TDR Targets

Basic information

Technical information

TDR Targets ID: 369366
Name: (2R)-1-(4-bromophenyl)sulfonyl-N-(1-oxo-3-phe nylpropan-2-yl)pyrrolidine-2-carboxamide
MW: 465.361 | Formula: C20H21BrN2O4S
H donors: 1 H acceptors: 4 LogP: 3.15 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=CC(Cc1ccccc1)NC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(cc1)Br
InChi: 1S/C20H21BrN2O4S/c21-16-8-10-18(11-9-16)28(26,27)23-12-4-7-19(23)20(25)22-17(14-24)13-15-5-2-1-3-6-15/h1-3,5-6,8-11,14,17,19H,4,7,12-13H2,(H,22,25)/t17?,19-/m1/s1
InChiKey: LTGDHABJFBCULP-WHCXFUJUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R)-N-(1-benzyl-2-oxo-ethyl)-1-(4-bromophenyl)sulfonyl-pyrrolidine-2-carboxamide
(2R)-N-(1-benzyl-2-oxoethyl)-1-(4-bromophenyl)sulfonyl-2-pyrrolidinecarboxamide
(2R)-1-(4-bromophenyl)sulfonyl-N-(1-oxo-3-phenyl-propan-2-yl)pyrrolidine-2-carboxamide
(2R)-N-(1-benzyl-2-keto-ethyl)-1-brosyl-pyrrolidine-2-carboxamide
(2R)-1-(4-bromophenyl)sulfonyl-N-(1-formyl-2-phenyl-ethyl)pyrrolidine-2-carboxamide
(2R)-1-(4-bromophenyl)sulfonyl-N-(1-formyl-2-phenylethyl)-2-pyrrolidinecarboxamide
(2R)-N-[1-(benzyl)-2-keto-ethyl]-1-(4-bromophenyl)sulfonyl-pyrrolidine-2-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Sus scrofa	Calpain 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	calpain C (C02 family)	Calpain 1	714 aa	715 aa	33.4 %
Schistosoma mansoni	calpain (C02 family)	Calpain 1	714 aa	684 aa	31.0 %
Echinococcus granulosus	calpain	Calpain 1	714 aa	695 aa	38.6 %
Echinococcus multilocularis	hypothetical protein	Calpain 1	714 aa	716 aa	33.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Echinococcus granulosus	calpain A	Calpain 1	714 aa	753 aa	31.5 %
Schistosoma japonicum	Calpain-9, putative	Calpain 1	714 aa	671 aa	33.8 %
Echinococcus multilocularis	calpain	Calpain 1	714 aa	695 aa	38.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cpg binding protein	0.0033	0.056	0.0566
Schistosoma mansoni	hypothetical protein	0.0016	0.0183	0.0179
Brugia malayi	TAR-binding protein	0.0074	0.1434	0.1669
Schistosoma mansoni	calpain (C02 family)	0.002	0.0266	0.0264
Trypanosoma cruzi	cysteine peptidase, putative	0.0013	0.0124	0.0333
Schistosoma mansoni	cpg binding protein	0.0035	0.0602	0.0609
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0013	0.0124	0.112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Echinococcus multilocularis	calpain 5	0.002	0.0266	0.0258
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0294	0.0335
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0016	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0183	0.0179
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Echinococcus granulosus	sodium channel protein	0.0102	0.2033	0.2026
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0294	0.0335
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0008	0.0008	0.0076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0124	0.1145
Trypanosoma cruzi	kinesin, putative	0.0014	0.0136	0.0368
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.002	0.0266	0.0681
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0056	0.1043	0.1036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0008	0.0076
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0183	0.0174
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	1
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0056	0.1043	0.2973
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0056	0.1043	0.1212
Trypanosoma brucei	calpain-like protein, putative	0.002	0.0266	0.1224
Schistosoma mansoni	hypothetical protein	0.0016	0.0183	0.0179
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0411	0.0413
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0008	0.0076
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0178	0.0199
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Echinococcus multilocularis	cathepsin b	0.0169	0.349	0.3485
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0053	0.0975	0.0992
Entamoeba histolytica	cysteine proteinase, putative	0.0021	0.0294	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Echinococcus granulosus	choline:ethanolamine kinase	0.0044	0.0797	0.079
Leishmania major	cathepsin L-like protease	0.0021	0.0294	0.0832
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0056	0.1043	0.4782
Echinococcus multilocularis	hypothetical protein	0.002	0.0266	0.0258
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0008	0.0076
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0056	0.1043	0.1062
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.0124	0.0119
Onchocerca volvulus		0.0021	0.0294	0.5181
Leishmania major	cathepsin L-like protease	0.0021	0.0294	0.0832
Giardia lamblia	Cathepsin B precursor	0.0058	0.1085	0.1105
Echinococcus multilocularis	tar DNA binding protein	0.0074	0.1434	0.1427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Brugia malayi	Choline/ethanolamine kinase family protein	0.0044	0.0797	0.0924
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0008	0.0008	0.0076
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0169	0.349	0.3571
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0403	0.855	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0008	0.0076
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0994	0.2831
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.002	0.0266	0.0739
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.7953
Plasmodium vivax	vivapain-2	0.0021	0.0294	0.2763
Echinococcus multilocularis	cathepsin b	0.0169	0.349	0.3485
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.128	0.3653
