Detailed information for compound 417561

Basic information

Technical information
  • TDR Targets ID: 417561
  • Name: N-[(2R)-1-[[(E,3R)-1-(benzenesulfonyl)-5-phen ylpent-1-en-3-yl]amino]-4-methyl-1-oxopentan- 2-yl]morpholine-4-carboxamide
  • MW: 527.675 | Formula: C28H37N3O5S
  • H donors: 2 H acceptors: 4 LogP: 3.68 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@H](C(=O)N[C@@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1)NC(=O)N1CCOCC1)C
  • InChi: 1S/C28H37N3O5S/c1-22(2)21-26(30-28(33)31-16-18-36-19-17-31)27(32)29-24(14-13-23-9-5-3-6-10-23)15-20-37(34,35)25-11-7-4-8-12-25/h3-12,15,20,22,24,26H,13-14,16-19,21H2,1-2H3,(H,29,32)(H,30,33)/b20-15+/t24-,26-/m1/s1
  • InChiKey: YUMYYTORLYHUFW-ZUDLOMHPSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(1R)-1-[[(E,1R)-3-(benzenesulfonyl)-1-phenethyl-allyl]carbamoyl]-3-methyl-butyl]morpholine-4-carboxamide
  • N-[(1R)-1-[[[(E,1R)-3-(benzenesulfonyl)-1-phenethylallyl]amino]-oxomethyl]-3-methylbutyl]-4-morpholinecarboxamide
  • N-[(2R)-4-methyl-1-oxo-1-[[(E,3R)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]amino]pentan-2-yl]morpholine-4-carboxamide
  • N-[(1R)-1-[[(E,1R)-3-besyl-1-phenethyl-allyl]carbamoyl]-3-methyl-butyl]morpholine-4-carboxamide
  • N-[(2R)-4-methyl-1-oxo-1-[[(E,3R)-5-phenyl-1-phenylsulfonylpent-1-en-3-yl]amino]pentan-2-yl]morpholine-4-carboxamide
  • N-[(1R)-3-methyl-1-[[(E,1R)-1-(2-phenylethyl)-3-phenylsulfonyl-prop-2-enyl]carbamoyl]butyl]morpholine-4-carboxamide
  • N-[(1R)-3-methyl-1-[oxo-[[(E,1R)-1-(2-phenylethyl)-3-phenylsulfonylprop-2-enyl]amino]methyl]butyl]-4-morpholinecarboxamide
  • N-[(2R)-4-methyl-1-oxo-1-[[(E,3R)-5-phenyl-1-phenylsulfonyl-pent-1-en-3-yl]amino]pentan-2-yl]morpholine-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Mus musculus cathepsin L Starlite/ChEMBL References
Mus musculus cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin C Starlite/ChEMBL References
Rattus norvegicus Cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Mus musculus cathepsin K Starlite/ChEMBL References
Mus musculus cathepsin B Starlite/ChEMBL References
Rattus norvegicus Cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis cathepsin C precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis papain family cysteine protease containing protein Get druggable targets OG5_129645 All targets in OG5_129645
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_129645 All targets in OG5_129645
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Babesia bovis cysteine protease 2 Get druggable targets OG5_129645 All targets in OG5_129645
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPC1 Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cathepsin C, putative Get druggable targets OG5_130494 All targets in OG5_130494
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin C precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Get druggable targets OG5_130494 All targets in OG5_130494
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii cathepsin c precursor Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei dipeptidyl aminopeptidase 2 Get druggable targets OG5_130494 All targets in OG5_130494
Babesia bovis preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis preprocathepsin c precursor Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax dipeptidyl aminopeptidase 1, putative Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum dipeptidyl aminopeptidase 2 Get druggable targets OG5_130494 All targets in OG5_130494
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_129645 All targets in OG5_129645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii Homo sapiens P3ECSL-related Get druggable targets OG5_130494 All targets in OG5_130494
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Get druggable targets OG5_130494 All targets in OG5_130494
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cathepsin C, putative Get druggable targets OG5_130494 All targets in OG5_130494
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii preprocathepsin c precursor, putative Get druggable targets OG5_130494 All targets in OG5_130494
Giardia lamblia Dipeptidyl-peptidase I precursor Get druggable targets OG5_130494 All targets in OG5_130494
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum dipeptidyl aminopeptidase 1 Get druggable targets OG5_130494 All targets in OG5_130494
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_130494 All targets in OG5_130494
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Get druggable targets OG5_130494 All targets in OG5_130494
