Detailed information for compound 346701

Basic information

Technical information
  • TDR Targets ID: 346701
  • Name: 4-bromo-N-[1-(cyanomethylcarbamoyl)cyclohexyl ]benzamide
  • MW: 364.237 | Formula: C16H18BrN3O2
  • H donors: 2 H acceptors: 3 LogP: 2.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)C1(CCCCC1)NC(=O)c1ccc(cc1)Br
  • InChi: 1S/C16H18BrN3O2/c17-13-6-4-12(5-7-13)14(21)20-16(8-2-1-3-9-16)15(22)19-11-10-18/h4-7H,1-3,8-9,11H2,(H,19,22)(H,20,21)
  • InChiKey: AGJGTOPQVLECER-UHFFFAOYSA-N  


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Synonyms

  • 4-bromo-N-[1-[(cyanomethylamino)-oxomethyl]cyclohexyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Oryctolagus cuniculus Cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 279 aa 28.0 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 328 aa 25.9 %
Neospora caninum hypothetical protein Cathepsin K   329 aa 381 aa 24.9 %
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 264 aa 29.9 %
Toxoplasma gondii cathepsin B Cathepsin K   329 aa 290 aa 26.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 310 aa 24.2 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 330 aa 28.5 %
Giardia lamblia Cathepsin B precursor Cathepsin K   329 aa 299 aa 27.4 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 290 aa 31.4 %
Echinococcus granulosus cathepsin L Cathepsin K   329 aa 356 aa 37.4 %
Trypanosoma brucei cysteine peptidase C (CPC) Cathepsin K   329 aa 270 aa 26.7 %
Babesia bovis papain family cysteine protease containing protein Cathepsin K   329 aa 331 aa 32.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin K   329 aa 348 aa 32.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin K   329 aa 323 aa 34.4 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin K   329 aa 333 aa 32.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 276 aa 26.4 %
Onchocerca volvulus Cathepsin K   329 aa 324 aa 40.7 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin K   329 aa 333 aa 32.1 %
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Cathepsin K   329 aa 270 aa 26.7 %
Onchocerca volvulus Cathepsin L homolog Cathepsin K   329 aa 316 aa 45.3 %
Leishmania donovani cysteine peptidase C (CPC) Cathepsin K   329 aa 264 aa 29.9 %
Giardia lamblia Cathepsin B precursor Cathepsin K   329 aa 278 aa 28.8 %
Babesia bovis cysteine protease 2 Cathepsin K   329 aa 343 aa 30.3 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 291 aa 33.7 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin K   329 aa 308 aa 32.1 %
Echinococcus multilocularis cathepsin L Cathepsin K   329 aa 354 aa 37.3 %
Toxoplasma gondii cathepsin CPC1 Cathepsin K   329 aa 351 aa 23.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Echinococcus granulosus cathepsin b Cathepsin K   329 aa 268 aa 24.6 %
Loa Loa (eye worm) hypothetical protein Cathepsin K   329 aa 277 aa 27.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 274 aa 27.7 %
Plasmodium knowlesi knowpain-1 Cathepsin K   329 aa 353 aa 28.6 %
Onchocerca volvulus Cathepsin K   329 aa 298 aa 31.9 %
Onchocerca volvulus Cathepsin K   329 aa 272 aa 29.0 %
Dictyostelium discoideum hypothetical protein Cathepsin K   329 aa 349 aa 33.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 369 aa 24.7 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin K   329 aa 319 aa 37.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 296 aa 24.7 %
Echinococcus multilocularis cathepsin L Cathepsin K   329 aa 316 aa 31.3 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin K   329 aa 302 aa 35.4 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin K   329 aa 342 aa 36.5 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 265 aa 26.8 %
Echinococcus granulosus cysteine protease Cathepsin K   329 aa 328 aa 46.6 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin K   329 aa 328 aa 47.9 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Onchocerca volvulus Cathepsin K   329 aa 310 aa 40.6 %
Dictyostelium discoideum hypothetical protein Cathepsin K   329 aa 338 aa 34.9 %
Onchocerca volvulus Cathepsin K   329 aa 319 aa 41.7 %
Trypanosoma cruzi cysteine protease, putative Cathepsin K   329 aa 318 aa 31.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 328 aa 27.7 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin K   329 aa 345 aa 29.9 %
Trypanosoma cruzi cysteine peptidase C (CPC), putative Cathepsin K   329 aa 264 aa 28.4 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin K   329 aa 375 aa 24.3 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin K   329 aa 323 aa 34.4 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin K   329 aa 318 aa 31.1 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin K   329 aa 305 aa 36.4 %
Schistosoma japonicum ko:K01365 cathepsin L [EC3.4.22.15], putative Cathepsin K   329 aa 322 aa 41.9 %
Echinococcus granulosus cathepsin L Cathepsin K   329 aa 316 aa 32.0 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 317 aa 26.5 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin K   329 aa 277 aa 25.3 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 27.2 %
Plasmodium yoelii cathepsin c precursor Cathepsin K   329 aa 292 aa 23.3 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 330 aa 32.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 326 aa 25.5 %
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Cathepsin K   329 aa 265 aa 26.0 %
Plasmodium berghei berghepain-1 Cathepsin K   329 aa 345 aa 31.6 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin K   329 aa 319 aa 44.5 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 299 aa 24.7 %