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Echinococcus granulosus	tar DNA binding protein	0.0074	0.1434	0.1427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0008	0.0076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Brugia malayi	cathepsin B-like cysteine proteinase	0.0169	0.349	0.4076
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trypanosoma brucei	kinesin, putative	0.0014	0.0136	0.0106
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0056	0.1043	0.1036
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Echinococcus granulosus	neuropeptide receptor A26	0.047	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.0124	0.4054
Plasmodium vivax	unspecified product	0.0013	0.0124	0.112
Loa Loa (eye worm)	hypothetical protein	0.0458	0.9757	1
Entamoeba histolytica	cysteine protease, putative	0.0021	0.0294	1
Brugia malayi	Papain family cysteine protease containing protein	0.0013	0.0124	0.0136
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0056	0.1043	0.2973
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0056	0.1043	0.1062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0294	0.0335
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.128	0.3653
Plasmodium vivax	calpain, putative	0.002	0.0266	0.2487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0056	0.1043	0.1062
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0056	0.1043	0.2973
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0008	0.0076
Leishmania major	cathepsin L-like protease	0.0067	0.128	0.603
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0056	0.1043	0.2973
Loa Loa (eye worm)	PDE1B protein	0.0056	0.1043	0.1062
Echinococcus granulosus	cathepsin L	0.0013	0.0124	0.0116
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0056	0.1043	0.2973
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0056	0.1043	0.1212
Brugia malayi	Papain family cysteine protease containing protein	0.0021	0.0294	0.0335
Echinococcus multilocularis	calpain	0.002	0.0266	0.0258
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1434	0.1462
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0056	0.1043	1
Onchocerca volvulus		0.0021	0.0294	0.5181
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0008	0.0076
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0294	0.0335
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0056	0.1043	0.7953
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0183	0.0179
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Echinococcus multilocularis	cysteine protease	0.0021	0.0294	0.0286
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.1043	0.2973
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Echinococcus granulosus	cysteine protease	0.0013	0.0124	0.0116
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0021	0.0294	0.2763
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0056	0.1043	0.1036
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.1043	0.2973
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0056	0.1043	0.7953
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0403	0.855	0.8549
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0266	0.0739
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0008	0.0076
Plasmodium vivax	choline kinase, putative	0.0044	0.0797	0.7624
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0056	0.1043	0.1062
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0008	0.0076
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0178	0.0174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0013	0.0124	0.1145
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.0124	0.0119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0056	0.1043	0.1036
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0294	0.0335
Loa Loa (eye worm)	calpain 5	0.0014	0.0136	0.0132
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.0124	0.4054
Echinococcus granulosus	cathepsin l1	0.0021	0.0294	0.0286
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0169	0.349	0.3571
Echinococcus granulosus	cathepsin l1	0.0016	0.0178	0.017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0266	0.1224
Brugia malayi	calpain family protein 1	0.0053	0.0975	0.1132
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.006	0.0052
Onchocerca volvulus	Cathepsin F homolog	0.0021	0.0294	0.5181
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0266	0.0739
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0056	0.1043	0.1036
Echinococcus multilocularis	cathepsin L cysteine protease	0.0021	0.0294	0.0286
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Onchocerca volvulus		0.0033	0.056	1
Echinococcus granulosus	cathepsin b	0.0169	0.349	0.3485
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0056	0.1043	0.1062
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0458	0.9757	1
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0183	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0008	0.0008	0.0076
Trypanosoma cruzi	cysteine protease, putative	0.0013	0.0124	0.0333
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1434	0.1462
Brugia malayi	calpain 7	0.002	0.0266	0.0301
Echinococcus granulosus	calpain 7 C02 family	0.002	0.0266	0.0258
Trypanosoma brucei	calpain-like protein, putative	0.002	0.0266	0.1224
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Loa Loa (eye worm)	cathepsin B	0.0058	0.1085	0.1105
Entamoeba histolytica	cysteine proteinase 1, putative	0.0013	0.0124	0.4054
Schistosoma mansoni	hypothetical protein	0.0016	0.0183	0.0179
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0183	0.0204
