Detailed information for compound 35074

Basic information

Technical information
  • TDR Targets ID: 35074
  • Name: N-[[4-(hydroxycarbamoyl)phenyl]methyl]naphtha lene-1-carboxamide
  • MW: 320.342 | Formula: C19H16N2O3
  • H donors: 3 H acceptors: 3 LogP: 2.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)c1ccc(cc1)CNC(=O)c1cccc2c1cccc2
  • InChi: 1S/C19H16N2O3/c22-18(21-24)15-10-8-13(9-11-15)12-20-19(23)17-7-3-5-14-4-1-2-6-16(14)17/h1-11,24H,12H2,(H,20,23)(H,21,22)
  • InChiKey: ZGWVWQGOLVOMQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[4-[(hydroxyamino)-oxomethyl]phenyl]methyl]-1-naphthalenecarboxamide
  • N-[4-(hydroxycarbamoyl)benzyl]-1-naphthamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serotonin receptor 0.001 0.0006 0.0087
Giardia lamblia DINP protein human, muc B family 0.002 0.0023 0.0085
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0006 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0006 0.0087
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0237 0.087
Schistosoma mansoni importin beta-1 0.003 0.004 0.057
Schistosoma mansoni Smad4 0.0008 0.0004 0.0057
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0066 0.094
Echinococcus granulosus histone deacetylase 6 0.0051 0.0075 0.1072
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0006 0.0087
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0023 0.0334
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.0082
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0047
Onchocerca volvulus 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0106
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0006 0.0087
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0106
Echinococcus granulosus Smad4 0.0008 0.0004 0.0057
Giardia lamblia Telomerase catalytic subunit 0.1642 0.2724 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0072 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0087
Brugia malayi follicle stimulating hormone receptor 0.001 0.0006 0.0008
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0229
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0035 0.0128
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0006 0.0087
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0006 0.0116
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0006 0.0087
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0075 0.1072
Brugia malayi RNA, U transporter 1 0.0085 0.0132 0.0181
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.0513 0.1881
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0006 0.0087
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0 0.0001
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0035 0.0127
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0062
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.0106
Echinococcus multilocularis somatostatin receptor 0.001 0.0006 0.0087
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.001
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0006 0.0087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.0106
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0023 0.0479
Onchocerca volvulus 0.001 0.0006 0.0006
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0006 0.0087
Echinococcus multilocularis orexin receptor type 2 0.001 0.0006 0.0087
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0063 0.0232
Brugia malayi Histone deacetylase family protein 0.0051 0.0075 0.0103
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0361 0.0592 1
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.0106
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.0057 0.0078
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.001 0.0014
Schistosoma mansoni DNA polymerase eta 0.002 0.0023 0.0334
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0006 0.0087
Echinococcus multilocularis smad 0.0008 0.0004 0.0057
Plasmodium vivax histone deacetylase, putative 0.0051 0.0075 0.0275
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0141
Onchocerca volvulus 0.001 0.0006 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0247
Brugia malayi Muscleblind-like protein 0.0155 0.0248 0.0342
Brugia malayi G protein-coupled receptor 0.001 0.0006 0.0008
Brugia malayi RE15519p 0.001 0.0006 0.0008
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.0024 0.0345
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0006 0.0116
Plasmodium falciparum flap endonuclease 1 0.0027 0.0035 0.0128
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0334
Schistosoma mansoni cpg binding protein 0.0065 0.0098 0.1398
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0006 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.001
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0057
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0006 0.0087
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0106
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0075 0.0274
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0002 0.0032
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1642 0.2724 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0087
Brugia malayi neuropeptide F receptor 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Schistosoma mansoni hypothetical protein 0.0034 0.0046 0.0664
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0229
Onchocerca volvulus 0.001 0.0006 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0106
Schistosoma mansoni hypothetical protein 0.032 0.0523 0.749
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0023 0.0085
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0063 0.0232
Echinococcus multilocularis Smad4 0.0008 0.0004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0155 0.0248 0.4753
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0017 0.0063
Leishmania major DNA polymerase kappa, putative 0.002 0.0023 0.0085
Echinococcus granulosus disco interacting protein 2 0.004 0.0057 0.081
Schistosoma mansoni hypothetical protein 0.0345 0.0564 0.8078
