TDR Targets

Basic information

Technical information

TDR Targets ID: 372928
Name: 2-[4-[benzyl(ethyl)amino]phenyl]-1,1,1,3,3,3- hexafluoropropan-2-ol
MW: 377.324 | Formula: C18H17F6NO
H donors: 1 H acceptors: 1 LogP: 5.1 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O)Cc1ccccc1
InChi: 1S/C18H17F6NO/c1-2-25(12-13-6-4-3-5-7-13)15-10-8-14(9-11-15)16(26,17(19,20)21)18(22,23)24/h3-11,26H,2,12H2,1H3
InChiKey: UWRRECCPOPWQFF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[4-[benzyl(ethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol
2-[4-[benzyl(ethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoro-2-propanol
2-[4-[ethyl(phenylmethyl)amino]phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear receptor subfamily 1, group H, member 3	Starlite/ChEMBL	References
Homo sapiens	nuclear receptor subfamily 1, group H, member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Bile acid receptor homolog	Get druggable targets OG5_134445	All targets in OG5_134445
Brugia malayi	ecdysteroid receptor	Get druggable targets OG5_134445	All targets in OG5_134445
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_134445	All targets in OG5_134445

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	photoreceptor-specific nuclear receptor	nuclear receptor subfamily 1, group H, member 3	387 aa	321 aa	28.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0237	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0237	0.0472
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0283	0.0201
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0469	0.1855
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0108	0.2182	0.6063
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0017	0.0135	0.0238
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0017	0.0135	0.0294
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0084	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0237	0.0472
Entamoeba histolytica	protein kinase, putative	0.0033	0.0484	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.216	0.6002
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0107	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	0.4245
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0045	0.0764	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0237	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.017	0.3579	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0017	0.0135	0.0294
Onchocerca volvulus	Putative nachr subunit	0.0017	0.0135	0.0117
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0237	0.0472
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0237	0.0472
Loa Loa (eye worm)	hypothetical protein	0.004	0.0648	0.1412
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0438	0.115
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0455	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0237	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0472
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0084	0.0384
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.3441
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0042	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0484	0.1279
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0237	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0045	0.0764	0.35
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0484	0.0404
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.216	1
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0151
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0484	0.0404
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.004	0.0648	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1279
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0017	0.0135	0.0238
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0237	0.0582
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0108	0.2182	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1279
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0951
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0237	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0017	0.0135	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1274	0.2841
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0237	0.0582
Schistosoma mansoni	nAChR subunit	0.0017	0.0135	0.0294
Echinococcus granulosus	beta LACTamase domain containing family member	0.0068	0.1274	0.3505
Entamoeba histolytica	protein kinase, putative	0.0033	0.0484	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.3441
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0017	0.0135	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0084	0.0151
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0237	0.0472
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0122
Echinococcus granulosus	methionine tRNA synthetase	0.0045	0.0764	0.2067
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1279
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0589	0.4245
Echinococcus multilocularis	nAChR subunit	0.0017	0.0135	0.0294
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.216	0.6002
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0017	0.0135	0.0238
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0068	0.1274	0.3505
Leishmania major	hypothetical protein, conserved	0.0068	0.1274	0.5673
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0237	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1274	0.2841
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0237	0.0472
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0493	0.1973
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0237	0.0582
Onchocerca volvulus		0.0017	0.0135	0.0117
Echinococcus multilocularis	glycine receptor subunit beta	0.0017	0.0135	0.0294
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.1274	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	0.1298
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0045	0.0764	0.3274
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0017	0.0133	0.029
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0237	0.0472
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.216	0.6002
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.216	0.6002
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	0.2408
