TDR Targets

Basic information

Technical information

TDR Targets ID: 375868
Name: 3-phenyl-N'-(3-phenylpropyl)-N,N-di(propan-2- yl)-2-pyridin-3-ylpentanediamide
MW: 485.66 | Formula: C31H39N3O2
H donors: 1 H acceptors: 3 LogP: 5.19 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CC(C(C(=O)N(C(C)C)C(C)C)c1cccnc1)c1ccccc1)NCCCc1ccccc1
InChi: 1S/C31H39N3O2/c1-23(2)34(24(3)4)31(36)30(27-18-12-19-32-22-27)28(26-16-9-6-10-17-26)21-29(35)33-20-11-15-25-13-7-5-8-14-25/h5-10,12-14,16-19,22-24,28,30H,11,15,20-21H2,1-4H3,(H,33,35)
InChiKey: BOGWASIPTJVFFS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N,N-diisopropyl-3-phenyl-N'-(3-phenylpropyl)-2-(3-pyridyl)pentanediamide
3-phenyl-N'-(3-phenylpropyl)-N,N-di(propan-2-yl)-2-pyridin-3-yl-pentanediamide
N,N-diisopropyl-3-phenyl-N'-(3-phenylpropyl)-2-(3-pyridyl)glutaramide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, shaker-related subfamily, member 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus granulosus	potassium voltage gated channel protein	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	Potassium voltage-gated channel subfamily A member 5, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_127659	All targets in OG5_127659
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus granulosus	potassium voltage gated channel subfamily A	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	Potassium voltage-gated channel protein Shaker, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus multilocularis	potassium voltage gated channel subfamily A	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus multilocularis	potassium voltage gated channel protein	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative	Get druggable targets OG5_127659	All targets in OG5_127659

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	voltage gated potassium channel	potassium voltage-gated channel, shaker-related subfamily, member 5	613 aa	521 aa	34.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	RE15519p	0.0014	0.0063	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0014	0.0063	0.0823
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0238	0.0882
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0018	0.0164
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0068	0.0894
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0014	0.0063	0.0572
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0061	0.0417	0.1229
Echinococcus multilocularis	transfer RNA-Gly	0.0008	0.0018	0.0237
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	voltage-gated potassium channel	0.0104	0.0738	0.9638
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0135	0.0399
Onchocerca volvulus		0.0014	0.0063	0.003
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0203	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.0765	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0038	0.0239	0.3128
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0206	0.0763
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0198	0.2583
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0063	0.0823
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0014	0.0063	0.0087
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0107	0.0396
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0147	0.1062	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0206	0.0926
Brugia malayi	Dopamine receptor	0.0014	0.0063	0.0087
Brugia malayi	Cam kinase protein 1	0.0033	0.0203	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0033	0.0298
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0239	0.2254
Echinococcus multilocularis	voltage gated potassium channel	0.0008	0.0018	0.0237
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0135	0.0609
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0014	0.0063	0.0087
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0068	0.0254
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0203	0.0597
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.004	0.0253	0.3311
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0196	0.0725
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.004	0.0181
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0063	0.0823
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0063	0.0823
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Entamoeba histolytica	hypothetical protein	0.0024	0.0135	0.0609
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0206	0.0763
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0033	0.0429
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0206	0.0926
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0104	0.0738	0.9638
Brugia malayi	G protein-coupled receptor F59B2.13	0.0014	0.0063	0.0087
Onchocerca volvulus		0.0014	0.0063	0.003
Plasmodium vivax	hexose transporter	0.0107	0.0765	0.2253
Brugia malayi	Dopamine receptor protein 1	0.0014	0.0063	0.0087
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0015	0.0067	0.0871
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	protein kinase	0.0033	0.0203	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.2171
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0738	0.6691
Brugia malayi	major facilitator superfamily protein	0.0015	0.0068	0.0094
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0206	0.0763
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0083	0.0308
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0206	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0018	0.0237
Brugia malayi	GnHR receptor homolog	0.0014	0.0063	0.0087
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0068	0.0308
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0063	0.0823
