TDR Targets

Basic information

Technical information

TDR Targets ID: 342749
Name: (2-iodophenyl)-[2-methyl-1-[(1-methylpiperidi n-2-yl)methyl]indol-3-yl]methanone
MW: 472.362 | Formula: C23H25IN2O
H donors: 0 H acceptors: 1 LogP: 5.28 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCCCC1Cn1c2ccccc2c(c1C)C(=O)c1ccccc1I
InChi: 1S/C23H25IN2O/c1-16-22(23(27)18-10-3-5-12-20(18)24)19-11-4-6-13-21(19)26(16)15-17-9-7-8-14-25(17)2/h3-6,10-13,17H,7-9,14-15H2,1-2H3
InChiKey: FPYAVJFDESIWFK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2-iodophenyl)-[2-methyl-1-[(1-methyl-2-piperidyl)methyl]indol-3-yl]methanone
(2-iodophenyl)-[2-methyl-1-[(1-methyl-2-piperidinyl)methyl]-3-indolyl]methanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Rattus norvegicus	Cannabinoid CB1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0419	0.624	0.6681
Echinococcus multilocularis	tubulin subunit beta	0.0556	0.87	1
Trypanosoma cruzi	alpha tubulin, putative	0.0419	0.624	0.4129
Echinococcus granulosus	beta tubulin	0.0556	0.87	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0144	0.1288	0.5
Giardia lamblia	Epsilon tubulin	0.0172	0.1802	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0419	0.624	0.6121
Trichomonas vaginalis	tubulin, putative	0.0169	0.1754	0.0629
Leishmania major	beta tubulin	0.0556	0.87	1
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.624	0.7053
Echinococcus multilocularis	hypothetical protein	0.0419	0.624	0.7053
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.624	0.6681
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Echinococcus granulosus	beta tubulin	0.0556	0.87	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0144	0.1288	0.5
Loa Loa (eye worm)	tubulin alpha 2	0.0276	0.3663	0.3462
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0419	0.624	0.6681
Echinococcus granulosus	tubulin alpha chain	0.0419	0.624	0.7053
Leishmania major	beta tubulin	0.0556	0.87	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0342	0.4852	0.4809
Treponema pallidum	cell division protein FtsZ	0.0144	0.1288	0.5
Loa Loa (eye worm)	tubulin alpha-3 chain	0.025	0.3197	0.2981
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.624	0.6681
Schistosoma mansoni	tubulin subunit delta	0.0144	0.1288	0.1436
Schistosoma mansoni	tubulin subunit beta	0.0144	0.1288	0.1436
Echinococcus multilocularis	Tubulin beta 2C chain	0.0556	0.87	1
Brugia malayi	Tubulin gamma chain	0.0342	0.4852	0.4852
Brugia malayi	Cell division protein ftsZ	0.0144	0.1288	0.1288
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.624	0.6681
Toxoplasma gondii	beta-tubulin, putative	0.0556	0.87	1
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Plasmodium vivax	tubulin alpha chain, putative	0.0419	0.624	0.6681
Trichomonas vaginalis	tubulin alpha chain, putative	0.0313	0.4331	0.4105
Echinococcus multilocularis	tubulin beta 1 chain	0.0556	0.87	1
Schistosoma mansoni	alpha tubulin	0.0419	0.624	0.7158
Brugia malayi	tubulin alpha chain - mouse	0.0419	0.624	0.624
Leishmania major	beta tubulin	0.0556	0.87	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0342	0.4845	0.4799
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.025	0.3197	0.2576
Leishmania major	beta tubulin	0.0556	0.87	1
Brugia malayi	Tubulin beta chain	0.0169	0.1754	0.1754
Schistosoma mansoni	tubulin subunit alpha	0.0144	0.1288	0.1436
Echinococcus multilocularis	Tubulin beta 2C chain	0.0556	0.87	1
Echinococcus multilocularis	tubulin delta chain	0.0144	0.1288	0.112
Trypanosoma cruzi	epsilon tubulin, putative	0.0342	0.4845	0.0798
Loa Loa (eye worm)	tubulin alpha chain	0.0419	0.624	0.6121
Echinococcus multilocularis	beta tubulin	0.0556	0.87	1
Schistosoma mansoni	hypothetical protein	0.0182	0.1983	0.224
Trypanosoma cruzi	epsilon tubulin, putative	0.0342	0.4845	0.0798
Leishmania major	beta tubulin	0.0556	0.87	1
Schistosoma mansoni	tubulin subunit epsilon	0.0342	0.4845	0.5546
