Detailed information for compound 369211

Basic information

Technical information
  • TDR Targets ID: 369211
  • Name: N-(cyanomethyl)-4-methyl-2-[3-[3-[2-(4-methyl piperazin-1-yl)-1,3-thiazol-4-yl]phenyl]pheny l]pentanamide
  • MW: 487.66 | Formula: C28H33N5OS
  • H donors: 1 H acceptors: 3 LogP: 5.23 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)C(c1cccc(c1)c1cccc(c1)c1csc(n1)N1CCN(CC1)C)CC(C)C
  • InChi: 1S/C28H33N5OS/c1-20(2)16-25(27(34)30-11-10-29)23-8-4-6-21(17-23)22-7-5-9-24(18-22)26-19-35-28(31-26)33-14-12-32(3)13-15-33/h4-9,17-20,25H,11-16H2,1-3H3,(H,30,34)
  • InChiKey: HLFQRRCBSFVYFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(cyanomethyl)-4-methyl-2-[3-[3-[2-(4-methylpiperazin-1-yl)thiazol-4-yl]phenyl]phenyl]pentanamide
  • N-(cyanomethyl)-4-methyl-2-[3-[3-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]phenyl]phenyl]pentanamide
  • N-(cyanomethyl)-4-methyl-2-[3-[3-[2-(4-methylpiperazino)thiazol-4-yl]phenyl]phenyl]valeramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0086 0.0785 0.1331
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0139 0.1598 0.2285
Echinococcus multilocularis survival motor neuron protein 1 0.0471 0.664 0.6602
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.0785 0.1331
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0377 0.027
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0189 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Echinococcus multilocularis cathepsin L 0.0047 0.0189 0.0079
Brugia malayi jmjC domain containing protein 0.0059 0.0377 0.0568
Schistosoma mansoni hypothetical protein 0.0338 0.4611 0.4611
Onchocerca volvulus Huntingtin homolog 0.0123 0.1348 0.7395
Leishmania major cathepsin L-like protease 0.0086 0.0785 0.1331
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0377 0.0377
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0377 0.0377
Toxoplasma gondii fructose-bisphospatase I 0.0139 0.1598 0.2285
Schistosoma mansoni tyrosine kinase 0.0041 0.0111 0.0111
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0081 0.0709 0.0606
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.0785 1
Brugia malayi jmjC domain containing protein 0.0059 0.0377 0.0568
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.0539 0.0701
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0375 0.5175 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.0718 0.0615
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0785 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Echinococcus granulosus survival motor neuron protein 1 0.0471 0.664 0.6602
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0198 0.0694
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0198 0.0173
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0189 0.1164
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.0785 0.1182
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0189 0.1164
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0122 0.1339 0.1243
Loa Loa (eye worm) hypothetical protein 0.0059 0.0379 0.057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0941 0.1417
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2226 0.2226
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.0785 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0189 0.1164
Onchocerca volvulus Huntingtin homolog 0.0123 0.1348 0.7395
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0025
Leishmania major cathepsin L-like protease 0.0086 0.0785 0.1331
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0377 0.0568
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0297 0.0447
Echinococcus multilocularis NMDA receptor 0.0081 0.0709 0.0606
Echinococcus granulosus cathepsin l1 0.0059 0.0379 0.0271
Schistosoma mansoni ATP-binding cassette transporter 0.0081 0.0709 0.0709
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0375 0.5175 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0147 0.1714 0.1621
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0189 0.0079
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0189 0.0189
Onchocerca volvulus 0.0086 0.0785 0.4029
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0122 0.1339 0.1243
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0198 0.0694
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0041 0.0111 0.0166
Brugia malayi hypothetical protein 0.0471 0.664 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.4108 0.6186
Leishmania major cathepsin L-like protease 0.0086 0.0785 0.1331
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Onchocerca volvulus 0.0086 0.0785 0.4029
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.057 0.0464
