Detailed information for compound 404239

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1071.23 | Formula: C52H74N14O11
  • H donors: 13 H acceptors: 12 LogP: -1.81 Rotable bonds: 35
    Rule of 5 violations (Lipinski): 4
  • SMILES: NC(=NCCCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)C1CCCCC1)Cc1ccc(cc1)O)C(C)C)NC(=O)C(CC(=O)N)N)N
  • InChi: 1S/C52H74N14O11/c1-29(2)42(64-45(70)36(15-9-21-58-52(55)56)60-44(69)35(53)26-41(54)68)48(73)61-37(23-31-17-19-34(67)20-18-31)46(71)65-43(32-13-7-4-8-14-32)49(74)62-38(25-33-27-57-28-59-33)50(75)66-22-10-16-40(66)47(72)63-39(51(76)77)24-30-11-5-3-6-12-30/h3,5-6,11-12,17-20,27-29,32,35-40,42-43,67H,4,7-10,13-16,21-26,53H2,1-2H3,(H2,54,68)(H,57,59)(H,60,69)(H,61,73)(H,62,74)(H,63,72)(H,64,70)(H,65,71)(H,76,77)(H4,55,56,58)
  • InChiKey: JEOOPTWICDJSIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0015
Toxoplasma gondii FATC domain-containing protein 0.1469 0.1858 0.242
Echinococcus granulosus nervana 2 0.0062 0.0038 0.0038
Echinococcus granulosus voltage gated potassium channel 0.0046 0.0018 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0501 0.0606 0.5
Loa Loa (eye worm) hypothetical protein 0.1583 0.2005 0.2005
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0968 0.121 0.121
Loa Loa (eye worm) hypothetical protein 0.0046 0.0018 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.0182 0.0182
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0501 0.0606 0.0606
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.2084 0.2653 0.2653
Trichomonas vaginalis PIKK family atypical protein kinase 0.4596 0.5899 0.5899
Echinococcus multilocularis nervana 2 0.0062 0.0038 0.0038
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0116 0.0108 0.0108
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0501 0.0606 1
Brugia malayi FAT domain containing protein 0.1136 0.1427 0.1427
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1469 0.1858 0.1858
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.538 0.538
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Entamoeba histolytica hypothetical protein 0.0501 0.0606 0.0606
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0501 0.0606 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0501 0.0606 0.0606
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7769 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0501 0.0606 0.0606
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2605 0.3326 0.3253
Trichomonas vaginalis PIKK family atypical protein kinase 0.6633 0.8532 0.8532
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.0606 0.0606
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0116 0.0108 0.0108
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.1136 0.1427 0.1427
Trichomonas vaginalis PIKK family atypical protein kinase 0.4642 0.5959 0.5959
Loa Loa (eye worm) hypothetical protein 0.0968 0.121 0.121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0015
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0606
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Leishmania major phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.4596 0.5899 0.5899
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0116 0.0108 0.0069
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.4188 0.5372 0.5372
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0108 0.0069
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.0606 0.0606
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1469 0.1858 0.1785
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.538 0.538
Entamoeba histolytica hypothetical protein 0.0501 0.0606 0.0606
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7769 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0501 0.0606 0.0606
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0116 0.0108 0.1216
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0523
Mycobacterium tuberculosis Conserved hypothetical protein 0.0501 0.0606 0.5
Entamoeba histolytica protein kinase, putative 0.01 0.0088 0.0088
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Entamoeba histolytica hypothetical protein 0.0501 0.0606 0.0606
Schistosoma mansoni immunophilin 0.0116 0.0108 0.0108
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0094 0.008 0.008
Leishmania major phosphatidylinositol kinase, putative 0.0501 0.0606 0.0504
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.1136 0.1427 0.1427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.7769 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1469 0.1858 0.1858
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0108 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0501 0.0606 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.1469 0.1858 0.1858
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0116 0.0108 0.1216
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2605 0.3326 0.3326
Schistosoma mansoni fkbp-rapamycin associated protein 0.1469 0.1858 0.1858
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.0047 0.0047
Entamoeba histolytica protein kinase, putative 0.01 0.0088 0.0088
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0116 0.0108 0.0108
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0501 0.0606 0.0606
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0159 0.0164 0.0164
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0606 0.0606
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.1637 0.2075 0.2075
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0108 0.0108
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0116 0.0108 0.0108
Trypanosoma cruzi target of rapamycin kinase 3 0.6186 0.7954 0.7946
Loa Loa (eye worm) hypothetical protein 0.1469 0.1858 0.1858
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0501 0.0606 0.0504
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0968 0.121 0.1175
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0501 0.0606 0.0606