Leishmania major	hypothetical protein, conserved	0.0056	0.1043	0.4782
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0178	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0178	0.0174
Schistosoma mansoni	cathepsin F (C01 family)	0.0021	0.0294	0.0293
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1434	0.1462
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.006	0.0052
Onchocerca volvulus		0.0021	0.0294	0.5181
Schistosoma mansoni	calpain C (C02 family)	0.002	0.0266	0.0264
Plasmodium falciparum	phosphodiesterase delta, putative	0.0056	0.1043	1
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Plasmodium vivax	vivapain-3	0.0013	0.0124	0.112
Giardia lamblia	hypothetical protein	0.0056	0.1043	0.1062
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.002	0.0266	0.0681
Echinococcus granulosus	calpain A	0.002	0.0266	0.0258
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0465	0.99	1
Echinococcus granulosus	calpain	0.002	0.0266	0.0258
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.002	0.0266	0.1224
Echinococcus multilocularis	cathepsin L	0.0013	0.0124	0.0116
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.0124	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Plasmodium vivax	vivapain-2	0.0021	0.0294	0.2763
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0021	0.0294	0.0293
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Loa Loa (eye worm)	cysteine protease	0.0021	0.0294	0.0293
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0183	0.0174
Schistosoma mansoni	cathepsin F (C01 family)	0.0021	0.0294	0.0293
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0056	0.1043	0.1212
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Giardia lamblia	Cathepsin B precursor	0.0058	0.1085	0.1105
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	1
Brugia malayi	RNA recognition motif domain containing protein	0.0074	0.1434	0.1669
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0056	0.1043	0.1036
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0021	0.0294	0.2763
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0056	0.1043	1
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0008	0.0076
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0183	0.0174
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0411	0.0471
Onchocerca volvulus	Cathepsin L homolog	0.0021	0.0294	0.5181
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0294	0.0335
Onchocerca volvulus		0.0021	0.0294	0.5181
Loa Loa (eye worm)	calpain family protein 1	0.0039	0.0675	0.0684
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0056	0.1043	0.1062
Echinococcus granulosus	cpg binding protein	0.0035	0.0602	0.0594
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0266	0.0739
Giardia lamblia	Hypothetical protein	0.0056	0.1043	0.1062
Brugia malayi	calpain family protein 1	0.0053	0.0975	0.1132
Echinococcus granulosus	calpain 5	0.002	0.0266	0.0258
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Entamoeba histolytica	protein kinase, putative	0.0014	0.0136	0.4482
Echinococcus multilocularis	cathepsin L cysteine protease	0.0021	0.0294	0.0286
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Loa Loa (eye worm)	fibroinase	0.0021	0.0294	0.0293
Toxoplasma gondii	cathepsin CPL	0.0021	0.0294	0.0289
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0102	0.2033	0.2026
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.1043	0.2973
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0266	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0975	0.0992
Echinococcus multilocularis	cysteine protease	0.0021	0.0294	0.0286
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0016	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0058	0.1085	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.056	0.0566
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0021	0.0294	0.0286
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0266	0.0739
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Loa Loa (eye worm)	RNA binding protein	0.0074	0.1434	0.1462
Onchocerca volvulus	Cathepsin L homolog	0.0021	0.0294	0.5181
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0056	0.1043	0.1212
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1434	0.1462
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.1043	0.9616
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Toxoplasma gondii	cathepsin B	0.0058	0.1085	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0294	0.0293
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0062	0.1186	0.119
Echinococcus granulosus	calpain A	0.0055	0.1027	0.102
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.1373	0.14
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0056	0.1043	0.1062
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0058	0.1085	0.8313
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0266	0.0739
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0056	0.1043	0.1036
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0056	0.1043	0.2973
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0056	0.1043	0.1062
Schistosoma mansoni	Mername-AA248 (C02 family)	0.002	0.0266	0.0264
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0932	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0932	0.0947
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0021	0.0294	0.0286
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0008	0.0076
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Schistosoma mansoni	tar DNA-binding protein	0.0074	0.1434	0.1462
Brugia malayi	cathepsin L-like precursor	0.0016	0.0178	0.0199
