Detailed information for compound 36779

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.435 | Formula: C22H24N2O8
  • H donors: 6 H acceptors: 8 LogP: 0.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN([C@H]1C(=O)C(=C([C@@]2([C@H]1[C@@H](O)[C@H]1[C@H](C)c3cccc(c3C(=O)C1=C2O)O)O)O)C(=O)N)C
  • InChi: 1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27,29-30,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1
  • InChiKey: YDUGFTMNXJLIFF-AKNGSSGZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0232 0.0708 0.0334
Brugia malayi WGR domain containing protein 0.0145 0.0405 0.0429
Brugia malayi Cytochrome P450 family protein 0.0062 0.0115 0.0121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.003 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.003 0.0032
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0032 0.5
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.273 0.9454 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.003 0.0032
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5988
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.008 0.0085
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0053 0.0084 0.0089
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0232 0.0708 0.12
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.003 0.0032
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.273 0.9454 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus multilocularis Immunoglobulin 0.0052 0.008 0.0071
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0053 0.0084 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.003 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0066 0.0129 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0232 0.0708 0.0748
Trypanosoma cruzi polo-like protein kinase, putative 0.273 0.9454 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0032 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.003 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0073 0.0077
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0039 0.0032 0.0056
Giardia lamblia Kinase, PLK 0.273 0.9454 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.003 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.003 0.0032
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.1247 0.4261 0.4489
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.003 0.0032
Echinococcus multilocularis neuroglian 0.0063 0.0118 0.0111
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 0.0748
Onchocerca volvulus Serine\/threonine kinase homolog 0.273 0.9454 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.003 0.0032
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0053 0.0084 0.0057
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.003 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.003 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.008 0.0176 0.0186
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.003 0.0018
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0232 0.0708 0.0696
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Onchocerca volvulus Tyrosine kinase homolog 0.0517 0.1706 0.1778
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0084 0.0055
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi ecdysteroid receptor 0.0038 0.003 0.0032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1647 0.5662 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus granulosus WGR domain containing protein 0.0045 0.0055 0.0026
Echinococcus multilocularis roundabout 2 0.0077 0.0167 0.0163
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0232 0.0708 0.0696
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi hypothetical protein 0.0052 0.008 0.0085
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0073 0.0077
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0475 0.156 0.165
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0232 0.0708 0.0334
Loa Loa (eye worm) hypothetical protein 0.0066 0.0129 0.0136
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0069 0.0138 0.0126
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.1247 0.4261 0.4499
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Loa Loa (eye worm) hypothetical protein 0.046 0.1508 0.1595
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Schistosoma mansoni nuclear hormone receptor 0.0038 0.003 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.003 0.0018
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0145 0.0405 0.0393
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.0077
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi nuclear hormone receptor 0.0038 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.003 0.0018
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.003 0.0032
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.003 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.0708 0.0717
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5988
Echinococcus granulosus poly adp ribose polymerase 2 0.008 0.0176 0.0155
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.003 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.003 0.0018
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 1
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.003 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.1091 0.3716 0.3909
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus multilocularis Immunoglobulin 0.0052 0.008 0.0071
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0232 0.0708 0.0719
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.003 0.0032
Schistosoma mansoni nephrin 0.0063 0.0118 0.0106
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5975
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 1
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.0708 0.0717
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0053 0.0084 0.0089
Echinococcus granulosus neuroglian 0.0063 0.0118 0.0093
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus granulosus twitchin 0.0074 0.0155 0.0133
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5975
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0053 0.0084 0.0071
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Schistosoma mansoni poly [ADP-ribose] polymerase 0.008 0.0176 0.0164
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 0.0717
Entamoeba histolytica steroid 5-alpha reductase, putative 0.1647 0.5662 0.5809
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0232 0.0708 0.0748
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.273 0.9454 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0232 0.0708 0.0748
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.003 0.0032
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0052 0.008 0.0067
Echinococcus granulosus defective proboscis extension response 0.0052 0.008 0.0053
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0232 0.0708 0.0717
Brugia malayi nuclear receptor NHR-88 0.0038 0.003 0.0032
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0032 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.273 0.9454 0.9454
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0232 0.0708 0.12
Schistosoma mansoni amine GPCR 0.0175 0.0508 0.0496
Loa Loa (eye worm) hypothetical protein 0.0422 0.1373 0.1452
Schistosoma mansoni thyroid hormone receptor 0.0038 0.003 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0284 0.03
Loa Loa (eye worm) hypothetical protein 0.0034 0.0017 0.0018
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0073 0.0077
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0232 0.0708 0.0735
Plasmodium falciparum polyprenol reductase, putative 0.0232 0.0708 1
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.1647 0.5662 0.5988
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.003 0.0018
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0232 0.0708 0.0717
Entamoeba histolytica hypothetical protein 0.0232 0.0708 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.003 0.0032
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0572 0.19 0.2009
Mycobacterium ulcerans hypothetical protein 0.1647 0.5662 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0053 0.0084 0.0075
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.003 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0035 0.0021 0.0022
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0039 0.0032 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Echinococcus granulosus serine:threonine protein kinase PLK1 0.273 0.9454 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.003 0.0018
Schistosoma mansoni cell adhesion molecule 0.0066 0.0129 0.0116
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.1647 0.5662 0.5988
Brugia malayi Synaptic glycoprotein SC2 0.0232 0.0708 0.0748
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0053 0.0084 0.0089
Schistosoma mansoni hypothetical protein 0.0034 0.0017 0.0005
Echinococcus granulosus poly ADP ribose polymerase 1 0.0145 0.0405 0.0398
Echinococcus granulosus roundabout 2 0.0077 0.0167 0.0145
Echinococcus multilocularis synaptic glycoprotein sc2 0.0232 0.0708 0.0735
Entamoeba histolytica serine/threonine protein kinase, putative 0.273 0.9454 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.003 0.0018
Echinococcus granulosus synaptic glycoprotein sc2 0.0232 0.0708 0.0719
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.003 0.0032
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.003 0.0018
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Loa Loa (eye worm) hypothetical protein 0.0053 0.0084 0.0089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0572 0.19 0.2009
Trypanosoma cruzi polo-like protein kinase, putative 0.273 0.9454 1
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.1647 0.5662 0.5988
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.003 0.0032
Brugia malayi WGR domain containing protein 0.008 0.0176 0.0186
Loa Loa (eye worm) hypothetical protein 0.1647 0.5662 0.5988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.003 0.0032
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.008 0.0176 0.0172
Schistosoma mansoni vesicular amine transporter 0.0052 0.008 0.0067
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Echinococcus granulosus poly (ADP ribose) polymerase 0.0045 0.0055 0.0026
Echinococcus granulosus Immunoglobulin 0.0052 0.008 0.0053
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.008 0.0176 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.003 0.0032
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0053 0.0084 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.003 0.0032
Brugia malayi Fibronectin type III domain containing protein 0.0052 0.008 0.0085
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0151 0.0425 0.0699
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.008 0.0176 0.0186
Onchocerca volvulus 0.0498 0.1638 0.1706
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0057 0.0097 0.0103
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0052 0.008 0.0067
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0475 0.156 0.1638
Plasmodium vivax polyprenol reductase, putative 0.0232 0.0708 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0167 0.0177
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0053 0.0084 0.0089
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0053 0.0084 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0017 0.0018
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0039 0.0032 0.5
Schistosoma mansoni coup transcription factor 0.0038 0.003 0.0018
Brugia malayi steroid hormone receptor 0.0038 0.003 0.0032
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0232 0.0708 0.0717
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.003 0.0018
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0053 0.0084 0.0089
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0145 0.0405 0.0415
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0115 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0038 0.003 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.008 0.0085
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0052 0.008 0.0071
Onchocerca volvulus 0.0232 0.0708 0.0719
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.003 0.0032
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0475 0.156 0.1623
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.003 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.1091 0.3716 0.3909
Trichomonas vaginalis CAMK family protein kinase 0.273 0.9454 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1647 0.5662 0.5975
Trypanosoma brucei poly(adp-ribose) polymerase 0.008 0.0176 0.0186
Trypanosoma brucei polo-like protein kinase 0.273 0.9454 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0032
Brugia malayi serine/threonine-protein kinase plk-2 0.273 0.9454 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0167 0.0177
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0084 0.0055