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Toxoplasma gondii	protein kinase, putative	0.0303	0.6571	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.1973
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.3441
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0484	0.0617
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0068	0.1274	0.3505
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.3441
Schistosoma mansoni	nAChR subunit	0.0017	0.0135	0.0294
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1274	0.2841
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0122
Echinococcus granulosus	nAChR subunit	0.0017	0.0135	0.0294
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0017	0.0135	0.0238
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0484	0.0404
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0484	0.0404
Leishmania major	glucose transporter, lmgt3	0.0033	0.0493	0.1952
Brugia malayi	nuclear hormone receptor	0.0022	0.0237	0.0472
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0484	0.0404
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0068	0.1274	0.2841
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0438	0.115
Trichomonas vaginalis	D-aminoacylase, putative	0.0068	0.1274	0.5732
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0283	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0207	0.4409	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0469	0.1002
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0469	0.5665
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0017	0.0135	0.0238
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0017	0.0135	0.0294
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.017	0.3579	0.8104
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0017	0.0135	0.0294
Brugia malayi	Sugar transporter family protein	0.0107	0.216	0.4865
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.017	0.3579	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.3441
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0469	0.1002
Mycobacterium tuberculosis	Conserved protein	0.0068	0.1274	0.1262
Leishmania major	leucyl-tRNA synthetase, putative	0.0017	0.0133	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0283	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0484	0.0404
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0108	0.2182	0.4914
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0107	0.0176
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0493	0.1973
Leishmania major	glucose transporter, lmgt1	0.0033	0.0493	0.1952
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0084	0.0384
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0237	0.0582
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0237	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0107	0.0176
Brugia malayi	hypothetical protein	0.0016	0.0107	0.0176
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0045	0.0764	0.1675
Brugia malayi	methionyl-tRNA synthetase	0.0045	0.0764	0.1675
Mycobacterium tuberculosis	Probable lipase LipE	0.0068	0.1274	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0151
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1279
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0017	0.0135	0.0294
Mycobacterium leprae	Probable lipase LipE	0.0068	0.1274	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0237	0.0582
Brugia malayi	excitatory GABA receptor EXP-1A	0.0017	0.0135	0.0238
Brugia malayi	Cam kinase protein 1	0.0033	0.0484	0.1036
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0151
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0237	0.0582
Loa Loa (eye worm)	beta-lactamase	0.0068	0.1274	0.2841
Brugia malayi	Cation transporter family protein	0.0017	0.0135	0.0238
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0493	0.3441
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.3441
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0084	0.0151
Brugia malayi	hypothetical protein	0.0016	0.0107	0.0176
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0469	0.1236
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0237	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0133	0.0235
Trichomonas vaginalis	esterase, putative	0.0068	0.1274	0.5732
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0045	0.0764	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0493	0.1973
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.216	0.6002
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0713
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0017	0.0135	0.0238
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0237	0.0582
Mycobacterium tuberculosis	Conserved protein	0.0068	0.1274	0.1262
Schistosoma mansoni	leucyl-tRNA synthetase	0.0017	0.0133	0.029
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0237	0.0354
Schistosoma mansoni	glucose transport protein	0.0107	0.216	0.6002
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0493	0.3441
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0237	0.0472
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0017	0.0135	0.0238
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0017	0.0135	0.0294
Onchocerca volvulus		0.0068	0.1274	0.2752
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0283	0.0713
Plasmodium falciparum	protein kinase 7	0.0303	0.6571	0.6542
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0017	0.0135	0.0294
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0107	0.0176
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0135	0.0238
Plasmodium vivax	hexose transporter	0.0107	0.216	0.2094
Mycobacterium ulcerans	beta-lactamase	0.0068	0.1274	0.5839
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0068	0.1274	0.1262
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0237	0.0582
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0237	0.0582
Onchocerca volvulus		0.0068	0.1274	0.2752
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0122
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0237	0.0582
Loa Loa (eye worm)	sugar transporter	0.0015	0.0084	0.0122
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0017	0.0135	0.0294
Plasmodium vivax	hypothetical protein, conserved	0.0068	0.1274	0.12
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0017	0.0135	0.0294
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0237	0.0582