Trypanosoma cruzi	kinesin, putative	0.0014	0.0136	0.0368
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0056	0.1043	0.1036
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0056	0.1043	0.7953
Loa Loa (eye worm)	calpain family protein 1	0.0053	0.0975	0.0992
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0013	0.0124	0.0333
Brugia malayi	RNA binding protein	0.0074	0.1434	0.1669
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0403	0.855	0.8761
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0016	0.0008
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0058	0.1085	0.5002
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0057	0.0057
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	1
Echinococcus multilocularis	neuropeptide receptor A26	0.047	1	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0932	0.1081
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Schistosoma mansoni	calpain-7 (C02 family)	0.002	0.0266	0.0264
Onchocerca volvulus		0.0016	0.0178	0.3081
Echinococcus multilocularis	neuropeptide s receptor	0.047	1	1
Echinococcus multilocularis	cpg binding protein	0.0035	0.0602	0.0594
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.7953
Plasmodium vivax	vivapain-1	0.0013	0.0124	0.112
Leishmania major	hypothetical protein, conserved	0.0056	0.1043	0.4782
Trypanosoma cruzi	cysteine proteinase, putative	0.0013	0.0124	0.0333
Entamoeba histolytica	cysteine proteinase 2	0.0013	0.0124	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0021	0.0294	0.2712
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.1043	0.9616
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0056	0.1043	0.1212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.1644
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0021	0.0294	0.0286
Onchocerca volvulus		0.0033	0.0546	0.973
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0266	0.0739
Onchocerca volvulus		0.0021	0.0294	0.5181
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0016	0.0008
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1043	0.1062
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Echinococcus granulosus	cathepsin b	0.0169	0.349	0.3485
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0056	0.1043	0.1036
Leishmania major	cathepsin L-like protease	0.0021	0.0294	0.0832
Echinococcus multilocularis	sodium channel protein	0.0102	0.2033	0.2026
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.002	0.0266	0.0739
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0013	0.0124	0.0119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0932	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0178	0.0174
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0403	0.855	0.8549
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0056	0.1043	0.1062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0008	0.0076
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0056	0.1043	0.1062
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.1027	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0169	0.349	0.3571
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.128	0.3653
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Trypanosoma brucei	hypothetical protein, conserved	0.0056	0.1043	0.7953
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0056	0.1043	0.1036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0014	0.0136	0.4482
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0016	0.0008
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0021	0.0294	0.0293
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0055	0.1027	0.102
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0058	0.1085	0.1105
Trypanosoma cruzi	cysteine proteinase, putative	0.0013	0.0124	0.0333
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0178	0.0199
Leishmania major	cathepsin L-like protease	0.0021	0.0294	0.0832
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0178	0.1644
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0056	0.1043	0.4782
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0846	0.0859
Echinococcus multilocularis	calpain family protein 1, d	0.0039	0.0675	0.0667
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0058	0.1085	0.3093
Schistosoma mansoni	cpg binding protein	0.0035	0.0602	0.0609
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Leishmania major	cathepsin L-like protease	0.0067	0.128	0.603
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Schistosoma mansoni	hypothetical protein	0.0016	0.0183	0.0179
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0056	0.1043	0.1036
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0169	0.349	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.1027	0.1045
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	0.9616
Onchocerca volvulus		0.0021	0.0294	0.5181
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.1043	0.2973
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0021	0.0294	0.2712
Brugia malayi	Papain family cysteine protease containing protein	0.0013	0.0124	0.0136
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.128	0.3653
Onchocerca volvulus		0.0021	0.0294	0.5181
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0675	0.0684
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0056	0.1043	0.7953
Leishmania major	cathepsin L-like protease	0.0067	0.128	0.603
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0056	0.1043	0.1062
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.002	0.0266	0.0681