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.0785 0.1182
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0375 0.5175 0.5121
Brugia malayi Cathepsin L-like precursor 0.0086 0.0785 0.1182
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0198 0.0299
Echinococcus granulosus cathepsin l1 0.0086 0.0785 0.0682
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.057 0.057
Echinococcus granulosus geminin 0.0338 0.4611 0.4551
Echinococcus granulosus lamin 0.0054 0.0297 0.0189
Echinococcus granulosus cathepsin b 0.0181 0.2226 0.214
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.0718 0.0615
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Entamoeba histolytica cysteine protease, putative 0.0086 0.0785 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Brugia malayi hypothetical protein 0.0072 0.057 0.0858
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0122 0.1339 0.1243
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0025
Echinococcus granulosus cathepsin L 0.0047 0.0189 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0081 0.0709 0.0606
Giardia lamblia Cathepsin B precursor 0.007 0.0539 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0377 0.027
Echinococcus granulosus glutamate receptor 2 0.0122 0.1339 0.1243
Brugia malayi cathepsin L-like precursor 0.0059 0.0379 0.057
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0139 0.1598 0.2826
Leishmania major cysteine peptidase A (CPA) 0.0086 0.0785 0.1331
Leishmania major 0.0375 0.5175 1
Entamoeba histolytica hypothetical protein 0.0072 0.057 0.6812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0297 0.0447
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0198 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2226 0.2226
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0785 0.1331
Loa Loa (eye worm) hypothetical protein 0.0059 0.0379 0.057
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0139 0.1598 0.2937
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.0785 0.0682
Loa Loa (eye worm) hypothetical protein 0.0054 0.0297 0.0447
Brugia malayi Guanylyl cyclase protein 23 0.0041 0.0111 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Onchocerca volvulus 0.0086 0.0785 0.4029
Schistosoma mansoni hypothetical protein 0.0072 0.057 0.057
Chlamydia trachomatis glutamine binding protein 0.0207 0.2631 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0198 0.0694
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0207 0.2631 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.024 0.0362
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0375 0.5175 0.5121
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0122 0.1339 0.1243
Schistosoma mansoni microtubule-associated protein tau 0.0692 1 1
Onchocerca volvulus 0.0086 0.0785 0.4029
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.0539 0.0845
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Plasmodium vivax vivapain-1 0.0047 0.0189 0.2242
Echinococcus multilocularis microtubule associated protein 2 0.0692 1 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0379 0.057
Loa Loa (eye worm) hypothetical protein 0.0081 0.0718 0.1082
Brugia malayi Cathepsin L-like precursor 0.0086 0.0785 0.1182
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0189 0.0155
Plasmodium vivax vivapain-2 0.0086 0.0785 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0785 1
Leishmania major cathepsin L-like protease 0.0086 0.0785 0.1331
Brugia malayi Cathepsin L-like precursor 0.0086 0.0785 0.1182
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0189 0.1164
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0377 0.027
Schistosoma mansoni tyrosine kinase 0.0041 0.0111 0.0111
Brugia malayi intermediate filament protein 0.0054 0.0297 0.0447
Leishmania major cathepsin L-like protease 0.0086 0.0785 0.1331
Schistosoma mansoni hypothetical protein 0.0081 0.0718 0.0718
Brugia malayi Cathepsin L-like precursor 0.0086 0.0785 0.1182
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0785 0.1331
Schistosoma mansoni glutamate receptor NMDA 0.0373 0.5141 0.5141
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.0785 0.0682
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0198 0.0694
Schistosoma mansoni hypothetical protein 0.0305 0.4108 0.4108
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0081 0.0718 0.0718
Schistosoma mansoni glutamate receptor NMDA 0.0147 0.1714 0.1714
Onchocerca volvulus 0.0096 0.0941 0.4961
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0539 0.0539
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0096 0.0941 0.0941