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0022 0.5
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.0513 0.1881
Brugia malayi Histone deacetylase family protein 0.0051 0.0075 0.0103
Brugia malayi glutaminase DH11.1 0.0284 0.0463 0.0637
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0006 0.0116
Echinococcus granulosus histone deacetylase 6 0.0051 0.0075 0.1072
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0006 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0006 0.0087
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0006 0.0087
Schistosoma mansoni cpg binding protein 0.0066 0.01 0.1439
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Schistosoma mansoni helicase 0.007 0.0106 0.1521
Echinococcus multilocularis disco interacting protein 2 0.004 0.0057 0.081
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.0498
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0006 0.0087
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0006 0.0087
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0006 0.0087
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0008 0.0028
Schistosoma mansoni adenoreceptor 0.001 0.0006 0.0087
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0247
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0106
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0087
Brugia malayi Flap endonuclease-1 0.0027 0.0035 0.0048
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0522
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0023 0.0445
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Schistosoma mansoni glutaminase 0.0284 0.0463 0.6635
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0522
Echinococcus multilocularis fmrfamide receptor 0.001 0.0006 0.0087
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0023 0.0244
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) glutaminase 0.0284 0.0463 0.8859
Trypanosoma brucei histone deacetylase 3 0.0051 0.0075 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.001
Echinococcus granulosus allatostatin A receptor 0.001 0.0006 0.0087
Brugia malayi AKH receptor 0.001 0.0006 0.0008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0022 0.0321
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0004 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0066 0.094
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Onchocerca volvulus 0.001 0.0006 0.0006
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.001
Echinococcus granulosus global transcription activator snf2l2 0.007 0.0106 0.1521
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0321
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Echinococcus granulosus geminin 0.0345 0.0564 0.8078
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.0081
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0007 0.0106
Brugia malayi Smad1 0.0008 0.0004 0.0005
Echinococcus granulosus importin subunit beta 1 0.003 0.004 0.057
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0139
Brugia malayi MH2 domain containing protein 0.0008 0.0004 0.0005
Brugia malayi neuropeptide F receptor 0.001 0.0006 0.0008
Brugia malayi GnHR receptor homolog 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0051 0.0075 0.1432
Trypanosoma brucei histone deacetylase 4 0.0051 0.0075 0.0274
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0886
Toxoplasma gondii histone deacetylase HDAC1 0.0051 0.0075 0.0274
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0008 0.0029
Onchocerca volvulus 0.001 0.0006 0.0006
Brugia malayi putative neuropeptide receptor 0.001 0.0006 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0229
Schistosoma mansoni hypothetical protein 0.0425 0.0698 1
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0006 0.0087
Schistosoma mansoni cpg binding protein 0.0066 0.01 0.1439
Brugia malayi Dopamine receptor protein 1 0.001 0.0006 0.0008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.0523 1
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0306
Echinococcus granulosus dna polymerase kappa 0.002 0.0023 0.0334
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0006 0.0087
Brugia malayi sulfakinin receptor protein 0.001 0.0006 0.0008
Echinococcus multilocularis g protein coupled receptor 0.001 0.0006 0.0087
Schistosoma mansoni opsin-like receptor 0.001 0.0006 0.0087
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0024 0.0029
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0035 0.022
Echinococcus multilocularis cpg binding protein 0.0066 0.01 0.1439
Onchocerca volvulus 0.001 0.0006 0.0006
Plasmodium falciparum telomerase reverse transcriptase 0.1642 0.2724 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0006 0.0087
Schistosoma mansoni neuropeptide receptor 0.001 0.0006 0.0087
Echinococcus granulosus BRK domain containing protein 0.0012 0.001 0.0143
Echinococcus multilocularis muscleblind protein 0.0155 0.0248 0.356
Loa Loa (eye worm) hypothetical protein 0.005 0.0072 0.1386
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0085
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0098 0.1867
Leishmania major modification methylase-like protein 0.0021 0.0024 0.0087
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0075 0.0274
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0229
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0103 0.0161 0.2436
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Toxoplasma gondii hypothetical protein 0.0051 0.0074 0.0271
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0022 0.0081
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0006 0.0087
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0052 0.0747
Brugia malayi CXXC zinc finger family protein 0.0065 0.0098 0.0134
Echinococcus multilocularis geminin 0.0345 0.0564 0.8078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0106
Loa Loa (eye worm) histone deacetylase 0.0051 0.0075 0.1432
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0022 0.0081
Plasmodium vivax histone deacetylase 2, putative 0.0051 0.0075 0.0275
