TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.248 | Formula: C22H13Cl2NO5
H donors: 3 H acceptors: 4 LogP: 5.11 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(=O)Nc1c(O)cc(c2c1oc(cc2=O)c1ccccc1Cl)O
InChi: 1S/C22H13Cl2NO5/c23-12-7-5-11(6-8-12)22(29)25-20-17(28)9-15(26)19-16(27)10-18(30-21(19)20)13-3-1-2-4-14(13)24/h1-10,26,28H,(H,25,29)
InChiKey: ACYJTSCCFDMXDK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0038	0.0172	0.3477
Entamoeba histolytica	rodhanase-like domain containing protein	0.004	0.0184	0.0731
Loa Loa (eye worm)	MBOAT family protein	0.0011	0.0021	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0021	0.0039
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)	0.009	0.0457	0.6161
Plasmodium vivax	carbamoyl phosphate synthetase, putative	0.0018	0.0061	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0013	0.0031	0.003
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0011	0.0021	0.0346
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0011	0.0021	0.0346
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0013	0.0031	0.0519
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.004	0.0184	0.0767
Echinococcus multilocularis	Polycystic kidney disease protein	0.0011	0.0023	0.039
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0508	0.0508
Mycobacterium ulcerans	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	0.0141	0.0741	1
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0011	0.0021	0.0039
Plasmodium falciparum	carbamoyl phosphate synthetase	0.0018	0.0061	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0035	0.0155	0.2654
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0013	0.0031	0.003
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0033	0.0144	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0334	0.0333
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0008	0.0002	0.0023
Brugia malayi	nuclear hormone receptor	0.0013	0.0031	0.003
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0011	0.0021	0.0346
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0038	0.0172	0.2946
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0013	0.0031	0.003
Trichomonas vaginalis	protein phosphatase 2C, putative	0.0068	0.0334	0.1436
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0033	0.0144	0.2469
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0011	0.0021	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0523	0.0522
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0013	0.0031	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0013	0.0031	0.003
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0035	0.0155	0.2094
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0033	0.0144	0.1949
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0033	0.0144	0.0144
Plasmodium vivax	multidomain scavenger receptor, putative	0.0011	0.0023	0.0626
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0013	0.0031	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0021	0.0039
Brugia malayi	Nuclear hormone receptor-like 1	0.0013	0.0031	0.003
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0166	0.0166
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0011	0.0021	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.002
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.003
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0011	0.0021	0.0346
Trichomonas vaginalis	cdc25b, putative	0.004	0.0184	0.0767
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0035	0.0155	0.2654
Schistosoma mansoni	zinc finger protein	0.0011	0.0021	0.0346
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0035	0.0155	0.2094
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.009	0.0457	1
Schistosoma mansoni	thyroid hormone receptor	0.0013	0.0031	0.0519
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0013	0.0031	0.0519
Leishmania major	carbamoyl-phosphate synthase, putative	0.0018	0.0061	0.0933
Schistosoma mansoni	nuclear hormone receptor	0.0013	0.0031	0.0519
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0011	0.0021	0.0346
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0032	0.0137	0.235
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0023
Schistosoma mansoni	aldehyde dehydrogenase	0.0035	0.0155	0.2654
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0013	0.0031	0.003
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.003
Schistosoma mansoni	RAR-like nuclear receptor	0.0013	0.0031	0.0519
Echinococcus granulosus	Polycystic kidney disease protein	0.0011	0.0023	0.039
Schistosoma mansoni	hypothetical protein	0.0011	0.0023	0.039
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0023
Onchocerca volvulus		0.0008	0.0006	0.0117
Plasmodium falciparum	LCCL domain-containing protein	0.0011	0.0023	0.0626
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0011	0.0021	0.0346
Loa Loa (eye worm)	hhat protein	0.0011	0.0021	0.002
Onchocerca volvulus	Bile acid receptor homolog	0.0013	0.0031	0.0596
Leishmania major	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.009	0.0457	1
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0007	0	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0035	0.0155	0.2094
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0013	0.0031	0.0519
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0033	0.0144	0.1949
Loa Loa (eye worm)	NADH-ubiquinone oxidoreductase 51 kDa subunit	0.009	0.0457	0.0456
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase I subunit F	0.009	0.0457	0.6161
Loa Loa (eye worm)	hypothetical protein	0.1812	1	1
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.004	0.0184	0.3147
Onchocerca volvulus		0.0013	0.0031	0.0596
Echinococcus granulosus	NADH dehydrogenase ubiquinone flavoprotein 1	0.009	0.0457	0.7824
Brugia malayi	MBOAT family protein	0.0011	0.0021	0.002
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.0414	0.2256	1
Entamoeba histolytica	leucine rich repeat / protein phosphatase 2C domain containing protein	0.0068	0.0334	0.1403
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.004	0.0184	0.3147
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0033	0.0144	0.2838
Onchocerca volvulus		0.0099	0.0508	1