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Onchocerca volvulus 0.0086 0.0785 0.4029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0379 0.3182
Giardia lamblia Cathepsin B precursor 0.007 0.0539 0.5
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.0111 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0785 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.0785 0.0682
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0224 0.0224
Mycobacterium ulcerans hypothetical protein 0.0047 0.0198 0.0694
Echinococcus multilocularis nmda type glutamate receptor 0.0292 0.3912 0.3844
Brugia malayi Glutamate receptor 1 precursor 0.0081 0.0709 0.1068
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Loa Loa (eye worm) hypothetical protein 0.0053 0.0282 0.0425
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.057 0.0464
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0122 0.1339 0.1243
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.0379 0.057
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0198 0.0173
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Brugia malayi hypothetical protein 0.0152 0.1784 0.2687
Brugia malayi Glutamate receptor 2 precursor 0.0081 0.0709 0.1068
Echinococcus multilocularis lamin dm0 0.0054 0.0297 0.0189
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0207 0.2631 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0207 0.2631 1
Loa Loa (eye worm) cysteine protease 0.0086 0.0785 0.1182
Schistosoma mansoni glutamate receptor AMPA 0.0081 0.0709 0.0709
Onchocerca volvulus 0.0086 0.0785 0.4029
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0122 0.1339 0.1243
Loa Loa (eye worm) hypothetical protein 0.0123 0.1348 0.203
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Entamoeba histolytica hypothetical protein 0.0072 0.057 0.6812
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0122 0.1339 0.1243
Echinococcus granulosus cathepsin b 0.0181 0.2226 0.214
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0785 0.4029
Brugia malayi hypothetical protein 0.0041 0.0111 0.0166
Brugia malayi Cathepsin L-like precursor 0.0086 0.0785 0.1182
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.0785 1
Echinococcus multilocularis cysteine protease 0.0086 0.0785 0.0682
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0198 0.0299
Giardia lamblia Cathepsin B precursor 0.007 0.0539 0.5
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.0539 0.0845
Loa Loa (eye worm) hypothetical protein 0.005 0.024 0.0362
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0025
Echinococcus multilocularis cathepsin b 0.0181 0.2226 0.214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Echinococcus granulosus lamin dm0 0.0054 0.0297 0.0189
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.0718 0.0718
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0198 0.0694
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0785 1
Echinococcus multilocularis glutamate receptor 2 0.0081 0.0709 0.0606
Loa Loa (eye worm) cathepsin B 0.007 0.0539 0.0811
Echinococcus multilocularis glutamate receptor NMDA 0.025 0.3282 0.3207
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0375 0.5175 0.7793
Loa Loa (eye worm) hypothetical protein 0.0152 0.1784 0.2687
Loa Loa (eye worm) hypothetical protein 0.0123 0.1348 0.203
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.0785 0.0682
Plasmodium vivax unspecified product 0.0047 0.0189 0.2242
Echinococcus granulosus glutamate receptor NMDA 0.025 0.3282 0.3207
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0297 0.0447
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0198 0.1302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0785 0.4029
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0111 0.0111
Brugia malayi Metabotropic glutamate receptor precursor. 0.0041 0.0111 0.0166
Echinococcus multilocularis nmda type glutamate receptor 0.0538 0.7661 0.7634
Loa Loa (eye worm) hypothetical protein 0.0047 0.0198 0.0299
Loa Loa (eye worm) RGC/RGC protein kinase 0.0041 0.0111 0.0166
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.2226 0.3353
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0189 0.0155
Schistosoma mansoni intermediate filament proteins 0.0054 0.0297 0.0297
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.0718 0.0615
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0189 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0198 0.5
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.0718 0.0615
Echinococcus multilocularis glutamate receptor 2 0.0122 0.1339 0.1243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Toxoplasma gondii cathepsin CPL 0.0086 0.0785 0.0531
