Detailed information for compound 34740

Basic information

Technical information
  • TDR Targets ID: 34740
  • Name: 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1 -yl]-6,7,8,9-tetrahydropyrimido[4,5-b]indoliz ine-10-carbonitrile
  • MW: 422.474 | Formula: C23H24F2N6
  • H donors: 0 H acceptors: 3 LogP: 3.23 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c2CCCCn2c2c1ncnc2N1CCN(CC1)CCc1ccc(c(c1)F)F
  • InChi: 1S/C23H24F2N6/c24-18-5-4-16(13-19(18)25)6-8-29-9-11-30(12-10-29)23-22-21(27-15-28-23)17(14-26)20-3-1-2-7-31(20)22/h4-5,13,15H,1-3,6-12H2
  • InChiKey: OPHRUEOXIZROLM-UHFFFAOYSA-N  


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Synonyms

  • 4-[4-[2-(3,4-difluorophenyl)ethyl]-1-piperazinyl]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
  • 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazino]-6,7,8,9-tetrahydropyrimido[4,5-b]indolizine-10-carbonitrile
  • 4-[4-[2-(3,4-difluorophenyl)ethyl]piperazin-1-yl]-6,7,8,9-tetrahydropyrimido[6,5-b]indolizine-10-carbonitrile
  • 4-[4-[2-(3,4-difluorophenyl)ethyl]-1-piperazinyl]-6,7,8,9-tetrahydropyrimido[6,5-b]indolizine-10-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Starlite/ChEMBL References
Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance-associated protein 7, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative Get druggable targets OG5_126561 All targets in OG5_126561
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense multidrug resistance-associated protein, putative,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia MRP-like ABC transporter Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana multidrug resistance protein, copy 1-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense multidrug resistance protein E,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Canalicular multispecific organic anion transporter 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter, ATP-binding protein domain containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense multidrug resistance protein A Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica multidrug resistance protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance-associated protein 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP)) Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi multidrug resistance related protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance protein E Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) multidrug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance protein E, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ATP-binding cassette protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0143 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Plasmodium falciparum serine repeat antigen 1 0.0041 0.0737 0.1476
Echinococcus granulosus cathepsin b 0.0344 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0135
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0097 0.2443 0.2333
Plasmodium falciparum cysteine proteinase falcipain 3 0.0179 0.4944 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0008 0.0008
Toxoplasma gondii cathepsin B 0.0135 0.3602 0.728
Giardia lamblia ABC transporter, putative 0.0021 0.0143 0.0024
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0041 0.0737 0.1476
Echinococcus granulosus cathepsin l1 0.0179 0.4944 0.4944
Giardia lamblia Cathepsin B precursor 0.0135 0.3602 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0097 0.2443 0.4932
Brugia malayi Cathepsin L-like precursor 0.0179 0.4944 0.494
Echinococcus granulosus multidrug resistance associated protein 1 0.0021 0.0143 0.0143
Giardia lamblia Cysteine protease 0.0041 0.0737 0.1737
Loa Loa (eye worm) fibroinase 0.0179 0.4944 0.4944
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0143 0.0274
Giardia lamblia Cathepsin B precursor 0.0041 0.0737 0.1737
Plasmodium falciparum serine repeat antigen 3 0.0041 0.0737 0.1476
Giardia lamblia Cathepsin L-like protease 0.0041 0.0737 0.1737
Entamoeba histolytica cysteine protease, putative 0.0041 0.0737 0.1476
Toxoplasma gondii cathepsin CPC2 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0737 0.1476
Leishmania major p-glycoprotein e 0.0021 0.0143 0.0163
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0737 0.0729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0737 0.1476
Plasmodium falciparum serine repeat antigen 9 0.0041 0.0737 0.1476
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0021 0.0143 0.0163
Plasmodium vivax vivapain-3 0.0097 0.2443 0.4932
Brugia malayi Cathepsin L-like precursor 0.0056 0.1204 0.1197
Giardia lamblia Hypothetical protein 0.0041 0.0737 0.1737
Brugia malayi Cathepsin L-like precursor 0.0123 0.3239 0.3233
Trypanosoma cruzi cysteine proteinase, putative 0.0097 0.2443 0.2333
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0737 0.1476
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0041 0.0737 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0737 0.1476
Giardia lamblia Cathepsin L precursor 0.0041 0.0737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0056 0.1204 0.1204
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0737 0.1476
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Onchocerca volvulus 0.0179 0.4944 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0135 0.3602 0.3596
Giardia lamblia Cathepsin L precursor 0.0041 0.0737 0.1737
Schistosoma mansoni cathepsin F (C01 family) 0.0123 0.3239 0.3233
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0041 0.0737 0.1476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Leishmania major cathepsin L-like protease 0.0179 0.4944 0.5951
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0135 0.3602 0.4332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Brugia malayi Papain family cysteine protease containing protein 0.0179 0.4944 0.494
