Detailed information for compound 345744

Basic information

Technical information
  • TDR Targets ID: 345744
  • Name: 4-[(2-morpholin-4-yl-4-oxochromen-7-yl)oxymet hyl]benzonitrile
  • MW: 362.379 | Formula: C21H18N2O4
  • H donors: 0 H acceptors: 2 LogP: 2.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)COc1ccc2c(c1)oc(cc2=O)N1CCOCC1
  • InChi: 1S/C21H18N2O4/c22-13-15-1-3-16(4-2-15)14-26-17-5-6-18-19(24)12-21(27-20(18)11-17)23-7-9-25-10-8-23/h1-6,11-12H,7-10,14H2
  • InChiKey: YVXINVZLYKYZSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(2-morpholino-4-oxo-chromen-7-yl)oxymethyl]benzonitrile
  • 4-[(2-morpholino-4-oxo-1-benzopyran-7-yl)oxymethyl]benzonitrile
  • 4-[(2-morpholin-4-yl-4-oxo-chromen-7-yl)oxymethyl]benzenecarbonitrile
  • 4-[(4-keto-2-morpholino-chromen-7-yl)oxymethyl]benzonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, DNA-activated, catalytic polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Echinococcus granulosus DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0135 0.0346
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0135 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Brugia malayi PAS domain containing protein 0.0048 0.1034 0.2663
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0375 0.3941
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0375 0.139
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0 0.5
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.072 0.072
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0744 0.0744
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0045 0.0116
Schistosoma mansoni cpg binding protein 0.0028 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0012 0.0138 0.0356
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0 0.5
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0218 0.1641
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0313 0.773 0.773
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0375 0.2821
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0744 0.0744
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.357 0.919
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0375 0.0965
Echinococcus multilocularis dual specificity protein kinase clk2 0.006 0.1328 0.1328
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.0138 0.5
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.015 0.0579
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0744 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.0135 0.0346
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0375 0.1447
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0375 0.139
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0014 0.017 0.0438
Brugia malayi hypothetical protein 0.0161 0.3884 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.017 0.1088
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0138 0.0845
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0 0.5
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0138 0.0845
Leishmania major protein kinase, putative 0.0013 0.015 0.0556
Plasmodium vivax serine/threonine kinase-1, putative 0.006 0.1328 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.001 0.0064 0.0064
Onchocerca volvulus 0.0036 0.072 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Brugia malayi Cytochrome P450 family protein 0.0016 0.0218 0.0561
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0744 0.0744
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.1328 0.513
Mycobacterium leprae Possible regulatory protein 0.0012 0.0138 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0 0.5
Toxoplasma gondii FATC domain-containing protein 0.0012 0.0135 0.1013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0375 0.0375
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0138 0.0535
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.017 0.128
Loa Loa (eye worm) hypothetical protein 0.0161 0.3884 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0135 0.0346
Brugia malayi Cytochrome P450 family protein 0.0016 0.0218 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Plasmodium falciparum protein serine/threonine kinase-1 0.006 0.1328 0.5
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0744 0.0744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Loa Loa (eye worm) hypothetical protein 0.0009 0.0042 0.0108
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0744 0.0744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Loa Loa (eye worm) CMGC/CLK protein kinase 0.006 0.1328 0.342
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0 0.5
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0022 0.0375 0.139
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.006 0.1328 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.017 0.1088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0135 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0135 0.0815
Giardia lamblia Kinase, CMGC CLK 0.006 0.1328 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0012 0.0135 0.052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0375 0.0965
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0375 0.2821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0138 0.0514
Leishmania major protein kinase, putative 0.0013 0.015 0.0556
Brugia malayi bHLH-PAS transcription factor 0.0036 0.072 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0375 0.1447
Brugia malayi Protein kinase domain containing protein 0.006 0.1328 0.342
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0 0.5
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0138 0.0845
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0744 0.5504
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0064 0.0273
Leishmania major cytochrome p450-like protein 0.0016 0.0218 0.0809
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0375 0.139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0744 0.3872
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0 0.5
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0744 0.2873
Schistosoma mansoni single-minded 0.0048 0.1034 0.1034
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0744 0.5601
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0 0.5
Mycobacterium ulcerans putative regulatory protein 0.0036 0.072 1
Leishmania major protein kinase, putative 0.006 0.1328 0.4928
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0218 0.0842
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0218 0.0842
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0375 0.0375
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0375 0.2821
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0 0.5
