TDR Targets

Basic information

Technical information

TDR Targets ID: 328838
Name: 6-[(4-nitrophenyl)methylsulfanyl]-9-[(2-pheny lphenyl)methyl]purine
MW: 453.516 | Formula: C25H19N5O2S
H donors: 0 H acceptors: 5 LogP: 5.44 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccc(cc1)CSc1ncnc2c1ncn2Cc1ccccc1c1ccccc1
InChi: 1S/C25H19N5O2S/c31-30(32)21-12-10-18(11-13-21)15-33-25-23-24(26-16-27-25)29(17-28-23)14-20-8-4-5-9-22(20)19-6-2-1-3-7-19/h1-13,16-17H,14-15H2
InChiKey: HLVDROLPPWIHMK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[(4-nitrophenyl)methylthio]-9-[(2-phenylphenyl)methyl]purine
6-[(4-nitrobenzyl)thio]-9-(2-phenylbenzyl)purine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 29 (equilibrative nucleoside transporter), member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	Get druggable targets OG5_127378	All targets in OG5_127378
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	Get druggable targets OG5_127378	All targets in OG5_127378
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Brugia malayi	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Entamoeba histolytica	nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus multilocularis	equilibrative nucleoside transporter protein	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus granulosus	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Brugia malayi	Nucleoside transporter family protein	Get druggable targets OG5_127378	All targets in OG5_127378
Schistosoma japonicum	Equilibrative nucleoside transporter 3, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus multilocularis	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Candida albicans	possible nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Giardia lamblia	Hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Candida albicans	possible nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus granulosus	equilibrative nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus multilocularis	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	purine nucleoside transporter	solute carrier family 29 (equilibrative nucleoside transporter), member 1	456 aa	396 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0095	0.001	0.001
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2888	0.3286	0.3265
Echinococcus granulosus	serine protein kinase ATM	0.1629	0.1809	0.1809
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	0.0551
Loa Loa (eye worm)	phosphatidylinositol 3	0.0556	0.0551	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.465	0.5353	0.5347
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0556	0.0551	0.052
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0556	0.0551	1
Loa Loa (eye worm)	hypothetical protein	0.1629	0.1809	0.1798
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0556	0.0551	0.0537
Onchocerca volvulus		0.0556	0.0551	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.8612	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0556	0.0551	0.0551
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0556	0.0551	0.0679
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.4073	0.4676	0.4659
Trichomonas vaginalis	PIKK family atypical protein kinase	0.685	0.7933	0.793
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0114	0.0032	0.0032
Echinococcus multilocularis	equilibrative nucleoside transporter protein	0.0098	0.0014	0.0014
Loa Loa (eye worm)	phosphatidylinositol 3	0.0556	0.0551	0.0537
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.8612	1	1
Echinococcus granulosus	equilibrative nucleoside transporter 3	0.0098	0.0014	0.0014
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0556	0.0551	0.0537
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2888	0.3286	0.3286
Schistosoma mansoni	immunophilin	0.0114	0.0032	0.0022
Trichomonas vaginalis	PIKK family atypical protein kinase	0.8612	1	1
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0556	0.0551	0.052
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0114	0.0032	0.0032
Plasmodium vivax	hypothetical protein, conserved	0.0556	0.0551	1
Trichomonas vaginalis	AGC family protein kinase	0.0138	0.0061	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.559	0.6456	0.6451
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2888	0.3286	0.3265
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0556	0.0551	0.0537
Entamoeba histolytica	hypothetical protein	0.0556	0.0551	0.0551
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0556	0.0551	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0014	0.0000082477
Loa Loa (eye worm)	hypothetical protein	0.0556	0.0551	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2888	0.3286	0.3277
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0114	0.0032	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2888	0.3286	0.3277
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2888	0.3286	0.3265
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0556	0.0551	0.0541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.685	0.7933	0.793
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0138	0.0061	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5146	0.5935	0.5929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2888	0.3286	0.3277
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0556	0.0551	0.0537
Loa Loa (eye worm)	phosphatidylinositol 3	0.0556	0.0551	0.0537
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.8612	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0556	0.0551	0.0537
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0095	0.001	0.001
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0114	0.0032	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0556	0.0551	0.0551
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.8612	1	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0556	0.0551	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0014	0.0000082477
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.6857	0.7942	0.7935
Entamoeba histolytica	protein kinase, putative	0.0138	0.0061	0.0061
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0556	0.0551	0.0551
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0095	0.001	0.001
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0556	0.0551	0.0551
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0556	0.0551	0.0541
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0556	0.0551	0.0551
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0114	0.0032	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1629	0.1809	0.1798
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	0.0551
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1629	0.1809	0.1809
Trichomonas vaginalis	PIKK family atypical protein kinase	0.685	0.7933	0.793
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0556	0.0551	0.0551
Schistosoma mansoni	hypothetical protein	0.1259	0.1376	0.1367
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6405	0.7412	0.7408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5777	0.6674	0.667
