Detailed information for compound 330747

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 266.336 | Formula: C14H22N2O3
  • H donors: 4 H acceptors: 2 LogP: -0.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCC(c1ccccc1)NC[C@H]1NC[C@@H]([C@@H]1O)O
  • InChi: 1S/C14H22N2O3/c1-19-9-12(10-5-3-2-4-6-10)15-7-11-14(18)13(17)8-16-11/h2-6,11-18H,7-9H2,1H3/t11-,12?,13+,14-/m1/s1
  • InChiKey: LBDZNBLTXQQPGI-NIWMIYJQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni coup transcription factor 0.0034 0.004 0.0342
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0343 0.0343
Onchocerca volvulus 0.0034 0.004 0.0011
Echinococcus multilocularis lysine specific demethylase 5A 0.0136 0.0452 0.3843
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.004 0.0313
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.004 0.0313
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0126 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.004 0.002
Brugia malayi hypothetical protein 0.0055 0.0126 0.0106
Toxoplasma gondii thioredoxin reductase 0.0042 0.0071 0.0604
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.005 0.005
Onchocerca volvulus Huntingtin homolog 0.0142 0.0475 0.0447
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0043 0.0338
Leishmania major hypothetical protein, conserved 0.0055 0.0126 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0043 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0043 0.0418
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.004 0.0388
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.004 0.002
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Schistosoma mansoni thyroid hormone receptor 0.0034 0.004 0.0342
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.005 0.0399
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0116 0.0097
Mycobacterium tuberculosis Probable reductase 0.0095 0.0284 0.0859
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0071 0.0719
Schistosoma mansoni hypothetical protein 0.0025 0.0004 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0139 0.0461 0.3938
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0043 0.0338
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.004 0.0011
Schistosoma mansoni protein phosphatase 2C 0.0036 0.005 0.0427
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.0327 0.0187
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.0284 0.0859
Loa Loa (eye worm) hypothetical protein 0.0049 0.0101 0.0101
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0043 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0452 0.3862
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0059 0.0588
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.005 0.0493
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.066 0.2556 0.5
Loa Loa (eye worm) hypothetical protein 0.2514 1 1
Schistosoma mansoni phd/f-box containing protein 0.0036 0.005 0.0427
Loa Loa (eye worm) jmjC domain-containing protein 0.0139 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.2514 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.004 0.0388
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0126 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0043 0.0043
Onchocerca volvulus 0.2514 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.004 0.0388
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0057 0.0132 0.0113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.004 0.002
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.005 0.0399
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.004 0.004
Brugia malayi nuclear hormone receptor 0.0034 0.004 0.002
Echinococcus multilocularis musashi 0.0031 0.003 0.0223
Onchocerca volvulus Huntingtin homolog 0.0142 0.0475 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.004 0.002
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.004 0.004
Brugia malayi jmjC domain containing protein 0.0036 0.005 0.003
Brugia malayi jmjC domain containing protein 0.0036 0.005 0.003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.004 0.0342
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.004 0.0313
Schistosoma mansoni lamin 0.0031 0.003 0.0252
Leishmania major trypanothione reductase 0.0042 0.0071 0.2704
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.0327 0.103
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0057 0.0132 0.113
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0071 0.2704
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0121 0.039 1
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Loa Loa (eye worm) mannosidase 0.0057 0.0132 0.0132
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0182 0.153
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0126 1
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.0946 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0121 0.039 0.1286
Schistosoma mansoni hypothetical protein 0.0053 0.0116 0.0995
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.004 0.004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.004 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.004 0.002
Schistosoma mansoni nuclear hormone receptor 0.0034 0.004 0.0342
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.004 0.0313
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.004 0.002
Echinococcus multilocularis phd:f box containing protein 0.0036 0.005 0.0399
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.004 0.0342
Loa Loa (eye worm) hypothetical protein 0.0142 0.0475 0.0475
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.004 0.004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.004 0.004
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.004 0.0342
Onchocerca volvulus 0.0053 0.0116 0.0087
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.0327 0.103
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.0327 0.103
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.004 0.0342
Schistosoma mansoni bromodomain containing protein 0.0073 0.0199 0.1698
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.004 0.0313
Loa Loa (eye worm) hypothetical protein 0.0045 0.0083 0.0083
Brugia malayi Bromodomain containing protein 0.0044 0.0082 0.0063
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.0284 0.0859
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.004 0.0342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.004 0.004
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0057 0.0132 0.1366
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0073 0.0594
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Schistosoma mansoni jumonji domain containing protein 0.0036 0.005 0.0427
Loa Loa (eye worm) hypothetical protein 0.0036 0.005 0.005
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.005 0.0427
Brugia malayi steroid hormone receptor 0.0034 0.004 0.002
Echinococcus granulosus lamin dm0 0.0031 0.003 0.0276
Plasmodium falciparum glutathione reductase 0.0042 0.0071 0.2704
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0121 0.039 0.1286
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.003 0.001
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0009 0.0046
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0136 0.0452 0.4758
Loa Loa (eye worm) hypothetical protein 0.0057 0.0132 0.0132
Brugia malayi jmjC domain containing protein 0.0036 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Treponema pallidum licC protein (licC) 0.0121 0.039 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.004 0.0313