Brugia malayi multidrug resistance related protein 1 0.0021 0.0143 0.0135
Schistosoma mansoni multidrug resistance protein 0.0021 0.0143 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0737 0.1476
Toxoplasma gondii cathepsin CPC1 0.0041 0.0737 0.1476
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.2443 0.4932
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.2443 0.4932
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0008 0.0008
Onchocerca volvulus Cathepsin F homolog 0.0179 0.4944 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0737 0.1476
Schistosoma mansoni cathepsin F (C01 family) 0.0179 0.4944 0.494
Leishmania major cathepsin L-like protease 0.0289 0.8303 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0123 0.3239 0.3239
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.2443 0.4932
Giardia lamblia Cathepsin L precursor 0.0041 0.0737 0.1737
Giardia lamblia Encystation-specific protease 0.0041 0.0737 0.1737
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0737 0.1476
Loa Loa (eye worm) hypothetical protein 0.0041 0.0737 0.0737
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Plasmodium falciparum serine repeat antigen 5 0.0041 0.0737 0.1476
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Echinococcus multilocularis cathepsin b 0.0344 1 1
Echinococcus granulosus cathepsin b 0.0344 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0143 0.0274
Loa Loa (eye worm) hypothetical protein 0.0041 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0123 0.3239 0.3239
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0021 0.0143 0.0163
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0179 0.4944 0.4944
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0041 0.0737 0.1476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Leishmania major cathepsin L-like protease 0.0179 0.4944 0.5951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Entamoeba histolytica hypothetical protein 0.0021 0.0143 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.8303 0.8278
Trypanosoma cruzi major cysteine proteinase, putative 0.0151 0.4096 0.401
Toxoplasma gondii cathepsin CPL 0.0179 0.4944 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0143 0.0274
Leishmania major cysteine peptidase A (CPA) 0.0179 0.4944 0.5951
Giardia lamblia Cathepsin L precursor 0.0041 0.0737 0.1737
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.4944 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0041 0.0737 0.1476
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.2443 0.2436
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0179 0.4944 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0021 0.0143 0.0143
Schistosoma mansoni multidrug resistance protein 0.0021 0.0143 0.0135
Entamoeba histolytica cysteine proteinase, putative 0.0123 0.3239 0.6544
Trypanosoma brucei cysteine peptidase C (CPC) 0.0135 0.3602 0.4238
Plasmodium falciparum serine repeat antigen 4 0.0041 0.0737 0.1476
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0179 0.4944 0.4944
Giardia lamblia Cathepsin L precursor 0.0041 0.0737 0.1737
Echinococcus multilocularis cathepsin L 0.0097 0.2443 0.2443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0097 0.2443 0.2818
Plasmodium vivax unspecified product 0.0097 0.2443 0.4932
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0021 0.0143 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Plasmodium falciparum serine repeat antigen 7 0.0041 0.0737 0.1476
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0143 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.3239 0.6544
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.8303 0.8278
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0737 0.0729
Brugia malayi Cathepsin L-like precursor 0.0179 0.4944 0.494
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Schistosoma mansoni cathepsin S (C01 family) 0.0041 0.0737 0.0729
Giardia lamblia Cathepsin B precursor 0.0041 0.0737 0.1737
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0737 0.1476
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0179 0.4944 0.4944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.2443 0.4932
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0143 0.0135
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0017 0.0008 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0737 0.1476
Leishmania major cathepsin L-like protease 0.0289 0.8303 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0123 0.3239 0.3233
Echinococcus multilocularis multidrug resistance associated protein 7 0.0021 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0041 0.0737 0.0737
Plasmodium vivax vivapain-1 0.0097 0.2443 0.4932
Loa Loa (eye worm) multidrug resistance protein 3 0.0017 0.0008 0.0008
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0041 0.0737 0.1476
Giardia lamblia Cathepsin L-like protease 0.0041 0.0737 0.1737
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0737 0.1737
Echinococcus multilocularis cysteine protease 0.0179 0.4944 0.4944
Brugia malayi cathepsin L precursor 0.0041 0.0737 0.0729
Entamoeba histolytica multidrug resistance protein, putative 0.0021 0.0143 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Entamoeba histolytica cysteine protease, putative 0.0179 0.4944 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0041 0.0737 0.1476
Giardia lamblia Cathepsin B precursor 0.0041 0.0737 0.1737
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0056 0.1204 0.1204
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0017 0.0008 0.5
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0017 0.0008 0.0008
Toxoplasma gondii preprocathepsin c precursor, putative 0.0041 0.0737 0.1476
