Detailed information for compound 342384

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 377.42 | Formula: C19H15N5O2S
  • H donors: 2 H acceptors: 3 LogP: 2.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)Nc1nc2ccccc2n(c1=O)C)Nc1nccs1
  • InChi: 1S/C19H15N5O2S/c1-24-15-5-3-2-4-14(15)22-16(18(24)26)21-13-8-6-12(7-9-13)17(25)23-19-20-10-11-27-19/h2-11H,1H3,(H,21,22)(H,20,23,25)
  • InChiKey: ORAFPHVRRVYRPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphorylase, glycogen Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Loa Loa (eye worm) glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Brugia malayi carbohydrate phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus Glycosyl transferase family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum Glycogen phosphorylase, brain form, putative Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis Glycosyl transferase, family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Giardia lamblia Glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Neospora caninum hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Onchocerca volvulus Glycogen phosphorylase homolog Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium parvum glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Chlamydia trachomatis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium hominis glycogen phosphorylase 1 Get druggable targets OG5_126999 All targets in OG5_126999
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0071
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0034 0.0122
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0141
Echinococcus multilocularis dna polymerase eta 0.0021 0.002 0.0334
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.002 0.0479
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0006 0.0009
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.002 0.0334
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0019 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0006 0.0141
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0000098982
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.0027
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.002 0.0345
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0006 0.0106
Schistosoma mansoni helicase 0.0006 0.00000038532 0.0000065514
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0761
Onchocerca volvulus 0.0068 0.0082 0.0082
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0029 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0247
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0026 0.0632
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0377 0.0499 1
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0005
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.02 0.0733
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0034 0.0122
Echinococcus granulosus glycogen phosphorylase 0.013 0.0167 0.2833
Echinococcus granulosus dnaJ subfamily B 0.0444 0.0588 1
Loa Loa (eye worm) hypothetical protein 0.0007 0 0.0008
Entamoeba histolytica glycogenphosphorylase, putative 0.0056 0.0067 0.1007
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0009 0.0033
Mycobacterium ulcerans glutaminase 0.0297 0.039 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0141
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0029 0.0732
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0006 0.0006
Brugia malayi MH1 domain containing protein 0.0009 0.0003 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0019 0.0321
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0032
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0003 0.0057
Brugia malayi glutaminase DH11.1 0.0297 0.039 0.0537
Brugia malayi ecdysteroid receptor 0.0011 0.0006 0.0009
Brugia malayi nuclear hormone receptor 0.0011 0.0006 0.0009
Schistosoma mansoni polybromo-1 0.0007 0.0001 0.0009
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0026 0.0632
Loa Loa (eye worm) hypothetical protein 0.0007 0 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0071
Plasmodium vivax helicase, putative 0.0006 0.00000038532 0.0000014139
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0092 0.0115 0.0422
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0019 0.0429
Schistosoma mansoni glycogen phosphorylase 0.0056 0.0067 0.1143
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0032
Schistosoma mansoni smad1 5 8 and 0.0009 0.0003 0.0057
Echinococcus multilocularis BRK domain 0.0013 0.0008 0.0143
Mycobacterium ulcerans hypothetical protein 0.0173 0.0224 0.5726
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0006 0.0106
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0 0.0004
Schistosoma mansoni smad1 5 8 and 0.0009 0.0003 0.0057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0004 0.0075
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2035 0.2725 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0032
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0003 0.0057
Echinococcus multilocularis disco interacting protein 2 0.0042 0.0048 0.081
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.002 0.0334
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0006 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0006 0.0106
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0155 0.02 0.0733
Entamoeba histolytica hypothetical protein 0.0025 0.0026 0.0139
Loa Loa (eye worm) BRM protein 0.0038 0.0042 0.0956
Echinococcus multilocularis global transcription activator snf2l2 0.0073 0.0089 0.1521
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0019 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0006 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0044 0.0747
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0006 0.0106
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0019 0.5
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0008 0.0012
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.0167 0.308
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0007 0.0025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0006 0.0106
