Detailed information for compound 377365

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1068.14 | Formula: C49H79F6NO17
  • H donors: 5 H acceptors: 7 LogP: 4.05 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@H]([C@@H]([C@H]2O)N(C)C)O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)O)O)[C@@H](CCOC(C(F)(F)F)C(F)(F)F)C[C@H](C(=O)/C=C/C(=C/[C@@H]1CO[C@@H]1O[C@H](C)[C@H]([C@H]([C@H]1OC)OC)O)/C)C
  • InChi: 1S/C49H79F6NO17/c1-13-33-30(22-67-45-42(65-12)41(64-11)37(60)26(5)69-45)18-23(2)14-15-31(57)24(3)19-29(16-17-66-46(48(50,51)52)49(53,54)55)39(25(4)32(58)20-34(59)71-33)73-44-38(61)36(56(9)10)40(27(6)70-44)72-35-21-47(8,63)43(62)28(7)68-35/h14-15,18,24-30,32-33,35-46,58,60-63H,13,16-17,19-22H2,1-12H3/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,47-/m1/s1
  • InChiKey: QNDGMWYLNUORHW-KSUBGMHHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Srms 0.012 0.0439 0.149
Schistosoma mansoni hypothetical protein 0.0041 0.0045 0.0153
Echinococcus granulosus tyrosine protein kinase HCK 0.0108 0.0377 0.1279
Schistosoma mansoni tyrosine kinase 0.0132 0.0499 0.1696
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0037 0.0022 0.0074
Echinococcus granulosus twitchin 0.0121 0.0445 0.151
Brugia malayi basement membrane proteoglycan precursor 0.0041 0.0045 0.0045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0208 0.0208
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0041 0.0045 0.0153
Echinococcus multilocularis peroxidasin 0.0074 0.0208 0.0706
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0041 0.0045 0.0153
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.005 0.0089 0.0232
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.062 0.2944 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0132 0.0499 0.1696
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0018 0.0061
Echinococcus granulosus c src tyrosine kinase 0.0036 0.0018 0.0061
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0084 0.0259 0.0878
Entamoeba histolytica protein kinase, putative 0.0108 0.0377 1
Loa Loa (eye worm) loechrig isoform VII 0.0037 0.0022 0.0022
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.062 0.2944 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0295 0.1313 0.4418
Schistosoma mansoni cell adhesion molecule 0.0074 0.0208 0.0706
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0035 0.0012 0.0039
Brugia malayi Immunoglobulin I-set domain containing protein 0.0089 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0084
Schistosoma mansoni nephrin 0.0074 0.0208 0.0706
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0078 0.023 0.0712
Loa Loa (eye worm) SRC-1 0.0132 0.0499 0.0499
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0041 0.0045 0.0153
Echinococcus multilocularis hemicentin 1 0.0074 0.0208 0.0706
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.062 0.2944 1
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0037 0.0022 0.0074
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0078 0.023 0.0712
Echinococcus multilocularis netrin receptor unc 5 0.0041 0.0045 0.0153
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.062 0.2944 1
Echinococcus multilocularis neuroglian 0.0121 0.0445 0.151
Schistosoma mansoni peroxidasin 0.0041 0.0045 0.0153
Schistosoma mansoni septate junction protein 0.0074 0.0208 0.0706
Schistosoma mansoni tyrosine kinase 0.0132 0.0499 0.1696
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0041 0.0045 0.0153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Schistosoma mansoni netrin receptor unc5 0.0041 0.0045 0.0153
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0074 0.0208 0.0218
Echinococcus multilocularis Immunoglobulin 0.0041 0.0045 0.0153
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.062 0.2944 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0084 0.0259 0.0272
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0074 0.0208 0.0706
Trypanosoma cruzi GMP reductase 0.062 0.2944 1
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0037 0.0022 0.0074
Schistosoma mansoni chloride channel protein 0.0037 0.0022 0.0074
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0035 0.0012 0.0039
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0074 0.0208 0.0706
Schistosoma mansoni protein kinase subunit gamma 0.0037 0.0022 0.0074
Schistosoma mansoni cell adhesion molecule 0.013 0.049 0.1663