Brugia malayi cathepsin L-like precursor 0.0123 0.3239 0.3233
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0737 0.1476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0737 0.0729
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.2443 0.2436
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.2443 0.4932
Echinococcus granulosus cathepsin L cysteine proteinase 0.0179 0.4944 0.4944
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0041 0.0737 0.1476
Loa Loa (eye worm) hypothetical protein 0.0056 0.1204 0.1204
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0344 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0179 0.4944 1
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0344 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0021 0.0143 0.0163
Leishmania major pentamidine resistance protein 1 0.0021 0.0143 0.0163
Echinococcus multilocularis multidrug resistance associated protein 1 0.0021 0.0143 0.0143
Trypanosoma cruzi cysteine protease, putative 0.0097 0.2443 0.2333
Entamoeba histolytica cysteine protease, putative 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0179 0.4944 1
Schistosoma mansoni cathepsin B (C01 family) 0.0041 0.0737 0.0729
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0008 0.0008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0737 0.0737
Echinococcus granulosus cysteine protease 0.0097 0.2443 0.2443
Schistosoma mansoni cathepsin C 0.0041 0.0737 0.0729
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0143 0.0274
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0041 0.0737 0.1476
Trypanosoma cruzi cruzipain precursor, putative 0.0056 0.1204 0.1076
Loa Loa (eye worm) hypothetical protein 0.0344 1 1
Giardia lamblia MRP-like ABC transporter 0.0021 0.0143 0.0024
Schistosoma mansoni cathepsin F (C01 family) 0.0179 0.4944 0.494
Plasmodium falciparum serine repeat antigen 6 0.0041 0.0737 0.1476
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0737 0.0729
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0737 0.1476
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0737 0.1476
Leishmania major cathepsin L-like protease 0.0289 0.8303 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0041 0.0737 0.0729
Trypanosoma cruzi cysteine peptidase, putative 0.0179 0.4944 0.4871
Loa Loa (eye worm) cysteine protease 0.0179 0.4944 0.4944
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.2443 0.2436
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0233 0.6597 0.6548
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.2443 0.4932
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0008 0.0008
Entamoeba histolytica ABC transporter, putative 0.0021 0.0143 0.0274
Onchocerca volvulus 0.0179 0.4944 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Schistosoma mansoni multidrug resistance protein 0.0021 0.0143 0.0135
Schistosoma mansoni multidrug resistance protein 0.0021 0.0143 0.0135
Echinococcus multilocularis cathepsin L cysteine protease 0.0179 0.4944 0.4944
Onchocerca volvulus 0.0179 0.4944 1
Giardia lamblia Cathepsin B precursor 0.0041 0.0737 0.1737
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0344 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.0737 0.0602
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0179 0.4944 0.4944
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0056 0.1204 0.1197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Leishmania major cathepsin L-like protease 0.0179 0.4944 0.5951
Plasmodium falciparum cysteine proteinase falcipain 1 0.0097 0.2443 0.4932
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0737 0.1737
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0737 0.1476
Onchocerca volvulus Cathepsin L homolog 0.0179 0.4944 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0021 0.0143 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0135 0.3602 0.728
Loa Loa (eye worm) hypothetical protein 0.0056 0.1204 0.1204
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0041 0.0737 0.0729
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0737 0.0729
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0143
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Giardia lamblia Hypothetical protein 0.0041 0.0737 0.1737
Giardia lamblia Cathepsin B precursor 0.0135 0.3602 1
Echinococcus granulosus cathepsin L 0.0041 0.0737 0.0737
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Loa Loa (eye worm) cathepsin B 0.0135 0.3602 0.3602
Trypanosoma cruzi cysteine peptidase, putative 0.0097 0.2443 0.2333
Plasmodium falciparum serine repeat antigen 2 0.0041 0.0737 0.1476
Entamoeba histolytica cysteine protease, putative 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Echinococcus granulosus cathepsin l1 0.0123 0.3239 0.3239
Trypanosoma cruzi cysteine proteinase, putative 0.0097 0.2443 0.2333
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.8303 0.8278
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0737 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Entamoeba histolytica cysteine protease, putative 0.0041 0.0737 0.1476
Entamoeba histolytica cysteine proteinase, putative 0.0179 0.4944 1
Entamoeba histolytica hypothetical protein 0.0041 0.0737 0.1476
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0344 1 1
Plasmodium vivax vivapain-2 0.0179 0.4944 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0056 0.1204 0.1197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Echinococcus multilocularis cysteine protease 0.0179 0.4944 0.4944
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0008 0.0008
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0737 0.0729
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0737 0.0729
Onchocerca volvulus Cathepsin L homolog 0.0179 0.4944 1