Plasmodium vivax	phosphodiesterase gamma, putative	0.0056	0.1043	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Echinococcus multilocularis	calpain A	0.0055	0.1027	0.102
Loa Loa (eye worm)	TAR-binding protein	0.0074	0.1434	0.1462
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0074	0.1434	0.1462
Loa Loa (eye worm)	ctsf protein	0.0021	0.0294	0.0293
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0458	0.9757	1
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Loa Loa (eye worm)	choline/ethanolamine kinase	0.0044	0.0797	0.081
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0056	0.1043	0.1036
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0458	0.9757	0.9757
Schistosoma mansoni	calpain-7 (C02 family)	0.002	0.0266	0.0264
Leishmania major	cathepsin L-like protease	0.0021	0.0294	0.0832
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.1043	0.9616
Plasmodium falciparum	choline kinase	0.0044	0.0797	0.7624
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0169	0.349	0.3571
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0183	0.0174
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.1209	0.1213
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0056	0.1043	0.9616
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0546	0.0551
Schistosoma mansoni	hypothetical protein	0.0035	0.0585	0.0591
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Echinococcus multilocularis	calpain 7 (C02 family)	0.002	0.0266	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0585	0.0591
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0056	0.1043	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0056	0.1043	0.2973
Trypanosoma brucei	calpain-like protein, putative	0.002	0.0266	0.1224
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0178	0.0174
Echinococcus multilocularis	choline:ethanolamine kinase	0.0044	0.0797	0.079
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0458	0.9757	0.9757
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0056	0.1043	0.2973
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Entamoeba histolytica	cysteine protease, putative	0.0013	0.0124	0.4054
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0458	0.9757	0.9757
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Entamoeba histolytica	cysteine proteinase, putative	0.0021	0.0294	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0021	0.0294	0.0822
Loa Loa (eye worm)	calpain	0.002	0.0266	0.0264
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.1043	0.2973
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Giardia lamblia	Cathepsin B precursor	0.0058	0.1085	0.1105
Brugia malayi	CXXC zinc finger family protein	0.0033	0.056	0.0646
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.1043	1
Brugia malayi	calpain 5	0.0014	0.0136	0.015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0008	0.0076
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0016	0.0178	0.0199
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0056	0.1043	0.1212
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0021	0.0294	0.0286
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.1164	0.332
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0294	0.2712
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0585	0.0675
Echinococcus granulosus	GPCR family 2	0.0016	0.0183	0.0174
Echinococcus granulosus	cathepsin L cysteine protease	0.0013	0.0124	0.0116
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.1043	0.2973
Toxoplasma gondii	phosphotransferase enzyme family protein	0.0044	0.0797	0.0798
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.1043	0.1047
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0169	0.349	0.3571
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.128	1
Leishmania major	cysteine peptidase A (CPA)	0.0021	0.0294	0.0832
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0008	0.0008	0.0076
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0021	0.0294	0.2763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0008	0.0076
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.1043	0.9616
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1043	0.1062
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0183	0.0174
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0008	0.0076
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0294	0.2712
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0458	0.9757	0.9757
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.002	0.0266	0.0739
Entamoeba histolytica	cysteine proteinase, putative	0.0013	0.0124	0.4054
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0102	0.2033	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0056	0.1043	0.9616
Loa Loa (eye worm)	histone methyltransferase	0.001	0.006	0.0053
Trypanosoma brucei	calpain-like protein, putative	0.002	0.0266	0.1224
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1043	0.1062
Trypanosoma brucei	antigen, putative	0.002	0.0266	0.1224
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0055	0.1027	0.102

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.128 uM	Inhibition of porcine erythrocyte mu calpain	ChEMBL.	16913717
Ki (binding)	= 0.128 uM	Inhibition of porcine erythrocyte mu calpain	ChEMBL.	16913717
Ki (binding)	= 4.42 uM	Inhibition of human liver cathepsin B	ChEMBL.	16913717
Ki (binding)	= 4.42 uM	Inhibition of human liver cathepsin B	ChEMBL.	16913717
Selectivity ratio (binding)	= 34.5	Selectivity ratio, Ki for human cathepsin B/Ki for porcine mu calpain	ChEMBL.	16913717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL213107
PubChem: 11849206

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 369366