Echinococcus granulosus serine protein kinase ATM 0.0012 0.0135 0.0135
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0375 0.2821
Brugia malayi CXXC zinc finger family protein 0.0028 0.0538 0.1386
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0 0.5
Schistosoma mansoni hypothetical protein 0.0403 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.015 0.0579
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0744 0.5504
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0138 0.0845
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0375 0.1447
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0744 0.276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Echinococcus multilocularis serine protein kinase ATM 0.0012 0.0135 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.006 0.1328 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0375 0.0375
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0313 0.773 0.773
Echinococcus granulosus cpg binding protein 0.003 0.0579 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0138 0.0845
Loa Loa (eye worm) hypothetical protein 0.0036 0.0744 0.1915
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.015 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0138 0.0845
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0138 0.0535
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1339 0.1339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0012 0.0135 0.0135
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0218 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0744 0.5504
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.1328 0.513
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0012 0.0135 0.1013
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0218 0.0561
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0008 0.0029 0.011
Echinococcus granulosus single minded 2 0.0036 0.072 0.072
Echinococcus granulosus hypothetical protein 0.0059 0.1317 0.1317
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.1034 0.1034
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0059 0.1317 0.339
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0138 0.0845
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0538 0.1386
Leishmania major protein kinase, putative 0.006 0.1328 0.4928
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.1328 0.513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0138 0.0138
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0375 0.0965
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0375 0.2821
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0042 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0375 0.0965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0135 0.0815
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0 0.5
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0375 0.0375
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0375 0.1447
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0138 0.0845
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.1328 0.513
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.2589 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.001 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0001 0.0001
Onchocerca volvulus 0.0028 0.0538 0.6882
Leishmania major hypothetical protein, conserved 0.0114 0.2695 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0375 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0135 0.0815
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0135 0.0815
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.006 0.1328 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0001 0.0001
Echinococcus multilocularis 0.0059 0.1317 0.1317
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1178 0.8865
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.006 0.1328 0.1328
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0064 0.0165
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.006 0.1328 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0135 0.0815
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0014 0.017 0.128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0375 0.0375
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0045
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0375 0.2821
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0375 0.0375
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0001 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0 0.5
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0138 0.0138
Brugia malayi hypoxia-induced factor 1 0.0149 0.357 0.919
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0744 0.0744
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0138 0.0845
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0012 0.0135 0.052
Echinococcus granulosus dual specificity protein kinase clk2 0.006 0.1328 0.1328
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0744 0.1915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0135 0.0815
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0138 0.0845
Schistosoma mansoni cpg binding protein 0.003 0.0579 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0744 0.0744
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0375 0.3941
Brugia malayi FAT domain containing protein 0.001 0.0064 0.0165
Schistosoma mansoni hypothetical protein 0.001 0.0064 0.0064
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0218 0.3029
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0138 0.0356
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0138 0.0138
Echinococcus multilocularis dnaJ subfamily B 0.0403 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0744 0.2873
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0375 0.139
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0138 0.0845
Echinococcus multilocularis cpg binding protein 0.003 0.0579 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.015 0.0579
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0375 0.2663
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.0135 0.0135
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0218 0.0561
Schistosoma mansoni cpg binding protein 0.003 0.0579 0.0579
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.006 0.1328 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.69 uM Inhibitory activity against DNA-dependent protein kinase receptor ChEMBL. 16302822
IC50 (binding) = 0.69 uM Inhibitory activity against DNA-dependent protein kinase receptor ChEMBL. 16302822

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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