Brugia malayi Cathepsin L-like precursor 0.0179 0.4944 0.494
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0041 0.0737 0.1476
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0737 0.0729
Schistosoma mansoni cathepsin s 0.0056 0.1204 0.1197
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.1204 0.1076
Leishmania major cathepsin L-like protease 0.0179 0.4944 0.5951
Echinococcus multilocularis cathepsin b 0.0344 1 1
Onchocerca volvulus 0.0179 0.4944 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0041 0.0737 0.1476
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0737 0.1737
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0008 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0344 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0008 0.0008
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0737 0.0729
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Giardia lamblia Cathepsin L precursor 0.0041 0.0737 0.1737
Entamoeba histolytica cysteine proteinase 2 0.0097 0.2443 0.4932
Echinococcus granulosus cathepsin L cysteine protease 0.0097 0.2443 0.2443
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.2443 0.2436
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0041 0.0737 0.1476
Giardia lamblia Cathepsin B precursor 0.0041 0.0737 0.1737
Onchocerca volvulus 0.0123 0.3239 0.6544
Giardia lamblia Cysteine protease 0.0041 0.0737 0.1737
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Entamoeba histolytica cysteine protease, putative 0.0097 0.2443 0.4932
Trypanosoma cruzi cruzipain precursor, putative 0.0289 0.8303 0.8278
Echinococcus granulosus cathepsin l cysteine peptidase 0.0179 0.4944 0.4944
Onchocerca volvulus 0.0179 0.4944 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0737 0.0729
Leishmania major ABC-thiol transporter 0.0021 0.0143 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0008 0.0008
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0041 0.0737 0.0737
Entamoeba histolytica cysteine protease, putative 0.0041 0.0737 0.1476
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0143 0.0024
Plasmodium vivax unspecified product 0.0056 0.1204 0.2422
Brugia malayi Cathepsin L-like precursor 0.0179 0.4944 0.494
Brugia malayi cathepsin F-like cysteine proteinase 0.0041 0.0737 0.0729
Onchocerca volvulus 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0041 0.0737 0.1476
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0041 0.0737 0.1476
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0008 0.0008
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0041 0.0737 0.1476
Onchocerca volvulus 0.0179 0.4944 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0737 0.0729
Brugia malayi Cathepsin L-like precursor 0.0179 0.4944 0.494
Loa Loa (eye worm) hypothetical protein 0.0041 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0123 0.3239 0.3239
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0041 0.0737 0.1737
Brugia malayi Cathepsin L-like precursor 0.0123 0.3239 0.3233
Brugia malayi Cathepsin L-like precursor 0.0179 0.4944 0.494
Loa Loa (eye worm) ctsf protein 0.0179 0.4944 0.4944
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0179 0.4944 1
Entamoeba histolytica cysteine protease, putative 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0041 0.0737 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.4944 0.4944
Onchocerca volvulus 0.0179 0.4944 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0737 0.0729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Plasmodium falciparum serine repeat antigen 8 0.0041 0.0737 0.1476
Plasmodium vivax vivapain-2 0.0179 0.4944 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0179 0.4944 0.4944
Loa Loa (eye worm) hypothetical protein 0.0041 0.0737 0.0737
Plasmodium vivax unspecified product 0.0041 0.0737 0.1476
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0041 0.0737 0.1476
Brugia malayi fibroinase precursor 0.0041 0.0737 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0097 0.2443 0.2818
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.2443 0.2436
Leishmania major cathepsin L-like protease 0.0179 0.4944 0.5951
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.8303 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0179 0.4944 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Giardia lamblia Cathepsin B precursor 0.0135 0.3602 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0179 0.4944 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0135 0.3602 0.3509
Brugia malayi cathepsin L-like cysteine proteinase 0.0041 0.0737 0.0729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0737 0.1476
Giardia lamblia Cysteine protease 0.0041 0.0737 0.1737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0123 0.3239 0.6544
Echinococcus granulosus cathepsin L 0.0097 0.2443 0.2443
Echinococcus multilocularis cathepsin L 0.0041 0.0737 0.0737
Giardia lamblia Cysteine protease 0.0041 0.0737 0.1737

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.229 uM Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line ChEMBL. 14998323
IC50 (binding) = 0.229 uM Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line ChEMBL. 14998323
IC50 (binding) < 0.25 uM Inhibitory concentration against multidrug resistance associated protein 1 ChEMBL. 16168641
IC50 (binding) < 0.25 uM Inhibitory concentration against multidrug resistance associated protein 1 ChEMBL. 16168641
IC50 (binding) = 10.52 uM Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell line ChEMBL. 14998323
IC50 (binding) = 10.52 uM Inhibitory activity against mouse transporter Pgp (P-glycoprotein) expressed in EMT6/AR1.0 cell line ChEMBL. 14998323

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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