Trypanosoma cruzi cysteine peptidase C (CPC), putative Cathepsin K   329 aa 264 aa 28.8 %
Plasmodium vivax vivapain-3 Cathepsin K   329 aa 327 aa 35.5 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 264 aa 29.2 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin K   329 aa 309 aa 34.6 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 331 aa 26.9 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin K   329 aa 269 aa 27.1 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin K   329 aa 290 aa 30.0 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin K   329 aa 265 aa 26.4 %
Onchocerca volvulus Cathepsin K   329 aa 311 aa 37.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 363 aa 25.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 380 aa 23.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 362 aa 25.1 %
Babesia bovis cathepsin C precursor, putative Cathepsin K   329 aa 269 aa 25.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 351 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.2684 0.5483
Brugia malayi neuropeptide F receptor 0.0125 0.5645 0.6505
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0534 0.1092
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.3558 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0532 0.1087
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0059 0.2115 0.2399
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0532 0.1087
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.3558 0.3558
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.8677 0.8677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0104 0.4551 0.9299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Onchocerca volvulus 0.0125 0.5645 1
Onchocerca volvulus 0.0086 0.3558 0.6303
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.0275 0.0275
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.3558 0.3558
Echinococcus granulosus g protein coupled receptor 0.0125 0.5645 0.5645
Echinococcus granulosus hypothetical protein 0.0125 0.5645 0.5645
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.1758 0.2026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1758 0.3592
Schistosoma mansoni hypothetical protein 0.0125 0.5645 0.5645
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0073 0.2852 0.3235
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.3558 0.4035
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0534 0.1092
Onchocerca volvulus 0.0125 0.5645 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Onchocerca volvulus 0.0125 0.5645 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.8677 0.8677
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3558 0.41
Brugia malayi G-protein coupled receptor 0.0125 0.5645 0.6505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1758 0.3592
Echinococcus granulosus cysteine protease 0.0047 0.1442 0.1442
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0039 0.1037 0.2119
Toxoplasma gondii cathepsin B 0.007 0.2684 0.7543
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0023 0.0153 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.5645 0.5645
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1442 0.1662
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.2115 0.2115
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.2115 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.3558 0.7269
Schistosoma mansoni hypothetical protein 0.0125 0.5645 0.5645
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.2115 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Giardia lamblia Kinase, AGC PKA 0.0023 0.0153 0.0571
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.1758 0.1758
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Giardia lamblia Cathepsin B precursor 0.007 0.2684 1
Echinococcus multilocularis g protein coupled receptor 0.0125 0.5645 0.5645
Schistosoma mansoni opsin-like receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis neuropeptide FF receptor 2 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1442 0.2947
Echinococcus multilocularis fmrfamide receptor 0.0125 0.5645 0.5645
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0125 0.5645 0.5645
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) ctsf protein 0.0086 0.3558 0.4035
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Echinococcus granulosus sex peptide receptor 0.0125 0.5645 0.5645
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.4895 1
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus granulosus dro:myosuppressin receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0086 0.3558 0.6303
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.0275 0.0317
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.8677 0.8677
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.1758 0.3592
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0125 0.5645 0.5645
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0125 0.5645 0.6505
Onchocerca volvulus Cathepsin L homolog 0.0086 0.3558 0.6303
Onchocerca volvulus 0.0086 0.3558 0.6303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0882 0.1803
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.5645 0.6402
Onchocerca volvulus 0.0125 0.5645 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine proteinase 2 0.0047 0.1442 0.2947
Brugia malayi G protein-coupled receptor 0.0125 0.5645 0.6505
Echinococcus multilocularis Glutaredoxin protein 5 0.0022 0.014 0.014
Echinococcus granulosus 7tm_1 domain containing protein 0.0125 0.5645 0.5645
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.3558 0.3558
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.1216 0.302