Echinococcus granulosus	serotonin receptor	0.0014	0.0063	0.0823
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0063	0.0823
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0014	0.0063	0.0823
Trichomonas vaginalis	DNA polymerase eta, putative	0.0042	0.0273	0.1229
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0018	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0068	0.0254
Echinococcus granulosus	potassium voltage gated channel protein	0.0008	0.0018	0.0237
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0018	0.0237
Onchocerca volvulus		0.0038	0.0239	0.0207
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0068	0.0308
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0298
Schistosoma mansoni	flap endonuclease-1	0.0024	0.0137	0.1791
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0063	0.0823
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0135	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.2171
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0033	0.0045
Brugia malayi	Trypsin family protein	0.0038	0.0239	0.033
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0033	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0206	0.0763
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Brugia malayi	Bloom's syndrome protein homolog	0.0067	0.046	0.0634
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0033	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	0.2222	1
Onchocerca volvulus		0.0015	0.0068	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0363	0.2698	1
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0068	0.0094
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0135	0.1275
Schistosoma mansoni	glucose transport protein	0.0107	0.0765	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.004	0.0253	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0203	0.2648
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0015	0.0067	0.0871
Loa Loa (eye worm)	sugar transporter	0.0107	0.0765	0.6942
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0238	0.0882
Echinococcus multilocularis	General substrate transporter	0.0092	0.0651	0.851
Echinococcus multilocularis	flap endonuclease 1	0.0027	0.0156	0.2044
Echinococcus multilocularis	dna polymerase kappa	0.0042	0.0273	0.3567
Echinococcus granulosus	dna polymerase kappa	0.0042	0.0273	0.3567
Loa Loa (eye worm)	voltage-gated potassium channel	0.0008	0.0018	0.0164
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.0765	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0033	0.0045
Brugia malayi	putative neuropeptide receptor NPR1	0.0014	0.0063	0.0087
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0203	0.2648
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Plasmodium falciparum	protein kinase 7	0.0303	0.2246	0.6612
Echinococcus granulosus	7tm_1 domain containing protein	0.0014	0.0063	0.0823
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0198	0.0889
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0033	0.0045
Entamoeba histolytica	recQ family DNA helicase	0.002	0.0107	0.0481
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0203	0.0752
Trichomonas vaginalis	DNA helicase recq, putative	0.0045	0.0296	0.1333
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0033	0.0045
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Onchocerca volvulus		0.0015	0.0068	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0068	0.0894
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0063	0.0823
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0206	0.0763
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0033	0.0298
Schistosoma mansoni	sugar transporter	0.0015	0.0068	0.0894
Leishmania major	protein kinase, putative	0.0033	0.0203	0.0751
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0206	0.0763
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	0.2222	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	blooms syndrome DNA helicase	0.002	0.0107	0.1395
Echinococcus granulosus	transmembrane protease serine 3	0.0038	0.0239	0.3128
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0033	0.0429
Onchocerca volvulus		0.0014	0.0063	0.003
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0014	0.0063	0.0087
Schistosoma mansoni	amine GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	Mastin	0.0038	0.0239	0.3128
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.004	0.038
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0033	0.0429
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0045	0.0296	0.1098
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0042	0.0271	0.0797
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0068	0.062
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0041	0.0265	0.0982
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0206	0.0763
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0014	0.0063	0.0823
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0063	0.0823
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0068	0.0254
Leishmania major	DNA polymerase eta, putative	0.0015	0.0067	0.0247
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.004	0.0253	0.2299
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0014	0.0063	0.0572
Echinococcus multilocularis	potassium voltage gated channel protein	0.0104	0.0738	0.9638
Onchocerca volvulus		0.0015	0.0068	0.0036
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	0.2222	1
Brugia malayi	AKH receptor	0.0014	0.0063	0.0087
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0014	0.0063	0.0823
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0198	0.0272
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0033	0.0429