Schistosoma mansoni coup transcription factor 0.0011 0.0006 0.0106
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0006 0.0141
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0006 0.0106
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0141
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0019 0.0069
Trichomonas vaginalis glutaminase, putative 0.0297 0.039 1
Brugia malayi Flap endonuclease-1 0.0028 0.0029 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0019 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0006 0.0009
Schistosoma mansoni smad 0.0009 0.0003 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0006 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0039
Loa Loa (eye worm) histone methyltransferase 0.001 0.0004 0.0101
Schistosoma mansoni hypothetical protein 0.0184 0.0239 0.4058
Loa Loa (eye worm) helicase DNA-binding protein 0.0013 0.0008 0.0191
Echinococcus multilocularis helicase 0.0006 0.00000038532 0.00000000010135
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Brugia malayi Disco-interacting protein 2 homolog 0.0042 0.0048 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0019 0.0069
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0029 0.0108
Schistosoma mansoni smad1 5 8 and 0.0009 0.0003 0.0057
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0007 0.0025
Brugia malayi steroid hormone receptor 0.0011 0.0006 0.0009
Echinococcus granulosus importin subunit beta 1 0.0031 0.0034 0.057
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0015 0.002
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.002 0.0074
Echinococcus granulosus snurportin 1 0.0334 0.0441 0.749
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.0167 0.308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.002 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Echinococcus multilocularis Chromo domain 0.0013 0.0008 0.0143
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0 0.0001
Schistosoma mansoni Smad4 0.0009 0.0003 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0445
Echinococcus multilocularis geminin 0.0184 0.0239 0.4058
Echinococcus granulosus global transcription activator snf2l2 0.0073 0.0089 0.1521
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0006 0.0009
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.0067 0.1007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0141
Echinococcus granulosus smad 0.0009 0.0003 0.0057
Brugia malayi nuclear receptor NHR-88 0.0011 0.0006 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0166 0.376
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0019 0.0479
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0003 0.0057
Plasmodium falciparum flap endonuclease 1 0.0028 0.0029 0.0108
Echinococcus multilocularis snurportin 1 0.0334 0.0441 0.749
Schistosoma mansoni glutaminase 0.0297 0.039 0.6635
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0019 0.0069
Brugia malayi isocitrate dehydrogenase 0.0017 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0141
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.002 0.0074
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.002 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0006 0.0009
Leishmania major telomerase reverse transcriptase, putative 0.2035 0.2725 1
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0008 0.0143
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0026 0.0093
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2035 0.2725 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0044 0.0747
Leishmania major mitochondrial DNA polymerase beta 0.0328 0.0432 0.1585
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0006 0.0106
Brugia malayi Muscleblind-like protein 0.0162 0.0209 0.0288
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0053 0.0195
Loa Loa (eye worm) glutaminase 2 0.0297 0.039 0.8859
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0006 0.0106
Schistosoma mansoni glycogen phosphorylase 0.013 0.0167 0.2833
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0006 0.0106
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.002 0.0334
Brugia malayi Importin beta-1 subunit 0.0031 0.0034 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0021 0.002 0.0074
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.0167 0.4256
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0006 0.0106
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0053 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0006 0.0009
Brugia malayi carbohydrate phosphorylase 0.013 0.0167 0.0229
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0006 0.0106
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0034 0.0122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0006 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0067 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0006 0.0106
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.0067 0.1007
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0008 0.0143
Brugia malayi hypothetical protein 0.0039 0.0044 0.006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0006 0.0106
Echinococcus multilocularis muscleblind protein 1 0.0162 0.0209 0.356
Echinococcus multilocularis Smad4 0.0009 0.0003 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0006 0.0106
Giardia lamblia DINP protein human, muc B family 0.0021 0.002 0.0071
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.002 0.0345
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.002 0.0479
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.002 0.0445
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0008 0.0143
Schistosoma mansoni glycogen phosphorylase 0.013 0.0167 0.2833
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.0432 0.1585
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0019 0.0069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0073 0.0269
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0007 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0071
Toxoplasma gondii hypothetical protein 0.0053 0.0063 0.0229
