Detailed information for compound 342680

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 606.703 | Formula: C35H42O9
  • H donors: 0 H acceptors: 3 LogP: 4.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1=C(CC=C(C)C)[C@]2(C(=O)C3=C1C=CC(O3)(C)C)OC(=O)C1=C[C@]3(C[C@@H]4[C@@]1(O2)[C@@](CC=C(C)C)(OC4(C)C)C3=O)OC
  • InChi: 1S/C35H42O9/c1-19(2)11-12-22-25(39-9)21-14-15-30(5,6)41-26(21)27(36)35(22)42-28(37)23-17-32(40-10)18-24-31(7,8)43-33(29(32)38,16-13-20(3)4)34(23,24)44-35/h11,13-15,17,24H,12,16,18H2,1-10H3/t24-,32-,33?,34+,35+/m0/s1
  • InChiKey: OJOANDFOHUOILN-GUWIUYSVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.002 0.0458
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0045 0.0756
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0005 0.0007
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0021 0.0077
Schistosoma mansoni smad 0.0009 0.0004 0.0066
Brugia malayi MH2 domain containing protein 0.0131 0.0168 0.0231
Echinococcus granulosus smad 0.0009 0.0004 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0115
Plasmodium falciparum importin beta, putative 0.0032 0.0035 0.0127
Onchocerca volvulus 0.0068 0.0084 0.0083
Schistosoma mansoni ap endonuclease 0.0021 0.002 0.0331
Schistosoma mansoni DNA polymerase eta 0.0021 0.002 0.0343
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.0028
Echinococcus granulosus dna polymerase eta 0.0021 0.002 0.0343
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.002 0.0072
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0085
Brugia malayi Muscleblind-like protein 0.0164 0.0212 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.0115
Plasmodium falciparum flap endonuclease 1 0.0029 0.003 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Entamoeba histolytica hypothetical protein 0.0039 0.0045 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.002 0.0343
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.0115
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.002 0.0072
Echinococcus multilocularis BRK domain 0.0013 0.0009 0.0153
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0256
Mycobacterium ulcerans glutaminase 0.03 0.0396 1
Schistosoma mansoni hypothetical protein 0.0337 0.0446 0.7492
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0012 0.0043
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0022 0.0021 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0026 0.0669
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0035 0.0127
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0168 0.3768
Brugia malayi glutaminase DH11.1 0.03 0.0396 0.0544
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Echinococcus multilocularis muscleblind protein 0.0164 0.0212 0.3566
Echinococcus multilocularis smad 0.0009 0.0004 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.0438 0.1604
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.003 0.0112
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0006 0.0001 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.002 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0009
Giardia lamblia Telomerase catalytic subunit 0.2029 0.2726 1
Toxoplasma gondii RNA-directed DNA polymerase 0.2029 0.2726 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.002 0.0244
Schistosoma mansoni polybromo-1 0.0007 0.0001 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0154
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0056
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.002 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus granulosus global transcription activator snf2l2 0.0074 0.0091 0.1529
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.002 0.021
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.0446 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0085
Trichomonas vaginalis lymphoid specific helicase, putative 0.0013 0.001 0.0253
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0022 0.0021 0.0354
Echinococcus multilocularis cpg binding protein 0.007 0.0086 0.1447
Loa Loa (eye worm) helicase DNA-binding protein 0.0013 0.0009 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Echinococcus granulosus importin subunit beta 1 0.0032 0.0035 0.0579
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0007 0.0115
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0055 0.0201
Echinococcus multilocularis geminin 0.0186 0.0242 0.4064
Schistosoma mansoni hypothetical protein 0.0006 0.0001 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0186 0.0242 0.4064
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0004 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.0009
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0056
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0022 0.0021 0.0354
Loa Loa (eye worm) glutaminase 0.03 0.0396 0.886
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0009
Brugia malayi SNF2 family N-terminal domain containing protein 0.0006 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0458
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0015 0.0256
Schistosoma mansoni importin beta-1 0.0032 0.0035 0.0579
Brugia malayi polybromodomain protein 0.0007 0.0001 0.0002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.002 0.0343
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0007 0.0006
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0108 0.0138 0.2731
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0007 0.0115
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.0115
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.0009
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0015 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0154
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.003 0.0768
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0015 0.0053
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0055 0.0198
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.003 0.0109
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.002 0.0343
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0203 0.0745
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0004 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0015 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0154
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0154
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0256
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0025
Brugia malayi Smad1 0.0009 0.0004 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.0227 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0007 0.0154
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0004 0.0066
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.002 0.0405
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.003 0.0112
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0042
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0001 0.0003
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2029 0.2726 1
Loa Loa (eye worm) Smad1 0.0009 0.0004 0.0089
Brugia malayi SET domain containing protein 0.0007 0.0002 0.0003