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.1442 0.1662
Echinococcus multilocularis G-protein coupled receptor, putative 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0027 0.0369 0.0418
Brugia malayi putative neuropeptide receptor 0.0125 0.5645 0.6505
Echinococcus multilocularis cathepsin L 0.0047 0.1442 0.1442
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0125 0.5645 0.6402
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2115 0.4322
Schistosoma mansoni neuropeptide receptor 0.0125 0.5645 0.5645
Echinococcus granulosus neuropeptide s receptor 0.0125 0.5645 0.5645
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.2684 0.3093
Echinococcus granulosus neuropeptide receptor 0.0125 0.5645 0.5645
Echinococcus granulosus serotonin receptor 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Echinococcus multilocularis orexin receptor type 2 0.0125 0.5645 0.5645
Brugia malayi cathepsin L-like precursor 0.0059 0.2115 0.2438
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0125 0.5645 0.5645
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1442 0.1662
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0077 0.3079 0.6291
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Echinococcus granulosus orexin receptor type 2 0.0125 0.5645 0.5645
Echinococcus multilocularis serotonin receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Schistosoma mansoni biogenic amine receptor 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Echinococcus granulosus cathepsin l1 0.0059 0.2115 0.2115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Echinococcus granulosus 7TM GPCR rhodopsin 0.0125 0.5645 0.5645
Schistosoma mansoni neuropeptide receptor 0.0125 0.5645 0.5645
Trypanosoma cruzi cysteine protease, putative 0.0047 0.1442 0.1662
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0033 0.0694 0.08
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0532 0.1087
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.5645 0.5645
Brugia malayi RE15519p 0.0125 0.5645 0.6505
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0125 0.5645 0.6505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0672 0.1372
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.5645 0.6402
Schistosoma mansoni alpha-1 adrenergic receptor 0.0125 0.5645 0.5645
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0369 0.0425
Echinococcus granulosus cathepsin b 0.0181 0.8677 0.8677
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0369 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Schistosoma mansoni opsin-like receptor 0.0125 0.5645 0.5645
Echinococcus granulosus nervana 2 0.0022 0.014 0.014
Schistosoma mansoni myosin xvIII 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.3558 0.3558
Echinococcus granulosus neuropeptide receptor A26 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0125 0.5645 0.6505
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.0275 0.0275
Echinococcus granulosus nervana 2 0.0022 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus multilocularis neuropeptide receptor A26 0.0125 0.5645 0.5645
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.1758 0.2315
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0125 0.5645 0.5645
Echinococcus multilocularis cysteine protease 0.0086 0.3558 0.3558
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.1442 0.1442
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1442 0.2947
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1442 0.2947
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.3558 0.3558
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0125 0.5645 0.6402
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0022 0.014 0.014
Schistosoma mansoni neuropeptide f receptor 76f 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.3558 0.41
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.8677 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0534 0.1092
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0125 0.5645 0.5645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.2115 0.4322
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0825 0.1685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Schistosoma mansoni opsin-like receptor 0.0125 0.5645 0.5645
Brugia malayi Serotonin receptor 0.0125 0.5645 0.6505
Loa Loa (eye worm) fibroinase 0.0086 0.3558 0.4035
Onchocerca volvulus 0.0125 0.5645 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.5645 0.5645
Brugia malayi p70 ribosomal S6 kinase beta 0.0034 0.0772 0.089
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0073 0.2852 0.2852
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0125 0.5645 0.5645
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) phosphatidylinositol 3 0.0033 0.0694 0.0787
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0125 0.5645 0.5645
Echinococcus multilocularis neuropeptide receptor 0.0125 0.5645 0.5645
Trypanosoma brucei rac serine-threonine kinase, putative 0.0036 0.0894 0.2059
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0125 0.5645 0.5645
Brugia malayi GnHR receptor homolog 0.0125 0.5645 0.6505
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Schistosoma mansoni neuropeptide receptor 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1442 0.2947
Echinococcus multilocularis cathepsin b 0.0181 0.8677 0.8677
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1442 0.1442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0687 0.1405
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.1758 0.1758
Loa Loa (eye worm) TYRA-2 protein 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.2684 0.2684
