0.0139 0.1671 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0705 0.9284 1
Brugia malayi Nuclear hormone receptor-like 1 0.0705 0.9284 1
Onchocerca volvulus 0.0139 0.1671 0.1789
Schistosoma mansoni neuropeptide receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis neuropeptide receptor 0.0139 0.1671 0.1661
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0705 0.9284 0.9284
Brugia malayi neuropeptide F receptor 0.0139 0.1671 0.1789
Schistosoma mansoni nuclear hormone receptor 0.0705 0.9284 0.9284
Loa Loa (eye worm) hypothetical protein 0.0705 0.9284 1
Leishmania major hypothetical protein, conserved 0.0029 0.0191 0.0152
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0373 0.4808 0.5172
Loa Loa (eye worm) hypothetical protein 0.0139 0.1671 0.1789
Loa Loa (eye worm) hypothetical protein 0.0091 0.102 0.1087
Brugia malayi orphan nuclear receptor NR2E1 0.0333 0.4272 0.4593
Onchocerca volvulus Glutamine synthetase homolog 0.0488 0.6359 0.6845
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0292
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0705 0.9284 0.9284
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0705 0.9284 0.9284
Echinococcus multilocularis orexin receptor type 2 0.0139 0.1671 0.1661
Echinococcus granulosus voltage dependent calcium channel 0.0091 0.102 0.1009
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0188 0.0256
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0139 0.1671 0.1661
Echinococcus multilocularis neuropeptide receptor A26 0.0139 0.1671 0.1661

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 ug ml-1 inhibitory concentration against anti-human coronavirus (HCoV) was determined in MRC-5 cells (human fibroblasts); Inactive ChEMBL. 15324901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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