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0203	0.2648
Onchocerca volvulus		0.0014	0.0063	0.003
Schistosoma mansoni	coup transcription factor	0.001	0.0033	0.0429
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0063	0.0823
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.0222	0.0822
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus multilocularis	enteropeptidase	0.0038	0.0239	0.3128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0033	0.0298
Echinococcus granulosus	General substrate transporter	0.0092	0.0651	0.851
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0135	0.0399
Loa Loa (eye worm)	hypothetical protein	0.004	0.0253	0.2299
Echinococcus granulosus	glycoprotein Antigen 5	0.0038	0.0239	0.3128
Plasmodium vivax	ATP-dependent DNA helicase Q1, putative	0.0019	0.0101	0.0297
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0198	0.0733
Onchocerca volvulus		0.0015	0.0068	0.0036
Echinococcus multilocularis	neuropeptide receptor A26	0.0014	0.0063	0.0823
Schistosoma mansoni	amine GPCR	0.0014	0.0063	0.0823
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Plasmodium falciparum	telomerase reverse transcriptase	0.0363	0.2698	0.7944
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0099	0.0703	0.9191
Onchocerca volvulus		0.0014	0.0063	0.003
Echinococcus granulosus	potassium voltage gated channel protein	0.0104	0.0738	0.9638
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0206	0.0763
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0038	0.0239	0.3128
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0203	0.0597
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0033	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0063	0.0572
Echinococcus granulosus	orexin receptor type 2	0.0014	0.0063	0.0823
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Onchocerca volvulus		0.0015	0.0068	0.0036
Onchocerca volvulus		0.0015	0.0068	0.0036
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0198	0.0889
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0033	0.0429
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0045	0.0296	0.1098
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0147	0.1062	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0033	0.0429
Schistosoma mansoni	growth hormone secretagogue receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0042	0.0273	0.1229
Brugia malayi	hypothetical protein	0.0015	0.0068	0.0094
Echinococcus granulosus	shaker cognate	0.0008	0.0018	0.0237
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0063	0.0823
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0068	0.0644
Schistosoma mansoni	voltage-gated potassium channel	0.0104	0.0738	0.9638
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0033	0.0045
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0113	0.0509
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0038	0.0239	0.3128
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0173	0.1265	0.4688
Schistosoma mansoni	amine GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0203	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0014	0.0063	0.0823
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0203	0.0597
Onchocerca volvulus		0.0015	0.0068	0.0036
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0147	0.1062	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0238	0.0882
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0008	0.0018	0.0237
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0038	0.0239	0.3128
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0033	0.0045
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0203	0.2648
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0014	0.0063	0.0572
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Trichomonas vaginalis	DNA helicase recq1, putative	0.0067	0.046	0.207
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0067	0.0092
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0203	0.0597
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0063	0.0572
Echinococcus granulosus	sex peptide receptor	0.0014	0.0063	0.0823
Giardia lamblia	Sugar-proton symporter	0.0015	0.0068	0.0254
Echinococcus granulosus	solute carrier family 22	0.0015	0.0068	0.0894
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0033	0.0429
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0198	0.1861
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0273	0.257
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0033	0.0429
Echinococcus granulosus	solute carrier family 22	0.0015	0.0068	0.0894
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0014	0.0063	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0033	0.0045
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0083	0.0308
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.0765	1
Brugia malayi	ORL1-like opioid receptor	0.0014	0.0063	0.0087
Plasmodium vivax	flap endonuclease 1, putative	0.0027	0.0156	0.0461
Onchocerca volvulus		0.0038	0.0239	0.0207
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0063	0.0823
Echinococcus multilocularis	transmembrane protease serine 3	0.0038	0.0239	0.3128
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0033	0.0429
Echinococcus granulosus	dna polymerase eta	0.0015	0.0067	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.2171
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0203	0.0279
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	0.2222	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0298
Leishmania major	hypothetical protein, conserved	0.0015	0.0068	0.0254
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0014	0.0063	0.0823
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0203	0.2648