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.5645 0.5645
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0095 0.4032 0.4646
Loa Loa (eye worm) cathepsin B 0.007 0.2684 0.3044
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Brugia malayi G-protein coupled receptor 0.0125 0.5645 0.6505
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.5645 0.5645
Echinococcus granulosus neuropeptide FF receptor 2 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1758 0.3592
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Entamoeba histolytica protein kinase, putative 0.0036 0.0894 0.1826
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Onchocerca volvulus 0.0125 0.5645 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.1758 0.4635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1369 0.2797
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0086 0.3558 0.6303
Giardia lamblia Cathepsin B precursor 0.007 0.2684 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni biogenic amine receptor 0.0125 0.5645 0.5645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.1442 0.3694
Loa Loa (eye worm) hypothetical protein 0.0027 0.0369 0.0418
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0356 0.0456
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.1758 0.4635
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0028 0.0454 0.169
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0125 0.5645 0.5645
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.1442 0.1662
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0086 0.3558 0.4035
Echinococcus multilocularis sex peptide receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis rac serine:threonine kinase 0.0025 0.0275 0.0275
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0125 0.5645 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.4895 1
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.3558 0.3558
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0039 0.1037 0.1037
Brugia malayi neuropeptide F receptor 0.0125 0.5645 0.6505
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.3558 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.1442 0.2947
Echinococcus multilocularis g-protein coupled receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0534 0.1092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0059 0.2115 0.3748
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.5645 0.5645
Brugia malayi Protein kinase domain containing protein 0.0036 0.0894 0.103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.5645 0.5645
Plasmodium vivax vivapain-3 0.0047 0.1442 0.4054
Echinococcus granulosus g protein coupled receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0687 0.1405
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Plasmodium vivax unspecified product 0.0047 0.1442 0.4054
Echinococcus multilocularis neuropeptide s receptor 0.0125 0.5645 0.5645
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.3558 0.3558
Giardia lamblia GTOR 0.0052 0.1758 0.655
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.0369 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Brugia malayi larval opioid receptor 0.0125 0.5645 0.6505
Schistosoma mansoni neuropeptide receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0111 0.4895 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.2115 0.2399
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus multilocularis nervana 2 0.0022 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Brugia malayi Dopamine receptor protein 2 0.0125 0.5645 0.6505
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.1442 0.2947
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.1758 0.3592
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0125 0.5645 0.5645
Brugia malayi Dopamine receptor 0.0125 0.5645 0.6505
Echinococcus multilocularis cysteine protease 0.0086 0.3558 0.3558
Echinococcus multilocularis dro:myosuppressin receptor 0.0125 0.5645 0.5645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.1442 0.3694
Onchocerca volvulus 0.0125 0.5645 1
Brugia malayi Dopamine receptor protein 1 0.0125 0.5645 0.6505
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0039 0.1037 0.1195
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.1758 0.2026
Loa Loa (eye worm) hypothetical protein 0.0027 0.0369 0.0418
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Brugia malayi Cathepsin L-like precursor 0.0027 0.0369 0.0425
Echinococcus multilocularis G protein coupled receptor 139 0.0125 0.5645 0.5645
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0125 0.5645 0.6505
Onchocerca volvulus 0.0086 0.3558 0.6303
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.5645 0.5645
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.1442 0.1662
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Onchocerca volvulus Cathepsin F homolog 0.0086 0.3558 0.6303
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Echinococcus granulosus cathepsin L 0.0047 0.1442 0.1442
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3558 0.41
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0086 0.3558 0.6303
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus granulosus G protein coupled receptor 139 0.0125 0.5645 0.5645
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.1442 0.4054
Loa Loa (eye worm) hypothetical protein 0.0181 0.8677 0.9843
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.4895 0.5641
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni amine GPCR 0.0125 0.5645 0.5645
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.1758 0.1758
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.3558 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0023 0.0153 0.0431