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 334 aa 367 aa 30.0 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 324 aa 34.6 %
Plasmodium falciparum cysteine proteinase falcipain 2b cathepsin K 329 aa 328 aa 34.5 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin L   334 aa 288 aa 26.7 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 341 aa 26.7 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 301 aa 23.6 %
Schistosoma japonicum ko:K01365 cathepsin L [EC3.4.22.15], putative Cathepsin S   330 aa 309 aa 44.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 36.4 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin L   334 aa 294 aa 23.8 %
Plasmodium vivax vivapain-3 Cathepsin L   334 aa 345 aa 30.7 %
Plasmodium berghei serine repeat antigen 1 Cathepsin S   330 aa 287 aa 25.4 %
Onchocerca volvulus Cathepsin L   334 aa 311 aa 40.8 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin L   334 aa 296 aa 31.8 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 275 aa 29.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 341 aa 375 aa 29.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Giardia lamblia Encystation-specific protease Cathepsin B   339 aa 272 aa 23.5 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 274 aa 48.2 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin L   334 aa 303 aa 23.4 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 273 aa 25.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin S   330 aa 319 aa 23.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 336 aa 25.9 %
Plasmodium knowlesi knowpain-1 Cathepsin L   334 aa 373 aa 27.6 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 271 aa 26.9 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.9 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Plasmodium knowlesi knowpain-4 Cathepsin B   339 aa 304 aa 24.3 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 309 aa 26.5 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 298 aa 23.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase Cathepsin B   339 aa 287 aa 22.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 24.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 302 aa 24.5 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 317 aa 33.8 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin L   334 aa 300 aa 41.0 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 303 aa 26.1 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 277 aa 26.0 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin L   334 aa 311 aa 35.0 %
Plasmodium vivax dipeptidyl aminopeptidase 1, putative Cathepsin B   339 aa 304 aa 27.0 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.2 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 347 aa 28.8 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 333 aa 28.8 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 28.6 %
Plasmodium vivax vivapain-1 Cathepsin L   334 aa 366 aa 28.4 %
Theileria parva cathepsin C, putative Cathepsin B   339 aa 295 aa 26.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 Cathepsin B   339 aa 367 aa 25.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 270 aa 25.6 %
Dictyostelium discoideum cysteine proteinase 5 precursor Cathepsin B   339 aa 303 aa 22.4 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 276 aa 26.8 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 274 aa 48.5 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 298 aa 28.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 25.9 %
Plasmodium vivax serine-repeat antigen 4 (SERA), putative Cathepsin S   330 aa 274 aa 23.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 295 aa 25.4 %
Babesia bovis papain family cysteine protease containing protein Cathepsin L   334 aa 321 aa 32.7 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 273 aa 26.0 %
Cryptosporidium hominis preprocathepsin c precursor Cathepsin B   339 aa 282 aa 29.4 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 337 aa 26.1 %
Giardia lamblia Dipeptidyl-peptidase I precursor Cathepsin L   334 aa 304 aa 28.3 %
Onchocerca volvulus Cathepsin B   339 aa 319 aa 38.9 %
Babesia bovis preprocathepsin c precursor, putative Cathepsin B   339 aa 282 aa 29.8 %
Echinococcus multilocularis cathepsin b Cathepsin S   330 aa 278 aa 28.8 %
Echinococcus granulosus cysteine protease Cathepsin L   334 aa 323 aa 44.3 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 309 aa 30.4 %
Cryptosporidium parvum preprocathepsin c precursor, putative Cathepsin B   339 aa 287 aa 30.3 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Echinococcus granulosus cathepsin b Cathepsin S   330 aa 288 aa 30.2 %