Echinococcus granulosus g protein coupled receptor 0.001 0.0006 0.0087
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0046 0.0064
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0087
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0006 0.0087
Brugia malayi polybromodomain protein 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Toxoplasma gondii hypothetical protein 0.0088 0.0136 0.05
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0022 0.0081
Echinococcus granulosus histone deacetylase 6 0.0051 0.0075 0.1072
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0075 0.1072
Echinococcus granulosus dnaJ subfamily B 0.0425 0.0698 1
Brugia malayi MH1 domain containing protein 0.0008 0.0004 0.0005
Onchocerca volvulus 0.001 0.0006 0.0006
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0006 0.0116
Echinococcus granulosus cpg binding protein 0.0066 0.01 0.1439
Brugia malayi larval opioid receptor 0.001 0.0006 0.0008
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Echinococcus granulosus histone deacetylase 7 0.0051 0.0075 0.1072
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0022 0.021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0106
Echinococcus multilocularis sex peptide receptor 0.001 0.0006 0.0087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0006 0.0087
Echinococcus granulosus neuropeptide s receptor 0.001 0.0006 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.004 0.0145
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0006 0.0087
Onchocerca volvulus 0.001 0.0006 0.0006
Schistosoma mansoni neuropeptide receptor 0.001 0.0006 0.0087
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0006 0.0087
Trichomonas vaginalis importin beta-1, putative 0.0024 0.003 0.0632
Schistosoma mansoni hypothetical protein 0.0014 0.0013 0.0184
Trichomonas vaginalis lymphoid specific helicase, putative 0.0013 0.0011 0.0214
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0522
Echinococcus multilocularis importin subunit beta 1 0.003 0.004 0.057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Echinococcus multilocularis neuropeptide receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0006 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0006 0.0087
Echinococcus granulosus histone deacetylase 0.0051 0.0075 0.1072
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0006 0.0087
Plasmodium falciparum histone deacetylase 2 0.0051 0.0075 0.0275
Echinococcus granulosus hypothetical protein 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Schistosoma mansoni histone deacetylase hda2 0.0051 0.0075 0.1072
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0 0.0001
Echinococcus multilocularis global transcription activator snf2l2 0.007 0.0106 0.1521
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0006 0.0008
Echinococcus multilocularis BRK domain 0.0012 0.001 0.0143
Echinococcus multilocularis dna polymerase eta 0.002 0.0023 0.0334
Schistosoma mansoni opsin-like receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) BRM protein 0.0045 0.0064 0.1227
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0237 0.087
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0023 0.0244
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0006 0.0087
Echinococcus multilocularis serotonin receptor 0.001 0.0006 0.0087
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0024 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.0106
Plasmodium falciparum histone deacetylase, putative 0.0051 0.0075 0.0275
Echinococcus multilocularis helicase 0.0006 0.0000000000070717 0.00000000010135
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0047
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0032
Echinococcus multilocularis histone deacetylase 0.0051 0.0075 0.1072
Echinococcus granulosus orexin receptor type 2 0.001 0.0006 0.0087
Brugia malayi BRM protein 0.007 0.0106 0.0146
Brugia malayi Dopamine receptor protein 2 0.001 0.0006 0.0008
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0248 0.356
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0017 0.033
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Brugia malayi SET domain containing protein 0.0007 0.0001 0.0002
Mycobacterium ulcerans glutaminase 0.0284 0.0463 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0023 0.0334
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0006 0.0087
Toxoplasma gondii exonuclease III APE 0.002 0.0022 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0106
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.1082
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0143
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) histone deacetylase 7A 0.0051 0.0075 0.1432
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0334
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0072 0.1386
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.0498
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0106
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0007 0.0106
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0062
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0008
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0017 0.0247
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0106
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0006 0.0087
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0023 0.0479
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0002 0.0032
Onchocerca volvulus 0.001 0.0006 0.0006
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Brugia malayi MH1 domain containing protein 0.0008 0.0004 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0066 0.094
Echinococcus multilocularis g protein coupled receptor 0.001 0.0006 0.0087
Brugia malayi MH2 domain containing protein 0.0008 0.0004 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0047
Entamoeba histolytica hypothetical protein 0.0103 0.0161 0.2436
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0006 0.0116
