Detailed information for compound 33852

Basic information

Technical information
  • TDR Targets ID: 33852
  • Name: 6-(3,4-dichlorophenyl)-3,4-dihydro-2H-pyrano[ 3,2-c][1,8]naphthyridin-5-one
  • MW: 347.195 | Formula: C17H12Cl2N2O2
  • H donors: 0 H acceptors: 2 LogP: 3.68 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1Cl)n1c(=O)c2CCCOc2c2c1nccc2
  • InChi: 1S/C17H12Cl2N2O2/c18-13-6-5-10(9-14(13)19)21-16-11(3-1-7-20-16)15-12(17(21)22)4-2-8-23-15/h1,3,5-7,9H,2,4,8H2
  • InChiKey: UHABFRPZSFDMKW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0255 0.0255
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0948 0.1109
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0264 0.7111 0.7111
Echinococcus granulosus 7tm_1 domain containing protein 0.0007 0.0019 0.0019
Brugia malayi Death domain containing protein 0.0015 0.0255 0.0316
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.006 0.0075
Loa Loa (eye worm) steroid hormone receptor 0.0105 0.2726 0.3383
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0948 0.1109
Loa Loa (eye worm) hypothetical protein 0.0055 0.1363 0.1692
Schistosoma mansoni amine GPCR 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.006 0.006
Echinococcus multilocularis tar DNA binding protein 0.0068 0.1708 0.1708
Echinococcus multilocularis serotonin receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.1261 0.1566
Loa Loa (eye worm) melatonin receptor type 1A 0.0007 0.0019 0.0023
Echinococcus granulosus orexin receptor type 2 0.0007 0.0019 0.0019
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.6821 0.6821
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0105 0.2726 0.3383
Loa Loa (eye worm) inositol-1 0.004 0.0948 0.1176
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0105 0.2726 1
Onchocerca volvulus 0.0105 0.2726 1
Brugia malayi nuclear hormone receptor 0.0049 0.12 0.1489
Schistosoma mansoni myosin xvIII 0.0007 0.0019 0.0019
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.12 0.1489
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1708 0.1708
Echinococcus multilocularis FTZ F1 alpha 0.0105 0.2726 0.2726
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0105 0.2726 0.2726
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0948 0.1109
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.1369 0.1395
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0105 0.2726 0.2726
Schistosoma mansoni thyroid hormone receptor 0.0368 1 1
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0019 0.0019
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.006 0.0062
Echinococcus granulosus G protein coupled receptor 139 0.0007 0.0019 0.0019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.3997 0.4072
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0007 0.0019 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0105 0.2726 0.3383
Schistosoma mansoni hypothetical protein 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0105 0.2726 0.3383
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.1135 0.1135
Echinococcus multilocularis g-protein coupled receptor 0.0007 0.0019 0.0019
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0007 0.0019 0.0019
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.6812 0.8455
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0164 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.2726 0.3383
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0008 0.006 0.0075
Schistosoma mansoni histamine h1 receptor 0.0007 0.0019 0.0019
Brugia malayi nuclear receptor RXR 0.0049 0.12 0.1489
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.006 0.006
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) DR-78 0.0049 0.12 0.1489
Schistosoma mansoni hypothetical protein 0.0078 0.1981 0.1981
Echinococcus multilocularis allatostatin A receptor 0.0007 0.0019 0.0019
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0007 0.0019 0.0019
Onchocerca volvulus Protein ultraspiracle homolog 0.0105 0.2726 1
Schistosoma mansoni hypothetical protein 0.0264 0.7111 0.7111
Mycobacterium ulcerans glutaminase 0.0298 0.8057 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0049 0.12 0.12
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.1363 0.1692
Brugia malayi Serotonin receptor 0.0007 0.0019 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0019 0.0019
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0007 0.0019 0.0019
Brugia malayi hypothetical protein 0.0055 0.1363 0.1692
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.1369 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.12 0.12
Schistosoma mansoni neuropeptide receptor 0.0007 0.0019 0.0019
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.006 0.0062
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0105 0.2726 0.2777
Entamoeba histolytica hypothetical protein 0.0078 0.1981 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.2726 0.3383
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0007 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0007 0.0019 0.0019
Brugia malayi neuropeptide F receptor 0.0007 0.0019 0.0023
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.1369 0.1699
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0105 0.2726 0.3383
Schistosoma mansoni alpha-1 adrenergic receptor 0.0007 0.0019 0.0019
Brugia malayi Nuclear hormone receptor E75 0.0049 0.12 0.1489
Schistosoma mansoni amine GPCR 0.0007 0.0019 0.0019
Schistosoma mansoni biogenic amine receptor 0.0007 0.0019 0.0019
Onchocerca volvulus 0.0049 0.12 0.4362
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Entamoeba histolytica hypothetical protein 0.0078 0.1981 1
