Detailed information for compound 342526

Basic information

Technical information
  • TDR Targets ID: 342526
  • Name: 3-prop-2-ynyl-1,3-benzothiazol-2-imine
  • MW: 188.249 | Formula: C10H8N2S
  • H donors: 0 H acceptors: 0 LogP: 2.06 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCn1c(=N)sc2c1cccc2
  • InChi: 1S/C10H8N2S/c1-2-7-12-8-5-3-4-6-9(8)13-10(12)11/h1,3-6,11H,7H2
  • InChiKey: PQPZPXLJTWLWNA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3-propargyl-1,3-benzothiazol-2-ylidene)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0154
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0017 0.0342
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0008 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0008 0.0011
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0154
Echinococcus granulosus helicase 0.0007 0.0001 0.001
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0035 0.0124
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0062 0.0225
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0017 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0025
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0035 0.0768
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0005 0.0066
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0023 0.0343
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.0231 0.0848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0008 0.0154
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0008 0.0115
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0115 0.0157 0.2731
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0008 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0008 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0008 0.0115
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0017 0.0256
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1888 0.2725 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0002 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0005 0.0089
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0023 0.0405
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0005 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0035 0.0127
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0005 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0008 0.0154
Mycobacterium tuberculosis Conserved hypothetical protein 0.0185 0.0258 1
Leishmania major DNA damage repair protein, putative 0.0007 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0022 0.0498
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0018
Schistosoma mansoni ap endonuclease 0.0022 0.0022 0.0331
Brugia malayi SNF2 family N-terminal domain containing protein 0.0007 0.0001 0.0001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0051 0.0756
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0002 0.0039
Schistosoma mansoni polybromo-1 0.0007 0.0001 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0042
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0017 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0078 0.0282
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Loa Loa (eye worm) BRM protein 0.004 0.0049 0.0968
Schistosoma mansoni hypothetical protein 0.0475 0.0678 1
Trichomonas vaginalis glutaminase, putative 0.0317 0.045 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0154
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0008 0.0115
Echinococcus granulosus DNA methyltransferase 2, putative 0.0023 0.0024 0.0354
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.0231 0.0848
Brugia malayi RNA, U transporter 1 0.0095 0.0129 0.0177
Leishmania major importin beta-1 subunit, putative 0.0027 0.003 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Schistosoma mansoni hypothetical protein 0.0007 0.0001 0.001
Brugia malayi Smad1 0.0009 0.0005 0.0006
Loa Loa (eye worm) glutaminase 2 0.0317 0.045 0.886
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0008 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0022 0.0331
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0154
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0048
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0022 0.021
Schistosoma mansoni Smad4 0.0009 0.0005 0.0066
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0023 0.0498
Giardia lamblia DNA repair protein RAD52 0.0403 0.0575 0.2108
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.003 0.0669
Brugia malayi hypothetical protein 0.0042 0.0051 0.0071
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0153
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0023 0.0498
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0008 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0023 0.0085
Echinococcus granulosus dna polymerase kappa 0.0022 0.0023 0.0343
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0023 0.0082
Trichomonas vaginalis importin beta-1, putative 0.0027 0.003 0.0669
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0023 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0017 0.0256
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0008 0.0115
Plasmodium falciparum flap endonuclease 1 0.003 0.0035 0.0127
Brugia malayi nuclear hormone receptor 0.0012 0.0008 0.0011
Entamoeba histolytica hypothetical protein 0.0042 0.0051 0.0892
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0008 0.0154
Echinococcus granulosus dna polymerase eta 0.0022 0.0023 0.0343
Toxoplasma gondii exonuclease III APE 0.0022 0.0022 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0008 0.0115
Brugia malayi Muscleblind-like protein 0.0173 0.0242 0.0333
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0002 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0006 0.0085
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0023 0.0082
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0008 0.0115
Plasmodium falciparum importin beta, putative 0.0033 0.0039 0.0144