Loa Loa (eye worm) hypothetical protein 0.0181 0.2226 0.3353
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0189 0.0189
Echinococcus granulosus glutamate receptor subunit protein glur 0.0081 0.0709 0.0606
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0025
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0081 0.0709 0.0606
Onchocerca volvulus 0.0054 0.0297 0.1114
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0198 0.0694
Echinococcus multilocularis lamin 0.0054 0.0297 0.0189
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.0718 0.1082
Echinococcus granulosus intermediate filament protein 0.0054 0.0297 0.0189
Schistosoma mansoni apoptosis regulator bax 0.0081 0.0718 0.0718
Schistosoma mansoni hypothetical protein 0.0081 0.0709 0.0709
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0189 0.2242
Plasmodium vivax vivapain-2 0.0086 0.0785 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0785 0.1331
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0189 0.1164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0041 0.0111 0.0166
Brugia malayi fructose-1,6-bisphosphatase 0.0375 0.5175 0.7793
Leishmania major cathepsin L-like protease 0.0086 0.0785 0.1331
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0379 0.3975
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Schistosoma mansoni survival motor neuron protein 0.0096 0.0941 0.0941
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Echinococcus granulosus cysteine protease 0.0047 0.0189 0.0079
Loa Loa (eye worm) glutamate receptor 1 0.0081 0.0709 0.1068
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0198 0.1302
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0338 0.4611 0.4611
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Entamoeba histolytica hypothetical protein 0.0072 0.057 0.6812
Schistosoma mansoni lamin 0.0054 0.0297 0.0297
Brugia malayi metabotropic glutamate receptor type 2 0.0041 0.0111 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.024 0.0362
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.0785 0.0682
Echinococcus granulosus tumor protein p63 0.0334 0.456 0.4499
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0377 0.027
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0375 0.5175 1
Loa Loa (eye worm) fibroinase 0.0086 0.0785 0.1182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Echinococcus multilocularis cathepsin b 0.0181 0.2226 0.214
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.2226 0.4178
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Plasmodium vivax vivapain-3 0.0047 0.0189 0.2242
Schistosoma mansoni protein kinase 0.0041 0.0111 0.0111
Echinococcus multilocularis cysteine protease 0.0086 0.0785 0.0682
Schistosoma mansoni glutamate receptor AMPA 0.0081 0.0709 0.0709
Brugia malayi hypothetical protein 0.0123 0.1348 0.203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Leishmania major cathepsin L-like protease 0.0086 0.0785 0.1331
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0198 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0709 0.0709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0379 0.3182
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0081 0.0709 0.0606
Echinococcus multilocularis tumor protein p63 0.0334 0.456 0.4499
Toxoplasma gondii fructose-bisphospatase II 0.0375 0.5175 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0041 0.0111 0.0166
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0785 1
Entamoeba histolytica hypothetical protein 0.0072 0.057 0.6812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0081 0.0709 0.0606
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0189 0.1164
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.2226 0.2226
Onchocerca volvulus Cathepsin F homolog 0.0086 0.0785 0.4029
Echinococcus multilocularis snurportin 1 0.0305 0.4108 0.4042
Onchocerca volvulus 0.0049 0.0224 0.0678
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0207 0.2631 0.5
Onchocerca volvulus 0.0047 0.0198 0.0525
Echinococcus multilocularis geminin 0.0338 0.4611 0.4551
Onchocerca volvulus 0.0086 0.0785 0.4029
Echinococcus multilocularis musashi 0.0054 0.0297 0.0189
Echinococcus granulosus nmda type glutamate receptor 0.0538 0.7661 0.7634
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0471 0.664 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0198 0.1302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Loa Loa (eye worm) ctsf protein 0.0086 0.0785 0.1182
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0189 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0198 0.0694
