Detailed information for compound 353185

Basic information

Technical information
  • TDR Targets ID: 353185
  • Name: [(2S)-1-phenylpropan-2-yl] N-[(1E,2S)-1-(morp holine-4-carbonylhydrazinylidene)hexan-2-yl]c arbamate
  • MW: 404.503 | Formula: C21H32N4O4
  • H donors: 2 H acceptors: 2 LogP: 3.12 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@H](NC(=O)O[C@H](Cc1ccccc1)C)/C=N/NC(=O)N1CCOCC1
  • InChi: 1S/C21H32N4O4/c1-3-4-10-19(16-22-24-20(26)25-11-13-28-14-12-25)23-21(27)29-17(2)15-18-8-6-5-7-9-18/h5-9,16-17,19H,3-4,10-15H2,1-2H3,(H,23,27)(H,24,26)/b22-16+/t17-,19-/m0/s1
  • InChiKey: VUVLQWZOUOAKHY-UQQRSYNHSA-N  


Substructure search Similarity search

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Synonyms

  • [(1S)-1-methyl-2-phenyl-ethyl] N-[(1S)-1-[(E)-(morpholine-4-carbonylhydrazono)methyl]pentyl]carbamate
  • N-[(1S)-1-[(E)-[[morpholino(oxo)methyl]hydrazono]methyl]pentyl]carbamic acid [(1S)-1-methyl-2-phenylethyl] ester
  • [(2S)-1-phenylpropan-2-yl] N-[(1E,2S)-1-(morpholin-4-ylcarbonylhydrazinylidene)hexan-2-yl]carbamate
  • N-[(1S)-1-[(E)-(morpholine-4-carbonylhydrazono)methyl]pentyl]carbamic acid [(1S)-1-methyl-2-phenyl-ethyl] ester
  • N-[(1S)-1-[(E)-[(morpholino-oxomethyl)hydrazono]methyl]pentyl]carbamic acid [(1S)-1-methyl-2-phenylethyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin H Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi cysteine proteinase, putative Cathepsin K   329 aa 349 aa 32.4 %
Loa Loa (eye worm) hypothetical protein Cathepsin K   329 aa 277 aa 27.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 274 aa 29.6 %
Echinococcus granulosus cysteine protease Cathepsin K   329 aa 327 aa 45.3 %
Babesia bovis cysteine protease 2 Cathepsin K   329 aa 326 aa 31.0 %
Onchocerca volvulus Cathepsin K   329 aa 271 aa 28.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 309 aa 24.9 %
Babesia bovis papain family cysteine protease containing protein Cathepsin K   329 aa 330 aa 32.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 326 aa 26.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 31.3 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin K   329 aa 383 aa 23.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 269 aa 29.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 377 aa 23.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 266 aa 30.5 %
Onchocerca volvulus Cathepsin K   329 aa 311 aa 37.6 %
Trypanosoma brucei cysteine peptidase C (CPC) Cathepsin K   329 aa 269 aa 27.5 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 363 aa 26.7 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 265 aa 27.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 354 aa 26.0 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin K   329 aa 342 aa 36.0 %
Echinococcus multilocularis cathepsin b Cathepsin K   329 aa 292 aa 25.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 344 aa 23.5 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 292 aa 33.2 %
Trypanosoma cruzi cysteine protease, putative Cathepsin K   329 aa 318 aa 33.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 352 aa 27.6 %
Onchocerca volvulus Cathepsin K   329 aa 319 aa 42.9 %
Dictyostelium discoideum hypothetical protein Cathepsin K   329 aa 344 aa 33.1 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin K   329 aa 310 aa 43.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin K   329 aa 327 aa 46.2 %
Plasmodium vivax dipeptidyl aminopeptidase 1, putative Cathepsin K   329 aa 282 aa 24.8 %
Plasmodium falciparum cysteine proteinase falcipain 2b cathepsin H 335 aa 340 aa 33.2 %
Toxoplasma gondii cathepsin B Cathepsin K   329 aa 291 aa 25.8 %
Onchocerca volvulus Cathepsin B-like cysteine proteinase 6 homolog Cathepsin K   329 aa 331 aa 26.6 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Echinococcus granulosus cathepsin L Cathepsin K   329 aa 316 aa 31.3 %
Schistosoma japonicum ko:K01365 cathepsin L [EC3.4.22.15], putative Cathepsin K   329 aa 324 aa 42.6 %
Echinococcus multilocularis cathepsin L Cathepsin K   329 aa 334 aa 38.9 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin K   329 aa 310 aa 32.3 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin K   329 aa 337 aa 33.5 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 279 aa 28.7 %
Giardia lamblia Cathepsin L-like protease Cathepsin K   329 aa 290 aa 25.9 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase Cathepsin K   329 aa 293 aa 30.0 %
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Cathepsin K   329 aa 264 aa 25.8 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin K   329 aa 286 aa 29.4 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin K   329 aa 275 aa 24.0 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 377 aa 25.7 %
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin K   329 aa 279 aa 29.0 %
Plasmodium falciparum serine repeat antigen 2 Cathepsin K   329 aa 302 aa 25.2 %
Echinococcus granulosus cathepsin L Cathepsin K   329 aa 337 aa 38.0 %
Plasmodium berghei berghepain-1 Cathepsin K   329 aa 346 aa 31.2 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin K   329 aa 318 aa 30.5 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 292 aa 32.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 343 aa 24.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 273 aa 27.5 %
Onchocerca volvulus Cathepsin K   329 aa 310 aa 41.6 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin K   329 aa 350 aa 33.1 %
Toxoplasma gondii cathepsin CPC1 Cathepsin K   329 aa 287 aa 25.8 %
Echinococcus granulosus cathepsin b Cathepsin K   329 aa 292 aa 25.7 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin K   329 aa 318 aa 36.2 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin K   329 aa 335 aa 33.4 %
Plasmodium vivax vivapain-3 Cathepsin K   329 aa 327 aa 36.7 %
Onchocerca volvulus Cathepsin L homolog Cathepsin K   329 aa 316 aa 44.6 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 300 aa 24.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 343 aa 24.5 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin K   329 aa 316 aa 35.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 343 aa 24.5 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 325 aa 28.3 %
Onchocerca volvulus Cathepsin K   329 aa 325 aa 42.5 %
Plasmodium knowlesi knowpain-1 Cathepsin K   329 aa 352 aa 31.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin K   329 aa 343 aa 24.5 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin K   329 aa 347 aa 30.5 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 274 aa 29.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 269 aa 29.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 274 aa 29.6 %
Giardia lamblia Cathepsin L precursor Cathepsin K   329 aa 267 aa 25.8 %