Treponema pallidum	fructose-bisphosphate aldolase	0.03	0.2222	1
Echinococcus multilocularis	sex peptide receptor	0.0014	0.0063	0.0823
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0363	0.2698	0.7944
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0014	0.0063	0.0823
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0068	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0038	0.0239	0.3128
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0187	0.2448
Schistosoma mansoni	sugar transporter	0.0015	0.0068	0.0894
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0068	0.0644
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.03	0.2222	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0203	0.0597
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0038	0.0239	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0135	0.1228
Brugia malayi	Sugar transporter family protein	0.0107	0.0765	0.1055
Schistosoma mansoni	amine GPCR	0.0014	0.0063	0.0823
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0104	0.0738	0.1017
Echinococcus multilocularis	fmrfamide receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	0.2222	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0068	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0068	0.0254
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0068	0.062
Trichomonas vaginalis	flap endonuclease-1, putative	0.0027	0.0156	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Onchocerca volvulus		0.0038	0.0239	0.0207
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Treponema pallidum	ATP-dependent DNA helicase	0.002	0.0107	0.0481
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Loa Loa (eye worm)	sugar transporter	0.0015	0.0068	0.062
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0038	0.0239	0.033
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	hypothetical protein	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0033	0.0429
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0203	0.0752
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0068	0.0308
Onchocerca volvulus		0.0014	0.0063	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0033	0.0045
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0033	0.0429
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0033	0.0429
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0135	0.0502
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0203	0.2648
Brugia malayi	neuropeptide F receptor	0.0014	0.0063	0.0087
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0298
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0014	0.0063	0.0823
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0033	0.0429
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0203	0.0597
Onchocerca volvulus		0.0014	0.0063	0.003
Onchocerca volvulus		0.0015	0.0068	0.0036
Brugia malayi	Sugar transporter family protein	0.0015	0.0068	0.0094
Brugia malayi	Serotonin receptor	0.0014	0.0063	0.0087
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0068	0.0254
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0273	0.1012
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0298
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0033	0.0045
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0018	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Toxoplasma gondii	protein kinase, putative	0.0303	0.2246	0.8323
Schistosoma mansoni	glucose transport protein	0.0107	0.0765	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0238	0.0701
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0063	0.0823
Giardia lamblia	Hexose transporter	0.0015	0.0068	0.0254
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0033	0.0429
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.004	0.0253	0.0939
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0107	0.0396
Onchocerca volvulus		0.0015	0.0068	0.0036
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0206	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Brugia malayi	hypothetical protein	0.0015	0.0068	0.0094
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0045	0.0296	0.1098
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0206	0.0926
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0014	0.0063	0.0087
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0135	0.0187
Onchocerca volvulus		0.0014	0.0063	0.003
Loa Loa (eye worm)	hypothetical protein	0.002	0.0107	0.0969
Schistosoma mansoni	myosin xvIII	0.0014	0.0063	0.0823
Entamoeba histolytica	protein kinase, putative	0.0033	0.0203	0.0912
Brugia malayi	G-protein coupled receptor	0.0014	0.0063	0.0087
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0033	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0198	0.1793
Onchocerca volvulus		0.0015	0.0068	0.0036
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0014	0.0063	0.003
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0068	0.0308
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0014	0.0063	0.0823
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0068	0.0308
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Trypanosoma brucei	unspecified product	0.001	0.0032	0.0118
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0068	0.0644
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0033	0.0298
Trypanosoma brucei	telomerase reverse transcriptase	0.0363	0.2698	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0063	0.0823
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.004	0.0253	0.0939
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Echinococcus multilocularis	dro:myosuppressin receptor	0.0014	0.0063	0.0823
Entamoeba histolytica	Flap nuclease, putative	0.0027	0.0156	0.0704
