TDR Targets

Basic information

Technical information

TDR Targets ID: 369304
Name: 9-hydroxy-4-(2-methylphenyl)-6H-pyrrolo[3,4-c ]carbazole-1,3-dione
MW: 342.347 | Formula: C21H14N2O3
H donors: 3 H acceptors: 3 LogP: 3.82 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc2c(c1)c1c([nH]2)cc(c2c1c(=O)[nH]c2=O)c1ccccc1C
InChi: 1S/C21H14N2O3/c1-10-4-2-3-5-12(10)13-9-16-17(19-18(13)20(25)23-21(19)26)14-8-11(24)6-7-15(14)22-16/h2-9,22,24H,1H3,(H,23,25,26)
InChiKey: ZAPMEPOQUZJTEJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

9-hydroxy-4-(o-tolyl)-6H-pyrrolo[3,4-c]carbazole-1,3-dione
9-hydroxy-4-(o-tolyl)-6H-pyrrolo[3,4-c]carbazole-1,3-quinone
9-hydroxy-4-(2-methylphenyl)-6H-pyrrolo[3,4-c]carbazole-1,3-quinone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	WEE1 G2 checkpoint kinase	Starlite/ChEMBL	References
Homo sapiens	checkpoint kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_130454	All targets in OG5_130454
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania mexicana	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania braziliensis	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Schistosoma japonicum	Serine/threonine-protein kinase Chk1, putative	Get druggable targets OG5_130454	All targets in OG5_130454
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma brucei	wee1-like protein kinase	Get druggable targets OG5_129875	All targets in OG5_129875
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	Get druggable targets OG5_130454	All targets in OG5_130454
Leishmania infantum	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania donovani	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania donovani	protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0174	0.0994	0.0994
Leishmania major	heat shock protein, putative	0.006	0.0197	0.0564
Brugia malayi	Cathepsin L-like precursor	0.0117	0.0591	0.4953
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Plasmodium vivax	heat shock protein, putative	0.006	0.0197	0.1979
Trypanosoma cruzi	target of rapamycin kinase 3	0.0102	0.0487	0.1454
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.0994	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Schistosoma mansoni	cathepsin s	0.0058	0.0178	0.1492
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Trypanosoma cruzi	heat shock protein, putative	0.006	0.0197	0.0587
Leishmania major	cathepsin L-like protease	0.0174	0.0994	0.2849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Entamoeba histolytica	protein kinase rad3, putative	0.0057	0.0177	0.1779
Schistosoma mansoni	heat shock protein	0.0147	0.0804	0.6739
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0178	0.0531
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0174	0.0994	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0102	0.0487	0.1397
Trypanosoma brucei	heat shock protein, putative	0.0147	0.0804	0.809
Plasmodium vivax	vivapain-1	0.009	0.0403	0.4054
Trypanosoma brucei	heat shock protein, putative	0.0147	0.0804	0.809
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0069	0.026	0.0746
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Entamoeba histolytica	hypothetical protein	0.0057	0.0177	0.1779
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0117	0.0591	0.1763
Trichomonas vaginalis	heat shock protein, putative	0.0117	0.0594	0.5981
Plasmodium falciparum	heat shock protein 90, putative	0.006	0.0197	0.1979
Plasmodium vivax	vivapain-3	0.009	0.0403	0.4054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Loa Loa (eye worm)	endoplasmin	0.0147	0.0804	0.6739
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0174	0.0994	1
Onchocerca volvulus		0.0174	0.0994	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0057	0.0177	0.0177
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0102	0.0487	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Trichomonas vaginalis	endoplasmin, putative	0.009	0.0406	0.4088
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Schistosoma mansoni	heat shock protein	0.0147	0.0804	0.6739
Toxoplasma gondii	Hsp90 domain-containing protein	0.006	0.0197	0.1979
Trypanosoma cruzi	cysteine protease, putative	0.009	0.0403	0.1202
Entamoeba histolytica	heat shock protein 90, putative	0.0147	0.0804	0.809
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0102	0.0487	0.4904
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.026	0.0777
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0177	0.1779
Brugia malayi	Endoplasmin precursor	0.0147	0.0804	0.6739