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0556	0.0551	0.0551
Trichomonas vaginalis	AGC family protein kinase	0.0138	0.0061	0.0047
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0556	0.0551	0.0551
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0114	0.0032	0.0018
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.8612	1	1
Loa Loa (eye worm)	hypothetical protein	0.1815	0.2028	0.2016
Entamoeba histolytica	hypothetical protein	0.0556	0.0551	0.0551
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.1259	0.1376	0.1376
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	0.052
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0556	0.0551	0.5
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0556	0.0551	0.0551
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1629	0.1809	0.1798
Echinococcus multilocularis	fk506 binding protein	0.0114	0.0032	0.0032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.8612	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1815	0.2028	0.2685
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0098	0.0014	0.0014
Echinococcus multilocularis		0.0556	0.0551	0.0551
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	0.0551
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0098	0.0014	0.0014
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0556	0.0551	0.0551
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0556	0.0551	0.0541
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0114	0.0032	0.0018
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0556	0.0551	0.0679
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	1
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0556	0.0551	0.0551
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0556	0.0551	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6405	0.7412	0.7408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6405	0.7412	0.7408
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0556	0.0551	0.0551
Echinococcus granulosus	serine/threonine protein kinase	0.0095	0.001	0.001
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0556	0.0551	0.0551
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6405	0.7412	0.7408
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0114	0.0032	0.0032
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0114	0.0032	0.0032
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0556	0.0551	0.0551
Plasmodium vivax	hypothetical protein	0.0556	0.0551	1
Schistosoma mansoni	immunophilin	0.0098	0.0014	0.0004
Schistosoma mansoni	immunophilin	0.0114	0.0032	0.0022
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0556	0.0551	0.0551
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1629	0.1809	0.1801
Brugia malayi	FAT domain containing protein	0.1259	0.1376	0.1364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4643	0.5345	0.5338
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0556	0.0551	0.0551
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0556	0.0551	0.0551
Trichomonas vaginalis	AGC family protein kinase	0.0138	0.0061	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.465	0.5353	0.5347
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0556	0.0551	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.685	0.7933	0.793
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1629	0.1809	0.1798
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2888	0.3286	0.3277
Entamoeba histolytica	protein kinase rad3, putative	0.1629	0.1809	0.1809
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6405	0.7412	0.7408
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0556	0.0551	0.0537
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0556	0.0551	0.0537
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1629	0.1809	0.1809
Loa Loa (eye worm)	phosphatidylinositol 3	0.0556	0.0551	0.0537
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0138	0.0061	0.0029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0556	0.0551	0.0537
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0114	0.0032	0.0032
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0556	0.0551	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.685	0.7933	0.793
Trichomonas vaginalis	conserved hypothetical protein	0.1259	0.1376	0.1364
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0556	0.0551	0.0679
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1629	0.1809	0.1809
Trichomonas vaginalis	PIKK family atypical protein kinase	0.465	0.5353	0.5347
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0556	0.0551	0.0551
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6405	0.7412	0.7408
Schistosoma mansoni	hypothetical protein	0.0556	0.0551	0.0541
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0556	0.0551	0.0551
Leishmania major	phosphatidylinositol kinase, putative	0.0556	0.0551	0.052
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0556	0.0551	0.0537
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.8612	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2888	0.3286	0.3286
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0556	0.0551	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.7352	0.8523	0.8521
Entamoeba histolytica	hypothetical protein	0.0556	0.0551	0.0551
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0114	0.0032	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0556	0.0551	0.0537
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0556	0.0551	0.0541
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0556	0.0551	0.0551
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1629	0.1809	0.1801
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0114	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.1755	0.1957	0.1946
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0556	0.0551	0.0551
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1073	0.1158	0.1158
Brugia malayi	Protein kinase domain containing protein	0.0138	0.0061	0.0047
Mycobacterium leprae	conserved hypothetical protein	0.0556	0.0551	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2311	0.2609	0.2599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5095	0.5875	0.5869
Brugia malayi	p70 ribosomal S6 kinase beta	0.013	0.0051	0.0037
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0556	0.0551	0.052
Loa Loa (eye worm)	hypothetical protein	0.1259	0.1376	0.1364
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.8612	1	1
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0114	0.0032	0.0032
Toxoplasma gondii	FATC domain-containing protein	0.1629	0.1809	0.2389
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2888	0.3286	0.3277
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0556	0.0551	0.0551
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1629	0.1809	0.1798
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0114	0.0032	0.0022
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2888	0.3286	0.328
Loa Loa (eye worm)	phosphatidylinositol 3	0.2888	0.3286	0.3277
