Detailed information for compound 415775

Basic information

Technical information
  • TDR Targets ID: 415775
  • Name: 3-(4-benzhydrylpiperazin-1-yl)-2-benzyl-N-hyd roxy-3-oxopropanamide
  • MW: 443.537 | Formula: C27H29N3O3
  • H donors: 2 H acceptors: 3 LogP: 3.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)C(C(=O)N1CCN(CC1)C(c1ccccc1)c1ccccc1)Cc1ccccc1
  • InChi: 1S/C27H29N3O3/c31-26(28-33)24(20-21-10-4-1-5-11-21)27(32)30-18-16-29(17-19-30)25(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,24-25,33H,16-20H2,(H,28,31)
  • InChiKey: KKFNCVBXPPZPPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-benzhydrylpiperazin-1-yl)-2-benzyl-3-oxo-propanehydroxamic acid
  • 3-(4-benzhydryl-1-piperazinyl)-2-benzyl-3-oxopropanehydroxamic acid
  • 3-(4-benzhydrylpiperazin-1-yl)-N-hydroxy-3-oxo-2-(phenylmethyl)propanamide
  • 3-(4-benzhydrylpiperazino)-2-benzyl-3-keto-propanehydroxamic acid
  • 3-[4-[di(phenyl)methyl]piperazin-1-yl]-N-hydroxy-3-oxo-2-(phenylmethyl)propanamide
  • 3-[4-[di(phenyl)methyl]piperazin-1-yl]-3-oxo-2-(phenylmethyl)propanehydroxamic acid
  • 3-[4-[di(phenyl)methyl]-1-piperazinyl]-3-oxo-2-(phenylmethyl)propanehydroxamic acid
  • 2-(benzyl)-3-[4-[di(phenyl)methyl]piperazin-1-yl]-3-keto-propanehydroxamic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.2388 0.2326
Echinococcus granulosus nuclear receptor nhr 48 0.0103 0.1044 0.0971
Brugia malayi hypothetical protein 0.0116 0.126 0.1881
Brugia malayi Steroid receptor seven-up type 2 0.0219 0.3061 0.4596
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0219 0.3061 0.3004
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0569 0.0857
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0072 0.05 0.5
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.1342 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0403 0.0325
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0072 0.05 0.0423
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.1342 0.1271
Plasmodium falciparum transporter, putative 0.0072 0.05 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0103 0.1044 0.1572
Brugia malayi ecdysteroid receptor 0.0219 0.3061 0.4596
Echinococcus granulosus serotonin transporter 0.0425 0.6645 0.6617
Schistosoma mansoni sodium-dependent amino acid transporter 0.0072 0.05 0.0423
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.009 0.081 0.4553
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0103 0.1044 0.0971
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0219 0.3061 0.4606
Schistosoma mansoni steroid hormone receptor ad4bp 0.0219 0.3061 0.3004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0219 0.3061 0.4606
Loa Loa (eye worm) norepinephrine transporter 0.0425 0.6645 1
Echinococcus multilocularis lamin 0.0082 0.0678 0.0602
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0219 0.3061 0.4167
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0403 0.0325
Loa Loa (eye worm) hypothetical protein 0.0219 0.3061 0.4606
Brugia malayi tailless protein 0.0103 0.1044 0.1556
Brugia malayi nuclear receptor RXR 0.0103 0.1044 0.1556
Brugia malayi TAR-binding protein 0.0067 0.0403 0.059
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0678 0.1021
Loa Loa (eye worm) hypothetical protein 0.0219 0.3061 0.4606
Schistosoma mansoni RAR-like nuclear receptor 0.0219 0.3061 0.3004
Schistosoma mansoni thyroid hormone receptor 0.0359 0.549 0.5453
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0072 0.05 0.0736
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Schistosoma mansoni nuclear hormone receptor 0.0103 0.1044 0.0971
Brugia malayi Ets-domain containing protein 0.0076 0.0569 0.084
Schistosoma mansoni intermediate filament proteins 0.0082 0.0678 0.0602
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0191 0.2566 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.3061 0.4606
Loa Loa (eye worm) hypothetical protein 0.0072 0.05 0.0753
Echinococcus granulosus lamin 0.0082 0.0678 0.0602
Loa Loa (eye worm) hypothetical protein 0.0072 0.05 0.0753
Loa Loa (eye worm) hypothetical protein 0.0072 0.05 0.0753
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0403 0.0325
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0569 0.0492
Loa Loa (eye worm) hypothetical protein 0.0116 0.126 0.1897
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0072 0.05 0.0423
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0219 0.3061 0.3004
