Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Tubulin gamma chain | 0.0309 | 0.4552 | 0.3589 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0416 | 0.6418 | 0.6683 |
Schistosoma mansoni | alpha tubulin | 0.0416 | 0.6418 | 0.6683 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0416 | 0.6418 | 0.6683 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0416 | 0.6418 | 0.6683 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0309 | 0.4552 | 0.4527 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | tubulin delta chain | 0.0134 | 0.1503 | 0.1565 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0598 | 0.9603 | 1 |
Onchocerca volvulus | 0.0567 | 0.9055 | 0.9674 | |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0416 | 0.6418 | 0.6683 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0241 | 0.3368 | 0.3337 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0416 | 0.6418 | 0.6067 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0598 | 0.9603 | 0.9601 |
Brugia malayi | Tubulin alpha-2 chain | 0.0416 | 0.6418 | 0.5784 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0309 | 0.4552 | 0.3765 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0416 | 0.6418 | 0.6067 |
Echinococcus multilocularis | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3368 | 0.3337 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.4077 | 0.4049 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0598 | 0.9603 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0598 | 0.9603 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0598 | 0.9603 | 1 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0309 | 0.4552 | 0.3765 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0175 | 0.2212 | 0.0876 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0598 | 0.9603 | 1 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0416 | 0.6418 | 0.6067 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0134 | 0.1503 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0175 | 0.2212 | 0.0876 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0217 | 0.0171 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0309 | 0.4552 | 0.3765 |
Echinococcus granulosus | tubulin delta chain | 0.0134 | 0.1503 | 0.1565 |
Echinococcus granulosus | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Echinococcus multilocularis | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Brugia malayi | Tubulin beta chain | 0.0175 | 0.2212 | 0.0835 |
Echinococcus granulosus | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Giardia lamblia | Gamma tubulin | 0.0309 | 0.4552 | 0.3765 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0416 | 0.6418 | 0.6067 |
Trypanosoma brucei | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0416 | 0.6418 | 0.6683 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Schistosoma mansoni | tubulin subunit beta | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0175 | 0.2212 | 0.0876 |
Schistosoma mansoni | alpha tubulin | 0.0416 | 0.6418 | 0.6683 |
Entamoeba histolytica | tubulin family protein | 0.0598 | 0.9603 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0598 | 0.9603 | 0.9533 |
Schistosoma mansoni | tubulin subunit alpha | 0.0416 | 0.6418 | 0.6683 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0416 | 0.6418 | 0.6683 |
Echinococcus multilocularis | beta tubulin | 0.0598 | 0.9603 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0598 | 0.9603 | 0.9601 |
Trypanosoma cruzi | beta tubulin, putative | 0.0598 | 0.9603 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Schistosoma mansoni | tubulin subunit alpha | 0.0416 | 0.6418 | 0.6683 |
Schistosoma mansoni | cell adhesion molecule | 0.0051 | 0.0047 | 0.0049 |
Echinococcus multilocularis | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus granulosus | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0416 | 0.6418 | 0.6683 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0416 | 0.6418 | 0.6683 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0598 | 0.9603 | 0.9601 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0598 | 0.9603 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0598 | 0.9603 | 1 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Toxoplasma gondii | beta tubulin | 0.0598 | 0.9603 | 1 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0416 | 0.6418 | 0.6067 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0598 | 0.9603 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0598 | 0.9603 | 0.9533 |
Schistosoma mansoni | tubulin subunit delta | 0.0134 | 0.1503 | 0.1565 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0416 | 0.6418 | 0.6683 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0134 | 0.1503 | 0.5 |