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Cathepsin K   329 aa 269 aa 27.5 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin K   329 aa 268 aa 26.5 %
Onchocerca volvulus Cathepsin K   329 aa 292 aa 31.2 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin K   329 aa 318 aa 39.3 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin K   329 aa 268 aa 28.4 %
Theileria parva cysteine proteinase, putative Cathepsin K   329 aa 330 aa 32.4 %
Dictyostelium discoideum hypothetical protein Cathepsin K   329 aa 267 aa 38.2 %
Plasmodium berghei dipeptidyl aminopeptidase 2 Cathepsin K   329 aa 268 aa 26.1 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin K   329 aa 348 aa 32.8 %
Giardia lamblia Cathepsin B precursor Cathepsin K   329 aa 273 aa 30.4 %
Echinococcus multilocularis cathepsin L Cathepsin K   329 aa 316 aa 30.7 %
Neospora caninum hypothetical protein Cathepsin K   329 aa 293 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.01 0.3132 1
Brugia malayi Cathepsin L-like precursor 0.01 0.3132 0.3132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Loa Loa (eye worm) fibroinase 0.01 0.3132 0.2931
Onchocerca volvulus 0.01 0.3132 1
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0285 0.0909
Echinococcus granulosus cathepsin l cysteine peptidase 0.01 0.3132 0.3132
Onchocerca volvulus Cathepsin L homolog 0.01 0.3132 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Trypanosoma cruzi cruzipain precursor, putative 0.01 0.3132 0.3132
Leishmania major cathepsin L-like protease 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Giardia lamblia Cathepsin B precursor 0.0075 0.1126 0.5
Echinococcus multilocularis cathepsin b 0.0186 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.01 0.3132 0.3132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Plasmodium vivax vivapain-2 0.01 0.3132 1
Entamoeba histolytica cysteine proteinase, putative 0.01 0.3132 1
Loa Loa (eye worm) cysteine protease 0.01 0.3132 0.2931
Echinococcus multilocularis cathepsin l cysteine peptidase 0.01 0.3132 0.3132
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.3132 0.3132
Leishmania major cathepsin L-like protease 0.01 0.3132 1
Entamoeba histolytica cysteine proteinase, putative 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Echinococcus granulosus cathepsin l1 0.0064 0.0285 0.0285
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0285 0.0285
Onchocerca volvulus 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Schistosoma mansoni cathepsin F (C01 family) 0.0064 0.0285 0.0285
Brugia malayi Cathepsin L-like precursor 0.01 0.3132 0.3132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Leishmania major cathepsin L-like protease 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0285 0.0909
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Brugia malayi Papain family cysteine protease containing protein 0.01 0.3132 0.3132
Loa Loa (eye worm) papain family cysteine protease containing protein 0.01 0.3132 0.2931
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Onchocerca volvulus 0.01 0.3132 1
Onchocerca volvulus 0.01 0.3132 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0075 0.1126 0.3596
Onchocerca volvulus 0.01 0.3132 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.3132 0.3132
Brugia malayi Cathepsin L-like precursor 0.01 0.3132 0.3132
Loa Loa (eye worm) cathepsin B 0.0075 0.1126 0.0866
Leishmania major cathepsin L-like protease 0.01 0.3132 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.01 0.3132 1
Leishmania major cathepsin L-like protease 0.01 0.3132 1
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.3132 0.3132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Brugia malayi Cathepsin L-like precursor 0.0064 0.0285 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Toxoplasma gondii cathepsin CPL 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Brugia malayi Cathepsin L-like precursor 0.01 0.3132 0.3132
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.3132 0.3132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Brugia malayi cathepsin L-like precursor 0.0064 0.0285 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0075 0.1126 0.1126
Onchocerca volvulus 0.01 0.3132 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.01 0.3132 0.2931
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.3132 1
Brugia malayi Cathepsin L-like precursor 0.01 0.3132 0.3132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0075 0.1126 0.1126
Loa Loa (eye worm) hypothetical protein 0.01 0.3132 0.2931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0285 0.0909
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.01 0.3132 1
Leishmania major cathepsin L-like protease 0.01 0.3132 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.01 0.3132 0.3132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Brugia malayi Cathepsin L-like precursor 0.01 0.3132 0.3132
Onchocerca volvulus Cathepsin L homolog 0.01 0.3132 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Echinococcus multilocularis cysteine protease 0.01 0.3132 0.3132
Giardia lamblia Cathepsin B precursor 0.0075 0.1126 0.5
Leishmania major cathepsin L-like protease 0.01 0.3132 1
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.3132 0.3132
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.3132 0.3132
Giardia lamblia Cathepsin B precursor 0.0075 0.1126 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.01 0.3132 0.3132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0075 0.1126 0.3596
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 1 1
Loa Loa (eye worm) ctsf protein 0.01 0.3132 0.2931
Brugia malayi Cathepsin L-like precursor 0.0064 0.0285 0.0285
Echinococcus granulosus cathepsin l1 0.01 0.3132 0.3132
Onchocerca volvulus Cathepsin F homolog 0.01 0.3132 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Onchocerca volvulus 0.01 0.3132 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0186 1 1
Loa Loa (eye worm) hypothetical protein 0.0186 1 1
Plasmodium vivax vivapain-2 0.01 0.3132 1
Echinococcus granulosus cathepsin b 0.0186 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0186 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 1 1
Echinococcus granulosus cathepsin b 0.0186 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.01 0.3132 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.01 0.3132 1
Echinococcus multilocularis cathepsin b 0.0186 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.01 0.3132 0.3132
Entamoeba histolytica cysteine protease, putative 0.01 0.3132 1
Echinococcus multilocularis cysteine protease 0.01 0.3132 0.3132
Leishmania major cysteine peptidase A (CPA) 0.01 0.3132 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0064 0.0285 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.3132 1

