TDR Targets

Basic information

Technical information

TDR Targets ID: 323250
Name: 1-[3-fluoro-4-(1-oxo-2,3-dihydroisoindol-4-yl )phenyl]-3-(3-methylphenyl)urea
MW: 375.396 | Formula: C22H18FN3O2
H donors: 3 H acceptors: 2 LogP: 3.43 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc(c1)C)Nc1ccc(c(c1)F)c1cccc2c1CNC2=O
InChi: 1S/C22H18FN3O2/c1-13-4-2-5-14(10-13)25-22(28)26-15-8-9-17(20(23)11-15)16-6-3-7-18-19(16)12-24-21(18)27/h2-11H,12H2,1H3,(H,24,27)(H2,25,26,28)
InChiKey: NYCPRYBQAIILPS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[3-fluoro-4-(1-oxoisoindolin-4-yl)phenyl]-3-(m-tolyl)urea
1-[3-fluoro-4-(1-oxo-4-isoindolinyl)phenyl]-3-(m-tolyl)urea
1-[3-fluoro-4-(1-ketoisoindolin-4-yl)phenyl]-3-(m-tolyl)urea
1-[3-fluoro-4-(1-oxoisoindolin-4-yl)phenyl]-3-(3-methylphenyl)urea
1-[3-fluoro-4-(1-oxo-4-isoindolinyl)phenyl]-3-(3-methylphenyl)urea
1-[3-fluoro-4-(1-ketoisoindolin-4-yl)phenyl]-3-(3-methylphenyl)urea
isoindolinone analog 10a