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.1342 0.2019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0012 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0219 0.3061 0.4596
Brugia malayi nuclear hormone receptor 0.0219 0.3061 0.4596
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.014 0.1674 0.1606
Onchocerca volvulus Protein ultraspiracle homolog 0.0219 0.3061 0.4167
Plasmodium vivax amine transporter, putative 0.0072 0.05 0.5
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.1342 0.1271
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0219 0.3061 0.3004
Loa Loa (eye worm) hypothetical protein 0.0116 0.126 0.1897
Loa Loa (eye worm) follicle stimulating hormone receptor 0.027 0.3942 0.5932
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0103 0.1044 0.0971
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0072 0.05 0.0423
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0219 0.3061 0.3004
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0072 0.05 0.0423
Schistosoma mansoni hypothetical protein 0.0147 0.1801 0.1734
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0208 0.0312
Brugia malayi orphan nuclear receptor NR2E1 0.0103 0.1044 0.1556
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.1342 0.1271
Echinococcus granulosus FTZ F1 alpha 0.0219 0.3061 0.3004
Schistosoma mansoni nuclear hormone receptor 0.0219 0.3061 0.3004
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0103 0.1044 0.0971
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0103 0.1044 0.0971
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0103 0.1044 0.0971
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.2388 0.2326
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0678 0.1004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0219 0.3061 0.3004
Schistosoma mansoni nuclear receptor 0.0103 0.1044 0.0971
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Loa Loa (eye worm) hypothetical protein 0.0425 0.6645 1
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.126 0.1881
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0103 0.1044 0.1572
Brugia malayi conserved hypotetical protein 0.0103 0.1044 0.1556
Echinococcus multilocularis nuclear receptor nhr 48 0.0103 0.1044 0.0971
Brugia malayi hypothetical protein 0.0103 0.1044 0.1556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0219 0.3061 0.4606
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0072 0.05 0.0753
Loa Loa (eye worm) nuclear receptor NHR-67 0.0103 0.1044 0.1572
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.1342 1
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.1342 1
Brugia malayi phosphofructokinase 0.0121 0.1342 0.2004
Loa Loa (eye worm) RNA binding protein 0.0067 0.0403 0.0607
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0219 0.3061 0.4596
Schistosoma mansoni ets-related 0.0231 0.3268 0.3213
Onchocerca volvulus 0.0082 0.0678 0.029
Loa Loa (eye worm) hypothetical protein 0.0219 0.3061 0.4606
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0219 0.3061 0.3004
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0569 0.0492
Brugia malayi steroid hormone receptor 0.0219 0.3061 0.4596
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0126 0.1444 1
Schistosoma mansoni jun-related protein 0.0147 0.1801 0.1734
Echinococcus multilocularis FTZ F1 alpha 0.0219 0.3061 0.3004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0116 0.126 0.1189
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0072 0.05 0.0423
Loa Loa (eye worm) hypothetical protein 0.0425 0.6645 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0219 0.3061 0.3004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0219 0.3061 0.4596
Onchocerca volvulus 0.0103 0.1044 0.0885
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Schistosoma mansoni alpha-glucosidase 0.0156 0.1951 0.1885
Plasmodium vivax hypothetical protein, conserved 0.0072 0.05 0.5
Brugia malayi 6-phosphofructokinase 0.0121 0.1342 0.2004
Loa Loa (eye worm) hypothetical protein 0.0425 0.6645 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0116 0.126 0.1189
Loa Loa (eye worm) hypothetical protein 0.0219 0.3061 0.4606
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0678 0.1021
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0403 0.0325
Echinococcus granulosus sodium and chloride dependent glycine 0.0072 0.05 0.0423
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0219 0.3061 0.3004
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0181 0.2391 0.2328