Plasmodium falciparum serine repeat antigen 8 Cathepsin B   339 aa 272 aa 25.0 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 325 aa 29.5 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin L   334 aa 311 aa 36.0 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 282 aa 26.2 %
Onchocerca volvulus Cathepsin L   334 aa 300 aa 24.3 %
Onchocerca volvulus Cathepsin B-like cysteine proteinase 6 homolog Cathepsin B   339 aa 326 aa 51.2 %
Schistosoma japonicum Cathepsin C precursor, putative Cathepsin B   339 aa 332 aa 26.8 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 25.0 %
Plasmodium vivax serine-repeat antigen (SERA), putative Cathepsin S   330 aa 293 aa 22.2 %
Toxoplasma gondii cathepsin B Cathepsin S   330 aa 265 aa 24.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium berghei berghepain-1 Cathepsin L   334 aa 353 aa 29.7 %
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase Cathepsin S   330 aa 266 aa 32.0 %
Loa Loa (eye worm) hypothetical protein Cathepsin S   330 aa 281 aa 28.5 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 276 aa 25.4 %
Plasmodium vivax unspecified product Cathepsin L   334 aa 366 aa 28.4 %
Onchocerca volvulus Cathepsin L homolog Cathepsin L   334 aa 322 aa 41.6 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 278 aa 26.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Echinococcus granulosus cathepsin b Cathepsin S   330 aa 276 aa 26.1 %
Drosophila melanogaster Cathepsin B1 Cathepsin S   330 aa 305 aa 27.2 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 279 aa 28.3 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 270 aa 25.6 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Onchocerca volvulus Cathepsin S   330 aa 289 aa 29.4 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 277 aa 26.0 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 38.0 %
Dictyostelium discoideum cysteine protease Cathepsin B   339 aa 283 aa 24.7 %
Plasmodium knowlesi knowpain-2 Cathepsin B   339 aa 302 aa 24.8 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin L   334 aa 323 aa 46.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 319 aa 25.7 %
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Cathepsin B   339 aa 334 aa 29.3 %
Plasmodium yoelii SERA-2 Cathepsin S   330 aa 267 aa 24.3 %
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Cathepsin L   334 aa 290 aa 27.6 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 332 aa 23.5 %
Plasmodium knowlesi cysteine protease, putative Cathepsin S   330 aa 291 aa 23.0 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin L   334 aa 318 aa 48.4 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin L   334 aa 277 aa 24.5 %
Neospora caninum hypothetical protein Cathepsin L   334 aa 299 aa 28.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 372 aa 23.7 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin L   334 aa 312 aa 42.0 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 325 aa 38.1 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin L   334 aa 360 aa 29.2 %
Babesia bovis cathepsin C precursor, putative Cathepsin B   339 aa 304 aa 26.6 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin L   334 aa 316 aa 30.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 23.4 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin L   334 aa 345 aa 35.4 %
Plasmodium yoelii cathepsin c precursor Cathepsin L   334 aa 292 aa 22.6 %
Plasmodium berghei dipeptidyl aminopeptidase 1, putative Cathepsin B   339 aa 319 aa 26.6 %
Onchocerca volvulus Cathepsin L   334 aa 325 aa 47.4 %
Plasmodium berghei dipeptidyl aminopeptidase 2 Cathepsin B   339 aa 314 aa 24.5 %
Toxoplasma gondii cathepsin CPC1 Cathepsin L   334 aa 295 aa 28.1 %
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 271 aa 27.7 %
Echinococcus multilocularis cathepsin b Cathepsin S   330 aa 288 aa 30.2 %
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Cathepsin B   339 aa 327 aa 30.3 %
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 273 aa 27.8 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 279 aa 25.8 %
Plasmodium vivax dipeptidyl aminopeptidase 3, putative cathepsin C 141 aa 152 aa 22.4 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin L   334 aa 359 aa 29.8 %
Trypanosoma cruzi cysteine protease, putative Cathepsin L   334 aa 323 aa 30.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.014623 0.185349 0.0697754
Loa Loa (eye worm) fibroinase 0.0226444 0.619525 0.53296