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.004 0.0342
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.066 0.2556 1
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0057 0.0132 0.1104
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0073 0.0735
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0182 0.1894
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.004 0.0342
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0094 0.0094
Echinococcus multilocularis GPCR, family 2 0.0035 0.0043 0.0338
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0136 0.0452 0.3843
Schistosoma mansoni thyroid hormone receptor 0.0034 0.004 0.0342
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.004 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.004 0.0388
Schistosoma mansoni hypothetical protein 0.0075 0.0204 0.1745
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0126 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.0284 0.0859
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0009 0.0057
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Loa Loa (eye worm) hypothetical protein 0.0142 0.0475 0.0475
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.004 0.002
Loa Loa (eye worm) intermediate filament protein 0.0031 0.003 0.003
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.004 0.0388
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.005 0.0399
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.0284 0.0859
Schistosoma mansoni lamin 0.0031 0.003 0.0252
Loa Loa (eye worm) glutathione reductase 0.0042 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0132 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.004 0.0342
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0057 0.0132 0.1366
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0071 0.0071
Loa Loa (eye worm) runx1 0.0315 0.117 0.117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.004 0.0313
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0071 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.004 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.004 0.0342
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0009 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.004 0.002
Echinococcus granulosus intermediate filament protein 0.0031 0.003 0.0276
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.004 0.002
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.066 0.2556 1
Echinococcus multilocularis Protein lozenge 0.0315 0.117 1
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.005 0.0493
Brugia malayi glutathione reductase 0.0042 0.0071 0.0051
Brugia malayi intermediate filament protein 0.0031 0.003 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.004 0.0313
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.066 0.2556 1
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.005 0.005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0043 0.0418
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0366
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0343 0.0324
Echinococcus granulosus lysine specific demethylase 5A 0.0139 0.0461 0.4852
Echinococcus multilocularis lamin 0.0031 0.003 0.0223
Brugia malayi hypothetical protein 0.0036 0.0047 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.004 0.002
Brugia malayi Thioredoxin reductase 0.0042 0.0071 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0132 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.004 0.0388
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0126 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0126 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0103
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.004 0.002
Schistosoma mansoni intermediate filament proteins 0.0031 0.003 0.0252
Brugia malayi Bromodomain containing protein 0.0087 0.0253 0.0234
Schistosoma mansoni lozenge 0.0315 0.117 1
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.005 0.0493
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0366
Loa Loa (eye worm) hypothetical protein 0.0109 0.0343 0.0343
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0343 0.0324
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.004 0.004
Brugia malayi hypothetical protein 0.0142 0.0475 0.0456
Echinococcus granulosus GPCR family 2 0.0035 0.0043 0.0418
Brugia malayi jmjC domain containing protein 0.0139 0.0461 0.0442
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.005 0.005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.0284 0.0859
Plasmodium vivax glutathione reductase, putative 0.0042 0.0071 0.2704
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0204 0.0185
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0126 0.2235
Brugia malayi hypothetical protein 0.0259 0.0946 0.0928
Brugia malayi jmjC domain containing protein 0.0136 0.0452 0.0433
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0071 0.2704
Loa Loa (eye worm) hypothetical protein 0.0036 0.005 0.005
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0057 0.0132 0.1104
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0059 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.004 0.002
Brugia malayi jmjC domain containing protein 0.0036 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0027
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Plasmodium falciparum thioredoxin reductase 0.0042 0.0071 0.2704
Echinococcus granulosus phd:f box containing protein 0.0036 0.005 0.0493
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.005 0.0427
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.0946 0.8078
Brugia malayi nuclear receptor NHR-88 0.0034 0.004 0.002
Echinococcus granulosus lamin 0.0031 0.003 0.0276
Echinococcus multilocularis transfer RNA-Trp 0.0057 0.0132 0.1104
Echinococcus multilocularis lamin dm0 0.0031 0.003 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.004 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.004 0.0313
Trypanosoma brucei trypanothione reductase 0.0042 0.0071 0.2704
Schistosoma mansoni jumonji/arid domain-containing protein 0.0139 0.0461 0.3938
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0126 0.0126
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.004 0.0388
Echinococcus granulosus FTZ F1 alpha 0.0034 0.004 0.0388
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0259 0.0946 0.0946
Schistosoma mansoni survival motor neuron protein 0.0053 0.0116 0.0995
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Brugia malayi ecdysteroid receptor 0.0034 0.004 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.004 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.004 0.002
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0366
Loa Loa (eye worm) hypothetical protein 0.0082 0.0233 0.0233

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 63 % Inhibitory activity against alpha-Mannosidase isolated from Almond at 1 mM ChEMBL. 15974577
Inhibition (functional) = 63 % Inhibitory activity against alpha-Mannosidase isolated from Almond at 1 mM ChEMBL. 15974577
Inhibition (functional) = 77 % Inhibitory activity against alpha-Mannosidase from jack bean at 1 mM ChEMBL. 15974577
Inhibition (functional) = 77 % Inhibitory activity against alpha-Mannosidase from jack bean at 1 mM ChEMBL. 15974577

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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