Schistosoma mansoni hypothetical protein 0.0444 0.0588 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0006 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0247
Brugia malayi BRM protein 0.0073 0.0089 0.0123
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0015 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Brugia malayi polybromodomain protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0006 0.0141
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0044 0.0747
Brugia malayi SET domain containing protein 0.0007 0.0001 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0019 0.0069
Schistosoma mansoni cpg binding protein 0.0069 0.0085 0.1439
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0006 0.0009
Entamoeba histolytica hypothetical protein 0.0039 0.0044 0.0522
Onchocerca volvulus 0.0011 0.0006 0.0006
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0029 0.0107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0006 0.0106
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0008 0.0143
Echinococcus granulosus dna polymerase kappa 0.0021 0.002 0.0334
Plasmodium falciparum importin beta, putative 0.0031 0.0034 0.0123
Toxoplasma gondii exonuclease III APE 0.002 0.0019 0.0069
Schistosoma mansoni hypothetical protein 0.0334 0.0441 0.749
Echinococcus multilocularis dna polymerase kappa 0.0021 0.002 0.0334
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0000098982
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0029 0.0501
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.0167 0.4256
Toxoplasma gondii RNA-directed DNA polymerase 0.2035 0.2725 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0006 0.0106
Loa Loa (eye worm) hypothetical protein 0.0162 0.0209 0.4753
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0162 0.0209 0.4753
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0019 0.0026
Entamoeba histolytica hypothetical protein 0.0039 0.0044 0.0522
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0056 0.0067 0.1718
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0015 0.0247
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0003 0.0076
Onchocerca volvulus Glycogen phosphorylase homolog 0.013 0.0167 0.0167
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.002 0.0015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0053 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0006 0.0106
Brugia malayi MH2 domain containing protein 0.013 0.0166 0.0228
Leishmania major DNA polymerase eta, putative 0.0021 0.002 0.0071
Echinococcus granulosus Chromo domain 0.0013 0.0008 0.0143
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Giardia lamblia Glycogen phosphorylase 0.013 0.0167 0.0611
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0328 0.0432 0.1585
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0247
Schistosoma mansoni importin beta-1 0.0031 0.0034 0.057
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0006 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0006 0.0009
Plasmodium vivax telomerase reverse transcriptase, putative 0.2035 0.2725 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0015 0.0053
Echinococcus multilocularis glycogen phosphorylase 0.013 0.0167 0.2833
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0029 0.0107
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0006 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0006 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0006 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0009
Schistosoma mansoni flap endonuclease-1 0.0026 0.0026 0.0439
Plasmodium falciparum telomerase reverse transcriptase 0.2035 0.2725 1
Echinococcus granulosus disco interacting protein 2 0.0042 0.0048 0.081
Echinococcus multilocularis dnaJ subfamily B 0.0444 0.0588 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0071
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0053
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0012
Echinococcus granulosus BRK domain containing protein 0.0013 0.0008 0.0143
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0141
Schistosoma mansoni DNA polymerase eta 0.0021 0.002 0.0334
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0003 0.0076
Trypanosoma brucei unspecified product 0.0014 0.0011 0.0039
Chlamydia trachomatis glycogen phosphorylase 0.013 0.0167 0.5
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0334 0.0441 1
Schistosoma mansoni ap endonuclease 0.002 0.0019 0.0321
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0015 0.033
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.002 0.0345
Trypanosoma brucei unspecified product 0.0014 0.0011 0.0039
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0026 0.0632
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0008 0.0143
Entamoeba histolytica hypothetical protein 0.0107 0.0136 0.2436
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0006 0.0009
Leishmania major modification methylase-like protein 0.0021 0.002 0.0074
Echinococcus multilocularis polybromo 1 0.0007 0.0001 0.0009
Echinococcus granulosus Glycosyl transferase family 35 0.013 0.0167 0.2833
Brugia malayi CXXC zinc finger family protein 0.0068 0.0082 0.0113
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0013 0.0008 0.0143
Echinococcus multilocularis cpg binding protein 0.0069 0.0085 0.1439
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0019 0.0461
Onchocerca volvulus 0.0042 0.0048 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0006 0.0106
Brugia malayi MH2 domain containing protein 0.0009 0.0003 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0071
Echinococcus granulosus geminin 0.0184 0.0239 0.4058
Giardia lamblia Telomerase catalytic subunit 0.2035 0.2725 1
Loa Loa (eye worm) Smad1 0.0009 0.0003 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0006 0.0106
Entamoeba histolytica hypothetical protein 0.0039 0.0044 0.0522
Schistosoma mansoni cpg binding protein 0.0068 0.0082 0.1398
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0006 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0006 0.0009
Loa Loa (eye worm) glycogen phosphorylase 0.013 0.0167 0.3783
Brugia malayi MH2 domain containing protein 0.0009 0.0003 0.0005
