TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 222.156 | Formula: C7H13NO5P---
H donors: 0 H acceptors: 5 LogP: -0.6 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(P(=O)([O-])[O-])CCN(C=O)[O-]
InChi: 1S/C7H15NO5P/c1-2-3-7(14(11,12)13)4-5-8(10)6-9/h6-7H,2-5H2,1H3,(H2,11,12,13)/q-1/p-2
InChiKey: LQKCMRUXGDYBFY-UHFFFAOYSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0038	0.0181	0.0386
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0407	0.4699	0.5907
Onchocerca volvulus		0.0032	0.0117	0.0633
Trichomonas vaginalis	esterase, putative	0.0035	0.0145	0.0085
Mycobacterium tuberculosis	Probable reductase	0.0104	0.0994	0.4079
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.6077	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0279	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0152	0.0323
Schistosoma mansoni	hypothetical protein	0.0035	0.0145	0.0036
Onchocerca volvulus		0.0032	0.0117	0.0633
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0152	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0145	0.0309
Brugia malayi	glutaminase DH11.1	0.0283	0.3185	0.6779
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.3425	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0038	0.0181	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0145	0.0309
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0145	0.0596
Leishmania major	trypanothione reductase	0.0046	0.0279	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0145	0.0596
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0145	0.0085
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0083	0.0737	0.1568
Echinococcus granulosus	lamin	0.0083	0.0737	0.0799
Echinococcus multilocularis	geminin	0.0172	0.183	0.1733
Onchocerca volvulus	Glucosylceramidase homolog	0.0174	0.185	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0038	0.0181	0.0065
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0145	0.0085
Brugia malayi	glutathione reductase	0.0046	0.0279	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Onchocerca volvulus		0.0032	0.0117	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.185	0.5239
Onchocerca volvulus		0.0032	0.0117	0.0633
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.0994	0.4079
Schistosoma mansoni	protein tyrosine phosphatase	0.0038	0.0181	0.0083
Brugia malayi	beta-lactamase family protein	0.0035	0.0145	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.0994	0.4079
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.2967	0.8615
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.0994	0.4079
Onchocerca volvulus		0.0032	0.0117	0.0633
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0279	0.1143
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0145	0.0185
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0032	0.0117	0.0249
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.2967	0.8615
Brugia malayi	Protein-tyrosine phosphatase	0.012	0.1183	0.2518
Echinococcus granulosus	lamin dm0	0.0083	0.0737	0.0799
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Schistosoma mansoni	hypothetical protein	0.005	0.0331	0.0276
Onchocerca volvulus		0.0032	0.0117	0.0633
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0104	0.0994	0.1636
Giardia lamblia	Fructose-bisphosphate aldolase	0.0303	0.3425	0.8249
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0279	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	glutaminase 2	0.0283	0.3185	0.6779
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.185	0.5239
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0407	0.4699	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0279	1
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0032	0.0117	0.0249
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.1137	0.4662
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.1137	0.187
Leishmania major	tyrosine specific protein phosphatase, putative	0.0032	0.0117	0.4205
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0145	0.4557
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.0994	0.4079
Schistosoma mansoni	lamin	0.0083	0.0737	0.0799
Onchocerca volvulus		0.0032	0.0117	0.0633
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0145	0.0596
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0145	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0034	0.0072
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0145	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Onchocerca volvulus		0.005	0.0331	0.1791
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0032	0.0117	0.0249
Trypanosoma brucei	trypanothione reductase	0.0046	0.0279	1
Brugia malayi	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Onchocerca volvulus		0.0032	0.0117	0.0633
Onchocerca volvulus		0.0032	0.0117	0.0633
Brugia malayi	hypothetical protein	0.0035	0.0145	0.0309
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0145	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Mycobacterium ulcerans	lipase LipD	0.0035	0.0145	0.0239
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0038	0.0181	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0192	0.0408
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0156	0.1623	0.1942
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0303	0.3425	0.8299
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0148	0.153	0.6276
Onchocerca volvulus		0.0032	0.0117	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.3425	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0038	0.0181	0.0083
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0407	0.4699	0.5907
Onchocerca volvulus		0.0032	0.0117	0.0633
Onchocerca volvulus		0.0035	0.0145	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1119	0.2381
Entamoeba histolytica	hypothetical protein	0.0035	0.0145	0.0351
Leishmania major	hypothetical protein, conserved	0.0035	0.0145	0.5215
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0181	0.0083
Entamoeba histolytica	hypothetical protein	0.0103	0.0974	0.236