Activities

Activity type Activity value Assay description Source Reference
beta t1/2 (ADMET) = 9 min Terminal half life in iv dosed Han Wistar rat ChEMBL. 16290936
CL (ADMET) = 16 ml/min.kg Clearance in Han Wistar rat ChEMBL. 16290936
F (ADMET) = 0 % Oral bioavailability in male Han Wistar rat ChEMBL. 16290936
IC50 (binding) = 0.94 nM Inhibition of recombinant human cathepsin K in a fluorescence assay ChEMBL. 16290936
IC50 (binding) = 0.94 nM Inhibition of recombinant human cathepsin K in a fluorescence assay ChEMBL. 16290936
IC50 (binding) = 130 nM Inhibition of rat cathepsin K ChEMBL. 16290936
IC50 (binding) = 130 nM Inhibition of rat cathepsin K ChEMBL. 16290936
IC50 (binding) = 230 nM Inhibition of recombinant human cathepsin H in a fluorescence assay ChEMBL. 16290936
IC50 (binding) = 230 nM Inhibition of recombinant human cathepsin H in a fluorescence assay ChEMBL. 16290936
IC50 (binding) = 270 nM Inhibition of recombinant human cathepsin B in a fluorescence assay ChEMBL. 16290936
IC50 (binding) = 270 nM Inhibition of recombinant human cathepsin B in a fluorescence assay ChEMBL. 16290936
IC50 (binding) = 540 nM Inhibition of recombinant human cathepsin L in a fluorescence assay ChEMBL. 16290936
IC50 (binding) = 540 nM Inhibition of recombinant human cathepsin L in a fluorescence assay ChEMBL. 16290936
Papp (ADMET) = 140 nm/s Permeability across MDCK cells ChEMBL. 16290936
Solubility = 0.06 mg/ml Solubility in fasted state-simulated intestinal fluid at pH 6.8 ChEMBL. 16290936
Vdss (ADMET) = 220 L/kg Volume of distribution in Han Wistar rat ChEMBL. 16290936

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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