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0105 0.2726 0.3383
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Echinococcus multilocularis neuropeptide receptor A26 0.0007 0.0019 0.0019
Brugia malayi neuropeptide F receptor 0.0007 0.0019 0.0023
Schistosoma mansoni nuclear receptor 0.0049 0.12 0.12
Onchocerca volvulus Bile acid receptor homolog 0.0105 0.2726 1
Brugia malayi Inositol-1 0.004 0.0948 0.1176
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.2726 0.3383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0105 0.2726 0.3383
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0008 0.006 0.0062
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0019 0.0023
Schistosoma mansoni hypothetical protein 0.0052 0.1261 0.1261
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.12 0.1222
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni biogenic amine receptor 0.0007 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.1369 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0008 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0007 0.0019 0.0023
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0105 0.2726 0.2726
Trypanosoma brucei protein kinase, putative 0.0056 0.1369 1
Echinococcus granulosus hypothetical protein 0.0007 0.0019 0.0019
Onchocerca volvulus 0.0053 0.1298 0.4724
Schistosoma mansoni netrin receptor unc5 0.0015 0.0255 0.0255
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.006 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0105 0.2726 0.3383
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.1363 0.1388
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.006 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0105 0.2726 0.3383
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0019 0.0019
Echinococcus granulosus tumor protein p63 0.0362 0.9816 1
Loa Loa (eye worm) RNA binding protein 0.0068 0.1708 0.212
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0019 0.0019
Brugia malayi putative neuropeptide receptor 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi glutaminase DH11.1 0.0298 0.8057 1
Brugia malayi ecdysteroid receptor 0.0105 0.2726 0.3383
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.12 0.1222
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0007 0.0019 0.0019
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.1369 1
Schistosoma mansoni biogenic amine receptor 0.0007 0.0019 0.0019
Echinococcus granulosus tachykinin peptides receptor 99D 0.0007 0.0019 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.1369 0.1369
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Echinococcus granulosus allatostatin A receptor 0.0007 0.0019 0.0019
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0007 0.0019 0.0023
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.006 0.0075
Schistosoma mansoni survival motor neuron protein 0.0052 0.1261 0.1261
Schistosoma mansoni 60S ribosomal protein L21 0.0006 0.0015 0.0015
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0007 0.0019 0.0019
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.0105 0.2726 0.2726
Entamoeba histolytica hypothetical protein 0.0078 0.1981 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0258 0.032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0019 0.0019
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0019 0.0019
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.1298 0.1298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.2726 0.2726
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0007 0.0019 0.0019
Brugia malayi G protein-coupled receptor F59B2.13 0.0007 0.0019 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0105 0.2726 0.3383
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.12 0.1489
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.12 0.1489
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0105 0.2726 0.2726
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0831 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.1096 0.8003
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0007 0.0019 0.0019
Echinococcus granulosus neuropeptide FF receptor 2 0.0007 0.0019 0.0019
Brugia malayi hypothetical protein 0.0049 0.12 0.1489
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.1981 0.1981
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0019 0.0019
Trichomonas vaginalis glutaminase, putative 0.0298 0.8057 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0007 0.0019 0.0023
Brugia malayi G-protein coupled receptor 0.0007 0.0019 0.0023
Brugia malayi G-protein coupled receptor 0.0007 0.0019 0.0023
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.1096 0.8003
Schistosoma mansoni nuclear hormone receptor 0.0105 0.2726 0.2726
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0007 0.0019 0.0023
Echinococcus granulosus death domain containing protein 0.0015 0.0255 0.0259
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.12 0.1489
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0019 0.0023
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0105 0.2726 0.2777
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0105 0.2726 0.2726
Loa Loa (eye worm) hypothetical protein 0.0055 0.1363 0.1692
Schistosoma mansoni inositol monophosphatase 0.004 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0012 0.0164 0.0204
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.1369 0.1637
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.12 0.12
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.12 0.12
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.1976 0.1976