Giardia lamblia | Alpha-tubulin | 0.0416 | 0.6418 | 0.6067 |
Trypanosoma cruzi | tubulin gamma chain | 0.0309 | 0.4552 | 0.3765 |
Giardia lamblia | Beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0416 | 0.6418 | 0.6683 |
Schistosoma mansoni | tubulin subunit alpha | 0.0416 | 0.6418 | 0.6683 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0598 | 0.9603 | 1 |
Echinococcus granulosus | tubulin alpha | 0.0309 | 0.4552 | 0.474 |
Echinococcus granulosus | tubulin epsilon chain | 0.0309 | 0.4552 | 0.474 |
Treponema pallidum | cell division protein FtsZ | 0.0134 | 0.1503 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0598 | 0.9603 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.0309 | 0.4552 | 0.3765 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0416 | 0.6418 | 0.6683 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0416 | 0.6418 | 0.6683 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0416 | 0.6418 | 0.3693 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0598 | 0.9603 | 0.9601 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0309 | 0.4552 | 0.3765 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0598 | 0.9603 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | tubulin alpha | 0.0309 | 0.4552 | 0.474 |
Echinococcus granulosus | alpha tubulin | 0.0416 | 0.6418 | 0.6683 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0241 | 0.3368 | 0.2303 |
Schistosoma mansoni | tubulin subunit alpha | 0.0134 | 0.1503 | 0.1565 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0416 | 0.6418 | 0.6067 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0416 | 0.6418 | 0.6683 |
Echinococcus granulosus | beta tubulin | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0416 | 0.6418 | 0.6067 |
Trypanosoma brucei | epsilon tubulin | 0.0309 | 0.4552 | 0.3765 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0416 | 0.6418 | 0.6067 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.006 | 0.0217 | 0.0226 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Echinococcus multilocularis | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0175 | 0.2212 | 0.0876 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0309 | 0.4552 | 0.3765 |
Leishmania major | epsilon tubulin, putative | 0.0309 | 0.4552 | 0.3765 |
Trypanosoma brucei | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0282 | 0.4077 | 0.4049 |
Schistosoma mansoni | tubulin subunit beta | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0175 | 0.2212 | 0.0876 |
Plasmodium falciparum | tubulin gamma chain | 0.0309 | 0.4552 | 0.3765 |
Loa Loa (eye worm) | tubulin beta chain | 0.0134 | 0.1503 | 0.1463 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.0309 | 0.4552 | 0.474 |
Plasmodium vivax | tubulin beta chain, putative | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0416 | 0.6418 | 0.6067 |
Trypanosoma brucei | tubulin gamma chain | 0.0309 | 0.4552 | 0.3765 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Mycobacterium leprae | cell division protein FtsZ | 0.0134 | 0.1503 | 0.5 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0134 | 0.1503 | 0.5 |
Schistosoma mansoni | alpha tubulin | 0.0416 | 0.6418 | 0.6683 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0416 | 0.6418 | 0.6401 |
Echinococcus granulosus | tubulin subunit TubB | 0.0416 | 0.6418 | 0.6683 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0416 | 0.6418 | 0.6067 |
Echinococcus multilocularis | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0416 | 0.6418 | 0.6067 |
Echinococcus granulosus | roundabout 2 | 0.006 | 0.0217 | 0.0226 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0416 | 0.6418 | 0.6683 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0416 | 0.6418 | 0.6067 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0416 | 0.6418 | 0.6683 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0309 | 0.4552 | 0.3765 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.6418 | 0.6401 |
Loa Loa (eye worm) | BEN-1 protein | 0.0598 | 0.9603 | 0.9601 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0309 | 0.4552 | 0.3765 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0309 | 0.4552 | 0.3765 |
Plasmodium falciparum | tubulin beta chain | 0.0598 | 0.9603 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0598 | 0.9603 | 0.9601 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Brugia malayi | tubulin alpha-2 chain | 0.0416 | 0.6418 | 0.5784 |