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0226444 0.619525 0.565548
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.014683 0.188597 0.0734835
Onchocerca volvulus 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014623 0.185349 0.299179
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296736 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0154229 0.228647 0.119216
Onchocerca volvulus 0.0226444 0.619525 1
Schistosoma mansoni cathepsin F (C01 family) 0.0226444 0.619525 0.565548
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0226444 0.619525 0.53296
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0226444 0.619525 0.565548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Brugia malayi Cathepsin L-like precursor 0.0226444 0.619525 0.565548
Leishmania major cathepsin L-like protease 0.0226444 0.619525 1
Echinococcus multilocularis cysteine protease 0.0226444 0.619525 0.565548
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0226444 0.619525 1
Echinococcus granulosus cathepsin b 0.0296736 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0226444 0.619525 0.565548
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.014683 0.188597 0.129933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Giardia lamblia Cathepsin B precursor 0.0154229 0.228647 1
Trypanosoma cruzi cysteine peptidase, putative 0.0226444 0.619525 0.565548
Plasmodium falciparum cysteine proteinase falcipain 3 0.0226444 0.619525 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.014683 0.188597 0.129933
Toxoplasma gondii cathepsin B 0.0154229 0.228647 0.0929391
Leishmania major cathepsin L-like protease 0.0226444 0.619525 1
Onchocerca volvulus Cathepsin F homolog 0.0226444 0.619525 1
Trypanosoma cruzi cysteine peptidase, putative 0.0226444 0.619525 0.565548
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0226444 0.619525 1
Loa Loa (eye worm) ctsf protein 0.0226444 0.619525 0.53296
Leishmania major cathepsin L-like protease 0.0226444 0.619525 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0154229 0.228647 0.210797
Loa Loa (eye worm) cathepsin B 0.0154229 0.228647 0.0531487
Leishmania major cathepsin L-like protease 0.0226444 0.619525 1
Onchocerca volvulus Cathepsin L homolog 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Brugia malayi Cathepsin L-like precursor 0.0226444 0.619525 0.565548
Leishmania major cathepsin L-like protease 0.0226444 0.619525 1
Echinococcus multilocularis cathepsin b 0.0296736 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Toxoplasma gondii cathepsin CPL 0.0226444 0.619525 1
Loa Loa (eye worm) cysteine protease 0.0226444 0.619525 0.53296
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296736 1 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.014683 0.188597 0.129933
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Onchocerca volvulus 0.0226444 0.619525 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0226444 0.619525 0.53296
Brugia malayi Papain family cysteine protease containing protein 0.0226444 0.619525 0.565548
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0296736 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296736 1 1
Echinococcus granulosus cathepsin l1 0.0226444 0.619525 0.565548
Loa Loa (eye worm) hypothetical protein 0.0296736 1 1
Brugia malayi Cathepsin L-like precursor 0.0226444 0.619525 0.565548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Echinococcus granulosus cathepsin l1 0.014623 0.185349 0.0697754
Giardia lamblia Cathepsin B precursor 0.0154229 0.228647 1
Onchocerca volvulus 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Entamoeba histolytica cysteine proteinase, putative 0.014623 0.185349 0.123377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Leishmania major cathepsin L-like protease 0.0226444 0.619525 1
Giardia lamblia Cathepsin B precursor 0.0154229 0.228647 1
Leishmania major cysteine peptidase A (CPA) 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Trypanosoma cruzi cysteine peptidase, putative 0.0226444 0.619525 0.565548
Brugia malayi Cathepsin L-like precursor 0.0226444 0.619525 0.565548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.014623 0.185349 0.0697754
Schistosoma mansoni cathepsin F (C01 family) 0.014623 0.185349 0.0697754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Entamoeba histolytica cysteine protease, putative 0.0226444 0.619525 1
Brugia malayi Cathepsin L-like precursor 0.014623 0.185349 0.0697754
Leishmania major cathepsin L-like protease 0.0226444 0.619525 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0226444 0.619525 0.565548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Onchocerca volvulus 0.0226444 0.619525 1