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0032	0.0117	0.3407
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0181	0.0083
Onchocerca volvulus		0.0035	0.0145	0.0785
Entamoeba histolytica	hypothetical protein	0.0035	0.0145	0.0351
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0156	0.1623	0.3455
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0038	0.0181	0.0065
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.185	0.5239
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.185	0.5239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Echinococcus multilocularis	survival motor neuron protein 1	0.0245	0.2718	0.2631
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Mycobacterium ulcerans	glutaminase	0.0283	0.3185	0.5242
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0038	0.0181	0.0065
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0181	0.0083
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.185	0.5239
Schistosoma mansoni	survival motor neuron protein	0.005	0.0331	0.0276
Trichomonas vaginalis	glutaminase, putative	0.0283	0.3185	0.9275
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.6077	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6077	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0279	0.0405
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6077	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0045	0.0265	0.0563
Brugia malayi	hypothetical protein	0.0032	0.0117	0.0249
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.2967	0.8615
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0181	0.0083
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0145	0.0309
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0032	0.0117	0.0284
Schistosoma mansoni	hypothetical protein	0.0035	0.0152	0.0045
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0038	0.0181	0.0065
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0145	0.0028
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0303	0.3425	0.8299
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0156	0.1623	0.1524
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.3425	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0721	0.1535
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0352	0.0749
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0145	0.0085
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Brugia malayi	Intermediate filament tail domain containing protein	0.0083	0.0737	0.1568
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.3425	1
Onchocerca volvulus		0.0032	0.0117	0.0633
Echinococcus granulosus	geminin	0.0172	0.183	0.2208
Brugia malayi	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	glutaminase	0.0283	0.3185	0.6779
Echinococcus granulosus	microtubule associated protein 2	0.0667	0.7874	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0145	0.0239
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0032	0.0117	0.0284
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Schistosoma mansoni	hypothetical protein	0.0172	0.183	0.2208
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.1965	0.5586
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.2967	0.8615
Brugia malayi	Protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Brugia malayi	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0145	0.0085
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Onchocerca volvulus		0.0032	0.0117	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Echinococcus multilocularis	lamin	0.0083	0.0737	0.0627
Schistosoma mansoni	lamin	0.0083	0.0737	0.0799
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0156	0.1623	0.1942
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0145	0.0239
Schistosoma mansoni	intermediate filament proteins	0.0083	0.0737	0.0799
Entamoeba histolytica	hypothetical protein	0.0035	0.0145	0.0351
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0156	0.1623	0.1524
Schistosoma mansoni	glutaminase	0.0283	0.3185	0.3956
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6077	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0034	0.121
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2718	0.5784
Onchocerca volvulus		0.0087	0.0786	0.4247
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0038	0.0181	0.0065
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0352	0.0749
Echinococcus multilocularis	musashi	0.0083	0.0737	0.0627
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0279	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0145	0.0028
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0145	0.0239
Onchocerca volvulus		0.0032	0.0117	0.0633
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0407	0.4699	0.4636
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0032	0.0117	0.3407
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.052	0.6077	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0032	0.0117	0.3407
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0737	0.1568
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.0125	0.1249	0.5122
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0145	0.0085
Onchocerca volvulus		0.0035	0.0145	0.0785
Trichomonas vaginalis	glucosylceramidase, putative	0.0184	0.1965	0.5586
Echinococcus multilocularis	microtubule associated protein 2	0.0667	0.7874	0.7849
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Onchocerca volvulus		0.0032	0.0117	0.0633
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0148	0.153	0.2518
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0032	0.0117	0.0284
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0145	0.0596
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Brugia malayi	hypothetical protein	0.0032	0.0117	0.0249
Schistosoma mansoni	hypothetical protein	0.0172	0.183	0.2208
Brugia malayi	cytoplasmic intermediate filament protein	0.0045	0.0265	0.0563
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0279	0.0593
Onchocerca volvulus		0.0083	0.0737	0.3981
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0407	0.4699	1