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Echinococcus granulosus g protein coupled receptor 0.0125 0.5645 0.5645
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0073 0.2852 0.3287
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0369 0.0418
Giardia lamblia Cathepsin B precursor 0.007 0.2684 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.0275 0.0561
Brugia malayi Melatonin receptor type 1A 0.0125 0.5645 0.6505
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.5645 0.5645
Entamoeba histolytica hypothetical protein 0.0089 0.3711 0.7581
Onchocerca volvulus 0.0125 0.5645 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.2684 0.7395
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.1758 0.1994
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.1442 0.1662
Loa Loa (eye worm) phosphatidylinositol 3 0.0183 0.8816 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0125 0.5645 0.5645
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0125 0.5645 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.4895 0.5641
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Schistosoma mansoni cathepsin s 0.0027 0.0369 0.0369
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0039 0.1037 0.2119
Schistosoma mansoni biogenic amine receptor 0.0125 0.5645 0.5645
Entamoeba histolytica protein kinase, putative 0.0036 0.0894 0.1826
Leishmania major cysteine peptidase A (CPA) 0.0086 0.3558 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.3558 0.7269
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0039 0.1037 0.1195
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) hypothetical protein 0.0059 0.2115 0.2399
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0039 0.1037 0.2119
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.1076 0.3025
Entamoeba histolytica cysteine protease, putative 0.0086 0.3558 0.7269
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.3558 0.4035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0969 0.1099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1442 0.1442
Loa Loa (eye worm) cysteine protease 0.0086 0.3558 0.4035
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0022 0.014 0.014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0125 0.5645 0.6402
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Onchocerca volvulus 0.0125 0.5645 1
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus multilocularis nervana 2 0.0022 0.014 0.014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.5645 0.5645
Onchocerca volvulus 0.0086 0.3558 0.6303
Schistosoma mansoni hypothetical protein 0.0125 0.5645 0.5645
Trypanosoma cruzi Protein kinase B 0.0025 0.0275 0.0317
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0153 0.0177
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.3558 0.41
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0125 0.5645 0.5645
Schistosoma mansoni hypothetical protein 0.0125 0.5645 0.5645
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0369 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.1214 0.248
Echinococcus granulosus cathepsin l1 0.0086 0.3558 0.3558
Brugia malayi Tachykinin-like peptides receptor 99D 0.0125 0.5645 0.6505
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.5645 0.6402
Echinococcus multilocularis cathepsin b 0.0181 0.8677 0.8677
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.5645 0.5645
Schistosoma mansoni adenoreceptor 0.0125 0.5645 0.5645
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0073 0.2852 0.2852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.5645 0.5645
Toxoplasma gondii cathepsin CPL 0.0086 0.3558 1
Brugia malayi ORL1-like opioid receptor 0.0125 0.5645 0.6505
Brugia malayi putative neuropeptide receptor NPR1 0.0125 0.5645 0.6505
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Onchocerca volvulus 0.0125 0.5645 1
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3558 0.41
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Echinococcus multilocularis g protein coupled receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.3558 0.3558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Echinococcus granulosus cathepsin b 0.0181 0.8677 0.8677
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0055 0.1895 0.7063
Plasmodium vivax unspecified product 0.0027 0.0369 0.1037
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0077 0.3079 0.6291
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0125 0.5645 0.5645
Brugia malayi Cathepsin L-like precursor 0.0059 0.2115 0.2438
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.3558 0.7269
Brugia malayi sulfakinin receptor protein 0.0125 0.5645 0.6505
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0125 0.5645 0.5645
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0894 0.1826
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.8677 1
Echinococcus granulosus fmrfamide receptor 0.0125 0.5645 0.5645
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.2684 0.6268
Onchocerca volvulus Cathepsin L homolog 0.0086 0.3558 0.6303
Plasmodium vivax vivapain-2 0.0086 0.3558 1
Echinococcus granulosus Glutaredoxin protein 5 0.0022 0.014 0.014
Plasmodium vivax vivapain-1 0.0047 0.1442 0.4054
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.5645 0.5645
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0023 0.0153 0.0153
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.1758 0.2026
Echinococcus granulosus serine/threonine protein kinase 0.0025 0.0275 0.0275
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0125 0.5645 0.6402