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2226 0.2226
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0189 0.0155
Loa Loa (eye worm) hypothetical protein 0.0049 0.0224 0.0337
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0785 0.1182
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0139 0.1598 0.2937
Brugia malayi RNA, U transporter 1 0.0081 0.0713 0.1074
Loa Loa (eye worm) glutamate receptor 2 0.0081 0.0709 0.1068
Brugia malayi Cathepsin L-like precursor 0.0086 0.0785 0.1182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Loa Loa (eye worm) hypothetical protein 0.0047 0.0198 0.0299
Loa Loa (eye worm) RGC/RGC protein kinase 0.0041 0.0111 0.0166
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0207 0.2631 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.024 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Onchocerca volvulus 0.0054 0.0297 0.1114
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.0785 0.0682
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0198 0.0173
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0379 0.0529
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0288 0.3859 0.3791
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Onchocerca volvulus 0.0059 0.0379 0.1602
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0189 0.0155
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0198 0.0694
Schistosoma mansoni hypothetical protein 0.0081 0.0718 0.0718
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Echinococcus granulosus snurportin 1 0.0305 0.4108 0.4042
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0041 0.0111 0.0166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0709 0.0709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0785 1
Brugia malayi Receptor family ligand binding region containing protein 0.0041 0.0111 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0785 0.1195
Loa Loa (eye worm) glutamate receptor 0.0041 0.0111 0.0166
Brugia malayi Cathepsin L-like precursor 0.0059 0.0379 0.057
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0709 0.0709
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.0718 0.1082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0025
Onchocerca volvulus 0.0152 0.1784 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0081 0.0709 0.0606
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0375 0.5175 0.5175
Loa Loa (eye worm) hypothetical protein 0.0047 0.0198 0.0299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0785 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0539 0.5868
Echinococcus granulosus glutamate NMDA receptor subunit 0.0147 0.1714 0.1621
Brugia malayi Cathepsin L-like precursor 0.0059 0.0379 0.057
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0785 0.1331
Entamoeba histolytica cysteine protease, putative 0.0047 0.0189 0.1164
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0041 0.0111 0.0166
Loa Loa (eye worm) hypothetical protein 0.0086 0.0785 0.1182
Schistosoma mansoni lamin 0.0054 0.0297 0.0297
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0198 0.0694
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0122 0.1339 0.1243
Echinococcus granulosus nmda type glutamate receptor 0.0292 0.3912 0.3844

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 32 ml/min.kg Clearance in rat at 0.5 mg/kg, iv ChEMBL. 16750630
IC50 (functional) = 59 nM Effect on degradation of bovine bone by rabbit osteoclast ChEMBL. 16750630
Ki (binding) = 1.3 nM Inhibition of human cathepsin K ChEMBL. 16750630
Ki (binding) = 1.3 nM Inhibition of human cathepsin K ChEMBL. 16750630
Ki (binding) = 390 nM Inhibition of human cathepsin L ChEMBL. 16750630
Ki (binding) = 390 nM Inhibition of human cathepsin L ChEMBL. 16750630
Ki (binding) = 1800 nM Inhibition of human cathepsin S ChEMBL. 16750630
Ki (binding) = 1800 nM Inhibition of human cathepsin S ChEMBL. 16750630
Ki (binding) = 22000 nM Inhibition of human cathepsin B ChEMBL. 16750630
Ki (binding) = 22000 nM Inhibition of human cathepsin B ChEMBL. 16750630
MRT (ADMET) = 54 min Mean residence time in rat at 0.5 mg/kg, iv ChEMBL. 16750630
Selectivity ratio (binding) = 300 Selectivity for cathepsin L over cathepsin K ChEMBL. 16750630
Selectivity ratio (binding) = 1384 Selectivity for cathepsin S over cathepsin K ChEMBL. 16750630
Selectivity ratio (binding) = 16923 Selectivity for cathepsin B over cathepsin K ChEMBL. 16750630
Vss (ADMET) = 1.7 L/Kg Volume of distribution in rat at 0.5 mg/kg, iv ChEMBL. 16750630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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