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.0009
Echinococcus granulosus helicase 0.0006 0.0001 0.001
Loa Loa (eye worm) glutaminase 2 0.03 0.0396 0.886
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Echinococcus granulosus polybromo 1 0.0007 0.0001 0.0019
Trypanosoma brucei unspecified product 0.0015 0.0012 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0115
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.002 0.0331
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0115
Echinococcus granulosus DNA methyltransferase 2, putative 0.0022 0.0021 0.0354
Trichomonas vaginalis glutaminase, putative 0.03 0.0396 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0154
Leishmania major DNA polymerase eta, putative 0.0007 0.0001 0.0003
Loa Loa (eye worm) BRM protein 0.0038 0.0043 0.0968
Schistosoma mansoni hypothetical protein 0.0448 0.0596 1
Brugia malayi RNA, U transporter 1 0.009 0.0113 0.0156
Leishmania major importin beta-1 subunit, putative 0.0026 0.0026 0.0097
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.0203 0.0745
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0042
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0001 0.0003
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0045 0.0756
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0068 0.0248
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0015 0.0056
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Schistosoma mansoni ap endonuclease 0.0021 0.002 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.002 0.0498
Brugia malayi polk-prov protein 0.0007 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0115
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0256
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066
Echinococcus granulosus dna polymerase kappa 0.0021 0.002 0.0343
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.002 0.0027
Onchocerca volvulus 0.0011 0.0007 0.0006
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0026 0.0669
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0075
Giardia lamblia DNA repair protein RAD52 0.0381 0.0505 0.1851
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0498
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0498
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0026 0.0669
Brugia malayi hypothetical protein 0.0039 0.0045 0.0062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Schistosoma mansoni Smad4 0.0009 0.0004 0.0066
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.002 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0072
Giardia lamblia DINP protein human, muc B family 0.0021 0.002 0.0072
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.002 0.039
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.0438 0.1604
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0021 0.0418
Schistosoma mansoni glutaminase 0.03 0.0396 0.6638
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0113
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0042
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0015 0.0342
Schistosoma mansoni cpg binding protein 0.007 0.0086 0.1447
Entamoeba histolytica hypothetical protein 0.0039 0.0045 0.0892
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0013 0.0009 0.0153
Plasmodium vivax helicase, putative 0.0006 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0049 0.1094
Brugia malayi Telomerase reverse transcriptase 0.5399 0.7266 1
Entamoeba histolytica hypothetical protein 0.0039 0.0045 0.0892
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.001 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0009
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2029 0.2726 1
Echinococcus multilocularis Smad4 0.0009 0.0004 0.0066
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.002 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.002 0.0069
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0007 0.0027
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.002 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.002 0.0244
Leishmania major DNA polymerase eta, putative 0.0021 0.002 0.0075
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.002 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.0115
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0007 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0042
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0007 0.0115
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.002 0.0517
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0001 0.0013
Toxoplasma gondii exonuclease III APE 0.0021 0.002 0.0072
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.002 0.5
Plasmodium vivax importin-beta 2, putative 0.0032 0.0035 0.0127
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0004 0.0066
Echinococcus multilocularis Chromo domain 0.0013 0.0009 0.0153
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.0009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0203 0.0742
Leishmania major DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0026 0.0094
Echinococcus multilocularis helicase 0.0006 0.0001 0.001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0115
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0115
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0022 0.0021 0.0077
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.002 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0012 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Mycobacterium ulcerans hypothetical protein 0.0174 0.0227 0.5726
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0381 0.0505 1
Brugia malayi BRM protein 0.0074 0.0091 0.0125
Toxoplasma gondii hypothetical protein 0.0053 0.0064 0.0234
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.003 0.0112
Brugia malayi Disco-interacting protein 2 homolog 0.0042 0.0049 0.0067
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0009 0.0013
Brugia malayi Flap endonuclease-1 0.0029 0.003 0.0042
Trichomonas vaginalis helicase, putative 0.0007 0.0002 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0154
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0015 0.0012 0.0193
Toxoplasma gondii DNA methyltransferase 2, putative 0.0022 0.0021 0.0077
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0006 0.0001 0.0013
Leishmania major modification methylase-like protein 0.0022 0.0021 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0007 0.0006
Echinococcus granulosus geminin 0.0186 0.0242 0.4064
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0007 0.0115
Trypanosoma brucei unspecified product 0.0015 0.0012 0.0043
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Loa Loa (eye worm) BRM protein 0.0047 0.0055 0.1238
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus multilocularis global transcription activator snf2l2 0.0074 0.0091 0.1529
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0212 0.3566
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0007 0.0115
Loa Loa (eye worm) hypothetical protein 0.0164 0.0212 0.476