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0005 0.0066
Brugia malayi MH2 domain containing protein 0.0139 0.0191 0.0263
Leishmania major DNA polymerase eta, putative 0.0022 0.0023 0.0085
Onchocerca volvulus 0.0072 0.0095 0.0095
Schistosoma mansoni ap endonuclease 0.0022 0.0022 0.0331
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0051 0.0756
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0023 0.0458
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0066
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0023 0.0024 0.0088
Loa Loa (eye worm) histone methyltransferase 0.001 0.0006 0.0113
Giardia lamblia Telomerase catalytic subunit 0.1888 0.2725 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0022 0.0331
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0008 0.0115
Schistosoma mansoni smad1 5 8 and 0.0009 0.0005 0.0066
Toxoplasma gondii RNA-directed DNA polymerase 0.1888 0.2725 1
Echinococcus multilocularis muscleblind protein 0.0173 0.0242 0.3566
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0039 0.0144
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0008 0.0115
Brugia malayi glutaminase DH11.1 0.0317 0.045 0.062
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.0191 0.3768
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0008 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.003 0.0669
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Brugia malayi polk-prov protein 0.0007 0.0001 0.0001
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0035 0.0127
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.0498 0.1826
Echinococcus multilocularis smad 0.0009 0.0005 0.0066
Schistosoma mansoni hypothetical protein 0.0357 0.0508 0.7492
Trichomonas vaginalis helicase, putative 0.0008 0.0002 0.0039
Trypanosoma brucei unspecified product 0.0015 0.0013 0.0048
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0023 0.0024 0.0088
Echinococcus multilocularis BRK domain 0.0013 0.001 0.0153
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0023 0.0343
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0008 0.0115
Mycobacterium ulcerans glutaminase 0.0317 0.045 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0017 0.0064
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0005 0.0066
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0008 0.0115
Echinococcus granulosus importin subunit beta 1 0.0033 0.0039 0.0579
Echinococcus multilocularis geminin 0.0197 0.0276 0.4064
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0062 0.0228
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0022 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0008 0.0011
Echinococcus granulosus Chromo domain 0.0013 0.001 0.0153
Echinococcus multilocularis cpg binding protein 0.0074 0.0098 0.1447
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0006 0.0008
Trichomonas vaginalis lymphoid specific helicase, putative 0.0014 0.0011 0.0253
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0023 0.0024 0.0354
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0357 0.0508 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Echinococcus granulosus global transcription activator snf2l2 0.0078 0.0104 0.1529
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0008 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0023 0.0082
Plasmodium vivax helicase, putative 0.0007 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0017 0.0061
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0458
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0023 0.0343
Schistosoma mansoni importin beta-1 0.0033 0.0039 0.0579
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0001 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0008 0.0115
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0001 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0002 0.0039
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0001 0.0013
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0017 0.0256
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0008 0.0115
Loa Loa (eye worm) glutaminase 0.0317 0.045 0.886
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0023 0.0024 0.0354
Loa Loa (eye worm) Smad1 0.0009 0.0005 0.0089
Schistosoma mansoni hypothetical protein 0.0197 0.0276 0.4064
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0007 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0154
Brugia malayi SET domain containing protein 0.0008 0.0002 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0008 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0008 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Schistosoma mansoni hypothetical protein 0.0197 0.0276 0.4064
Trypanosoma brucei unspecified product 0.0015 0.0013 0.0048
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0039 0.0579
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0005 0.0089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0002 0.0039
Brugia malayi MH2 domain containing protein 0.0009 0.0005 0.0006
Schistosoma mansoni helicase 0.0078 0.0104 0.1529
Plasmodium falciparum telomerase reverse transcriptase 0.1888 0.2725 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0003 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0008 0.0154
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0045 0.0056 0.0819
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0035 0.0124
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0023 0.0517
Echinococcus granulosus Helicase SANT associated DNA binding 0.0007 0.0001 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0008 0.0115
Plasmodium vivax DEAD/DEAH helicase, putative 0.0012 0.0008 0.0031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0085 0.0313
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0008 0.0115
Echinococcus multilocularis snurportin 1 0.0357 0.0508 0.7492
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0017 0.0256