Onchocerca volvulus 0.0078 0.023 0.0242
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.062 0.2944 1
Brugia malayi vesicle-fusing ATPase 0.0049 0.0084 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.023 0.0712
Brugia malayi Immunoglobulin domain containing protein 0.0041 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0132 0.0499 0.1696
Loa Loa (eye worm) hypothetical protein 0.013 0.049 0.049
Schistosoma mansoni basigin related 0.0041 0.0045 0.0153
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0074 0.0208 0.0706
Schistosoma mansoni basigin related 0.0041 0.0045 0.0153
Brugia malayi Fibronectin type III domain containing protein 0.0089 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0089 0.0282 0.0282
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0084 0.0259 0.5
Giardia lamblia AAA family ATPase 0.005 0.0089 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0652 0.0652
Brugia malayi CLC chloride channel protein 0.0037 0.0022 0.0022
Echinococcus granulosus roundabout 2 0.0163 0.0652 0.2216
Loa Loa (eye worm) LAD-2 short isoform 0.0041 0.0045 0.0045
Trypanosoma cruzi GMP reductase 0.062 0.2944 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0089 0.0282 0.0958
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.062 0.2944 0.2944
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Loa Loa (eye worm) vesicle-fusing ATPase 0.0049 0.0084 0.0084
Schistosoma mansoni vesicular amine transporter 0.0089 0.0282 0.0958
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.062 0.2944 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0132 0.0499 0.1696
Brugia malayi Immunoglobulin domain containing protein 0.0041 0.0045 0.0045
Brugia malayi Peroxidasin 0.0074 0.0208 0.0208
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0041 0.0045 0.0153
Brugia malayi AMP-binding enzyme family protein 0.0078 0.023 0.023
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.008 0.0237 0.0736
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0037 0.0022 0.0074
Echinococcus granulosus tyrosine kinase 0.012 0.0439 0.149
Brugia malayi valosin containing protein 0.0049 0.0084 0.0084
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0036 0.0018 0.0061
Schistosoma mansoni cell division control protein 48 aaa family protein 0.008 0.0237 0.0805
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0041 0.0045 0.0153
Brugia malayi protein-tyrosine kinase 0.012 0.0439 0.0439
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0041 0.0045 0.0153
Schistosoma mansoni hypothetical protein 0.0041 0.0045 0.0153
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0037 0.0022 0.0074
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Echinococcus granulosus neuroglian 0.0074 0.0208 0.0706
Schistosoma mansoni septate junction protein 0.0074 0.0208 0.0706
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.062 0.2944 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0078 0.023 0.0712
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0295 0.1313 0.4418
Brugia malayi Voltage gated chloride channel family protein 0.0037 0.0022 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0115 0.0317
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0132 0.0499 0.1696
Loa Loa (eye worm) hypothetical protein 0.0089 0.0282 0.0282
Echinococcus multilocularis Immunoglobulin subtype 0.0041 0.0045 0.0153
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0109 0.0381 0.1293
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2029 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0282 0.0282
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0041 0.0045 0.0153
Brugia malayi chloride channel protein 7 0.0037 0.0022 0.0022
Onchocerca volvulus Tyrosine kinase homolog 0.1931 0.951 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0045 0.0045
Echinococcus granulosus lachesin 0.0074 0.0208 0.0706
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Treponema pallidum Mg2+ transport protein (mgtE) 0.0037 0.0022 0.5
Echinococcus granulosus roundabout 2 0.0074 0.0208 0.0706
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.023 0.0712
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Echinococcus granulosus roundabout 2 0.0074 0.0208 0.0706
Echinococcus granulosus low density lipoprotein receptor ldl 0.0041 0.0045 0.0153