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0192	0.0408
Echinococcus granulosus	intermediate filament protein	0.0083	0.0737	0.0799
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Echinococcus granulosus	survival motor neuron protein 1	0.0245	0.2718	0.3353
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0331	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0718	0.1528
Giardia lamblia	DNA repair protein RAD52	0.036	0.4127	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0145	0.0596
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.185	0.5239
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.185	0.5239
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.3425	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0145	0.0309
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0156	0.1623	0.1942
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0145	0.0309
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0032	0.0117	0.4205
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0145	0.0596
Onchocerca volvulus		0.0032	0.0117	0.0633
Entamoeba histolytica	hypothetical protein	0.0035	0.0145	0.0351
Onchocerca volvulus		0.0032	0.0117	0.0633
Loa Loa (eye worm)	intermediate filament protein	0.0083	0.0737	0.1568
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0038	0.0181	0.0083
Onchocerca volvulus		0.0032	0.0117	0.0633
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0148	0.153	0.2518
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0156	0.1623	0.3455
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0265	0.2967	0.6314
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0181	0.0083
Onchocerca volvulus		0.0032	0.0117	0.0633
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0352	0.0749
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0145	0.0239
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0145	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0145	0.0309
Onchocerca volvulus		0.0032	0.0117	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0721	0.1535
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.3425	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.2967	0.8615
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.004	0.0211	0.0094
Onchocerca volvulus		0.0032	0.0117	0.0633
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0265	0.2967	0.6314
Brugia malayi	beta-lactamase family protein	0.0035	0.0145	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0145	0.0309
Brugia malayi	hypothetical protein	0.0026	0.0034	0.0072
Brugia malayi	beta-lactamase	0.0035	0.0145	0.0309
Brugia malayi	Thioredoxin reductase	0.0046	0.0279	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0145	0.0309
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0145	0.0596
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.1137	0.4662
Echinococcus multilocularis	lamin dm0	0.0083	0.0737	0.0627
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6077	1
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.036	0.4127	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.0994	0.4079
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0145	0.0036
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0145	0.4557
Brugia malayi	intermediate filament protein	0.0083	0.0737	0.1568
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0145	0.0036
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Onchocerca volvulus		0.0032	0.0117	0.0633
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0038	0.0181	0.0083
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.004	0.0211	0.012
Onchocerca volvulus		0.0032	0.0117	0.0633
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Onchocerca volvulus		0.0083	0.0737	0.3981
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Plasmodium falciparum	glutathione reductase	0.0046	0.0279	0.0405
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.3425	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0352	0.0749
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0032	0.0117	0.3407
Toxoplasma gondii	ABC1 family protein	0.0035	0.0145	0.0185
Brugia malayi	hypothetical protein	0.0245	0.2718	0.5784
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.1137	0.4662
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0145	0.4557
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0279	0.0405
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0145	0.0596
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0279	0.0405
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.2438	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0032	0.0117	0.0249
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0145	0.0596
Schistosoma mansoni	microtubule-associated protein tau	0.0667	0.7874	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0303	0.3425	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0211	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6077	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0265	0.2967	0.8615
Brugia malayi	Protein-tyrosine phosphatase 1	0.0032	0.0117	0.0249
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0103	0.0974	0.236
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0145	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0721	0.1535
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0032	0.0117	0.0249
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0032	0.0117	0.0249
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0145	0.0036
Onchocerca volvulus	4.1 G protein, putative homolog	0.0032	0.0117	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.0249
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0145	0.0036
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0279	0.0405

Activities

Activity type	Activity value	Assay description	Source	Reference
Log IC50 (binding)	= 5.09	Inhibitory concentration against DOXP reductoisomerase	ChEMBL.	15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 422577

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 336819