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Entamoeba histolytica	cysteine proteinase, putative	0.0117	0.0591	0.5946
Leishmania major	cathepsin L-like protease	0.0174	0.0994	0.2849
Brugia malayi	Cathepsin L-like precursor	0.0174	0.0994	0.833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Echinococcus granulosus	cathepsin L	0.009	0.0403	0.0403
Schistosoma mansoni	cathepsin F (C01 family)	0.0117	0.0591	0.4953
Brugia malayi	Cathepsin L-like precursor	0.0174	0.0994	0.833
Echinococcus multilocularis	cysteine protease	0.0174	0.0994	0.0994
Schistosoma mansoni	cathepsin F (C01 family)	0.0174	0.0994	0.833
Schistosoma mansoni	cathepsin F (C01 family)	0.0174	0.0994	0.833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Brugia malayi	FAT domain containing protein	0.0044	0.0086	0.0718
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0102	0.0487	0.1397
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0177	0.1779
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0044	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Entamoeba histolytica	cysteine proteinase, putative	0.009	0.0403	0.4054
Onchocerca volvulus		0.0174	0.0994	1
Trypanosoma brucei	heat shock protein 84, putative	0.006	0.0197	0.1979
Echinococcus multilocularis	cathepsin L cysteine protease	0.0174	0.0994	0.0994
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0102	0.0487	0.4904
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0117	0.0591	0.4953
Mycobacterium ulcerans	heat shock protein 90	0.0117	0.0594	0.5
Echinococcus granulosus	heat shock protein	0.0147	0.0804	0.0804
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0147	0.0804	0.2399
Echinococcus granulosus	cysteine protease	0.009	0.0403	0.0403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0177	0.1779
Onchocerca volvulus		0.0174	0.0994	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0057	0.0177	0.1482
Entamoeba histolytica	cysteine proteinase, putative	0.009	0.0403	0.4054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Loa Loa (eye worm)	phosphatidylinositol 3	0.0102	0.0487	0.4085
Loa Loa (eye worm)	heat shock protein 75	0.006	0.0197	0.1649
Brugia malayi	Papain family cysteine protease containing protein	0.009	0.0403	0.3377
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0102	0.0487	0.4904
Brugia malayi	heat shock protein 90	0.0147	0.0804	0.6739
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Echinococcus multilocularis	heat shock protein	0.0147	0.0804	0.0804
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0117	0.0594	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0591	0.4953
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Trypanosoma brucei	heat shock protein, putative	0.0147	0.0804	0.809
Toxoplasma gondii	cathepsin CPL	0.0174	0.0994	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0102	0.0487	0.4085
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.009	0.0403	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0174	0.0994	0.2966
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.009	0.0403	0.1202
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0174	0.0994	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0117	0.0594	0.0594
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Echinococcus multilocularis	serine protein kinase ATM	0.0057	0.0177	0.0177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Brugia malayi	Cathepsin L-like precursor	0.0174	0.0994	0.833
Loa Loa (eye worm)	heat shock protein 90	0.0147	0.0804	0.6739
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.004	0.04
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Plasmodium falciparum	heat shock protein 90, putative	0.006	0.0197	0.1979
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Brugia malayi	Hsp90 protein	0.006	0.0197	0.1649
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.1461	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0102	0.0487	0.1454
Echinococcus granulosus	serine protein kinase ATM	0.0057	0.0177	0.0177
Trypanosoma cruzi	hypothetical protein, conserved	0.0511	0.3351	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.009	0.0403	0.3377
Trypanosoma brucei	heat shock protein, putative	0.0147	0.0804	0.809
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Plasmodium vivax	unspecified product	0.009	0.0403	0.4054
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0174	0.0994	1
Brugia malayi	Cathepsin L-like precursor	0.0174	0.0994	0.833
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0223	0.2241
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0117	0.0594	0.1704