Brugia malayi Cathepsin L-like precursor 0.0226444 0.619525 0.565548
Trypanosoma cruzi cysteine peptidase, putative 0.0226444 0.619525 0.565548
Trypanosoma cruzi cruzipain precursor, putative 0.0226444 0.619525 0.565548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013494 0.124243 0.200545
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0226444 0.619525 1
Plasmodium vivax vivapain-2 0.0226444 0.619525 1
Plasmodium vivax vivapain-2 0.0226444 0.619525 1
Leishmania major cathepsin L-like protease 0.0226444 0.619525 1
Onchocerca volvulus 0.0226444 0.619525 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Brugia malayi cathepsin L-like precursor 0.014623 0.185349 0.0697754
Onchocerca volvulus 0.0226444 0.619525 1
Brugia malayi Cathepsin L-like precursor 0.0226444 0.619525 0.565548
Brugia malayi Cathepsin L-like precursor 0.014623 0.185349 0.0697754
Loa Loa (eye worm) hypothetical protein 0.0226444 0.619525 0.53296
Entamoeba histolytica cysteine proteinase, putative 0.0226444 0.619525 1
Echinococcus multilocularis cysteine protease 0.0226444 0.619525 0.565548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154229 0.228647 0.119216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Echinococcus multilocularis cathepsin b 0.0296736 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0226444 0.619525 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0296736 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0226444 0.619525 0.565548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014623 0.185349 0.299179
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.014683 0.188597 0.129933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013494 0.124243 0.200545
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0226444 0.619525 0.565548
Entamoeba histolytica cysteine proteinase, putative 0.0226444 0.619525 1
Schistosoma mansoni cathepsin F (C01 family) 0.0226444 0.619525 0.565548
Onchocerca volvulus Cathepsin L homolog 0.0226444 0.619525 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0154229 0.228647 0.369068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0226444 0.619525 1
Echinococcus granulosus cathepsin b 0.0296736 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0296736 1 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of cathepsin S in mouse splenocytes assessed as MHC2 associated invariant chain degradation at 1 uM ChEMBL. 18572405
Activity (functional) 0 Effect on gliding motility in Toxoplasma gondii RH at 50 uM ChEMBL. 17145790
Activity (functional) 0 Effect on MIC2 protein accmulation in Toxoplasma gondii at 50 uM ChEMBL. 17145790
Activity (functional) 0 Reduction of AMA1 secretion in Toxoplasma gondii 2F1 at 50 uM ChEMBL. 17145790
Activity (functional) 0 Reduction of MIC5 secretion in Toxoplasma gondii 2F1 at 50 uM ChEMBL. 17145790
Activity (functional) 0 Reduction of MIC10 secretion in Toxoplasma gondii 2F1 at 50 uM ChEMBL. 17145790
Activity (functional) 0 Analgesic activity in intrathecally dosed Wistar rat partial ligation of sciatic nerve neuropathic pain model assessed as reduction of mechanical hyperalgesia at 10 nmol after 14 days ChEMBL. 17551020
Activity (functional) 0 Effect on contralateral mechanical thresholds in intrathecally dosed Wistar rat partial ligation of sciatic nerve neuropathic pain model ChEMBL. 17551020
Activity (functional) 0 Inhibition of rat recombinant cathepsin S-induced hyperalgesia in naive Wistar rat at 50 nmol administered 30 mins before cathepsin S challenge ChEMBL. 17551020
Activity (functional) 0 Analgesic activity in intrathecally dosed Wistar rat partial ligation of sciatic nerve neuropathic pain model assessed as attenuation of allodynia at 50 nmol after 7 days ChEMBL. 17551020
Activity (functional) 0 Analgesic activity in intrathecally dosed Wistar rat partial ligation of sciatic nerve neuropathic pain model assessed as attenuation of allodynia at 50 nmol after 14 days ChEMBL. 17551020
Activity (functional) 0 Antinociceptive activity in intrathecally dosed Wistar rat partial ligation of sciatic nerve 3-day neuropathic pain model assessed as alteration of mechanical allodynia at 50 nmol ChEMBL. 17551020
Activity (ADMET) 0 Toxicity in Wistar rat assessed as effect on motor behavior by rotorod test ChEMBL. 17551020
Activity (functional) 0 Reduction of microglial activation in Wistar rat partial ligation of sciatic nerve neuropathic pain model at 30 nmol ChEMBL. 17551020