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0017	0.0135	0.0238
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0589	0.0779
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.216	0.6002
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0017	0.0135	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0333	0.0692
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0237	0.0472
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0017	0.0135	0.0294
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0101	0.2018	0.4539
Brugia malayi	Calcitonin receptor-like protein seb-1	0.004	0.0648	0.1412
Plasmodium vivax	hypothetical protein, conserved	0.0017	0.0133	0.005
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0283	0.2935
Brugia malayi	beta-lactamase family protein	0.0068	0.1274	0.2841
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0237	0.0582
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0108	0.2182	0.2224
Schistosoma mansoni	nAChR subunit	0.0017	0.0135	0.0294
Leishmania major	glucose transporter, lmgt2	0.0033	0.0493	0.1952
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0068	0.1274	0.1262
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0173	0.3649	0.3595
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0484	0.0404
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Mycobacterium ulcerans	hypothetical protein	0.0068	0.1274	0.5839
Plasmodium falciparum	methionine--tRNA ligase, putative	0.0017	0.0133	0.005
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0484	0.1927
Loa Loa (eye worm)	ACC-1 protein	0.0017	0.0135	0.0238
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0017	0.0135	0.0294
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0237	0.0472
Trichomonas vaginalis	D-aminoacylase, putative	0.0068	0.1274	0.5732
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0472
Mycobacterium tuberculosis	Probable lipase LipD	0.0068	0.1274	0.1262
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1279
Brugia malayi	latrophilin 2 splice variant baaae	0.0027	0.0362	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Brugia malayi	protein ZK524.3	0.0017	0.0133	0.0235
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0108	0.2182	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Brugia malayi	ecdysteroid receptor	0.0207	0.4409	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0107	0.0217
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0151
Mycobacterium tuberculosis	Probable esterase LipL	0.0068	0.1274	0.1262
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0122
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0237	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1274	0.2841
Giardia lamblia	Leucyl-tRNA synthetase	0.0017	0.0133	0.0728
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0237	0.0582
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0084	0.0384
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0135	0.0238
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0283	0.0308
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0493	0.1952
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0484	0.1036
Leishmania major	methionyl-tRNA synthetase, putative	0.0045	0.0764	0.3241
Trypanosoma cruzi	hexose transporter	0.0033	0.0493	0.3441
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.017	0.3579	1
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.0122
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0237	0.0472
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0135	0.0238
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.3441
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0122
Toxoplasma gondii	tRNA ligases class I (M) protein	0.0017	0.0133	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0017	0.0135	0.0294
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0237	0.0582
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0484	0.0404
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1279
Schistosoma mansoni	glucose transport protein	0.0107	0.216	0.6002
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0713
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0017	0.0135	0.0294
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.216	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0472
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0017	0.0135	0.0294
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0017	0.0135	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0589	0.2408
Echinococcus multilocularis	methionine tRNA synthetase	0.0045	0.0764	0.2067
Brugia malayi	Cation transporter family protein	0.0017	0.0135	0.0238
Onchocerca volvulus		0.0017	0.0135	0.0117
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0017	0.0135	0.0294
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0589	0.051
Echinococcus multilocularis	General substrate transporter	0.0092	0.1821	0.5045
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0237	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Schistosoma mansoni	nAChR subunit	0.0017	0.0135	0.0294
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0084	0.0151
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0202	0.0125
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0237	0.0472
Plasmodium vivax	methionine--tRNA ligase, putative	0.0045	0.0764	0.0686
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0237	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Brugia malayi	beta-lactamase	0.0068	0.1274	0.2841
Onchocerca volvulus		0.0068	0.1274	0.2752
Echinococcus multilocularis	glycine receptor subunit beta	0.0017	0.0135	0.0294
Mycobacterium leprae	conserved hypothetical protein	0.0068	0.1274	1
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0283	0.0578
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0151
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0484	0.1279
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0084	0.0151
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0472
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0017	0.0135	0.0238
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.004	0.0648	0.1412
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1279
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0469	0.1236
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0017	0.0135	0.0294