Entamoeba histolytica cysteine protease, putative 0.0047 0.1442 0.2947
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus multilocularis g protein coupled receptor 0.0125 0.5645 0.5645
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0125 0.5645 0.6505
Echinococcus multilocularis neuropeptide receptor 0.0125 0.5645 0.5645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.1442 0.2947
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0687 0.1405
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0089 0.3711 0.7581
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0125 0.5645 0.5645
Onchocerca volvulus Neuropeptide F receptor homolog 0.0125 0.5645 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0039 0.1037 0.2119
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0023 0.0153 0.0431
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus multilocularis somatostatin receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Echinococcus granulosus alpha 1A adrenergic receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0125 0.5645 0.5645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0672 0.1372
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.4895 0.5641
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Entamoeba histolytica protein kinase, putative 0.0034 0.0772 0.1578
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.3558 0.7269
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0205 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.3558 0.7269
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.5645 0.5645
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0205 1 1
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0051 0.1668 0.3409
Schistosoma mansoni growth hormone secretagogue receptor 0.0125 0.5645 0.5645
Echinococcus granulosus serine threonine protein kinase nrc 0.0023 0.0153 0.0153
Brugia malayi AKH receptor 0.0125 0.5645 0.6505
Echinococcus granulosus somatostatin receptor 0.0125 0.5645 0.5645
Brugia malayi Cathepsin L-like precursor 0.0059 0.2115 0.2438
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0039 0.1037 0.2487
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.5645 0.5645
Plasmodium vivax vivapain-2 0.0086 0.3558 1
Schistosoma mansoni histamine h1 receptor 0.0125 0.5645 0.5645
Echinococcus granulosus neuropeptide receptor 0.0125 0.5645 0.5645
Echinococcus granulosus tachykinin peptides receptor 99D 0.0125 0.5645 0.5645
Loa Loa (eye worm) AGC/AKT protein kinase 0.0036 0.0894 0.1014
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0039 0.1037 0.2119
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.3558 0.41
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Brugia malayi Serotonin receptor 0.0125 0.5645 0.6505
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.5645 0.5645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.2115 0.4322
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.1216 0.1401
Leishmania major cathepsin L-like protease 0.0086 0.3558 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.3558 0.7269
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0034 0.0772 0.0876
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Entamoeba histolytica protein kinase 2, putative 0.0023 0.0153 0.0313
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.5645 0.5645
Brugia malayi Cathepsin L-like precursor 0.0086 0.3558 0.41
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.5645 0.5645
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.0275 0.0561
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0111 0.4895 1
Brugia malayi hypothetical protein 0.0125 0.5645 0.6505
Onchocerca volvulus 0.0125 0.5645 1
Echinococcus granulosus g-protein coupled receptor 0.0125 0.5645 0.5645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.5645 0.5645
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402
Echinococcus multilocularis serotonin receptor 0.0125 0.5645 0.5645
Brugia malayi G protein-coupled receptor F59B2.13 0.0125 0.5645 0.6505
Echinococcus multilocularis fmrfamide receptor 0.0125 0.5645 0.5645
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.5645 0.5645
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.1758 0.2315
Echinococcus multilocularis allatostatin A receptor 0.0125 0.5645 0.5645
Echinococcus granulosus allatostatin A receptor 0.0125 0.5645 0.5645
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.5645 0.5645
Brugia malayi follicle stimulating hormone receptor 0.0125 0.5645 0.6505
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.3558 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0125 0.5645 0.6402
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.1442 0.1442
Toxoplasma gondii AGC kinase 0.0034 0.0772 0.217
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1076 0.2199
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.8677 0.8677
Loa Loa (eye worm) hypothetical protein 0.0125 0.5645 0.6402

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.018 uM Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 2.3 uM Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 10 uM Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate ChEMBL. 16302794
Ki (binding) = 17 uM Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 0.018 uM Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 2.3 uM Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 10 uM Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate ChEMBL. 16302794
Ki app (binding) = 17 uM Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate ChEMBL. 16302794

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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