Trypanosoma brucei	zeta tubulin, putative	0.0444	0.6675	0.7085
Brugia malayi	Tubulin beta chain	0.0144	0.1288	0.1288
Leishmania major	beta tubulin	0.0556	0.87	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0419	0.624	0.7053
Mycobacterium ulcerans	cell division protein FtsZ	0.0144	0.1288	0.5
Schistosoma mansoni	tubulin subunit alpha	0.0419	0.624	0.7158
Echinococcus multilocularis	tubulin alpha	0.0313	0.4331	0.4766
Echinococcus granulosus	Tubulin beta 2C chain	0.0556	0.87	1
Schistosoma mansoni	tubulin subunit gamma	0.0342	0.4852	0.5555
Leishmania major	beta tubulin	0.0556	0.87	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0556	0.87	0.8658
Echinococcus granulosus	tubulin alpha chain	0.0419	0.624	0.7053
Toxoplasma gondii	alpha tubulin TUBA1	0.0419	0.624	0.6434
Plasmodium falciparum	alpha tubulin 1	0.0419	0.624	0.6681
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0276	0.3663	0.3205
Brugia malayi	tubulin alpha-2 chain	0.0419	0.624	0.624
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.624	0.7053
Echinococcus multilocularis	peroxisome assembly protein 26	0.0419	0.624	0.7053
Trypanosoma cruzi	zeta tubulin, putative	0.0444	0.6675	0.5167
Toxoplasma gondii	beta tubulin	0.0556	0.87	1
Trypanosoma brucei	beta tubulin	0.0556	0.87	1
Mycobacterium leprae	cell division protein FtsZ	0.0144	0.1288	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0556	0.87	1
Leishmania major	beta tubulin	0.0556	0.87	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0342	0.4845	0.4799
Loa Loa (eye worm)	tubulin alpha 2	0.0106	0.0621	0.0323
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Schistosoma mansoni	tubulin subunit alpha	0.0419	0.624	0.7158
Echinococcus granulosus	tubulin alpha chain	0.0419	0.624	0.7053
Leishmania major	beta tubulin	0.0556	0.87	1
Trypanosoma brucei	zeta tubulin	0.0444	0.6675	0.7085
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Trypanosoma brucei	tubulin gamma chain	0.0342	0.4852	0.4461
Loa Loa (eye worm)	hypothetical protein	0.025	0.3197	0.2981
Echinococcus multilocularis	Tubulin beta 2C chain	0.0556	0.87	1
Brugia malayi	Tubulin alpha chain	0.0419	0.624	0.624
Loa Loa (eye worm)	tubulin beta chain	0.0144	0.1288	0.1011
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0323	0.451	0.3926
Loa Loa (eye worm)	tubulin beta-4 chain	0.0556	0.87	0.8658
Echinococcus granulosus	Tubulin beta 2C chain	0.0556	0.87	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0556	0.87	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0313	0.4331	0.3666
Trichomonas vaginalis	tubulin gamma chain, putative	0.0556	0.87	1
Leishmania major	beta tubulin	0.0556	0.87	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0169	0.1754	0.0629
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0276	0.3663	0.3462
Echinococcus multilocularis	beta tubulin	0.0556	0.87	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0556	0.87	1
Schistosoma mansoni	tubulin subunit beta	0.0556	0.87	1
Trypanosoma brucei	epsilon tubulin	0.0313	0.4331	0.371
Echinococcus granulosus	tubulin beta 1 chain	0.0556	0.87	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0556	0.87	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0419	0.624	0.6681
Echinococcus granulosus	peroxisome assembly protein 26	0.0419	0.624	0.7053
Echinococcus granulosus	tubulin alpha chain	0.0419	0.624	0.7053
Echinococcus multilocularis	tubulin epsilon chain	0.0342	0.4845	0.5382
Schistosoma mansoni	tubulin subunit beta	0.0556	0.87	1
Echinococcus multilocularis	geminin	0.0182	0.1983	0.1954
Plasmodium falciparum	alpha tubulin 2	0.0419	0.624	0.6681
Echinococcus multilocularis	tubulin subunit TubB	0.0419	0.624	0.7053
Loa Loa (eye worm)	tubulin alpha 2	0.0276	0.3663	0.3462
Trypanosoma cruzi	beta tubulin, putative	0.0556	0.87	1
Plasmodium falciparum	tubulin beta chain	0.0556	0.87	1
Leishmania major	beta tubulin	0.0556	0.87	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0419	0.624	0.7053