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7769 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0501 0.0606 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Trichomonas vaginalis PIKK family atypical protein kinase 0.1469 0.1858 0.1858
Trichomonas vaginalis PIKK family atypical protein kinase 0.4642 0.5959 0.5959
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.4188 0.5372 0.5372
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6186 0.7954 0.7931
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0108 0.0069
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0569
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1469 0.1858 0.1858
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.01 0.0087 0.0087
Entamoeba histolytica protein kinase, putative 0.0094 0.008 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0501 0.0606 0.0606
Leishmania major hypothetical protein, unknown function 0.0501 0.0606 0.0504
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0501 0.0606 0.0569
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0501 0.0606 0.0606
Giardia lamblia GTOR 0.7769 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.7769 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0108 0.0069
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7769 1 1
Schistosoma mansoni hypothetical protein 0.0501 0.0606 0.0606
Echinococcus multilocularis Glutaredoxin protein 5 0.0062 0.0038 0.0038
Echinococcus granulosus Glutaredoxin protein 5 0.0062 0.0038 0.0038
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0606
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2605 0.3326 0.33
Leishmania major phosphatidylinositol kinase related protein, putative 0.0501 0.0606 0.0504
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0501 0.0606 0.0569
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1469 0.1858 0.1858
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0501 0.0606 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0148 0.015 0.015
Echinococcus multilocularis nervana 2 0.0062 0.0038 0.0038
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0501 0.0606 0.0606
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0018 0.0018
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0116 0.0108 0.5
Echinococcus multilocularis 0.0501 0.0606 0.0606
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.0182 0.0182
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0015 0.0015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0015 0.0015
Echinococcus multilocularis fk506 binding protein 0.0116 0.0108 0.0108
Plasmodium vivax hypothetical protein 0.0501 0.0606 1
Trichomonas vaginalis conserved hypothetical protein 0.0968 0.121 0.121
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7769 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2605 0.3326 0.33
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0015 0.0015
Trichomonas vaginalis immunophilin, putative 0.0116 0.0108 0.0108
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0501 0.0606 0.0606
Echinococcus granulosus nervana 2 0.0062 0.0038 0.0038
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7769 1 1
Echinococcus granulosus serine/threonine protein kinase 0.0069 0.0047 0.0047
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3227 0.4129 0.4077
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0606 0.0606
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2605 0.3326 0.3267
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.01 0.0087 0.0087
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7769 1 1
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0501 0.0606 0.0606
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2605 0.3326 0.3326
Schistosoma mansoni immunophilin 0.0116 0.0108 0.0108
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0069 0.0047 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.7769 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5043 0.6477 0.6477
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0015 0.0015
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0159 0.0164 0.0164
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0108 0.0108
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0501 0.0606 0.0606
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2605 0.3326 0.3267
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0047 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0501 0.0606 0.0606
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.0047 0.0047
Leishmania major phosphatidylinositol 3-kinase, putative 0.2605 0.3326 0.3253
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0062 0.0038 0.0038
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0501 0.0606 0.0569
Entamoeba histolytica hypothetical protein 0.1469 0.1858 0.1858
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.538 0.538
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0501 0.0606 0.0606
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Echinococcus granulosus serine protein kinase ATM 0.1469 0.1858 0.1858
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0501 0.0606 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7769 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0501 0.0606 0.0606
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0501 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0501 0.0606 0.0606
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0501 0.0606 0.0606
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3674 0.4707 0.466
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0116 0.0108 0.0108
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0501 0.0606 0.0606
Brugia malayi Protein kinase domain containing protein 0.01 0.0088 0.0088
Entamoeba histolytica protein kinase 2, putative 0.0063 0.0039 0.0039
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6186 0.7954 0.7935
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0063 0.0039 0.0039
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0501 0.0606 0.0569
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0159 0.0164 0.0164