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	geminin	0.0164	0.0793	0.0793
Schistosoma mansoni	hypothetical protein	0.0015	0.0006	0.0006
Loa Loa (eye worm)	glutaminase 2	0.0276	0.1389	0.1386
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.1898	1	1
Schistosoma mansoni	topbp1	0.0019	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0151	0.0149
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0519	0.2681	0.2661
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.0017
Brugia malayi	Pax transcription activation domain interacting protein	0.0019	0.0028	0.0026
Mycobacterium tuberculosis	Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase)	0.0519	0.2681	0.2607
Schistosoma mansoni	hypothetical protein	0.0036	0.0118	0.0118
Mycobacterium tuberculosis	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)	0.1898	1	1
Trichomonas vaginalis	replication factor C large subunit, putative	0.0019	0.0028	0.00000014924
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.018	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0111	0.0108
Brugia malayi	glutaminase DH11.1	0.0276	0.1389	0.1386
Schistosoma mansoni	topbp1	0.0019	0.0028	0.0028
Schistosoma mansoni	geranylgeranyl pyrophosphate synthase	0.0685	0.3563	0.3563
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.1898	1	1
Brugia malayi	geranylgeranyl pyrophosphate synthetase	0.0685	0.3563	0.3561
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0111	0.0083
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0004	0.0004
Echinococcus multilocularis	geranylgeranyl pyrophosphate synthase	0.0685	0.3563	0.3563
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0028	0.0026
Entamoeba histolytica	geranylgeranyl pyrophosphate synthase, putative	0.0519	0.2681	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0118	0.0118
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0111	0.001
Schistosoma mansoni	chromosome transmission fidelity factor	0.0019	0.0028	0.0028
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0019	0.0028	0.0000005609
Loa Loa (eye worm)	hypothetical protein	0.0033	0.01	0.0097
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.0452	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0173	0.0171
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0144	0.0689	0.0595
Leishmania major	polyprenyl synthase, putative	0.0685	0.3563	0.3449
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0172	0.017
Onchocerca volvulus		0.0047	0.0173	0.181
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0173	0.0171
Schistosoma mansoni	hypothetical protein	0.0041	0.0143	0.0143
Mycobacterium tuberculosis	Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate	0.0519	0.2681	0.2607
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0173	0.0171
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.1136	0.1136
Treponema pallidum	fructose-bisphosphate aldolase	0.0295	0.149	0.4135
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0183	0.0894	0.0892
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.1136	0.1136
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0006	0.0003
Trichomonas vaginalis	geranylgeranyl diphosphate synthase, putative	0.1898	1	1
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.1898	1	1
Schistosoma mansoni	glutathione synthetase	0.0519	0.2681	0.2681
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.1898	1	1
Echinococcus granulosus	prenyl decaprenyl diphosphate synthase	0.0519	0.2681	0.2681
Trypanosoma brucei	solanesyl-diphosphate synthase, putative	0.0519	0.2681	0.2661
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0019	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0111	0.0108
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0173	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0002
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0173	0.0146
Echinococcus multilocularis	nibrin	0.0019	0.0028	0.0028
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0295	0.149	0.1466
Echinococcus multilocularis	lamin	0.0027	0.0069	0.0069
Entamoeba histolytica	hypothetical protein	0.0036	0.0118	0.0337
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.01	0.0097
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0295	0.149	0.1466
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0173	0.0074
Echinococcus multilocularis	farnesyl pyrophosphate synthase	0.1898	1	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0069	0.0069
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0183	0.0183
Echinococcus granulosus	Niemann Pick C1 protein	0.0142	0.0678	0.0678
Brugia malayi	Polyprenyl synthetase family protein	0.0519	0.2681	0.268
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0069	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0111	0.0108
Trypanosoma brucei	farnesyl pyrophosphate synthase	0.1898	1	1
Onchocerca volvulus		0.0027	0.0069	0.0514
Schistosoma mansoni	hypothetical protein	0.0033	0.01	0.01
Brugia malayi	topoisomerase	0.0019	0.0028	0.0026
Entamoeba histolytica	geranylgeranyl pyrophosphate synthetase, putative	0.0519	0.2681	1
Schistosoma mansoni	trans-prenyltransferase	0.0519	0.2681	0.2681
Echinococcus multilocularis	musashi	0.0027	0.0069	0.0069
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0172	0.0172
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.0452	0.045
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0067	0.0064
Echinococcus granulosus	lamin	0.0027	0.0069	0.0069
Echinococcus granulosus	geranylgeranyl pyrophosphate synthase	0.0685	0.3563	0.3563
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0295	0.149	0.1466
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0006	0.0003
Echinococcus multilocularis	geminin	0.0164	0.0793	0.0793
Echinococcus granulosus	nibrin	0.0019	0.0028	0.0028
Giardia lamblia	Fructose-bisphosphate aldolase	0.0295	0.149	0.1466
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0295	0.149	0.5508
Loa Loa (eye worm)	glutaminase	0.0276	0.1389	0.1386
Schistosoma mansoni	patched 1	0.0043	0.0151	0.0151
Onchocerca volvulus		0.0047	0.0172	0.1794
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0173	0.0074
Echinococcus multilocularis	replication factor c subunit 1	0.0019	0.0028	0.0028
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0069	0.0067
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0173	0.0547
Schistosoma mansoni	hypothetical protein	0.0041	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0173	0.0171
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0006	0.0006
Echinococcus granulosus	roundabout 2	0.0018	0.0019	0.0019
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0019	0.0028	0.00000014924
Schistosoma mansoni	microtubule-associated protein tau	0.1362	0.7153	0.7153
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0006	0.0006
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0173	0.0146
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.018	0.0178
Trypanosoma cruzi	polyprenyl synthase, putative	0.0685	0.3563	0.3544
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0111	0.0108
Schistosoma mansoni	hypothetical protein	0.0047	0.0172	0.0172
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0519	0.2681	0.2661
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0069	0.0067
Schistosoma mansoni	hypothetical protein	0.0015	0.0006	0.0006
Echinococcus multilocularis	microtubule associated protein 2	0.1362	0.7153	0.7153
Echinococcus granulosus	decaprenyl diphosphate synthase subunit 1	0.0519	0.2681	0.2681
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0173	0.0171
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0173	0.0146
Plasmodium falciparum	geranylgeranyl pyrophosphate synthase, putative	0.1898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0028	0.0026
Brugia malayi	CHE-14 protein	0.0043	0.0151	0.0149
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0173	0.0146