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0403 0.0607
Brugia malayi RNA binding protein 0.0067 0.0403 0.059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0219 0.3061 0.4596
Brugia malayi PAS domain containing protein 0.0051 0.0134 0.0184
Brugia malayi nuclear receptor RXR 0.0116 0.126 0.1881
Onchocerca volvulus 0.0082 0.0678 0.029
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0219 0.3061 0.3004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0072 0.05 0.0423
Brugia malayi Nuclear hormone receptor-like 1 0.0219 0.3061 0.4596
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0103 0.1044 0.0971
Brugia malayi photoreceptor-specific nuclear receptor 0.0219 0.3061 0.4596
Loa Loa (eye worm) hypothetical protein 0.0081 0.0652 0.0981
Brugia malayi nuclear hormone receptor family member nhr-6 0.0103 0.1044 0.1556
Brugia malayi hypothetical protein 0.0172 0.2231 0.3345
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Schistosoma mansoni sodium/chloride dependent transporter 0.0425 0.6645 0.6617
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.1342 1
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.009 0.081 0.4872
Schistosoma mansoni sodium/chloride dependent transporter 0.0072 0.05 0.0423
Schistosoma mansoni single-minded 0.0051 0.0134 0.0054
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Brugia malayi Nuclear hormone receptor E75 0.0103 0.1044 0.1556
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0072 0.05 0.0423
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0219 0.3061 0.3004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0403 0.0607
Brugia malayi bZIP transcription factor family protein 0.0181 0.2391 0.3586
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0219 0.3061 0.4596
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Echinococcus multilocularis thyroid hormone receptor alpha 0.0359 0.549 0.5453
Echinococcus multilocularis serotonin transporter 0.0425 0.6645 0.6617
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.1342 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0072 0.05 0.0423
Echinococcus granulosus intermediate filament protein 0.0082 0.0678 0.0602
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0072 0.05 0.0423
Brugia malayi Ets-domain containing protein 0.0076 0.0569 0.084
Loa Loa (eye worm) hypothetical protein 0.0072 0.05 0.0753
Brugia malayi ecdysone receptor 0.0103 0.1044 0.1556
Schistosoma mansoni hypothetical protein 0.0429 0.6707 0.668
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0072 0.05 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0219 0.3061 0.4596
Loa Loa (eye worm) hypothetical protein 0.0072 0.05 0.0753
Schistosoma mansoni thyroid hormone receptor 0.0359 0.549 0.5453
Onchocerca volvulus 0.0142 0.1715 0.1977
Schistosoma mansoni nuclear receptor nhr-48 0.0103 0.1044 0.0971
Echinococcus multilocularis microtubule associated protein 2 0.0618 1 1
Echinococcus granulosus lamin dm0 0.0082 0.0678 0.0602
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.1342 0.2019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0081 0.0122
Plasmodium falciparum amino acid transporter, putative 0.0072 0.05 0.5
Schistosoma mansoni gabp alpha 0.0076 0.0569 0.0492
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0181 0.2391 0.2328
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0064 0.0365 0.1276
Schistosoma mansoni hypothetical protein 0.014 0.1674 0.1606
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0072 0.05 0.0753
Loa Loa (eye worm) hypothetical protein 0.0116 0.126 0.1897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0219 0.3061 0.4606
Loa Loa (eye worm) DR-78 0.0103 0.1044 0.1572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0219 0.3061 0.4606
Loa Loa (eye worm) phosphofructokinase 0.0121 0.1342 0.2019
Trichomonas vaginalis aldehyde oxidase, putative 0.0191 0.2566 1
Brugia malayi nuclear receptor NHR-67 0.0103 0.1044 0.1556
Schistosoma mansoni hypothetical protein 0.0429 0.6707 0.668
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0219 0.3061 0.3004
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.1342 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0116 0.126 0.1897
Loa Loa (eye worm) hypothetical protein 0.0116 0.126 0.1897
Echinococcus multilocularis geminin 0.0429 0.6707 0.668
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0116 0.126 0.1189
Onchocerca volvulus 0.0105 0.1063 0.0915