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.12 0.1489
Schistosoma mansoni zinc finger protein 0.0049 0.12 0.12
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.1096 0.1116
Brugia malayi tailless protein 0.0049 0.12 0.1489
Echinococcus multilocularis G-protein coupled receptor, putative 0.0007 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0049 0.12 0.12
Schistosoma mansoni nuclear receptor 0.0049 0.12 0.12
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0019 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.2726 0.2777
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.1369 1
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0019 0.0023
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0258 0.0258
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.1708 0.212
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.12 0.1489
Schistosoma mansoni opsin-like receptor 0.0007 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0105 0.2726 0.3383
Brugia malayi G protein-coupled receptor 0.0007 0.0019 0.0023
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0007 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Brugia malayi MAP kinase sur-1 0.0056 0.1369 0.1699
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0105 0.2726 0.3383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0105 0.2726 0.3383
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0019 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.006 0.006
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0008 0.006 0.0075
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.1369 1
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1708 0.1708
Loa Loa (eye worm) hypothetical protein 0.0055 0.1363 0.1692
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0164 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.2726 0.2777
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0019 0.0019
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0019 0.0019
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Entamoeba histolytica hypothetical protein 0.0078 0.1981 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) acetyltransferase 0.0155 0.4117 0.5111
Echinococcus granulosus g protein coupled receptor 0.0007 0.0019 0.0019
Echinococcus granulosus Ankyrin 0.0015 0.0258 0.0263
Loa Loa (eye worm) glutaminase 2 0.0298 0.8057 1
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0019 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0019 0.0019
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.1369 1
Schistosoma mansoni opsin-like receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) TAR-binding protein 0.0068 0.1708 0.212
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.006 0.0075
Brugia malayi RNA binding protein 0.0068 0.1708 0.212
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.006 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0105 0.2726 0.3383
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Echinococcus granulosus serotonin receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0105 0.2726 0.3383
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0255 0.0316
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1708 0.1708
Echinococcus multilocularis G protein coupled receptor 139 0.0007 0.0019 0.0019
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0019 0.0023
Brugia malayi Protein kinase domain containing protein 0.0016 0.0268 0.0333
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.1096 0.5
Echinococcus multilocularis sex peptide receptor 0.0007 0.0019 0.0019
Echinococcus granulosus neuropeptide receptor A26 0.0007 0.0019 0.0019
Brugia malayi steroid hormone receptor 0.0105 0.2726 0.3383
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0948 0.0948
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.1363 0.1692
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0007 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0049 0.12 0.12
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0007 0.0019 0.0019
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.12 0.1222
Brugia malayi AKH receptor 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0105 0.2726 0.2726
Loa Loa (eye worm) hypothetical protein 0.0053 0.1298 0.1611
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0007 0.0019 0.0023
Schistosoma mansoni opsin-like receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.006 0.006
Brugia malayi Melatonin receptor type 1A 0.0007 0.0019 0.0023
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0105 0.2726 0.3383
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.1135 0.1156
Brugia malayi Serotonin receptor 0.0007 0.0019 0.0023
Schistosoma mansoni neuropeptide receptor 0.0007 0.0019 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0164 0.0164
Brugia malayi hypothetical protein 0.0253 0.6821 0.8466
Brugia malayi conserved hypotetical protein 0.0049 0.12 0.1489
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.1369 0.1637
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0255 0.0871
Brugia malayi nuclear receptor RXR 0.0055 0.1363 0.1692
Echinococcus multilocularis neuropeptide FF receptor 2 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi nuclear receptor NHR-88 0.0105 0.2726 0.3383
Brugia malayi nuclear receptor NHR-67 0.0049 0.12 0.1489
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.1981 0.1981
Loa Loa (eye worm) hypothetical protein 0.0105 0.2726 0.3383
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0019 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0105 0.2726 0.3383