Entamoeba histolytica	nucleoside transporter, putative	0.0098	0.0014	0.0014
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1629	0.1809	0.1809
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0114	0.0032	0.0032
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0114	0.0032	0.0018
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0556	0.0551	0.0537
Entamoeba histolytica	protein kinase, putative	0.0138	0.0061	0.0061
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0556	0.0551	1
Trypanosoma cruzi	Protein kinase B	0.0095	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.1815	0.2028	0.2016
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.1259	0.1376	0.1376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5146	0.5935	0.5929
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0556	0.0551	0.0541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1073	0.1158	0.1145
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0556	0.0551	0.0537
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0556	0.0551	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5095	0.5875	0.5869
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0556	0.0551	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0114	0.0032	0.0032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4643	0.5345	0.5338
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0556	0.0551	0.0551
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0556	0.0551	0.0551
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0556	0.0551	0.0537
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0114	0.0032	0.0032
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1629	0.1809	0.1783
Trichomonas vaginalis	PIKK family atypical protein kinase	0.465	0.5353	0.5347
Echinococcus multilocularis	Zinc finger, PHD finger	0.0556	0.0551	0.0551
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0114	0.0032	0.0018
Toxoplasma gondii	target of rapamycin (TOR), putative	0.6405	0.7412	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0556	0.0551	0.0541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.8612	1	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0556	0.0551	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0556	0.0551	0.0537
Trichomonas vaginalis	fk506-binding protein, putative	0.0114	0.0032	0.0018
Giardia lamblia	Hypothetical protein	0.0556	0.0551	0.0551
Echinococcus multilocularis	rac serine:threonine kinase	0.0095	0.001	0.001
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0114	0.0032	0.0018
Entamoeba histolytica	hypothetical protein	0.0556	0.0551	0.0551
Entamoeba histolytica	protein kinase, putative	0.013	0.0051	0.0051
Trypanosoma cruzi	target of rapamycin kinase 3	0.6857	0.7942	0.7942
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0556	0.0551	0.0551
Echinococcus granulosus	equilibrative nucleoside transporter	0.0098	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0014	0.0000082477
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1629	0.1809	0.1798
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6405	0.7412	0.7408
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0556	0.0551	0.0551
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	0.052
Giardia lamblia	Hypothetical protein	0.0098	0.0014	0.0014
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0556	0.0551	0.0537
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0556	0.0551	0.0541
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0556	0.0551	0.0537
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.8612	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0138	0.0061	0.0047
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.8612	1	1
Loa Loa (eye worm)	FKBP5 protein	0.0114	0.0032	0.0018
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.013	0.0051	0.0037
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.6857	0.7942	0.7935
Leishmania major	hypothetical protein, conserved	0.0556	0.0551	0.052
Trichomonas vaginalis	conserved hypothetical protein	0.1073	0.1158	0.1145
Entamoeba histolytica	hypothetical protein	0.1629	0.1809	0.1809
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0556	0.0551	0.0537
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0556	0.0551	0.052
Giardia lamblia	GTOR	0.8612	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1629	0.1809	0.1809
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2888	0.3286	0.3277
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0556	0.0551	0.0551
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0556	0.0551	0.0537
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5146	0.5935	0.5929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4643	0.5345	0.5338
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0114	0.0032	0.0032
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0556	0.0551	0.052
Loa Loa (eye worm)	hypothetical protein	0.1073	0.1158	0.1145
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2888	0.3286	0.3286
Trichomonas vaginalis	immunophilin, putative	0.0114	0.0032	0.0018
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.8612	1	1
Loa Loa (eye worm)	hypothetical protein	0.0556	0.0551	0.0537
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0556	0.0551	0.0537
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.8612	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0556	0.0551	0.0537
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0556	0.0551	0.052
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.3577	0.4094	0.4075
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2888	0.3286	0.3265
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0556	0.0551	0.0537
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0098	0.0014	0.0014
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.8612	1	1
Leishmania major	hypothetical protein, unknown function	0.0556	0.0551	0.052
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0556	0.0551	0.0551
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0556	0.0551	0.0551
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2888	0.3286	0.3286
Echinococcus multilocularis	serine protein kinase ATM	0.1629	0.1809	0.1809
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	0.0551
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	0.0551
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0556	0.0551	0.0537
Trichomonas vaginalis	AGC family protein kinase	0.0138	0.0061	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0138	0.0061	0.0047
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0556	0.0551	0.0551
Trichomonas vaginalis	AGC family protein kinase	0.0138	0.0061	0.0047
Onchocerca volvulus		0.0556	0.0551	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 281 nM	Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane	ChEMBL.	15481982
Ki (binding)	= 281 nM	Inhibition of [3H]-NBTI binding to nucleoside transport protein of human erythrocyte membrane	ChEMBL.	15481982

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 17860382

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 328838