Detailed information for compound 323250

Basic information

Technical information
  • TDR Targets ID: 323250
  • Name: 1-[3-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl )phenyl]-3-(3-methylphenyl)urea
  • MW: 375.396 | Formula: C22H18FN3O2
  • H donors: 3 H acceptors: 2 LogP: 3.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C)Nc1ccc(c(c1)F)c1cccc2c1CNC2=O
  • InChi: 1S/C22H18FN3O2/c1-13-4-2-5-14(10-13)25-22(28)26-15-8-9-17(20(23)11-15)16-6-3-7-18-19(16)12-24-21(18)27/h2-11H,12H2,1H3,(H,24,27)(H2,25,26,28)
  • InChiKey: NYCPRYBQAIILPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-fluoro-4-(1-oxoisoindolin-4-yl)phenyl]-3-(m-tolyl)urea
  • 1-[3-fluoro-4-(1-oxo-4-isoindolinyl)phenyl]-3-(m-tolyl)urea
  • 1-[3-fluoro-4-(1-ketoisoindolin-4-yl)phenyl]-3-(m-tolyl)urea
  • 1-[3-fluoro-4-(1-oxoisoindolin-4-yl)phenyl]-3-(3-methylphenyl)urea
  • 1-[3-fluoro-4-(1-oxo-4-isoindolinyl)phenyl]-3-(3-methylphenyl)urea
  • 1-[3-fluoro-4-(1-ketoisoindolin-4-yl)phenyl]-3-(3-methylphenyl)urea
  • isoindolinone analog 10a