Schistosoma mansoni RAR-like nuclear receptor 0.0105 0.2726 0.2726
Onchocerca volvulus 0.0049 0.12 0.4362
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0105 0.2726 0.2726
Loa Loa (eye worm) hypothetical protein 0.0105 0.2726 0.3383
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.1369 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0007 0.0019 0.0019
Brugia malayi hypothetical protein 0.0055 0.1363 0.1692
Onchocerca volvulus 0.0052 0.1261 0.4591
Echinococcus multilocularis tumor protein p63 0.0362 0.9816 0.9816
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi Steroid receptor seven-up type 2 0.0105 0.2726 0.3383
Echinococcus granulosus sex peptide receptor 0.0007 0.0019 0.0019
Schistosoma mansoni neuropeptide f receptor 76f 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0055 0.1363 0.1692
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus neuropeptide receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.1369 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni adenoreceptor 0.0007 0.0019 0.0019
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0948 0.6921
Brugia malayi GnHR receptor homolog 0.0007 0.0019 0.0023
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0019 0.0019
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1708 0.1708
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Brugia malayi sulfakinin receptor protein 0.0007 0.0019 0.0023
Echinococcus granulosus neuropeptide s receptor 0.0007 0.0019 0.0019
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0105 0.2726 0.2777
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.12 0.1489
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.4117 0.4117
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) TYRA-2 protein 0.0007 0.0019 0.0023
Echinococcus granulosus neuropeptide receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0105 0.2726 0.3383
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.1369 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Brugia malayi hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0007 0.0019 0.0019
Echinococcus granulosus g protein coupled receptor 0.0007 0.0019 0.0019
Brugia malayi Uncoordinated protein 44 0.0015 0.0255 0.0316
Brugia malayi RE15519p 0.0007 0.0019 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Echinococcus granulosus geminin 0.0181 0.4841 0.4932
Loa Loa (eye worm) glutaminase 0.0298 0.8057 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.1981 0.2018
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.12 0.1222
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0007 0.0019 0.0019
Brugia malayi TAR-binding protein 0.0068 0.1708 0.212
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.2726 0.3383
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Echinococcus multilocularis neuropeptide s receptor 0.0007 0.0019 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0255 0.0316
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi hypothetical protein 0.0078 0.1981 0.2459
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.006 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.2726 0.3383
Schistosoma mansoni glutaminase 0.0298 0.8057 0.8057
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0105 0.2726 0.2777
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.1708 0.212
Echinococcus granulosus 7TM GPCR rhodopsin 0.0007 0.0019 0.0019
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.6821 0.6948
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.1363 0.1363
Echinococcus granulosus ecdysone induced protein 78C 0.0105 0.2726 0.2777
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0991 0.0419
Brugia malayi Dopamine receptor protein 1 0.0007 0.0019 0.0023
Echinococcus granulosus dro:myosuppressin receptor 0.0007 0.0019 0.0019
Schistosoma mansoni inositol monophosphatase 0.004 0.0948 0.0948
Schistosoma mansoni steroid hormone receptor ad4bp 0.0105 0.2726 0.2726
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.2726 0.2726
Echinococcus granulosus tar DNA binding protein 0.0068 0.1708 0.174
Brugia malayi Dopamine receptor 0.0007 0.0019 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0105 0.2726 0.3383
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0019 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.12 0.1222
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.1369 0.1637
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.1369 0.1637
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.4117 0.4117
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0019 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0181 0.4841 0.4841
Schistosoma mansoni amine GPCR 0.0007 0.0019 0.0019
Echinococcus multilocularis somatostatin receptor 0.0007 0.0019 0.0019
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.006 0.006
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.1096 0.1295
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.12 0.12
Schistosoma mansoni thyroid hormone receptor 0.0368 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.006 0.0062
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi ORL1-like opioid receptor 0.0007 0.0019 0.0023
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.1369 0.1369
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0007 0.0019 0.0023
Schistosoma mansoni hypothetical protein 0.0181 0.4841 0.4841
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0255 0.0255
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0948 0.0965
Loa Loa (eye worm) hypothetical protein 0.0015 0.0255 0.0316
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.12 0.12