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0206	0.0763
Leishmania major	glucose transporter, lmgt2	0.0033	0.0206	0.0763
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0014	0.0063	0.0823
Echinococcus multilocularis	glycoprotein Antigen 5	0.0038	0.0239	0.3128
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0273	0.257
Brugia malayi	sulfakinin receptor protein	0.0014	0.0063	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0068	0.0201
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.004	0.0253	0.3311
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.0765	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.03	0.2222	0.8237
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Echinococcus granulosus	Mastin	0.0038	0.0239	0.3128
Schistosoma mansoni	sugar transporter	0.0015	0.0068	0.0894
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0063	0.0823
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0203	0.0597
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0068	0.0894
Loa Loa (eye worm)	flap endonuclease-1	0.0027	0.0156	0.1419
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	blooms syndrome DNA helicase	0.0047	0.0308	0.4019
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0108	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0135	0.1769
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0206	0.0763
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0027	0.0156	0.058
Onchocerca volvulus		0.0014	0.0063	0.003
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0298
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0014	0.0063	0.003
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	trypsin family protein	0.0038	0.0239	0.2171
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0008	0.0018	0.0025
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0033	0.0429
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Giardia lamblia	Sgs1 DNA helicase, putative	0.004	0.0253	0.0939
Loa Loa (eye worm)	melatonin receptor type 1A	0.0014	0.0063	0.0572
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0063	0.0823
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.0765	1
Entamoeba histolytica	recQ family helicase, putative	0.0045	0.0296	0.1333
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0011	0.004	0.015
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.004	0.0253	0.0349
Echinococcus multilocularis	bloom syndrome protein	0.0067	0.046	0.6011
Schistosoma mansoni	hypothetical protein	0.0014	0.0063	0.0823
Echinococcus multilocularis	shaker cognate	0.0008	0.0018	0.0237
Brugia malayi	Flap endonuclease-1	0.0027	0.0156	0.0216
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.0765	0.3444
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0203	0.1839
Loa Loa (eye worm)	G-protein coupled receptor	0.0014	0.0063	0.0572
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0014	0.0063	0.0823
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0008	0.0018	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0063	0.0823
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.03	0.2222	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.2171
Entamoeba histolytica	protein kinase, putative	0.0033	0.0203	0.0912
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0018	0.0237
Echinococcus granulosus	voltage gated potassium channel	0.0008	0.0018	0.0237
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0068	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0173	0.1265	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0067	0.0092
Echinococcus granulosus	neuropeptide receptor A26	0.0014	0.0063	0.0823
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0238	0.0882
Onchocerca volvulus		0.0014	0.0063	0.003
Schistosoma mansoni	histamine h1 receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0198	0.2583
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0118	0.111
Echinococcus multilocularis	g protein coupled receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Plasmodium falciparum	protein kinase 6	0.0456	0.3396	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Brugia malayi	Telomerase reverse transcriptase	0.0966	0.7256	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0206	0.0763
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0027	0.0156	0.058
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.004	0.2978
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0015	0.0067	0.03
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.2171
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0198	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0067	0.0605
Echinococcus granulosus	neuropeptide s receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0198	0.1793
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0135	0.0502
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0038	0.0239	0.3128
Brugia malayi	Dopamine receptor protein 2	0.0014	0.0063	0.0087
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0014	0.0063	0.0823
Echinococcus granulosus	neuropeptide Y receptor	0.0014	0.0063	0.0823
Brugia malayi	Serotonin receptor	0.0014	0.0063	0.0087
Brugia malayi	Trypsin-like protease protein 5	0.0038	0.0239	0.033
Onchocerca volvulus		0.0014	0.0063	0.003
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0135	0.1769
Brugia malayi	Melatonin receptor type 1A	0.0014	0.0063	0.0087
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.0765	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0033	0.0429
Echinococcus multilocularis	serotonin receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0033	0.0298
Schistosoma mansoni	vesicular amine transporter	0.0008	0.0018	0.0237