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.1342 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0103 0.1044 0.0885
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0219 0.3061 0.3004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0103 0.1044 0.0971
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0219 0.3061 0.4596
Loa Loa (eye worm) hypothetical protein 0.0219 0.3061 0.4606
Brugia malayi Nuclear hormone receptor E75 0.0103 0.1044 0.1556
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0072 0.05 0.0423
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.2388 0.3594
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0219 0.3061 0.4596
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Onchocerca volvulus Bile acid receptor homolog 0.0219 0.3061 0.4167
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0425 0.6645 0.6617
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0219 0.3061 0.4596
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.2388 0.3582
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0219 0.3061 0.3004
Brugia malayi nuclear hormone receptor 0.0103 0.1044 0.1556
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0103 0.1044 0.0885
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.2388 0.2326
Treponema pallidum sodium- and chloride- dependent transporter 0.0425 0.6645 1
Brugia malayi hypothetical protein 0.0142 0.1715 0.2567
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.009 0.081 0.4872
Echinococcus granulosus thyroid hormone receptor alpha 0.0103 0.1044 0.0971
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0103 0.1044 0.1556
Echinococcus granulosus sodium and chloride dependent glycine 0.0072 0.05 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0219 0.3061 0.4596
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0072 0.05 0.0423
Schistosoma mansoni zinc finger protein 0.0103 0.1044 0.0971
Toxoplasma gondii hypothetical protein 0.0072 0.05 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0219 0.3061 0.3004
Brugia malayi follicle stimulating hormone receptor 0.027 0.3942 0.5925
Brugia malayi nuclear receptor NHR-88 0.0103 0.1044 0.1556
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.014 0.1674 0.1606
Schistosoma mansoni lipoxygenase 0.0061 0.0302 0.0223
Echinococcus granulosus jun protein 0.0181 0.2391 0.2328
Onchocerca volvulus 0.0103 0.1044 0.0885
Schistosoma mansoni retinoic acid receptor RXR 0.0219 0.3061 0.3004
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0208 0.0312
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0219 0.3061 0.3004
Brugia malayi hypothetical protein 0.0103 0.1044 0.1556
Brugia malayi hypothetical protein 0.0252 0.363 0.5454
Schistosoma mansoni nuclear receptor 0.0103 0.1044 0.0971
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0219 0.3061 0.3004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0103 0.1044 0.0971
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0219 0.3061 0.4596
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0103 0.1044 0.0971
Brugia malayi hypoxia-induced factor 1 0.0158 0.2 0.2996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0219 0.3061 0.4606
Loa Loa (eye worm) hypothetical protein 0.0072 0.05 0.0753
Loa Loa (eye worm) hypothetical protein 0.0219 0.3061 0.4606
Schistosoma mansoni coup transcription factor 0.0219 0.3061 0.3004
Loa Loa (eye worm) hypothetical protein 0.0172 0.2231 0.3358
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0072 0.05 0.0736
Schistosoma mansoni alpha-glucosidase 0.0156 0.1951 0.1885
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0064 0.0365 0.1276
Brugia malayi Fli-1 protein 0.0231 0.3268 0.4909
Echinococcus multilocularis sodium and chloride dependent glycine 0.0072 0.05 0.0423
Brugia malayi Cytochrome P450 family protein 0.0055 0.0208 0.0294
Echinococcus granulosus geminin 0.0429 0.6707 0.668
Loa Loa (eye worm) serotonin transporter b 0.0425 0.6645 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0403 0.0325
Schistosoma mansoni nuclear hormone receptor 0.0103 0.1044 0.0971
Onchocerca volvulus 0.0219 0.3061 0.4167
Schistosoma mansoni lamin 0.0082 0.0678 0.0602
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0219 0.3061 0.3004
Brugia malayi 6-phosphofructokinase 0.0121 0.1342 0.2004
Brugia malayi hypothetical protein 0.0072 0.05 0.0736
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0219 0.3061 0.3004
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0072 0.05 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0219 0.3061 0.3004