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0008 0.0008
Trypanosoma cruzi Protein kinase B 0.0069 0.0047 0.0008
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0501 0.0606 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0501 0.0606 0.0606
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0116 0.0108 0.0108
Entamoeba histolytica hypothetical protein 0.0501 0.0606 0.0606
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1469 0.1858 0.1826
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0501 0.0606 0.0523
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1469 0.1858 0.1858
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0501 0.0606 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Trichomonas vaginalis fk506-binding protein, putative 0.0116 0.0108 0.0108
Giardia lamblia Hypothetical protein 0.0501 0.0606 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0501 0.0606 0.0606
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2605 0.3326 0.3326
Echinococcus granulosus serine threonine protein kinase nrc 0.0063 0.0039 0.0039
Loa Loa (eye worm) phosphatidylinositol 3 0.2605 0.3326 0.3326
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0159 0.0164 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Trichomonas vaginalis PIKK family atypical protein kinase 0.4642 0.5959 0.5959
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0501 0.0606 0.0606
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7769 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Giardia lamblia Phosphatidylinositol 4-kinase 0.0501 0.0606 0.0569
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0015 0.0015
Echinococcus multilocularis rac serine:threonine kinase 0.0069 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0015 0.0015
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7769 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0501 0.0606 0.0606
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0108 0.002
Loa Loa (eye worm) FKBP5 protein 0.0116 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.7769 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1637 0.2075 0.2075
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0501 0.0606 0.0606
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Schistosoma mansoni immunophilin 0.01 0.0087 0.0087
Onchocerca volvulus 0.0501 0.0606 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0116 0.0108 0.0108
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0501 0.0606 0.0606
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.0018 0.0018
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0501 0.0606 0.0569
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0501 0.0606 0.0606
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Toxoplasma gondii target of rapamycin (TOR), putative 0.5778 0.7427 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0501 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Brugia malayi p70 ribosomal S6 kinase beta 0.0094 0.008 0.008
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0501 0.0606 0.0606
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1136 0.1427 0.1427
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.5211 0.6694 0.6694
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0148 0.015 0.015
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0501 0.0606 0.0606
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0108 0.0069
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7769 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1637 0.2075 0.2715
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0062 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.1136 0.1427 0.1427
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0569
Leishmania major hypothetical protein, conserved 0.0501 0.0606 0.0504
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0501 0.0606 0.0606
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Entamoeba histolytica protein kinase rad3, putative 0.1469 0.1858 0.1858
Leishmania major phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.4188 0.5372 0.5372
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0501 0.0606 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.538 0.538
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0501 0.0606 0.0569
Loa Loa (eye worm) hypothetical protein 0.0138 0.0136 0.0136
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2605 0.3326 0.3326
Trichomonas vaginalis PIKK family atypical protein kinase 0.1469 0.1858 0.1858
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1469 0.1858 0.1826
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0501 0.0606 0.0606
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1469 0.1858 0.1858
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0116 0.0108 0.5
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0501 0.0606 0.0569
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0116 0.0108 0.0108
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0501 0.0606 0.0606
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0063 0.0039 0.0039
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0116 0.0108 0.0108
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.01 0.0087 0.0087
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0501 0.0606 0.0606
Plasmodium vivax hypothetical protein, conserved 0.0501 0.0606 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.01 0.0088 0.0088
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0116 0.0108 0.0069
Onchocerca volvulus 0.0501 0.0606 0.5
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1136 0.1427 0.1427
Echinococcus multilocularis serine protein kinase ATM 0.1469 0.1858 0.1858

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 114 % In vivo residual angiotensin II like activity of the compound was determined in an rat blood pressure assay ChEMBL. 2913307

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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