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0135	0.0238
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0237	0.0582
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0017	0.0133	0.029
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1279
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0484	0.1279
Mycobacterium ulcerans	sugar transporter	0.0015	0.0084	0.0384
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0237	0.0582
Brugia malayi	beta-lactamase family protein	0.0068	0.1274	0.2841
Brugia malayi	methionyl-tRNA synthetase	0.0017	0.0133	0.0235
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.0122
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0961
Echinococcus multilocularis	leucyl tRNA synthetase	0.0017	0.0133	0.029
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Schistosoma mansoni	hypothetical protein	0.0027	0.0362	0.0936
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.017	0.3579	1
Onchocerca volvulus	Bile acid receptor homolog	0.0207	0.4409	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0469	0.1236
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.216	0.6002
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0484	0.3362
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.017	0.3579	1
Trypanosoma brucei	hypothetical protein, conserved	0.0068	0.1274	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.3441
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0472
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0217	0.0641
Mycobacterium leprae	Probable methionyl-tRNA synthase MetS	0.0045	0.0764	0.5239
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0017	0.0135	0.0294
Brugia malayi	nuclear receptor RXR	0.0016	0.0107	0.0176
Toxoplasma gondii	ABC1 family protein	0.0068	0.1274	0.1835
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.017	0.3579	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0237	0.0582
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0484	0.1036
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0237	0.0582
Loa Loa (eye worm)	sugar transporter	0.0107	0.216	0.4865
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0283	0.0201
Mycobacterium tuberculosis	Conserved protein	0.0068	0.1274	0.1262
Schistosoma mansoni	nAChR subunit	0.0017	0.0135	0.0294
Loa Loa (eye worm)	LGC-31 protein	0.0017	0.0135	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0472
Trichomonas vaginalis	D-aminoacylase, putative	0.0068	0.1274	0.5732
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0017	0.0135	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0484	0.1036
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0017	0.0135	0.0294
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0237	0.0472
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0045	0.0764	0.5712
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.0017	0.0133	0.061
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0108	0.2182	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0469	0.1002
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.0107	0.0217
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.216	0.6002
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0469	0.1002
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0469	0.1236
Schistosoma mansoni	nAChR subunit	0.0017	0.0135	0.0294
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0237	0.0582
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0237	0.0472
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.3441
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0151
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0237	0.0472
Onchocerca volvulus		0.0017	0.0135	0.0117
Trichomonas vaginalis	penicillin-binding protein, putative	0.0068	0.1274	0.5732
Plasmodium vivax	methionine--tRNA ligase, putative	0.0017	0.0133	0.005
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0107	0.0176
Schistosoma mansoni	coup transcription factor	0.0022	0.0237	0.0582
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0237	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0107	0.0176
Giardia lamblia	Methionyl-tRNA synthetase	0.0045	0.0764	1
Onchocerca volvulus		0.0017	0.0135	0.0117
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0283	0.0713
Plasmodium falciparum	methionine--tRNA ligase	0.0045	0.0764	0.0686
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0493	0.1973
Entamoeba histolytica	hypothetical protein	0.0024	0.0283	0.428
Schistosoma mansoni	methionine-tRNA synthetase	0.0045	0.0764	0.2067
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0135	0.0238
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0589	0.4245
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0068	0.1274	0.3505
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0107	0.0176
Leishmania major	protein kinase, putative	0.0033	0.0484	0.1907
Mycobacterium tuberculosis	Probable hydrolase	0.0068	0.1274	0.1262
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0151
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.1274	1
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0237	0.0472
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.0122
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.3441
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0107	0.0217
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0173	0.3649	0.3595
Schistosoma mansoni	hypothetical protein	0.0107	0.216	0.6002
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0237	0.0582
Treponema pallidum	methionyl-tRNA synthetase	0.0017	0.0133	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0237	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0237	0.0472
Wolbachia endosymbiont of Brugia malayi	leucyl-tRNA synthetase	0.0017	0.0133	0.0728
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0237	0.0472
Plasmodium falciparum	hexose transporter	0.0107	0.216	0.2094
Mycobacterium ulcerans	lipase LipD	0.0068	0.1274	0.5839
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0283	0.0578
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0017	0.0135	0.0294
Echinococcus granulosus	glycine receptor subunit beta	0.0017	0.0135	0.0294
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0045	0.0764	0.5712
Trichomonas vaginalis	penicillin-binding protein, putative	0.0068	0.1274	0.5732