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.001 0.0143
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0229
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0006 0.0087
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0006 0.0087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0106
Brugia malayi G-protein coupled receptor 0.001 0.0006 0.0008
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0006 0.0087
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.0106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0087
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0005 0.0101
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0127
Mycobacterium ulcerans hypothetical protein 0.0165 0.0265 0.5726
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Echinococcus granulosus fmrfamide receptor 0.001 0.0006 0.0087
Schistosoma mansoni histamine h1 receptor 0.001 0.0006 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0087
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0006 0.0008
Echinococcus multilocularis neuropeptide receptor 0.001 0.0006 0.0087
Plasmodium vivax importin-beta 2, putative 0.003 0.004 0.0146
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0079 0.0291
Echinococcus granulosus helicase 0.0006 0.0000000000070717 0.00000000010135
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Schistosoma mansoni opsin-like receptor 0.001 0.0006 0.0087
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.0106
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0006 0.0087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0066 0.1255
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0006 0.0116
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0237 0.087
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0006 0.0087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0247
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0017 0.0062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0052 0.0747
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0006 0.0116
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.0698 1
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0075 0.1072
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0023 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.0513 0.1881
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0141
Onchocerca volvulus 0.001 0.0006 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0085
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0522
Onchocerca volvulus 0.001 0.0006 0.0006
Brugia malayi Importin beta-1 subunit 0.003 0.004 0.0055
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0006 0.0008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.003 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.001
Echinococcus granulosus flap endonuclease 1 0.0027 0.0035 0.0501
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.0024 0.0345
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0032
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0229
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Schistosoma mansoni neuropeptide receptor 0.001 0.0006 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0006 0.0087
Onchocerca volvulus 0.001 0.0006 0.0006
Echinococcus multilocularis Chromo domain 0.0012 0.001 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0066 0.094
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Schistosoma mansoni biogenic amine receptor 0.001 0.0006 0.0087
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0632
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.0106
Echinococcus granulosus g protein coupled receptor 0.001 0.0006 0.0087
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0006 0.0087
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0087
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0321
Brugia malayi ORL1-like opioid receptor 0.001 0.0006 0.0008
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0196 0.376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0017 0.0024
Leishmania major histone deacetylase, putative 0.0051 0.0075 0.0274
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0007 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0032
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.004 0.0057 0.081
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0035 0.0732
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0006 0.0087
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1642 0.2724 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0004 0.0076
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0006 0.0087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0066 0.094
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0006 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.001
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.0513 0.1881
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0196 0.376
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0075 0.1072
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0002 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0087
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0106
Brugia malayi Serotonin receptor 0.001 0.0006 0.0008
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0006 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0006 0.0087
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0023 0.0334
Echinococcus multilocularis serotonin receptor 0.001 0.0006 0.0087
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0006 0.0008
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0006 0.0116
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0017 0.0063
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0007 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0106
Echinococcus granulosus polybromo 1 0.0006 0.0001 0.0009
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0006 0.0087
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.0024 0.0345