Echinococcus multilocularis	prenyl (decaprenyl) diphosphate synthase	0.0519	0.2681	0.2681
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.018	0.0178
Schistosoma mansoni	hypothetical protein	0.0015	0.0006	0.0006
Schistosoma mansoni	lamin	0.0027	0.0069	0.0069
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0173	0.0547
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0173	0.0146
Brugia malayi	hypothetical protein	0.0019	0.0028	0.0026
Trypanosoma cruzi	solanesyl-diphosphate synthase	0.0519	0.2681	0.2661
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0144	0.0689	0.2492
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0118	0.0118
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0111	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0006	0.0003
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.1898	1	1
Mycobacterium tuberculosis	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)	0.0519	0.2681	0.2607
Schistosoma mansoni	DNA ligase IV	0.0019	0.0028	0.0028
Echinococcus granulosus	microtubule associated protein 2	0.1362	0.7153	0.7153
Trypanosoma cruzi	farnesyl pyrophosphate synthase	0.1898	1	1
Plasmodium falciparum	octaprenyl pyrophosphate synthase	0.0519	0.2681	0.2661
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0144	0.0689	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0228	0.1136	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0111	0.0108
Echinococcus granulosus	farnesyl pyrophosphate synthase	0.1898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0028	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0452	0.045
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0069	0.0069
Loa Loa (eye worm)	polyprenyl synthetase	0.1898	1	1
Echinococcus multilocularis	protein patched	0.0043	0.0151	0.0151
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0519	0.2681	0.2661
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0295	0.149	0.1466
Schistosoma mansoni	hypothetical protein	0.0041	0.0143	0.0143
Schistosoma mansoni	lamin	0.0027	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0028	0.0026
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0151	0.0151
Brugia malayi	hypothetical protein	0.0019	0.0028	0.0026
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0519	0.2681	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0173	0.0547
Echinococcus granulosus	replication factor c subunit 1	0.0019	0.0028	0.0028
Entamoeba histolytica	hypothetical protein	0.0036	0.0118	0.0337
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0006	0.0006
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0006	0.0006
Mycobacterium ulcerans	polyprenyl synthetase IdsB	0.0519	0.2681	0.2661
Trypanosoma cruzi	polyprenyl synthase, putative	0.0685	0.3563	0.3544
Schistosoma mansoni	hypothetical protein	0.0015	0.0006	0.0006
Loa Loa (eye worm)	geranylgeranyl pyrophosphate synthetase	0.0685	0.3563	0.3561
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0111	0.0083
Echinococcus granulosus	intermediate filament protein	0.0027	0.0069	0.0069
Mycobacterium ulcerans	glutaminase	0.0276	0.1389	0.1364
Giardia lamblia	Farnesyl diphosphate synthase	0.1898	1	1
Mycobacterium leprae	PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)	0.0519	0.2681	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0295	0.149	0.1466
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0295	0.149	0.1466
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0028	0.0026
Schistosoma mansoni	farnesyl pyrophosphate synthase	0.1898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0028	0.0026
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0151	0.0149
Entamoeba histolytica	hypothetical protein	0.0036	0.0118	0.0337
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0818	0.4266	0.4266
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0173	0.0146
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0183	0.0894	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0048	0.018	0.0178
Leishmania major	farnesyl pyrophosphate synthase	0.1898	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0019	0.0017
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0519	0.2681	1
Plasmodium vivax	geranylgeranyl pyrophosphate synthase	0.1898	1	1
Schistosoma mansoni	hypothetical protein	0.0164	0.0793	0.0793
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.0452	0.1598
Echinococcus granulosus	GPCR family 2	0.0015	0.0006	0.0006
Entamoeba histolytica	bifunctional short chain isoprenyl diphosphate synthase, putative	0.0519	0.2681	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0295	0.149	0.1466
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.0452	0.0452
Schistosoma mansoni	glutaminase	0.0276	0.1389	0.1389
Onchocerca volvulus	Tyrosine kinase homolog	0.0171	0.083	1
Chlamydia trachomatis	geranylgeranyl pyrophosphate synthase	0.0519	0.2681	1
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0006	0.0003
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0295	0.149	0.1466
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0151	0.0123
Toxoplasma gondii	ATPase, AAA family protein	0.0019	0.0028	0.00000014924
Echinococcus granulosus	lamin dm0	0.0027	0.0069	0.0069
Brugia malayi	DKFZp564C0469 protein	0.0019	0.0028	0.0026
Mycobacterium ulcerans	polyprenyl diphosphate synthetase, GrcC1	0.0519	0.2681	0.2661
Echinococcus multilocularis	Niemann Pick C1 protein	0.0142	0.0678	0.0678
Trypanosoma cruzi	farnesyl pyrophosphate synthase, putative	0.1898	1	1
Brugia malayi	hypothetical protein	0.0036	0.0118	0.0115
Entamoeba histolytica	hypothetical protein	0.0036	0.0118	0.0337
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0173	0.0547
Treponema pallidum	octaprenyl-diphosphate synthase	0.0685	0.3563	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0295	0.149	0.5508
Schistosoma mansoni	hypothetical protein	0.0164	0.0793	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0069	0.0067
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0173	0.0171
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0111	0.0083
Schistosoma mansoni	hypothetical protein	0.0041	0.0143	0.0143
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0151	0.0151
Trichomonas vaginalis	glutaminase, putative	0.0276	0.1389	0.1364
Echinococcus granulosus	expressed conserved protein	0.0093	0.042	0.042
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0004	0.0004
Brugia malayi	intermediate filament protein	0.0027	0.0069	0.0067
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0173	0.0146
Echinococcus multilocularis	roundabout 2	0.0018	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0202	0.02
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0019	0.0028	0.00000014924
Leishmania major	solanesyl-diphosphate synthase, putative	0.0519	0.2681	0.2552
Echinococcus multilocularis	decaprenyl diphosphate synthase subunit 1	0.0519	0.2681	0.2681
Onchocerca volvulus		0.0027	0.0069	0.0514
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0118	0.0118
Echinococcus multilocularis	expressed conserved protein	0.0093	0.042	0.042
Onchocerca volvulus		0.0167	0.081	0.9743
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.046	0.046
Loa Loa (eye worm)	polyprenyl synthetase	0.0519	0.2681	0.268
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0006	0.0006
Plasmodium vivax	octaprenyl pyrophosphate synthase, putative	0.0519	0.2681	0.2661
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0151	0.0151
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0173	0.0547
Brugia malayi	hypothetical protein	0.0228	0.1136	0.1134

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 52 nM	Inhibition of Vascular endothelial growth factor receptor 2 (KDR)	ChEMBL.	15357981
IC50 (binding)	= 52 nM	Inhibition of Vascular endothelial growth factor receptor 2 (KDR)	ChEMBL.	15357981

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 5329899

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 323250