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0102	0.0487	0.4904
Trypanosoma cruzi	heat shock protein 90, putative	0.0147	0.0804	0.2399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Onchocerca volvulus	Cathepsin F homolog	0.0174	0.0994	1
Trypanosoma cruzi	cysteine proteinase, putative	0.009	0.0403	0.1202
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0177	0.1779
Trypanosoma cruzi	heat shock protein 85, putative	0.0147	0.0804	0.2399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Plasmodium falciparum	cysteine proteinase falcipain 1	0.009	0.0403	0.4054
Onchocerca volvulus		0.0174	0.0994	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Trichomonas vaginalis	heat shock protein, putative	0.009	0.0406	0.4088
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0174	0.0994	0.833
Entamoeba histolytica	cysteine protease, putative	0.0174	0.0994	1
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Giardia lamblia	Grp94/Hsp90	0.0117	0.0594	0.7394
Onchocerca volvulus	Cathepsin L homolog	0.0174	0.0994	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0117	0.0591	0.5946
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0177	0.1779
Trichomonas vaginalis	heat shock protein, putative	0.0117	0.0594	0.5981
Schistosoma mansoni	serine/threonine protein kinase	0.0203	0.1193	1
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Trypanosoma cruzi	cysteine peptidase, putative	0.0174	0.0994	0.2966
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Echinococcus granulosus	heat shock protein 90	0.0147	0.0804	0.0804
Brugia malayi	Papain family cysteine protease containing protein	0.009	0.0403	0.3377
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0038	0.004	0.0119
Plasmodium falciparum	endoplasmin, putative	0.009	0.0406	0.4088
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0117	0.0591	0.5946
Trypanosoma cruzi	cysteine proteinase, putative	0.009	0.0403	0.1202
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Toxoplasma gondii	heat shock protein HSP90	0.0147	0.0804	0.809
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.004	0.04
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0177	0.1779
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0174	0.0994	0.0994
Entamoeba histolytica	90 kDa heat shock protein, putative	0.006	0.0197	0.1979
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0591	0.4953
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Leishmania major	cathepsin L-like protease	0.0174	0.0994	0.2849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0058	0.0178	0.1492
Echinococcus granulosus	cathepsin L cysteine protease	0.009	0.0403	0.0403
Trypanosoma brucei	Heat shock protein 83, putative	0.0147	0.0804	0.809
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0178	0.1492
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.026	0.0777
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0102	0.0487	0.0487
Plasmodium vivax	heat shock protein 86, putative	0.0147	0.0804	0.809
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0086	0.0718
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.006	0.0197	0.0197
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0057	0.0177	0.0528
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0223	0.2241
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0102	0.0487	0.4085
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0117	0.0594	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0058	0.0178	0.0531
Leishmania major	cathepsin L-like protease	0.0174	0.0994	0.2849
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0057	0.0177	0.0177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0069	0.026	0.0746
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0102	0.0487	0.4904
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Leishmania major	hypothetical protein, conserved	0.0531	0.3488	1
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.009	0.0403	0.4054
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0174	0.0994	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0591	0.4953
Trypanosoma cruzi	Heat shock protein 83, putative	0.0147	0.0804	0.2399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.009	0.0403	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.009	0.0403	0.1202
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0102	0.0487	0.1397
Toxoplasma gondii	heat shock protein 75, putative	0.006	0.0197	0.1979
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Onchocerca volvulus		0.0174	0.0994	1