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0153
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0023 0.0085
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0042 0.0051 0.0892
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0154
Echinococcus multilocularis disco interacting protein 2 0.0045 0.0056 0.0819
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0022 0.0082
Schistosoma mansoni helicase 0.0007 0.0001 0.001
Toxoplasma gondii hypothetical protein 0.0098 0.0133 0.0488
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0008 0.0115
Trypanosoma brucei telomerase reverse transcriptase 0.1888 0.2725 1
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0023 0.0343
Echinococcus granulosus flap endonuclease 1 0.003 0.0035 0.051
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0008 0.0007
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0023 0.0244
Brugia malayi MH1 domain containing protein 0.0009 0.0005 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0008 0.0154
Echinococcus granulosus cpg binding protein 0.0074 0.0098 0.1447
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.0678 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0022 0.5
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.001 0.0014
Schistosoma mansoni helicase 0.0007 0.0001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0022 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0008 0.0115
Echinococcus multilocularis Smad4 0.0009 0.0005 0.0066
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0008 0.0011
Entamoeba histolytica hypothetical protein 0.0027 0.003 0.0524
Echinococcus granulosus smad 0.0009 0.0005 0.0066
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0022 0.0498
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0008 0.0154
Loa Loa (eye worm) CXXC zinc finger family protein 0.0072 0.0095 0.1878
Leishmania major DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Trypanosoma brucei mitochondrial DNA polymerase beta 0.035 0.0498 0.1829
Schistosoma mansoni cpg binding protein 0.0074 0.0098 0.1447
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0023 0.0343
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0023 0.0085
Leishmania major telomerase reverse transcriptase, putative 0.1888 0.2725 1
Echinococcus granulosus BRK domain containing protein 0.0013 0.001 0.0153
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0023 0.0085
Echinococcus granulosus muscleblind protein 0.0173 0.0242 0.3566
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0008 0.0115
Loa Loa (eye worm) hypothetical protein 0.0173 0.0242 0.476
Plasmodium vivax telomerase reverse transcriptase, putative 0.1888 0.2725 1
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0008 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0051 0.0756
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.0153
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0039 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Schistosoma mansoni coup transcription factor 0.0012 0.0008 0.0115
Schistosoma mansoni cpg binding protein 0.0072 0.0095 0.1407
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Entamoeba histolytica hypothetical protein 0.0115 0.0157 0.2731
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0017 0.0256
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0035 0.0127
Schistosoma mansoni flap endonuclease-1 0.0027 0.003 0.0448
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0008 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0008 0.0154
Trypanosoma brucei unspecified product 0.0022 0.0023 0.0085
Echinococcus granulosus snurportin 1 0.0357 0.0508 0.7492
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0022 0.0442
Brugia malayi polybromodomain protein 0.0007 0.0001 0.0002
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0023 0.0024 0.0088
Brugia malayi CXXC zinc finger family protein 0.0072 0.0095 0.0131
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0017 0.0064
Loa Loa (eye worm) helicase DNA-binding protein 0.0013 0.001 0.0204
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0062 0.0225
Echinococcus multilocularis Chromo domain 0.0013 0.001 0.0153
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0023 0.0032
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0035 0.0681
Schistosoma mansoni smad 0.0009 0.0005 0.0066
Echinococcus granulosus polybromo 1 0.0007 0.0001 0.0019
Brugia malayi nuclear receptor NHR-88 0.0012 0.0008 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0008 0.0115
Echinococcus multilocularis flap endonuclease 1 0.003 0.0035 0.051
Echinococcus multilocularis helicase 0.0007 0.0001 0.001
Echinococcus multilocularis dna polymerase eta 0.0022 0.0023 0.0343
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0008 0.0115
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Echinococcus granulosus disco interacting protein 2 0.0045 0.0056 0.0819
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0017 0.0256
Brugia malayi steroid hormone receptor 0.0012 0.0008 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0023 0.0032
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0098 0.0133 0.0488
Brugia malayi ecdysteroid receptor 0.0012 0.0008 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0773
Echinococcus granulosus dnaJ subfamily B 0.0475 0.0678 1
Leishmania major mitochondrial DNA polymerase beta 0.035 0.0498 0.1829
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0017 0.0064
Schistosoma mansoni hypothetical protein 0.0042 0.0051 0.0756
Onchocerca volvulus 0.0012 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0042 0.0051 0.0892
Schistosoma mansoni cpg binding protein 0.0074 0.0098 0.1447
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0153
Schistosoma mansoni glutaminase 0.0317 0.045 0.6638
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0006 0.0085