Brugia malayi Importin beta-1 subunit 0.0032 0.0035 0.0048
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0056
Onchocerca volvulus 0.0042 0.0049 0.0048
Entamoeba histolytica Flap nuclease, putative 0.0029 0.003 0.0602
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0082 0.1374
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0007 0.0027
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0015 0.0056
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0035 0.0127
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0055 0.0198
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0168 0.3768
Echinococcus multilocularis disco interacting protein 2 0.0042 0.0049 0.0819
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Entamoeba histolytica hypothetical protein 0.0039 0.0045 0.0892
Plasmodium vivax hypothetical protein, conserved 0.0006 0.0001 0.0002
Toxoplasma gondii hypothetical protein 0.0093 0.0117 0.0429
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.002 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.0009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0075 0.0275
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.002 0.0517
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Brugia malayi isocitrate dehydrogenase 0.0017 0.0015 0.0021
Echinococcus multilocularis snurportin 1 0.0337 0.0446 0.7492
Schistosoma mansoni helicase 0.0074 0.0091 0.1529
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0005
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0042 0.0049 0.0819
Plasmodium falciparum Snf2-related CBP activator, putative 0.0006 0.0001 0.0002
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.003 0.0109
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Plasmodium falciparum telomerase reverse transcriptase 0.2029 0.2726 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0186 0.0242 0.4064
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Echinococcus multilocularis polybromo 1 0.0007 0.0001 0.0019
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0035 0.0579
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0012 0.0043
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0075
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.002 0.0343
Schistosoma mansoni cpg binding protein 0.007 0.0086 0.1447
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0072
Leishmania major telomerase reverse transcriptase, putative 0.2029 0.2726 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0004 0.0066
Entamoeba histolytica hypothetical protein 0.0026 0.0026 0.0524
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.0115
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.0438 0.1606
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Loa Loa (eye worm) CXXC zinc finger family protein 0.0068 0.0084 0.1878
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0115
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.002 0.0498
Echinococcus granulosus cpg binding protein 0.007 0.0086 0.1447
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0115
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0004 0.0066
Leishmania major DNA polymerase kappa, putative 0.0021 0.002 0.0075
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Echinococcus multilocularis dnaJ subfamily B 0.0448 0.0596 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.002 0.0072
Echinococcus granulosus flap endonuclease 1 0.0029 0.003 0.051
Echinococcus multilocularis dna polymerase kappa 0.0021 0.002 0.0343
Trypanosoma brucei telomerase reverse transcriptase 0.2029 0.2726 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Echinococcus granulosus Smad4 0.0009 0.0004 0.0066
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0007 0.0115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0072
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.0115
Brugia malayi CXXC zinc finger family protein 0.0068 0.0084 0.0115
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0022 0.0021 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.002 0.0442
Echinococcus granulosus snurportin 1 0.0337 0.0446 0.7492
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0015 0.0256
Schistosoma mansoni flap endonuclease-1 0.0026 0.0027 0.0448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trypanosoma brucei unspecified product 0.0021 0.002 0.0075
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.0115
Entamoeba histolytica hypothetical protein 0.0108 0.0138 0.2731
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Echinococcus granulosus BRK domain containing protein 0.0013 0.0009 0.0153
Schistosoma mansoni cpg binding protein 0.0068 0.0084 0.1407
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.002 0.0069
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0035 0.0127
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0007 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0045 0.0756
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.003 0.0112
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0056
Loa Loa (eye worm) hypothetical protein 0.0164 0.0212 0.476
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0009
Echinococcus granulosus muscleblind protein 0.0164 0.0212 0.3566
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0009
Plasmodium vivax telomerase reverse transcriptase, putative 0.2029 0.2726 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0773
Echinococcus granulosus dnaJ subfamily B 0.0448 0.0596 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.0028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0115
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0015 0.0056
Schistosoma mansoni hypothetical protein 0.0039 0.0045 0.0756
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.0438 0.1606
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0093 0.0117 0.0429
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0072
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.0115
Echinococcus multilocularis dna polymerase eta 0.0021 0.002 0.0343
Echinococcus granulosus Helicase SANT associated DNA binding 0.0006 0.0001 0.001
Echinococcus multilocularis flap endonuclease 1 0.0029 0.003 0.051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0009
Echinococcus granulosus disco interacting protein 2 0.0042 0.0049 0.0819
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0256
Leishmania major DNA damage repair protein, putative 0.0007 0.0001 0.0003
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.003 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0004 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0075
Schistosoma mansoni hypothetical protein 0.0013 0.0009 0.0153
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0055 0.0198
Echinococcus granulosus Chromo domain 0.0013 0.0009 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0115

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5 uM Cytotoxicity of the compound against 1A9 ovarian cancer cells ChEMBL. 16134928

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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