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0022 0.0479
Schistosoma mansoni hypothetical protein 0.0345 0.0564 0.8078
Brugia malayi G-protein coupled receptor 0.001 0.0006 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0141
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0004 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0022 0.0461
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0004 0.0057
Schistosoma mansoni flap endonuclease-1 0.0024 0.0031 0.0439
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Brugia malayi Dopamine receptor 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0051 0.0075 0.1432
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Echinococcus multilocularis allatostatin A receptor 0.001 0.0006 0.0087
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0087
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0006 0.0087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0006 0.0087
Schistosoma mansoni polybromo-1 0.0006 0.0001 0.0009
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0087
Schistosoma mansoni biogenic amine receptor 0.001 0.0006 0.0087
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0006 0.0087
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0007 0.0106
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0007 0.0141
Echinococcus granulosus neuropeptide receptor 0.001 0.0006 0.0087
Echinococcus granulosus somatostatin receptor 0.001 0.0006 0.0087
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0006 0.0087
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0006 0.0087
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.0106
Echinococcus granulosus Chromo domain 0.0012 0.001 0.0143
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0247
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0006 0.0087
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0007 0.0007
Brugia malayi Melatonin receptor type 1A 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Echinococcus multilocularis fmrfamide receptor 0.001 0.0006 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0007
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0127
Loa Loa (eye worm) glutaminase 2 0.0284 0.0463 0.8859
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0075 0.1072
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0006 0.0087
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0007 0.0141
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0006 0.0087
Loa Loa (eye worm) Smad1 0.0008 0.0004 0.0076
Toxoplasma gondii RNA-directed DNA polymerase 0.1642 0.2724 1
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0143
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.0106
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0006 0.0087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0087 0.0319
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0062
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0008 0.0029
Leishmania major DNA polymerase eta, putative 0.002 0.0023 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0006 0.0087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0006 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0087
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0088 0.0136 0.05
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0229
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0006 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.001
Echinococcus granulosus neuropeptide receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0035 0.0669
Plasmodium vivax telomerase reverse transcriptase, putative 0.1642 0.2724 1
Onchocerca volvulus 0.001 0.0006 0.0006
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Schistosoma mansoni smad 0.0008 0.0004 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0087
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.0024 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.001
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0022 0.0461
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0022 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0022 0.0429
Echinococcus granulosus g protein coupled receptor 0.001 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0004 0.0057
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.004 0.0145
Onchocerca volvulus 0.001 0.0006 0.0006
Onchocerca volvulus 0.0065 0.0098 0.0098
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0143
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0063 0.0232
Onchocerca volvulus 0.0011 0.0007 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0004 0.0076
Echinococcus granulosus sex peptide receptor 0.001 0.0006 0.0087
Trypanosoma brucei telomerase reverse transcriptase 0.1642 0.2724 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0085
Loa Loa (eye worm) BRM protein 0.0036 0.005 0.0956
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0017 0.0247
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0006 0.0087
Echinococcus granulosus muscleblind protein 0.0155 0.0248 0.356
Schistosoma mansoni biogenic amine receptor 0.001 0.0006 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.001
Trypanosoma brucei unspecified product 0.002 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0229
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0143
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0063 0.0232
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0012
Schistosoma mansoni neuropeptide receptor 0.001 0.0006 0.0087
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0006 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0035 0.0501
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.0024 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0066 0.009
Echinococcus multilocularis g protein coupled receptor 0.001 0.0006 0.0087
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0023 0.0085
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0006 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0085
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0087