Schistosoma mansoni nephrin related 0.0041 0.0045 0.0153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0045 0.0045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0208 0.0208
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0074 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Echinococcus multilocularis Immunoglobulin 0.0089 0.0282 0.0958
Echinococcus multilocularis Immunoglobulin 0.0041 0.0045 0.0153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0045
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0041 0.0045 0.0045
Echinococcus granulosus tyrosine protein kinase Src64B 0.0132 0.0499 0.1696
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.023 0.0712
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0131 0.0372
Schistosoma mansoni hypothetical protein 0.0041 0.0045 0.0153
Brugia malayi ancient conserved domain protein 2 0.0037 0.0022 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.023 0.0712
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0078 0.023 0.0712
Brugia malayi Immunoglobulin I-set domain containing protein 0.0044 0.0058 0.0058
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0074 0.0208 0.0706
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0258 0.1128 0.1128
Leishmania major inosine-5-monophosphate dehydrogenase 0.062 0.2944 1
Brugia malayi SRC-1 0.0132 0.0499 0.0499
Echinococcus multilocularis tyrosine protein kinase Blk 0.012 0.0439 0.149
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.008 0.0237 0.0488
Loa Loa (eye worm) TK protein kinase 0.0108 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0041 0.0045 0.0153
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0084 0.0259 0.0878
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0041 0.0045 0.0153
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0044 0.0058 0.0196
Brugia malayi AMP-binding enzyme family protein 0.0078 0.023 0.023
Loa Loa (eye worm) chloride channel 3 0.0037 0.0022 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0078 0.023 0.0712
Echinococcus granulosus Immunoglobulin 0.0041 0.0045 0.0153
Echinococcus granulosus H:Cl exchange transporter 4 0.0037 0.0022 0.0074
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0258 0.1128 0.1128
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Loa Loa (eye worm) TK protein kinase 0.0044 0.0058 0.0058
Echinococcus granulosus Immunoglobulin 0.0041 0.0045 0.0153
Schistosoma mansoni septate junction protein 0.0041 0.0045 0.0153
Loa Loa (eye worm) TK protein kinase 0.012 0.0439 0.0439
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0037 0.0022 0.0074
Echinococcus granulosus tyrosine protein kinase Fyn 0.0132 0.0499 0.1696
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0132 0.0499 0.1696
Echinococcus granulosus contactin 0.0074 0.0208 0.0706
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0041 0.0045 0.0153
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0132 0.0499 0.1696
Echinococcus granulosus defective proboscis extension response 0.0089 0.0282 0.0958
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0084 0.0259 0.0878
Echinococcus granulosus tyrosine protein kinase Src42A 0.0109 0.0381 0.1293
Schistosoma mansoni cell adhesion molecule 0.0041 0.0045 0.0153
Echinococcus granulosus neuroglian 0.0121 0.0445 0.151
Mycobacterium ulcerans ATPase 0.005 0.0089 0.0232
Schistosoma mansoni tyrosine kinase 0.0086 0.0266 0.0902
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.012 0.0439 0.149
Echinococcus granulosus tyrosine protein kinase Src42A 0.0132 0.0499 0.1696
Schistosoma mansoni chloride channel protein 0.0037 0.0022 0.0074
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0037 0.0022 0.0074
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0132 0.0499 0.1696
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0045 0.0045
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0045 0.0045
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0131 0.0397
Echinococcus granulosus basement membrane specific heparan sulfate 0.0041 0.0045 0.0153
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.008 0.0237 0.0405
Brugia malayi CBS domain containing protein 0.0037 0.0022 0.0022
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0059 0.0131 1
Trypanosoma cruzi Valosin-containing protein, putative 0.008 0.0237 0.0736
Echinococcus granulosus tyrosine protein kinase Blk 0.012 0.0439 0.149
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0132 0.0499 0.1696