Echinococcus granulosus	cathepsin l1	0.0117	0.0591	0.0591
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0057	0.0177	0.1482
Leishmania major	cathepsin L-like protease	0.0174	0.0994	0.2849
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0177	0.1482
Schistosoma mansoni	heat shock protein	0.006	0.0197	0.1649
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.006	0.0197	0.1979
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Echinococcus multilocularis	heat shock protein 90	0.0117	0.0594	0.0594
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Trypanosoma cruzi	cruzipain precursor, putative	0.0174	0.0994	0.2966
Loa Loa (eye worm)	cysteine protease	0.0174	0.0994	0.833
Brugia malayi	Cathepsin L-like precursor	0.0174	0.0994	0.833
Trypanosoma cruzi	heat shock protein 85, putative	0.0117	0.0594	0.1774
Trypanosoma cruzi	cysteine peptidase, putative	0.0174	0.0994	0.2966
Plasmodium vivax	unspecified product	0.0058	0.0178	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0102	0.0487	0.4904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0057	0.0177	0.1779
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.009	0.0403	0.3377
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.009	0.0403	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Schistosoma mansoni	hypothetical protein	0.0044	0.0086	0.0718
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0102	0.0487	0.4904
Brugia malayi	cathepsin L-like precursor	0.0117	0.0591	0.4953
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.009	0.0403	0.3377
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0057	0.0177	0.1482
Trypanosoma brucei	heat shock protein 90, putative	0.0147	0.0804	0.809
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0117	0.0594	0.7394
Trypanosoma brucei	heat shock protein, putative	0.0147	0.0804	0.809
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0102	0.0487	0.4904
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0057	0.0177	0.0528
Brugia malayi	cathepsin F-like cysteine proteinase	0.0058	0.0178	0.1492
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.006	0.0197	0.0197
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0174	0.0994	0.0994
Plasmodium vivax	vivapain-2	0.0174	0.0994	1
Loa Loa (eye worm)	hypothetical protein	0.0174	0.0994	0.833
Echinococcus granulosus	heat shock protein 90	0.0117	0.0594	0.0594
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0064	0.0223	0.2241
Toxoplasma gondii	FATC domain-containing protein	0.0057	0.0177	0.1779
Entamoeba histolytica	heat shock protein 90, putative	0.0147	0.0804	0.809
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Echinococcus multilocularis	endoplasmin	0.0117	0.0594	0.0594
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0102	0.0487	0.0487
Plasmodium vivax	vivapain-2	0.0174	0.0994	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.0994	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0102	0.0487	0.1454
Trichomonas vaginalis	heat shock protein, putative	0.0147	0.0804	0.809
Plasmodium vivax	endoplasmin, putative	0.0147	0.0804	0.809
Leishmania major	cathepsin L-like protease	0.0174	0.0994	0.2849
Trypanosoma cruzi	cysteine peptidase, putative	0.0174	0.0994	0.2966
Toxoplasma gondii	heat shock protein 90, putative	0.0147	0.0804	0.809
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0177	0.1779
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Trichomonas vaginalis	heat shock protein, putative	0.006	0.0197	0.1979
Giardia lamblia	GTOR	0.0102	0.0487	0.6062
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.0994	1
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0117	0.0594	0.5
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Trypanosoma brucei	heat shock protein, putative	0.0147	0.0804	0.809
Trypanosoma brucei	heat shock protein, putative	0.0147	0.0804	0.809
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0102	0.0487	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.009	0.0403	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0117	0.0591	0.4953
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Loa Loa (eye worm)	fibroinase	0.0174	0.0994	0.833
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0064	0.0223	0.2241
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0203	0.1193	1
Echinococcus multilocularis	cysteine protease	0.0174	0.0994	0.0994
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0102	0.0487	0.4085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Onchocerca volvulus		0.0117	0.0591	0.5946