Loa Loa (eye worm) helicase DNA-binding protein 0.0012 0.001 0.0191
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0007 0.0106
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0066 0.094
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0062
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.0024 0.0087
Onchocerca volvulus 0.001 0.0006 0.0006
Echinococcus multilocularis BRK domain containing protein 0.0012 0.001 0.0143
Brugia malayi Serotonin receptor 0.001 0.0006 0.0008
Echinococcus multilocularis snurportin 1 0.032 0.0523 0.749
Leishmania major importin beta-1 subunit, putative 0.0024 0.003 0.0111
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0023 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0006 0.0087
Trichomonas vaginalis glutaminase, putative 0.0284 0.0463 1
Brugia malayi hypothetical protein 0.0037 0.0052 0.0072
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Echinococcus granulosus g-protein coupled receptor 0.001 0.0006 0.0087
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0005
Echinococcus granulosus snurportin 1 0.032 0.0523 0.749
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0006 0.0087
Plasmodium falciparum importin beta, putative 0.003 0.004 0.0146
Brugia malayi isocitrate dehydrogenase 0.0016 0.0017 0.0024
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.004 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.001
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0035 0.0127
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0306
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0087
Schistosoma mansoni myosin xvIII 0.001 0.0006 0.0087
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0004 0.0057
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.0024 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0000098982
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0445
Echinococcus granulosus smad 0.0008 0.0004 0.0057
Brugia malayi hypothetical protein 0.001 0.0006 0.0008
Leishmania major telomerase reverse transcriptase, putative 0.1642 0.2724 1
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0007 0.0106
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.0143
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0006 0.0087
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0006 0.0087
Brugia malayi Telomerase reverse transcriptase 0.437 0.7266 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0085
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0006 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0066 0.094
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0087
Giardia lamblia DNA repair protein RAD52 0.0361 0.0592 0.2171
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0265 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0006 0.0087
Schistosoma mansoni hypothetical protein 0.0037 0.0052 0.0747
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0052 0.0747
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.0000098982
Echinococcus granulosus dna polymerase eta 0.002 0.0023 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0229
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0017 0.0247
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0116
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0022 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0001 0.0000098982
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.0082
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0632
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0075 0.0274
Brugia malayi MH2 domain containing protein 0.0124 0.0196 0.027
Echinococcus multilocularis polybromo 1 0.0006 0.0001 0.0009
Leishmania major histone deacetylase, putative 0.0051 0.0075 0.0274
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0006 0.0087
Trypanosoma brucei histone deacetylase, putative 0.0051 0.0075 0.0274
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0072 0.01
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0095 0.1366
Loa Loa (eye worm) hypothetical protein 0.0155 0.0248 0.4753
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0022 0.0321
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0141
Echinococcus multilocularis histone deacetylase 7 0.0051 0.0075 0.1072
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0006 0.0087
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0007 0.0106
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.0022
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0006 0.0008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.0106
Schistosoma mansoni amine GPCR 0.001 0.0006 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0085
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0062
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0006 0.0087
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0006 0.0087
Onchocerca volvulus 0.004 0.0057 0.0057
Onchocerca volvulus 0.001 0.0006 0.0006

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 830 nM Tested for inhibitory concentration of the compound required to inhibit 50% of histone deacetylase (HDAC) purified from human T cell leukemia Jurkat cell ChEMBL. 11992774
IC50 (binding) = 830 nM Inhibitory concentration against histone deacetylase ChEMBL. 14613312
IC50 (binding) = 830 nM Inhibitory concentration against histone deacetylase ChEMBL. 14613312
IC50 (functional) = 9700 nM Inhibitory concentration against HCT116 cells proliferation ChEMBL. 14613312
IC50 (functional) = 9700 nM Inhibitory concentration against HCT116 cells proliferation ChEMBL. 14613312
IC50 (functional) = 9.7 uM Tested for antiproliferative activity against HCT-116 colorectal human carcinoma cell using WST-1 assay ChEMBL. 11992774
IC50 (functional) = 9.7 uM Tested for antiproliferative activity against HCT-116 colorectal human carcinoma cell using WST-1 assay ChEMBL. 11992774

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11992774

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.