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0006 0.0106
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0008 0.0143
Brugia malayi RNA, U transporter 1 0.0089 0.0111 0.0153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0247
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0006 0.0106
Brugia malayi Smad1 0.0009 0.0003 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.0027
Schistosoma mansoni hypothetical protein 0.0184 0.0239 0.4058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0006 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0006 0.0141
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0029 0.0669
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0034 0.057
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0006 0.0009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0032
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0015 0.0247
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.0184
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0042 0.0048 0.081
Echinococcus granulosus Smad4 0.0009 0.0003 0.0057
Loa Loa (eye worm) CXXC zinc finger family protein 0.0068 0.0082 0.1867
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0015 0.0053
Loa Loa (eye worm) hypothetical protein 0.0042 0.0048 0.1082
Schistosoma mansoni helicase 0.0073 0.0089 0.1521
Echinococcus granulosus glycogen phosphorylase 0.013 0.0167 0.2833
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0019 0.0461
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0107 0.0136 0.2436
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0141
Schistosoma mansoni hypothetical protein 0.0039 0.0044 0.0747
Schistosoma mansoni cpg binding protein 0.0069 0.0085 0.1439
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0019 0.0069
Loa Loa (eye worm) BRM protein 0.0047 0.0054 0.1227
Echinococcus granulosus muscleblind protein 0.0162 0.0209 0.356
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0141
Echinococcus multilocularis muscleblind protein 0.0162 0.0209 0.356
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.002 0.0244
Echinococcus multilocularis Glycosyl transferase, family 35 0.013 0.0167 0.2833
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0006 0.0006
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0015 0.0053
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0053
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0004 0.0006
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0053 0.0195
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.002 0.0074
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.002 0.0071
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0003 0.0057
Entamoeba histolytica hypothetical protein 0.0039 0.0044 0.0522
Toxoplasma gondii hypothetical protein 0.0092 0.0115 0.0421
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0166 0.376
Giardia lamblia DNA repair protein RAD52 0.0377 0.0499 0.1829
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.0224 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0071
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0053
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0029 0.0107
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0029 0.0107
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0006 0.0106
Schistosoma mansoni ap endonuclease 0.002 0.0019 0.0321
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0006 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.02 0.0733
Plasmodium vivax importin-beta 2, putative 0.0031 0.0034 0.0123
Echinococcus granulosus polybromo 1 0.0007 0.0001 0.0009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.002 0.0334
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0011 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0004 0.0075
Trypanosoma brucei telomerase reverse transcriptase 0.2035 0.2725 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0006 0.0106
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0053
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0056 0.0067 0.2521
Brugia malayi Telomerase reverse transcriptase 0.5414 0.7266 1
Echinococcus granulosus cpg binding protein 0.0069 0.0085 0.1439
Leishmania major importin beta-1 subunit, putative 0.0025 0.0026 0.0093
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0006 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0003 0.0057
Trichomonas vaginalis lymphoid specific helicase, putative 0.0013 0.0009 0.0214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0006 0.0106
Schistosoma mansoni helicase 0.0006 0.00000038532 0.0000065514
Leishmania major DNA polymerase kappa, putative 0.0021 0.002 0.0071
Echinococcus granulosus dna polymerase eta 0.0021 0.002 0.0334
Echinococcus granulosus flap endonuclease 1 0.0028 0.0029 0.0501
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.002 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0006 0.0141
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0029 0.022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0328 0.0432 0.1585
Trypanosoma brucei unspecified product 0.0021 0.002 0.0071
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0498
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.002 0.0074
Echinococcus granulosus helicase 0.0006 0.00000038532 0.00000000010135
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0015 0.0247
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.008 0.1366
Echinococcus multilocularis glycogen phosphorylase 0.013 0.0167 0.2833
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0019 0.5
Echinococcus multilocularis smad 0.0009 0.0003 0.0057
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0006 0.0009
Loa Loa (eye worm) glutaminase 0.0297 0.039 0.8859

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.48 uM Inhibitory concentration against glycogen phosphorylase of rabbit muscle ChEMBL. 16143521
IC50 (binding) = 0.48 uM Inhibitory concentration against glycogen phosphorylase of rabbit muscle ChEMBL. 16143521

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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