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0206	0.0926
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0033	0.0429
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0027	0.0156	0.058
Schistosoma mansoni	protein kinase	0.0033	0.0203	0.2648
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0135	0.0502
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0068	0.0254
Onchocerca volvulus		0.0014	0.0063	0.003
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	0.2222	1
Brugia malayi	Trypsin family protein	0.0038	0.0239	0.033
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.004	0.0253	0.3311
Trypanosoma brucei	unspecified product	0.0035	0.0222	0.0822
Leishmania major	glucose transporter, lmgt3	0.0033	0.0206	0.0763
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0118	0.0437
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Echinococcus granulosus	solute carrier family 22	0.0015	0.0068	0.0894
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0206	0.0763
Echinococcus multilocularis	dna polymerase eta	0.0015	0.0067	0.0871
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0135	0.1275
Schistosoma mansoni	DNA helicase recq1	0.004	0.0253	0.3311
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0014	0.0063	0.0823
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0008	0.0018	0.0237
Trichomonas vaginalis	DNA helicase recq, putative	0.0067	0.046	0.207
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0014	0.0063	0.0572
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0203	0.2648
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0187	0.2448
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.0765	0.2837
Echinococcus granulosus	neuropeptide FF receptor 2	0.0014	0.0063	0.0823
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0068	1
Onchocerca volvulus		0.0015	0.0068	0.0036
Echinococcus granulosus	g protein coupled receptor	0.0014	0.0063	0.0823
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0198	0.0272
Schistosoma mansoni	opsin-like receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0068	0.0308
Plasmodium vivax	sugar transporter, putative	0.0015	0.0068	0.0201
Brugia malayi	neuropeptide F receptor	0.0014	0.0063	0.0087
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Onchocerca volvulus		0.0014	0.0063	0.003
Brugia malayi	ecdysteroid receptor	0.001	0.0033	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1103	1
Echinococcus granulosus	neuropeptide receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Schistosoma mansoni	opsin-like receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0063	0.0823
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0015	0.0067	0.0871
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0135	0.0502
Giardia lamblia	Telomerase catalytic subunit	0.0363	0.2698	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Schistosoma mansoni	hypothetical protein	0.0014	0.0063	0.0823
Echinococcus multilocularis	potassium voltage gated channel protein	0.0008	0.0018	0.0237
Echinococcus granulosus	7TM GPCR rhodopsin	0.0014	0.0063	0.0823
Onchocerca volvulus		0.0015	0.0068	0.0036
Loa Loa (eye worm)	RecQ helicase	0.0067	0.046	0.4173
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0038	0.0239	0.3128
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Mycobacterium tuberculosis	Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed))	0.0007	0.0006	0.0052
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0038	0.0239	0.3128
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0118	0.0437
Schistosoma mansoni	neuropeptide receptor	0.0014	0.0063	0.0823
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0363	0.2698	1
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0206	0.0926
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0033	0.0429
Schistosoma mansoni	hypothetical protein	0.0038	0.0239	0.3128
Onchocerca volvulus		0.0015	0.0068	0.0036
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0108	0.1018
Onchocerca volvulus		0.0038	0.0239	0.0207
Echinococcus granulosus	fmrfamide receptor	0.0014	0.0063	0.0823
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0033	0.0045
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Toxoplasma gondii	RNA-directed DNA polymerase	0.0363	0.2698	1
Echinococcus multilocularis	serotonin receptor	0.0014	0.0063	0.0823
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0033	0.0429
Echinococcus granulosus	g-protein coupled receptor	0.0014	0.0063	0.0823
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0206	0.0926
Brugia malayi	Trypsin family protein	0.0038	0.0239	0.033
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0068	0.0894
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0014	0.0063	0.0823
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0203	0.1839
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0203	0.2648
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0203	0.0597
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0015	0.0067	0.0605
Onchocerca volvulus		0.0014	0.0063	0.003
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	0.2222	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0083	0.0308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Schistosoma mansoni	neuropeptide F-like receptor	0.0014	0.0063	0.0823
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Schistosoma mansoni	adenoreceptor	0.0014	0.0063	0.0823
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0033	0.0045
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0203	0.0912
Trypanosoma cruzi	hexose transporter	0.0033	0.0206	0.0763
Brugia malayi	follicle stimulating hormone receptor	0.0014	0.0063	0.0087