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.3441
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0469	0.9573
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0237	0.0582
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0237	0.0582
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0017	0.0135	0.0294
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0484	0.0617
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.0122
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0017	0.0135	0.0294
Loa Loa (eye worm)	ACC-1 protein	0.0017	0.0135	0.0238
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0122
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.0122
Onchocerca volvulus		0.0028	0.0374	0.0672
Schistosoma mansoni	protein kinase	0.0033	0.0484	0.1279
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0484	0.1036
Onchocerca volvulus		0.0017	0.0135	0.0117
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0068	0.1274	0.1262
Onchocerca volvulus		0.0017	0.0135	0.0117
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0173	0.3649	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0238
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.1677
Echinococcus granulosus	glycine receptor subunit beta	0.0017	0.0135	0.0294
Brugia malayi	steroid hormone receptor	0.0022	0.0237	0.0472
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.1973
Chlamydia trachomatis	leucine--tRNA ligase	0.0017	0.0133	0.4701
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0237	0.0582
Onchocerca volvulus		0.0022	0.0237	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0133	0.0235
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0108	0.2182	0.6063
Brugia malayi	Cation transporter family protein	0.0017	0.0135	0.0238
Schistosoma mansoni	methionine-tRNA synthetase	0.0017	0.0133	0.029
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0237	0.0472
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0017	0.0135	0.0238
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.0135	0.0238
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0154	0.0587
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0202	0.0125
Treponema pallidum	leucyl-tRNA synthetase	0.0017	0.0133	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0068	0.1274	0.5839
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0017	0.0135	0.0238
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0151
Schistosoma mansoni	glucose transport protein	0.0107	0.216	0.6002
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.017	0.3579	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0469	0.2489
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0133	0.0235
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0484	0.0404
Toxoplasma gondii	methionyl-tRNA synthetase	0.0045	0.0764	0.1048
Brugia malayi	hypothetical protein	0.0015	0.0084	0.0122
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0108	0.2182	0.6063
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0151
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0589	0.051
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0237	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1274	0.2841
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0362	0.0758
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0151
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0068	0.1274	0.2841
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0434	0.952	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.1677
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0107	0.0217
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0107	0.0176
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0017	0.0135	0.0294
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0017	0.0135	0.0294
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0017	0.0135	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0122
Schistosoma mansoni	glucose transporter	0.0015	0.0084	0.0151
Schistosoma mansoni	nAChR subunit	0.0017	0.0135	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1274	0.2841
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0017	0.0135	0.0238
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0017	0.0135	0.0294
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.017	0.3579	0.8104
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0237	0.0354
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0484	0.0617
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.3441
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0028	0.0374	0.0786
Chlamydia trachomatis	methionine--tRNA ligase	0.0017	0.0133	0.4701
Echinococcus granulosus	General substrate transporter	0.0092	0.1821	0.5045
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0068	0.1274	0.5839
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0017	0.0135	0.0238

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 71 %	Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay	ChEMBL.	16876993
Activity (functional)	= 71 %	Transactivation of LXRbeta relative to T0901317 by luciferase reporter gene assay	ChEMBL.	16876993
Activity (functional)	= 100 %	Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay	ChEMBL.	16876993
Activity (functional)	= 100 %	Transactivation of LXRalpha relative to T0901317 by luciferase reporter gene assay	ChEMBL.	16876993
EC50 (functional)	= 0.4 uM	Transactivation of LXRbeta by luciferase reporter gene assay	ChEMBL.	16876993
EC50 (functional)	= 0.4 uM	Transactivation of LXRbeta by luciferase reporter gene assay	ChEMBL.	16876993
EC50 (functional)	= 1.1 uM	Transactivation of LXRalpha by luciferase reporter gene assay	ChEMBL.	16876993
EC50 (functional)	= 1.1 uM	Transactivation of LXRalpha by luciferase reporter gene assay	ChEMBL.	16876993
IC50 (binding)	= 0.03 uM	Binding affinity to LXRbeta by radioligand displacement assay	ChEMBL.	16876993
IC50 (binding)	= 0.03 uM	Binding affinity to LXRbeta by radioligand displacement assay	ChEMBL.	16876993
IC50 (binding)	= 0.05 uM	Binding affinity to LXRalpha by radioligand displacement assay	ChEMBL.	16876993
IC50 (binding)	= 0.05 uM	Binding affinity to LXRalpha by radioligand displacement assay	ChEMBL.	16876993

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL383959
PubChem: 11574384

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 372928