Schistosoma mansoni	hypothetical protein	0.0182	0.1983	0.224
Echinococcus granulosus	tubulin subunit beta	0.0556	0.87	1
Leishmania major	beta tubulin	0.0556	0.87	1
Loa Loa (eye worm)	BEN-1 protein	0.0556	0.87	0.8658
Echinococcus granulosus	tubulin gamma 1 chain	0.0342	0.4852	0.5391
Entamoeba histolytica	tubulin alpha chain, putative	0.0419	0.624	0.3607
Trichomonas vaginalis	tubulin alpha chain, putative	0.0169	0.1754	0.0629
Echinococcus granulosus	alpha tubulin	0.0419	0.624	0.7053
Loa Loa (eye worm)	tubulin beta chain	0.0556	0.87	0.8658
Trypanosoma brucei	beta tubulin	0.0556	0.87	1
Brugia malayi	beta-tubulin, identical	0.0556	0.87	0.87
Schistosoma mansoni	alpha tubulin	0.0419	0.624	0.7158
Echinococcus granulosus	tubulin alpha	0.0313	0.4331	0.4766
Loa Loa (eye worm)	alpha-tubulin	0.0419	0.624	0.6121
Trichomonas vaginalis	tubulin alpha chain, putative	0.0556	0.87	1
Trypanosoma brucei	alpha tubulin	0.0419	0.624	0.6459
Brugia malayi	bZIP transcription factor family protein	0.0091	0.0352	0.0352
Entamoeba histolytica	tubulin family protein	0.0556	0.87	1
Trypanosoma cruzi	zeta tubulin, putative	0.0444	0.6675	0.5167
Brugia malayi	Tubulin alpha chain	0.0144	0.1288	0.1288
Trypanosoma brucei	alpha tubulin	0.0419	0.624	0.6459
Schistosoma mansoni	tubulin subunit beta	0.0556	0.87	1
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.624	0.6681
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Echinococcus granulosus	Tubulin beta 2C chain	0.0556	0.87	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0419	0.624	0.6434
Leishmania major	beta tubulin	0.0556	0.87	1
Leishmania major	gamma-tubulin	0.0342	0.4852	0.0817
Trichomonas vaginalis	tubulin, putative	0.0556	0.87	1
Echinococcus granulosus	tubulin subunit TubB	0.0419	0.624	0.7053
Trypanosoma cruzi	tubulin gamma chain	0.0342	0.4852	0.0817
Schistosoma mansoni	tubulin subunit beta	0.0556	0.87	1
Leishmania major	zeta tubulin, putative	0.0444	0.6675	0.5167
Echinococcus granulosus	Tubulin beta 2C chain	0.0556	0.87	1
Giardia lamblia	Alpha-tubulin	0.0419	0.624	0.6681
Plasmodium vivax	tubulin alpha chain, putative	0.0419	0.624	0.6681
Echinococcus granulosus	Tubulin alpha 1 chain	0.0419	0.624	0.7053
Loa Loa (eye worm)	hypothetical protein	0.0629	1	1
Schistosoma mansoni	alpha tubulin	0.0419	0.624	0.7158
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Trichomonas vaginalis	tubulin beta chain, putative	0.0169	0.1754	0.0629
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.624	0.6681
Echinococcus granulosus	Tubulin alpha 1 chain	0.0419	0.624	0.7053
Trypanosoma brucei	beta tubulin	0.0556	0.87	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0419	0.624	0.7053
Leishmania major	beta tubulin	0.0556	0.87	1
Trypanosoma brucei	tubulin delta chain	0.0323	0.451	0.3968
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0556	0.87	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0556	0.87	1
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.624	0.7053
Loa Loa (eye worm)	tubulin alpha chain	0.0419	0.624	0.6121
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Trypanosoma brucei	beta tubulin	0.0556	0.87	1
Entamoeba histolytica	tubulin family protein	0.0556	0.87	1
Echinococcus granulosus	tubulin delta chain	0.0144	0.1288	0.112
Trypanosoma brucei	beta tubulin	0.0313	0.4331	0.371
Plasmodium falciparum	tubulin gamma chain	0.0342	0.4852	0.4809
Entamoeba histolytica	tubulin alpha-1 chain	0.0419	0.624	0.3607
Echinococcus multilocularis	tubulin gamma 1 chain	0.0342	0.4852	0.5391
Trypanosoma brucei	epsilon tubulin	0.0342	0.4845	0.445
Loa Loa (eye worm)	BEN-1 protein	0.0556	0.87	0.8658
Echinococcus granulosus	tubulin alpha 3 chain	0.0419	0.624	0.7053
Leishmania major	beta tubulin	0.0556	0.87	1
Loa Loa (eye worm)	beta-tubulin	0.0556	0.87	0.8658
Echinococcus multilocularis	Tubulin beta 2C chain	0.0556	0.87	1
Giardia lamblia	Alpha-tubulin	0.0419	0.624	0.6681