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0038	0.0239	0.3128
Brugia malayi	G-protein coupled receptor	0.0014	0.0063	0.0087
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0014	0.0063	0.0087
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0014	0.0063	0.0823
Echinococcus multilocularis	G protein coupled receptor 139	0.0014	0.0063	0.0823
Plasmodium falciparum	flap endonuclease 1	0.0027	0.0156	0.0461
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0068	0.0308
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0033	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Onchocerca volvulus		0.0015	0.0068	0.0036
Echinococcus granulosus	G protein coupled receptor 139	0.0014	0.0063	0.0823
Onchocerca volvulus		0.0014	0.0063	0.003
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0033	0.0429
Echinococcus granulosus	hypothetical protein	0.0014	0.0063	0.0823
Schistosoma mansoni	protein kinase	0.0033	0.0203	0.2648
Onchocerca volvulus		0.0038	0.0239	0.0207
Echinococcus granulosus	neuropeptides capa receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus multilocularis	allatostatin A receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus multilocularis	neuropeptide s receptor	0.0014	0.0063	0.0823
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0092	0.034
Echinococcus multilocularis	g-protein coupled receptor	0.0014	0.0063	0.0823
Mycobacterium ulcerans	sugar transporter	0.0015	0.0068	0.0644
Onchocerca volvulus		0.0015	0.0068	0.0036
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0014	0.0063	0.0823
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0135	0.1275
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0198	0.2583
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0033	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.004	0.0253	0.3311
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	glucose transporter	0.0015	0.0068	0.0894
Trypanosoma brucei	unspecified product	0.001	0.0032	0.0118
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0108	0.1018
Trypanosoma cruzi	DNA polymerase eta, putative	0.0015	0.0067	0.0247
Brugia malayi	larval opioid receptor	0.0014	0.0063	0.0087
Schistosoma mansoni	sugar transporter	0.0015	0.0068	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0298
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0063	0.0823
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0206	0.0763
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0033	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.0765	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0014	0.0063	0.0572
Echinococcus multilocularis	orexin receptor type 2	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0135	0.1769
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Schistosoma mansoni	hypothetical protein	0.0014	0.0063	0.0823
Schistosoma mansoni	hypothetical protein	0.0038	0.0239	0.3128
Onchocerca volvulus		0.0038	0.0239	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Trypanosoma brucei	DNA polymerase eta, putative	0.0015	0.0067	0.0247
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0118	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	DNA helicase recq5	0.004	0.0253	0.3311
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0238	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Brugia malayi	steroid hormone receptor	0.001	0.0033	0.0045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0014	0.0063	0.0823
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0014	0.0063	0.0572
Schistosoma mansoni	opsin-like receptor	0.0014	0.0063	0.0823
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0033	0.0298
Onchocerca volvulus	Putative transporter	0.0015	0.0068	0.0036
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0068	0.0094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0008	0.0018	0.0237
Onchocerca volvulus		0.0014	0.0063	0.003
Echinococcus granulosus	tm gpcr rhodopsin	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.2171
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0203	0.0751
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0135	0.1769
Echinococcus granulosus	biogenic amine 5HT receptor	0.0014	0.0063	0.0823
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0203	0.0752
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0033	0.0429
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0018	0.0237
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0033	0.0045
Brugia malayi	hypothetical protein	0.0015	0.0068	0.0094
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0456	0.3396	1
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0018	0.0237
Brugia malayi	Sugar transporter family protein	0.0015	0.0068	0.0094
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0008	0.0018	0.0237
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0008	0.0018	0.0237
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.004	0.0253	0.0746
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0107	0.0396
Echinococcus multilocularis	neuropeptide receptor	0.0014	0.0063	0.0823
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0173	0.1265	0.3724
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.0765	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0273	0.1012
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0038	0.0239	0.3128
Echinococcus multilocularis	somatostatin receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	neuropeptide f receptor 76f	0.0014	0.0063	0.0823
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0033	0.0045
Schistosoma mansoni	hypothetical protein	0.0107	0.0765	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0152	0.1379
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0196	0.1774