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.149 0.1466
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.149 0.5508
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0519 0.2681 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0689 0.0595
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0173 0.0074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0003
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.149 0.4135
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.149 0.1466
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.149 0.1466
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0048 0.018 0.0178
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0111 0.001
Echinococcus granulosus lamin dm0 0.0027 0.0069 0.0069
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0519 0.2681 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0173 0.0171
Entamoeba histolytica hypothetical protein 0.0036 0.0118 0.0337
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1898 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0118 0.0337
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0006
Schistosoma mansoni DNA ligase IV 0.0019 0.0028 0.0028
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0069 0.0067
Loa Loa (eye worm) polyprenyl synthetase 0.0519 0.2681 0.268
Echinococcus granulosus intermediate filament protein 0.0027 0.0069 0.0069
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0519 0.2681 0.2661
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0519 0.2681 0.2681
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.018 0.0178
Schistosoma mansoni microtubule-associated protein tau 0.1362 0.7153 0.7153
Schistosoma mansoni hypothetical protein 0.0164 0.0793 0.0793
Onchocerca volvulus 0.0027 0.0069 0.0514
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0006 0.0006
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0519 0.2681 1
Brugia malayi topoisomerase 0.0019 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0026
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0173 0.0074
Schistosoma mansoni topbp1 0.0019 0.0028 0.0028
Echinococcus multilocularis microtubule associated protein 2 0.1362 0.7153 0.7153
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1898 1 1
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0685 0.3563 0.3561
Schistosoma mansoni trans-prenyltransferase 0.0519 0.2681 0.2681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.149 0.1466
Onchocerca volvulus 0.0167 0.081 0.9743
Mycobacterium ulcerans glutaminase 0.0276 0.1389 0.1364
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0519 0.2681 1
Schistosoma mansoni lamin 0.0027 0.0069 0.0069
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0028 0.0000005609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0202 0.02
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0028 0.00000014924
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0519 0.2681 1
Brugia malayi intermediate filament protein 0.0027 0.0069 0.0067
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0519 0.2681 0.2681
Schistosoma mansoni hypothetical protein 0.0047 0.0172 0.0172
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0118 0.0118
Brugia malayi glutaminase DH11.1 0.0276 0.1389 0.1386
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0519 0.2681 0.2681
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0519 0.2681 0.2661
Mycobacterium ulcerans hypothetical protein 0.0047 0.0173 0.0146
Loa Loa (eye worm) hypothetical protein 0.0047 0.0173 0.0171
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0111 0.0311
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.149 0.1466
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.149 0.1466
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0519 0.2681 0.2607
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0173 0.0146
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0028 0.0028
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0689 0.0663
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0006 0.0003
Brugia malayi hypothetical protein 0.0019 0.0028 0.0026
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.01 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0173 0.0146
Echinococcus multilocularis protein dispatched 1 0.0049 0.0183 0.0183
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0685 0.3563 0.3563
Schistosoma mansoni hypothetical protein 0.0036 0.0118 0.0118
Schistosoma mansoni cell adhesion molecule 0.0015 0.0004 0.0004
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0004 0.0004
Echinococcus multilocularis musashi 0.0027 0.0069 0.0069
Leishmania major farnesyl pyrophosphate synthase 0.1898 1 1
Giardia lamblia Farnesyl diphosphate synthase 0.1898 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.018 0.0178
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0173 0.0547
Schistosoma mansoni lamin 0.0027 0.0069 0.0069
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1898 1 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0028 0.0028
Echinococcus multilocularis nibrin 0.0019 0.0028 0.0028
Trypanosoma cruzi polyprenyl synthase, putative 0.0685 0.3563 0.3544
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.046 0.046
Trypanosoma cruzi polyprenyl synthase, putative 0.0685 0.3563 0.3544
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0026
Treponema pallidum octaprenyl-diphosphate synthase 0.0685 0.3563 1
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0685 0.3563 0.3561
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0173 0.0146
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1898 1 1
Echinococcus multilocularis protein patched 0.0043 0.0151 0.0151
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0519 0.2681 0.2661
Leishmania major solanesyl-diphosphate synthase, putative 0.0519 0.2681 0.2552
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.018 0.0178
Onchocerca volvulus 0.0027 0.0069 0.0514
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0006 0.0006
Echinococcus multilocularis lamin 0.0027 0.0069 0.0069
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.01 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0026
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0452 0.045
Loa Loa (eye worm) polyprenyl synthetase 0.1898 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0118 0.0118
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0028 0.00000014924
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.0143
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0111 0.0083
Echinococcus granulosus nibrin 0.0019 0.0028 0.0028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0173 0.0146
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0685 0.3563 0.3563
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1898 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0069 0.0067
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.083 1
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0519 0.2681 0.2607
Brugia malayi hypothetical protein 0.0019 0.0028 0.0026
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0519 0.2681 0.2661
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0452 0.1598
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1898 1 1
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0519 0.2681 0.2661
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0173 0.0547
Loa Loa (eye worm) hypothetical protein 0.0047 0.0173 0.0171
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1898 1 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0173 0.0171
Echinococcus granulosus microtubule associated protein 2 0.1362 0.7153 0.7153
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0173 0.0146
Loa Loa (eye worm) glutaminase 2 0.0276 0.1389 0.1386
Brugia malayi CHE-14 protein 0.0043 0.0151 0.0149
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0069 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0151 0.0123
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0006
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1898 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0173 0.0547
Echinococcus multilocularis lamin dm0 0.0027 0.0069 0.0069
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0173 0.0146
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0151 0.0151
Echinococcus multilocularis expressed conserved protein 0.0093 0.042 0.042
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0002
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0519 0.2681 0.2661
Entamoeba histolytica hypothetical protein 0.0036 0.0118 0.0337
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0108
Schistosoma mansoni survival motor neuron protein 0.0047 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0006
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0678 0.0678
Schistosoma mansoni hypothetical protein 0.0033 0.01 0.01
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0151 0.0149
Echinococcus granulosus geminin 0.0164 0.0793 0.0793
Trichomonas vaginalis glutaminase, putative 0.0276 0.1389 0.1364
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0519 0.2681 0.2607
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0047 0.0173 0.0171
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0173 0.0547
Schistosoma mansoni hypothetical protein 0.0164 0.0793 0.0793
Loa Loa (eye worm) hypothetical protein 0.0228 0.1136 0.1134
Brugia malayi hypothetical protein 0.0228 0.1136 0.1134
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0519 0.2681 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0108
Echinococcus multilocularis geminin 0.0164 0.0793 0.0793
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0452 0.0452
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0689 0.2492
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.149 0.1466
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0519 0.2681 0.2661
Loa Loa (eye worm) hypothetical protein 0.0099 0.0452 0.045
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0678 0.0678
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0173 0.0171
Loa Loa (eye worm) glutaminase 0.0276 0.1389 0.1386
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0118 0.0118
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.149 0.5508
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.1136 0.1136
Echinococcus granulosus lamin 0.0027 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0108
Echinococcus granulosus expressed conserved protein 0.0093 0.042 0.042
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0685 0.3563 0.3563
Loa Loa (eye worm) hypothetical protein 0.0027 0.0067 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0006 0.0003
Onchocerca volvulus 0.0047 0.0173 0.181
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1898 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.4266 0.4266
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0519 0.2681 0.2681
Schistosoma mansoni patched 1 0.0043 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0108
Brugia malayi hypothetical protein 0.0036 0.0118 0.0115
Onchocerca volvulus 0.0047 0.0172 0.1794
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1898 1 1
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1898 1 1
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1898 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0017
Echinococcus multilocularis GPCR, family 2 0.0015 0.0006 0.0006
Brugia malayi DKFZp564C0469 protein 0.0019 0.0028 0.0026
Echinococcus multilocularis roundabout 2 0.0018 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.0143
Schistosoma mansoni topbp1 0.0019 0.0028 0.0028
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1898 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0111 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0026
Leishmania major polyprenyl synthase, putative 0.0685 0.3563 0.3449
Echinococcus granulosus roundabout 2 0.0018 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0041 0.0143 0.0143
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0006 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0894 0.0892
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0519 0.2681 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0028 0.00000014924
Echinococcus granulosus GPCR family 2 0.0015 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.149 0.1466
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.1136 0.1136
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0519 0.2681 0.2661
Schistosoma mansoni intermediate filament proteins 0.0027 0.0069 0.0069
Schistosoma mansoni glutaminase 0.0276 0.1389 0.1389
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.0894 0.0892
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0519 0.2681 0.2661
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1898 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.149 0.1466
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0111 0.0083
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0028 0.0026
Entamoeba histolytica hypothetical protein 0.0036 0.0118 0.0337
Loa Loa (eye worm) hypothetical protein 0.0043 0.0151 0.0149
Toxoplasma gondii ATPase, AAA family protein 0.0019 0.0028 0.00000014924
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1898 1 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0151 0.0151
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0173 0.0146
Brugia malayi Polyprenyl synthetase family protein 0.0519 0.2681 0.268
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0172 0.017
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0173 0.0547
Schistosoma mansoni glutathione synthetase 0.0519 0.2681 0.2681

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 52 nM Inhibition of Vascular endothelial growth factor receptor 2 (KDR) ChEMBL. 15357981
IC50 (binding) = 52 nM Inhibition of Vascular endothelial growth factor receptor 2 (KDR) ChEMBL. 15357981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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