Giardia lamblia	Beta tubulin	0.0556	0.87	1
Trypanosoma brucei	alpha tubulin	0.0419	0.624	0.6459
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0419	0.624	0.7053
Leishmania major	beta tubulin	0.0556	0.87	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0419	0.624	0.7053
Echinococcus granulosus	geminin	0.0182	0.1983	0.1954
Loa Loa (eye worm)	hypothetical protein	0.0276	0.3663	0.3462
Giardia lamblia	Gamma tubulin	0.0342	0.4852	0.4809
Brugia malayi	Tubulin alpha-2 chain	0.0419	0.624	0.624
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0419	0.624	0.6121
Leishmania major	epsilon tubulin, putative	0.0342	0.4845	0.0798
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.624	0.7053
Trypanosoma brucei	epsilon tubulin	0.0342	0.4845	0.445
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Brugia malayi	alpha-tubulin	0.0419	0.624	0.624
Trichomonas vaginalis	tubulin alpha chain, putative	0.0169	0.1754	0.0629
Echinococcus granulosus	tubulin alpha 3 chain	0.0419	0.624	0.7053
Plasmodium vivax	tubulin epsilon chain, putative	0.0342	0.4845	0.4799
Echinococcus multilocularis	tubulin alpha 1C chain	0.0419	0.624	0.7053
Echinococcus multilocularis	tubulin alpha 3 chain	0.0419	0.624	0.7053
Brugia malayi	Tubulin beta-1 chain	0.0556	0.87	0.87
Echinococcus multilocularis	tubulin alpha chain	0.0419	0.624	0.7053
Giardia lamblia	Beta tubulin	0.0556	0.87	1
Schistosoma mansoni	tubulin subunit beta	0.0556	0.87	1
Onchocerca volvulus		0.0169	0.1754	1
Schistosoma mansoni	tubulin subunit beta	0.0556	0.87	1
Plasmodium vivax	tubulin beta chain, putative	0.0556	0.87	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0419	0.624	0.7053
Echinococcus granulosus	tubulin epsilon chain	0.0342	0.4845	0.5382
Trichomonas vaginalis	tubulin, putative	0.0173	0.181	0.0704
Schistosoma mansoni	tubulin subunit alpha	0.0419	0.624	0.7158
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0556	0.87	1
Trichomonas vaginalis	tubulin, putative	0.0169	0.1754	0.0629
Plasmodium vivax	tubulin gamma chain, putative	0.0342	0.4852	0.4809
Trichomonas vaginalis	tubulin beta chain, putative	0.0419	0.624	0.6681
Leishmania major	beta tubulin	0.0556	0.87	1
Giardia lamblia	Beta tubulin	0.0556	0.87	1
Brugia malayi	Tubulin alpha-2 chain	0.0419	0.624	0.624
Trypanosoma brucei	alpha tubulin	0.0419	0.624	0.6459
Loa Loa (eye worm)	alpha-tubulin	0.0419	0.624	0.6121
Loa Loa (eye worm)	tubulin beta-2A chain	0.0556	0.87	0.8658
Loa Loa (eye worm)	tubulin gamma chain	0.0342	0.4852	0.4689
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0419	0.624	0.7053
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0419	0.624	0.7053
Leishmania major	beta tubulin	0.0556	0.87	1
Echinococcus granulosus	tubulin alpha chain	0.0419	0.624	0.7053
Leishmania major	alpha tubulin	0.0419	0.624	0.4129
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0169	0.1754	0.0629
Toxoplasma gondii	beta-1 tubulin, putative	0.0556	0.87	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 6.7 nM	Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 6.7 nM	Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 10 nM	Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 10 nM	Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 34 nM	Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 34 nM	Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 34 nM	Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 34 nM	Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 83 nM	Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 83 nM	Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 1200 nM	Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940	ChEMBL.	16190764
Ki (binding)	= 1200 nM	Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55,940	ChEMBL.	16190764

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL370884
PubChem: 11532939

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 342749