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0273	0.1012
Leishmania major	telomerase reverse transcriptase, putative	0.0363	0.2698	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0203	0.0597
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	0.2222	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0068	0.0894
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0015	0.0067	0.0628
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0018	0.0237
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0033	0.0045
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0068	0.0254
Echinococcus multilocularis	neuropeptide Y receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	cercarial elastase (S01 family)	0.0038	0.0239	0.3128
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Echinococcus granulosus	bloom syndrome protein	0.0067	0.046	0.6011
Echinococcus multilocularis	neuropeptides capa receptor	0.0014	0.0063	0.0823
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0008	0.0018	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0068	0.062
Brugia malayi	putative neuropeptide receptor	0.0014	0.0063	0.0087
Onchocerca volvulus		0.0014	0.0063	0.003
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0068	0.0644
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0038	0.0239	0.3128
Echinococcus granulosus	solute carrier family 22	0.0015	0.0068	0.0894
Brugia malayi	hypothetical protein	0.0038	0.0239	0.033
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0238	0.0882
Echinococcus granulosus	flap endonuclease 1	0.0027	0.0156	0.2044
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0206	0.0763
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0068	0.0094
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0206	0.0926
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0068	0.0894
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0033	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Brugia malayi	major facilitator superfamily protein	0.0015	0.0068	0.0094
Echinococcus granulosus	allatostatin A receptor	0.0014	0.0063	0.0823
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0068	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0239	0.2171
Leishmania major	glucose transporter, lmgt1	0.0033	0.0206	0.0763
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0238	0.0882
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0033	0.0429
Brugia malayi	nuclear hormone receptor	0.001	0.0033	0.0045
Echinococcus granulosus	somatostatin receptor	0.0014	0.0063	0.0823
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0033	0.0429
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Echinococcus granulosus	enteropeptidase	0.0038	0.0239	0.3128
Brugia malayi	hypothetical protein	0.0014	0.0063	0.0087
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0118	0.0437
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Loa Loa (eye worm)	hypothetical protein	0.001	0.0033	0.0298
Schistosoma mansoni	amine GPCR	0.0014	0.0063	0.0823
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0135	0.0502
Schistosoma mansoni	glucose transport protein	0.0107	0.0765	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0196	0.0725
Entamoeba histolytica	recQ family helicase, putative	0.0019	0.0101	0.0454
Giardia lamblia	Flap structure-specific endonuclease	0.0027	0.0156	0.058
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0027	0.0156	0.058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0033	0.0298
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0014	0.0063	0.0823
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0068	0.0254
Brugia malayi	polk-prov protein	0.0032	0.0196	0.027
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0015	0.0067	0.0871
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0054	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0063	0.0572
Brugia malayi	nuclear receptor NHR-88	0.001	0.0033	0.0045
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0206	0.0763
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0033	0.0429
Plasmodium falciparum	hexose transporter	0.0107	0.0765	0.2253
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0068	0.0894
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0014	0.0063	0.0823
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0014	0.0063	0.0823
Brugia malayi	G protein-coupled receptor	0.0014	0.0063	0.0087
Loa Loa (eye worm)	TYRA-2 protein	0.0014	0.0063	0.0572
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0033	0.0429
Echinococcus granulosus	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0068	0.0254
Onchocerca volvulus		0.0015	0.0068	0.0036
Schistosoma mansoni	biogenic amine receptor	0.0014	0.0063	0.0823
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0014	0.0063	0.0823
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0068	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0068	0.0308
Brugia malayi	Trypsin family protein	0.0038	0.0239	0.033
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0008	0.0018	0.0237
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0014	0.0063	0.0823
Schistosoma mansoni	DNA polymerase eta	0.0015	0.0067	0.0871

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 589 nM	Inhibition of Kv1.5	ChEMBL.	16949818
IC50 (binding)	= 589 nM	Inhibition of Kv1.5	ChEMBL.	16949818
Ratio (ADMET)	< 3	P-gp substrate susceptibility as ratio of B-to-A vs A-to-B transport	ChEMBL.	16949818
Ratio (ADMET)	< 3	P-gp substrate susceptibility as ratio of B-to-A vs A-to-B transport	ChEMBL.	16949818

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL439539
PubChem: 16068517

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 375868