Brugia malayi isocitrate dehydrogenase 0.0018 0.0017 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0002 0.0039
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0023 0.0024 0.0418
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0022 0.039
Giardia lamblia DINP protein human, muc B family 0.0022 0.0023 0.0082
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0022 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.0498 0.1826
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0003 0.0042
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0023 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0008 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0023 0.0244
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0022 0.5
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0008 0.0115
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0008 0.0115
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0154
Leishmania major DNA polymerase eta, putative 0.0007 0.0001 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0022 0.0079
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0023 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0008 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0022 0.0079
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0014 0.0011 0.0042
Entamoeba histolytica hypothetical protein 0.0042 0.0051 0.0892
Brugia malayi Telomerase reverse transcriptase 0.5023 0.7266 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0056 0.1094
Brugia malayi MH2 domain containing protein 0.0009 0.0005 0.0006
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1888 0.2725 1
Echinococcus multilocularis polybromo 1 0.0007 0.0001 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0008 0.0115
Brugia malayi BRM protein 0.0078 0.0104 0.0143
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0403 0.0575 1
Mycobacterium ulcerans hypothetical protein 0.0185 0.0258 0.5726
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0035 0.0127
Toxoplasma gondii hypothetical protein 0.0057 0.0073 0.0267
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0017 0.0256
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0008 0.0115
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.003 0.0107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.0231 0.0845
Plasmodium falciparum Snf2-related CBP activator, putative 0.0007 0.0001 0.0002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0022 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0048
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0022 0.0479
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0023 0.0024 0.0088
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0012 0.0008 0.0031
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0153
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0013 0.001 0.0153
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0008 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0002 0.0039
Echinococcus granulosus Smad4 0.0009 0.0005 0.0066
Plasmodium vivax importin-beta 2, putative 0.0033 0.0039 0.0144
Leishmania major DNA polymerase kappa, putative 0.0022 0.0023 0.0085
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0022 0.0031
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0017 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0093 0.1374
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0008 0.0115
Entamoeba histolytica Flap nuclease, putative 0.003 0.0035 0.0602
Onchocerca volvulus 0.0045 0.0056 0.0055
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0062 0.0225
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0039 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0191 0.3768
Loa Loa (eye worm) hypothetical protein 0.0173 0.0242 0.476
Schistosoma mansoni DNA polymerase eta 0.0022 0.0023 0.0343
Echinococcus multilocularis muscleblind protein 1 0.0173 0.0242 0.3566
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0008 0.0115
Echinococcus multilocularis global transcription activator snf2l2 0.0078 0.0104 0.1529
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0017 0.0024
Brugia malayi Importin beta-1 subunit 0.0033 0.0039 0.0054
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0008 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0013 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0002 0.0039
Echinococcus granulosus geminin 0.0197 0.0276 0.4064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0023 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0008 0.0011
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0008 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0002 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0154
Loa Loa (eye worm) BRM protein 0.005 0.0063 0.1238
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0003 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0008 0.0011
Brugia malayi Flap endonuclease-1 0.003 0.0035 0.0048
Echinococcus multilocularis BRK domain containing protein 0.0013 0.001 0.0153
Brugia malayi Disco-interacting protein 2 homolog 0.0045 0.0056 0.0076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0008 0.0115
Leishmania major modification methylase-like protein 0.0023 0.0024 0.0088
Toxoplasma gondii DNA methyltransferase 2, putative 0.0023 0.0024 0.0088
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0007 0.0001 0.0013
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0193
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0001 0.0003

Activities

Activity type Activity value Assay description Source Reference
Survival (functional) = 23 % Average percent survival of C57Bl/6 mice thymocytes from dexamethasone (5 uM) induced apoptosis at 5 uM ChEMBL. 16190767
Survival (functional) = 23 % Average percent survival of C57Bl/6 mice thymocytes from dexamethasone (5 uM) induced apoptosis at 5 uM ChEMBL. 16190767

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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