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0174	0.0994	0.833
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0178	0.1492
Echinococcus granulosus	cathepsin l1	0.0174	0.0994	0.0994
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0102	0.0487	0.1454
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Leishmania major	cysteine peptidase A (CPA)	0.0174	0.0994	0.2849
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0102	0.0487	0.4085
Entamoeba histolytica	cysteine proteinase 2	0.009	0.0403	0.4054
Treponema pallidum	heat shock protein 90	0.0117	0.0594	0.5
Trypanosoma brucei	heat shock protein, putative	0.0147	0.0804	0.809
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0102	0.0487	0.1397
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0058	0.0178	0.1492
Entamoeba histolytica	cysteine proteinase, putative	0.009	0.0403	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0038	0.004	0.0333
Onchocerca volvulus		0.0174	0.0994	1
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0086	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0223	0.1867
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0178	0.1492
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.009	0.0403	0.4054
Trypanosoma cruzi	heat shock protein 90, putative	0.0087	0.0382	0.1141
Schistosoma mansoni	endoplasmin	0.0147	0.0804	0.6739
Onchocerca volvulus	Cathepsin L homolog	0.0174	0.0994	1
Echinococcus multilocularis	cathepsin L	0.009	0.0403	0.0403
Leishmania major	cathepsin L-like protease	0.0174	0.0994	0.2849
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.026	0.0777
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Echinococcus multilocularis	heat shock protein 90	0.0147	0.0804	0.0804
Echinococcus multilocularis	cathepsin L cysteine protease	0.0174	0.0994	0.0994
Trypanosoma brucei	wee1-like protein kinase	0.0069	0.026	0.2619
Brugia malayi	Papain family cysteine protease containing protein	0.0174	0.0994	0.833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0177	0.1779
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0102	0.0487	0.4904
Entamoeba histolytica	cysteine protease, putative	0.009	0.0403	0.4054
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0057	0.0177	0.1482
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0057	0.0177	0.1779
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0102	0.0487	0.1454
Loa Loa (eye worm)	ctsf protein	0.0174	0.0994	0.833
Leishmania major	cathepsin L-like protease	0.0174	0.0994	0.2849
Leishmania major	heat shock protein 83-1	0.0147	0.0804	0.2305
Plasmodium vivax	heat shock protein 90, putative	0.006	0.0197	0.1979
Onchocerca volvulus		0.0174	0.0994	1
Brugia malayi	Cathepsin L-like precursor	0.0174	0.0994	0.833
Schistosoma mansoni	endoplasmin	0.0147	0.0804	0.6739
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0174	0.0994	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0117	0.0594	0.1774
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0147	0.0804	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0178	0.1492
Echinococcus granulosus	endoplasmin	0.0117	0.0594	0.0594
Plasmodium falciparum	heat shock protein 90	0.0147	0.0804	0.809
Brugia malayi	Protein kinase domain containing protein	0.0203	0.1193	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0147	0.0804	0.2399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0174	0.0994	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0174	0.0994	1
Trichomonas vaginalis	heat shock protein, putative	0.0117	0.0594	0.5981
Trypanosoma brucei	heat shock protein 90, putative	0.0147	0.0804	0.809
Loa Loa (eye worm)	phosphatidylinositol 3	0.0102	0.0487	0.4085
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0044	0.0086	0.0086
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0102	0.0487	0.1397

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.82	Inhibition of human Wee1	ChEMBL.	18976834
IC50 (binding)	= 0.15 uM	Inhibition of human Wee1 in presence of 9.5 uM ATP	ChEMBL.	16884302
IC50 (binding)	= 0.15 uM	Inhibition of human Wee1 in presence of 9.5 uM ATP	ChEMBL.	16884302
IC50 (binding)	= 0.15 uM	Inhibition of human Wee1	ChEMBL.	18976834
IC50 (binding)	= 0.3 uM	Inhibition at human Chk1 in presence of 4 uM ATP	ChEMBL.	16884302
IC50 (binding)	= 0.3 uM	Inhibition at human Chk1 in presence of 4 uM ATP	ChEMBL.	16884302
Ratio IC50 (binding)	= 2	Ratio of IC50 for Chk1/IC50 for Wee1	ChEMBL.	16884302

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL384829
PubChem: 11844608

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 369304