Schistosoma mansoni | tubulin subunit beta | 0.0598 | 0.9603 | 1 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Brugia malayi | Tubulin alpha chain | 0.0416 | 0.6418 | 0.5784 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0621 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Schistosoma mansoni | tubulin subunit gamma | 0.0309 | 0.4552 | 0.474 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0598 | 0.9603 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Brugia malayi | alpha-tubulin | 0.0416 | 0.6418 | 0.5784 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.058 | 0.9286 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0217 | 0.0171 |
Echinococcus multilocularis | tubulin epsilon chain | 0.0309 | 0.4552 | 0.474 |
Giardia lamblia | Alpha-tubulin | 0.0416 | 0.6418 | 0.6067 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0416 | 0.6418 | 0.6683 |
Giardia lamblia | Beta tubulin | 0.0598 | 0.9603 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0416 | 0.6418 | 0.6401 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0416 | 0.6418 | 0.6401 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0175 | 0.2212 | 0.0876 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0309 | 0.4552 | 0.3765 |
Trypanosoma brucei | beta tubulin | 0.0598 | 0.9603 | 1 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0416 | 0.6418 | 0.3693 |
Loa Loa (eye worm) | alpha-tubulin | 0.0416 | 0.6418 | 0.6401 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0134 | 0.1503 | 0.1565 |
Schistosoma mansoni | tubulin subunit epsilon | 0.0309 | 0.4552 | 0.474 |
Loa Loa (eye worm) | tubulin beta chain | 0.0598 | 0.9603 | 0.9601 |
Loa Loa (eye worm) | alpha-tubulin | 0.0416 | 0.6418 | 0.6401 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.0309 | 0.4552 | 0.474 |
Trypanosoma brucei | beta tubulin | 0.0309 | 0.4552 | 0.3765 |
Trypanosoma brucei | epsilon tubulin | 0.0309 | 0.4552 | 0.3765 |
Echinococcus granulosus | tubulin alpha chain | 0.0416 | 0.6418 | 0.6683 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0282 | 0.4077 | 0.4049 |
Giardia lamblia | Beta tubulin | 0.0598 | 0.9603 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0416 | 0.6418 | 0.6067 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0598 | 0.9603 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0051 | 0.0047 | 0.0049 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Leishmania major | gamma-tubulin | 0.0309 | 0.4552 | 0.3765 |
Trichomonas vaginalis | tubulin, putative | 0.0598 | 0.9603 | 1 |
Plasmodium falciparum | alpha tubulin 1 | 0.0416 | 0.6418 | 0.6067 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0107 | 0.1028 | 0.0986 |
Trypanosoma brucei | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Leishmania major | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Echinococcus granulosus | tubulin subunit beta | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0175 | 0.2212 | 0.0876 |
Echinococcus multilocularis | hypothetical protein | 0.0416 | 0.6418 | 0.6683 |
Trypanosoma brucei | beta tubulin | 0.0598 | 0.9603 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0598 | 0.9603 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0598 | 0.9603 | 1 |
Leishmania major | beta tubulin | 0.0598 | 0.9603 | 1 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0416 | 0.6418 | 0.6067 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0416 | 0.6418 | 0.6683 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0416 | 0.6418 | 0.6067 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0282 | 0.4077 | 0.4049 |
Trypanosoma brucei | alpha tubulin | 0.0416 | 0.6418 | 0.6067 |
Brugia malayi | tubulin alpha chain - mouse | 0.0416 | 0.6418 | 0.5784 |
Brugia malayi | Tubulin alpha-2 chain | 0.0416 | 0.6418 | 0.5784 |
Trypanosoma brucei | alpha tubulin, putative | 0.0175 | 0.2212 | 0.0876 |
Echinococcus multilocularis | tubulin subunit beta | 0.0598 | 0.9603 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0282 | 0.4077 | 0.3178 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.007 ug ml-1 | In vitro antibacterial activity of the compound against penicillin-resistant Streptococcus pneumoniae A28272 | ChEMBL. | 15482927 |
MIC (functional) | = 0.06 ug ml-1 | In vitro antibacterial activity of the compound against methicillin-sensitive Staphylococcus aureus A15090 | ChEMBL. | 15482927 |
MIC (functional) | = 0.25 ug ml-1 | In vitro antibacterial activity of the compound against methicillin-sensitive Enterococcus faecalis A20688 | ChEMBL. | 15482927 |
PD50 (functional) | = 2.1 mg kg-1 | In vivo efficacy (PD50) against lethal S. aureus systemic infection model in mice | ChEMBL. | 15482927 |
PD50 (functional) | = 2.1 mg kg-1 | In vivo efficacy (PD50) against lethal S. aureus systemic infection model in mice | ChEMBL. | 15482927 |
Solubility | > 2.7 mg ml-1 | Equilibrium water solubility of the compound at pH 3.8 | ChEMBL. | 15482927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.