Brugia malayi intermediate filament protein 0.0082 0.0678 0.1004
Brugia malayi hypothetical protein 0.0116 0.126 0.1881
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0191 0.2566 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0072 0.05 0.0423
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Echinococcus multilocularis jun protein 0.0181 0.2391 0.2328
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.1342 0.1271
Schistosoma mansoni sodium/chloride dependent transporter 0.0072 0.05 0.0423
Loa Loa (eye worm) hypothetical protein 0.0176 0.2304 0.3468
Echinococcus multilocularis lamin dm0 0.0082 0.0678 0.0602
Onchocerca volvulus 0.0425 0.6645 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0072 0.05 0.0423
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0072 0.05 0.0736
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0116 0.126 0.1189
Schistosoma mansoni hypothetical protein 0.0057 0.0242 0.0162
Loa Loa (eye worm) hypothetical protein 0.0072 0.05 0.0753
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0425 0.6645 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0103 0.1044 0.0971
Loa Loa (eye worm) steroid hormone receptor 0.0219 0.3061 0.4606
Brugia malayi Cytochrome P450 family protein 0.0089 0.0791 0.1174
Toxoplasma gondii hypothetical protein 0.0072 0.05 0.5
Loa Loa (eye worm) solute carrier family 6 member 4 0.0425 0.6645 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.1342 0.9173
Brugia malayi nuclear receptor NHR-88 0.0219 0.3061 0.4596
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0072 0.05 0.0736
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0072 0.05 0.5
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0072 0.05 0.0423
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.126 0.1881
Loa Loa (eye worm) hypothetical protein 0.0103 0.1044 0.1572
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0103 0.1044 0.0971
Brugia malayi nuclear hormone receptor family member odr-7 0.0103 0.1044 0.1556
Loa Loa (eye worm) hypothetical protein 0.0219 0.3061 0.4606
Echinococcus multilocularis ecdysone induced protein 78C 0.0219 0.3061 0.3004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0219 0.3061 0.4596
Loa Loa (eye worm) cytochrome P450 family protein 0.0089 0.0791 0.119
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0081 0.0104
Loa Loa (eye worm) hypothetical protein 0.0107 0.1101 0.1656
Echinococcus granulosus tar DNA binding protein 0.0067 0.0403 0.0325
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0403 0.0325
Loa Loa (eye worm) hypothetical protein 0.0082 0.0678 0.1021
Loa Loa (eye worm) fli-1 protein 0.0231 0.3268 0.4918
Echinococcus multilocularis sodium and chloride dependent glycine 0.0072 0.05 0.0423
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0057 0.0229 0.017
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0219 0.3061 0.3004
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0134 0.0054
Echinococcus multilocularis musashi 0.0082 0.0678 0.0602
Loa Loa (eye worm) hypothetical protein 0.0116 0.126 0.1897
Loa Loa (eye worm) hypothetical protein 0.0065 0.0377 0.0568
Schistosoma mansoni lamin 0.0082 0.0678 0.0602
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.1342 1
Schistosoma mansoni microtubule-associated protein tau 0.0618 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0219 0.3061 0.4596
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0219 0.3061 0.4606
Loa Loa (eye worm) CYP4Cod1 0.0055 0.0208 0.0312
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.2 0.3009
Brugia malayi Cytochrome P450 family protein 0.0055 0.0208 0.0294
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0072 0.05 0.0423
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0302 0.0223
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0302 0.0223
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0403 0.059

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 0 % Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM ChEMBL. 17326615
Inhibition (binding) = 0 % Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM ChEMBL. 17326615
Inhibition (binding) = 14 % Inhibition of pig kidney microsomal APN at 10 uM ChEMBL. 17326615
Inhibition (binding) = 14 % Inhibition of pig kidney microsomal APN at 10 uM ChEMBL. 17326615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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