Activity (functional) 0 Analgesic activity in Wistar rat partial ligation of sciatic nerve model of neuropathic pain assessed as reversal of allodynia at 30 nmol after 3 to 5 days ChEMBL. 17551020
Activity (functional) 0 Analgesic activity in Wistar rat partial ligation of sciatic nerve model of neuropathic pain assessed as reversal of allodynia at 30 nmol after 7 days ChEMBL. 17551020
Activity (functional) 0 Analgesic activity in intrathecally dosed Wistar rat partial ligation of sciatic nerve neuropathic pain model assessed as reduction of mechanical hyperalgesia at 50 nmol after 14 days ChEMBL. 17551020
Activity (functional) 0 Effect on sarcosine-induced hyperalgesia in Wistar rat ChEMBL. 17551020
Activity (functional) 0 Effect on NMDA-induced hyperalgesia in Wistar rat ChEMBL. 17551020
IC50 (binding) Inhibition of human recombinant cathepsin H after 10 mins ChEMBL. 17535802
IC50 (binding) = 0.5 nM Inhibition of mouse recombinant cathepsin S ChEMBL. 17590332
IC50 (binding) = 0.5 nM Inhibition of mouse recombinant cathepsin S ChEMBL. 17590332
IC50 (binding) = 1.2 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (functional) = 1.2 nM Inhibition of antigen presentation in mouse B cells ChEMBL. 17590332
IC50 (binding) = 1.2 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 1.7 nM Inhibition of rat spleen cathepsin S ChEMBL. 17590332
IC50 (binding) = 1.7 nM Inhibition of rat spleen cathepsin S ChEMBL. 17590332
IC50 (binding) = 1.9 nM Inhibition of human cathepsin-S ChEMBL. 23639544
IC50 (binding) = 3 nM Inhibition of human cathepsin-B ChEMBL. 23639544
IC50 (binding) = 4 nM Inhibition of human cathepsin-K ChEMBL. 23639544
IC50 (binding) = 4.1 nM Inhibition of rat liver lysosomal cathepsin L ChEMBL. 17590332
IC50 (binding) = 4.1 nM Inhibition of rat liver lysosomal cathepsin L ChEMBL. 17590332
IC50 (binding) = 5.7 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 5.7 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 6.2 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 6.2 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 7.1 nM Inhibition of mouse recombinant cathepsin L ChEMBL. 17590332
IC50 (binding) = 7.1 nM Inhibition of mouse recombinant cathepsin L ChEMBL. 17590332
IC50 (binding) = 388 nM Inhibition of mouse recombinant cathepsin K ChEMBL. 17590332
IC50 (binding) = 388 nM Inhibition of mouse recombinant cathepsin K ChEMBL. 17590332
IC50 (binding) = 735 nM Inhibition of rat liver lysosomal cathepsin B ChEMBL. 17590332
IC50 (binding) = 735 nM Inhibition of rat liver lysosomal cathepsin B ChEMBL. 17590332
IC50 (binding) = 1277 nM Inhibition of mouse recombinant cathepsin B ChEMBL. 17590332
IC50 (binding) = 1277 nM Inhibition of mouse recombinant cathepsin B ChEMBL. 17590332
IC50 (binding) = 4504 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 4504 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 0.001 uM Inhibition of human recombinant cathepsin S after 10 mins ChEMBL. 17535802
IC50 (binding) = 0.007 uM Inhibition of human recombinant cathepsin L after 10 mins ChEMBL. 17535802
IC50 (binding) = 1.36 uM Inhibition of human recombinant cathepsin B after 10 mins ChEMBL. 17535802
IC50 (functional) = 10 uM Inhibition of Toxoplasma gondii 2F1 invasion in HFF cells by red/green invasion assay ChEMBL. 17145790
IC50 (binding) > 10 uM Inhibition of human recombinant cathepsin C after 10 mins ChEMBL. 17535802
IC50 (functional) = 10 uM Inhibition of Toxoplasma gondii 2F1 invasion in HFF cells by red/green invasion assay ChEMBL. 17145790
IC50 (binding) = 21.2 uM Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs ChEMBL. 17535802
IC50 (functional) = 25 uM Inhibition of microneme protein secretion in Toxoplasma gondii 2F1 ChEMBL. 17145790
IC50 (functional) = 25 uM Inhibition of microneme protein secretion in Toxoplasma gondii 2F1 ChEMBL. 17145790
IC50 (binding) = 25.5 uM Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs ChEMBL. 17535802
IC50 (binding) = 39.8 uM Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs ChEMBL. 17535802
Inhibition (functional) = 70 % Inhibition of Toxoplasma gondii 2F1 invasion in HFF cells assessed as beta-galactosidase activity at 50 uM relative to control ChEMBL. 17145790
Inhibition (functional) = 70 % Inhibition of Toxoplasma gondii 2F1 invasion in HFF cells assessed as beta-galactosidase activity at 50 uM relative to control ChEMBL. 17145790

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Toxoplasma gondii ChEMBL23 17145790

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

6 literature references were collected for this gene.

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