Schistosoma mansoni roundabout 0.0074 0.0208 0.0706
Schistosoma mansoni tyrosine kinase 0.0036 0.0018 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0115 0.0317
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0045 0.0045
Brugia malayi Heparan sulfate 0.0041 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Treponema pallidum hemolysin (tlyC) 0.0037 0.0022 0.5
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0041 0.0045 0.0153
Echinococcus multilocularis c src tyrosine kinase 0.0036 0.0018 0.0061
Loa Loa (eye worm) GMP reductase 0.0258 0.1128 0.1128
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0045 0.0045
Echinococcus multilocularis roundabout 2 0.0074 0.0208 0.0706
Toxoplasma gondii cell division protein CDC48CY 0.0084 0.0259 0.081
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.062 0.2944 1
Echinococcus granulosus H:Cl exchange transporter 3 0.0037 0.0022 0.0074
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0584 0.276 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0018 0.0061
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0044 0.0058 0.0196
Schistosoma mansoni cell adhesion molecule 0.0041 0.0045 0.0153
Schistosoma mansoni cell adhesion molecule 0.0074 0.0208 0.0706
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.023 0.0712
Schistosoma mansoni hypothetical protein 0.0041 0.0045 0.0153
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0584 0.276 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.062 0.2944 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0282 0.0282
Echinococcus granulosus tyrosine protein kinase Fyn 0.0132 0.0499 0.1696
Trypanosoma brucei Valosin-containing protein 0.008 0.0237 0.0736
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0132 0.0499 0.1696
Echinococcus granulosus Immunoglobulin 0.0089 0.0282 0.0958
Toxoplasma gondii cell division protein CDC48AP 0.005 0.0089 0.0232
Schistosoma mansoni nephrin 0.0121 0.0445 0.151
Echinococcus granulosus hemicentin 1 0.0074 0.0208 0.0706
Echinococcus multilocularis neuroglian 0.0074 0.0208 0.0706
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Echinococcus granulosus netrin receptor unc 5 0.0041 0.0045 0.0153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0131 0.0372
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0018 0.0061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Brugia malayi ancient conserved domain protein 4 0.0037 0.0022 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0078 0.023 0.023
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0074 0.0208 0.0208
Loa Loa (eye worm) IMP dehydrogenase 1 0.062 0.2944 0.2944
Schistosoma mansoni titin 0.0074 0.0208 0.0706
Loa Loa (eye worm) hypothetical protein 0.0078 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0045
Echinococcus multilocularis tyrosine protein kinase HCK 0.0108 0.0377 0.1279
Loa Loa (eye worm) hypothetical protein 0.0078 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0074 0.0208 0.0706
Echinococcus multilocularis tyrosine protein kinase otk 0.0074 0.0208 0.0706
Echinococcus multilocularis Immunoglobulin 0.0089 0.0282 0.0958
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0037 0.0022 0.0074
Mycobacterium ulcerans hypothetical protein 0.0078 0.023 0.0712
Echinococcus multilocularis tyrosine protein kinase Abl 0.0036 0.0018 0.0061
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0132 0.0499 0.1696
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0035 0.0012 0.0012
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0089 0.0282 0.0958
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0045
Echinococcus granulosus tyrosine protein kinase otk 0.0074 0.0208 0.0706
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.013 0.049 0.1663
Echinococcus multilocularis roundabout 2 0.0074 0.0208 0.0706
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0074 0.0208 0.0706
Echinococcus multilocularis lachesin 0.0074 0.0208 0.0706
Loa Loa (eye worm) hypothetical protein 0.0074 0.0208 0.0208
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0037 0.0022 0.0074
Loa Loa (eye worm) hypothetical protein 0.0163 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0045
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.008 0.0237 0.0786
Brugia malayi Immunoglobulin domain containing protein 0.0041 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0089 0.0282 0.0282