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9.2 uM Growth inhibitory activity against tetracycline-resistant ML308-225 bacterial strain of Escherichia coli ChEMBL. 8176712
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory activity against tetracycline-susceptible S. aureus strain RN450 ChEMBL. 8176712
MIC (functional) = 0.25 ug ml-1 Minimum inhibitory activity against tetracycline-susceptible E. faecalis strain ATCC9790 ChEMBL. 8176712
MIC (functional) = 0.5 ug ml-1 Inhibitory activity against tetracycline uptake in everted membrane vesicles derived from Tc-resistant Escherichia coli bearing class B tetracycline resistance efflux protein (Tet) ChEMBL. 8176712
MIC (functional) = 0.5 ug ml-1 Minimum inhibitory activity against tetracycline-susceptible E. coli strain D31m4 ChEMBL. 8176712
MIC (functional) = 6.25 ug ml-1 Minimum inhibitory activity against tetracycline-susceptible E. faecalis strain ATCC9790 (Tet L on plasmid MV158) ChEMBL. 8176712
MIC (functional) = 6.25 ug ml-1 Minimum inhibition concentration of the compound against E. faecalis ChEMBL. 12127528
MIC (functional) = 6.25 ug ml-1 Minimum inhibition concentration of the compound against Methicillin resistant S. aureus ChEMBL. 12127528
MIC (functional) = 12.5 ug ml-1 Minimum inhibitory activity against tetracycline-susceptible E. coli strain D31m4 (Tet B on plasmid pHCMI) ChEMBL. 8176712
MIC (functional) = 12.5 ug ml-1 Minimum inhibitory activity against tetracycline-susceptible S. aureus strain RN450 (Tet K on plasmid pT181) ChEMBL. 8176712
MIC (functional) = 50 ug ml-1 Minimum inhibitory activity against tetracycline-susceptible E. coli strain ML308-225 (Tet A on plasmid pIP15) ChEMBL. 8176712
MIC (functional) > 50 ug ml-1 Minimum inhibitory activity against tetracycline-susceptible E. coli strain ML308-225 (Tet B on plasmid R222) ChEMBL. 8176712
MIC (functional) > 50 ug ml-1 Minimum inhibition concentration of the compound against S. aureus ChEMBL. 12127528

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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