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0019 0.0019
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0831 0.5
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.006 0.006
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.12 0.12
Loa Loa (eye worm) hypothetical protein 0.0253 0.6821 0.8466
Echinococcus granulosus somatostatin receptor 0.0007 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0015 0.0255 0.0255
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.12 0.1222
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0105 0.2726 0.2726
Brugia malayi putative neuropeptide receptor NPR1 0.0007 0.0019 0.0023
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0991 1
Brugia malayi nuclear receptor NHR-88 0.0049 0.12 0.1489
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni nuclear hormone receptor 0.0049 0.12 0.12
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0948 0.6921
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1708 0.1708
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.006 0.0062
Schistosoma mansoni coup transcription factor 0.0105 0.2726 0.2726
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0164 0.0204
Echinococcus multilocularis geminin 0.0181 0.4841 0.4841
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0985 0.0985
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0019 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.12 0.4362
Loa Loa (eye worm) hypothetical protein 0.0008 0.006 0.0075
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.1096 0.1295
Echinococcus multilocularis dro:myosuppressin receptor 0.0007 0.0019 0.0019
Echinococcus granulosus fmrfamide receptor 0.0007 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0105 0.2726 0.3383
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.2726 0.3383
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0105 0.2726 0.2777
Brugia malayi nuclear hormone receptor 0.0105 0.2726 0.3383
Brugia malayi Tachykinin-like peptides receptor 99D 0.0007 0.0019 0.0023
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.1369 0.1369
Schistosoma mansoni growth hormone secretagogue receptor 0.0007 0.0019 0.0019
Echinococcus granulosus alpha 1A adrenergic receptor 0.0007 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0105 0.2726 0.2726
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0264 0.7111 0.7245
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.12 0.12
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.12 0.4362
Brugia malayi hypothetical protein 0.0049 0.12 0.1489
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.1976 0.2013
Brugia malayi ecdysone receptor 0.0049 0.12 0.1489
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0105 0.2726 0.3383
Schistosoma mansoni amine GPCR 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0019 0.0019
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0255 0.0259
Brugia malayi Nuclear hormone receptor E75 0.0049 0.12 0.1489
Schistosoma mansoni hypothetical protein 0.0007 0.0019 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0105 0.2726 0.2726
Echinococcus granulosus g protein coupled receptor 0.0007 0.0019 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0253 0.6812 0.8455
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0007 0.0019 0.0019
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.1363 0.1363
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.4117 0.5111
Loa Loa (eye worm) hypothetical protein 0.0049 0.12 0.1489
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0007 0.0019 0.0023
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0055 0.1363 0.1692
Schistosoma mansoni retinoic acid receptor RXR 0.0105 0.2726 0.2726
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.1363 0.1692
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0255 0.0259
Brugia malayi larval opioid receptor 0.0007 0.0019 0.0023
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0007 0.0019 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0105 0.2726 0.3383
Echinococcus multilocularis serotonin receptor 0.0007 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0007 0.0019 0.0019
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.1369 0.1395
Echinococcus granulosus FTZ F1 alpha 0.0105 0.2726 0.2777
Schistosoma mansoni hypothetical protein 0.0007 0.0019 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.2726 0.3383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0007 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0007 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0019 0.0023
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0019 0.0019
Schistosoma mansoni neuropeptide receptor 0.0007 0.0019 0.0019
Brugia malayi Dopamine receptor protein 2 0.0007 0.0019 0.0023
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0019 0.0019
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0948 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0007 0.0019 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.1363 0.1363
Echinococcus multilocularis Ankyrin 0.0015 0.0258 0.0258
Echinococcus multilocularis orexin receptor type 2 0.0007 0.0019 0.0019

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) 0 % In vitro percent inhibition of LTD4 release from sensitized guinea pig lung fragment at dose of 10 microM; No data ChEMBL. No reference
Inhibition (functional) = 48 % In vitro percent inhibition of LTD4 release from sensitized guinea pig lung fragment at dose of 3 microM ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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