Loa Loa (eye worm) chloride channel protein 7 0.0037 0.0022 0.0022
Echinococcus granulosus Immunoglobulin subtype 0.0041 0.0045 0.0153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0208 0.0208
Echinococcus granulosus peroxidasin 0.0074 0.0208 0.0706
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0041 0.0045 0.0153
Mycobacterium tuberculosis Putative conserved ATPase 0.005 0.0089 0.0232
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0584 0.276 0.9369
Toxoplasma gondii IMP dehydrogenas 0.062 0.2944 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0044 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0078 0.023 0.023
Brugia malayi Prion-like- 0.0074 0.0208 0.0208
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0078 0.023 0.0712
Loa Loa (eye worm) hypothetical protein 0.0037 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Fyn 0.0132 0.0499 0.1696
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0041 0.0045 0.0153
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0326 0.1469 0.4951
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0089 0.0282 0.0958
Echinococcus multilocularis roundabout 2 0.0163 0.0652 0.2216
Brugia malayi Tyrosine-protein kinase abl-1 0.0036 0.0018 0.0018
Trypanosoma brucei GMP reductase 0.062 0.2944 1
Entamoeba histolytica cdc48-like protein, putative 0.008 0.0237 0.0488
Onchocerca volvulus 0.1887 0.929 0.9768
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0074 0.0208 0.0706
Brugia malayi hypothetical protein 0.0041 0.0045 0.0045
Leishmania major guanosine monophosphate reductase 0.062 0.2944 1
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0037 0.0022 0.0074
Schistosoma mansoni cell adhesion molecule 0.0074 0.0208 0.0706
Schistosoma mansoni basigin related 0.0041 0.0045 0.0153
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Schistosoma mansoni neuroglian 0.0074 0.0208 0.0706
Echinococcus granulosus tyrosine protein kinase Lyn 0.0132 0.0499 0.1696
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.062 0.2944 1
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0041 0.0045 0.0153
Echinococcus granulosus H:Cl exchange transporter 7 0.0037 0.0022 0.0074
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0078 0.023 0.0712
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0132 0.0499 0.1696
Brugia malayi basement membrane proteoglycan 0.0041 0.0045 0.0045
Echinococcus multilocularis hemicentin 1 0.0074 0.0208 0.0706
Schistosoma mansoni chloride channel protein 0.0037 0.0022 0.0074
Schistosoma mansoni netrin receptor unc5 0.0041 0.0045 0.0153
Loa Loa (eye worm) hypothetical protein 0.0089 0.0282 0.0282
Loa Loa (eye worm) VCP protein 0.0035 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.012 0.0439 0.149
Brugia malayi GMP reductase 0.0258 0.1128 0.1128
Schistosoma mansoni hypothetical protein 0.0041 0.0045 0.0153
Onchocerca volvulus Putative GMP reductase 0.0258 0.1128 0.1187
Schistosoma mansoni septate junction protein 0.0041 0.0045 0.0153
Brugia malayi loechrig isoform VII 0.0037 0.0022 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0115 0.0317
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0037 0.0022 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.023 0.0712
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0326 0.1469 0.4951
Onchocerca volvulus 0.0037 0.0022 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.023 0.0712
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0115 0.0317
Brugia malayi hypothetical protein 0.0089 0.0282 0.0282
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0074 0.0208 0.0706

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 4 ug ml-1 In vitro antimicrobial activity against Staphylococcus aureus X1 ChEMBL. 3398001
MIC (functional) = 4 ug ml-1 In vitro antimicrobial activity against Streptococcus epidermidis EPI1 ChEMBL. 3398001
MIC (functional) = 8 ug ml-1 In vitro antimicrobial activity against Staphylococcus pyogenes C203 ChEMBL. 3398001
MIC (functional) = 32 ug ml-1 In vitro antimicrobial activity against Streptococcus pneumoniae ChEMBL. 3398001
MIC (functional) > 128 ug ml-1 In vitro antimicrobial activity against Streptococcus faecium X66 ChEMBL. 3398001
MIC (functional) > 128 ug ml-1 In vitro antimicrobial activity against Haemophilus influenzae. ChEMBL. 3398001

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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