Echinococcus granulosus	FTZ F1 alpha	0.0013	0.0031	0.0519
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0013	0.0031	0.003
Loa Loa (eye worm)	hhat protein	0.0011	0.0021	0.002
Treponema pallidum	nitrogen fixation protein (rnfC)	0.002	0.0071	1
Wolbachia endosymbiont of Brugia malayi	AICAR transformylase/IMP cyclohydrolase PurH	0.0141	0.0741	1
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0011	0.0021	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0021	0.0039
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.1812	1	1
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0009	0.0012	0.016
Mycobacterium leprae	Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf	0.0141	0.0741	1
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.0414	0.2256	1
Trichomonas vaginalis	cdc25b, putative	0.004	0.0184	0.0767
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative	0.009	0.0457	1
Mycobacterium ulcerans	carbamoyl phosphate synthase large subunit	0.0018	0.0061	0.0827
Loa Loa (eye worm)	doublecortin family protein	0.0011	0.0023	0.0023
Echinococcus granulosus	lipoxygenase domain containing protein	0.0011	0.0023	0.039
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0031	0.0132	0.0132
Brugia malayi	diacylglycerol acyltransferase	0.0011	0.0021	0.002
Schistosoma mansoni	NADH-ubiquinone oxidoreductase	0.009	0.0457	0.7824
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0013	0.0031	0.0519
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0011	0.0021	0.0346
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0038	0.0172	0.0172
Trichomonas vaginalis	protein phosphatase type 2C, putative	0.0068	0.0334	0.1436
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0013	0.0031	0.003
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.004	0.0184	0.0767
Brugia malayi	NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor	0.009	0.0457	0.0456
Schistosoma mansoni	lipoxygenase	0.0011	0.0023	0.039
Brugia malayi	Rhodanese-like domain containing protein	0.004	0.0184	0.0184
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0011	0.0021	0.0346
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0013	0.0031	0.0519
Brugia malayi	hypothetical protein	0.0099	0.0508	0.0508
Echinococcus multilocularis	FTZ F1 alpha	0.0013	0.0031	0.0519
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.004	0.0184	0.0767
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0038	0.0172	0.3477
Onchocerca volvulus		0.004	0.0184	0.3615
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0038	0.0172	0.2946
Onchocerca volvulus		0.004	0.0184	0.3615
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.003
Schistosoma mansoni	loxhd1	0.0011	0.0023	0.039
Brugia malayi	nuclear receptor NHR-88	0.0013	0.0031	0.003
Brugia malayi	hypothetical protein	0.0215	0.1152	0.1152
Brugia malayi	hypothetical protein	0.0011	0.0023	0.0023
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.004	0.0184	0.0767
Brugia malayi	MBOAT family protein	0.0011	0.0021	0.002
Schistosoma mansoni	rab6-interacting	0.0011	0.0023	0.039
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0011	0.0021	0.0346
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0011	0.0021	0.0346
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0035	0.0155	0.2094
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0013	0.0031	0.0519
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0013	0.0031	0.003
Echinococcus multilocularis	transcription factor Dp 1	0.0022	0.0083	0.1411
Brugia malayi	MBOAT family protein	0.0011	0.0021	0.002
Mycobacterium ulcerans	membrane protein ComEA	0.002	0.0071	0.0951
Onchocerca volvulus	Protein ultraspiracle homolog	0.0013	0.0031	0.0596
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0013	0.0031	0.003
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0011	0.0021	0.0346
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0038	0.0172	0.2946
Echinococcus granulosus	RUN	0.0011	0.0023	0.039
Wolbachia endosymbiont of Brugia malayi	carbamoyl phosphate synthase large subunit	0.0018	0.0061	0.0827
Brugia malayi	MBOAT family protein	0.0011	0.0021	0.002
Toxoplasma gondii	aldehyde dehydrogenase	0.0035	0.0155	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0013	0.0031	0.003
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0013	0.0031	0.0519
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0013	0.0031	0.0519
Toxoplasma gondii	carbamoylphosphate synthetase	0.0018	0.0061	0.3022
Trypanosoma brucei	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0.009	0.0457	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0011	0.0023	0.039
Schistosoma mansoni	thyroid hormone receptor	0.0013	0.0031	0.0519
Entamoeba histolytica	rodhanase-like domain containing protein	0.004	0.0184	0.0731
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0013	0.0031	0.0519
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0011	0.0021	0.002
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0013	0.0031	0.0519
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0038	0.0172	0.0172
Onchocerca volvulus		0.004	0.0184	0.3615
Loa Loa (eye worm)	hypothetical protein	0.004	0.0184	0.0184
Onchocerca volvulus		0.0011	0.0021	0.0398
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0013	0.0031	0.0519
Echinococcus multilocularis	sterol O acyltransferase 1	0.0113	0.0584	1
Trypanosoma cruzi	NADH-ubiquinone oxidoreductase, mitochondrial, putative	0.009	0.0457	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0584	0.0583
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0032	0.0137	0.235
Echinococcus granulosus	transcription factor Dp 1	0.0022	0.0083	0.1411
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0013	0.0031	0.003
Echinococcus multilocularis	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.009	0.0457	0.7824
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0013	0.0031	0.003
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0011	0.0021	0.0346
Brugia malayi	Doublecortin family protein	0.0011	0.0023	0.0023
Brugia malayi	Rhodanese-like domain containing protein	0.004	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.002
Loa Loa (eye worm)	steroid hormone receptor	0.0013	0.0031	0.003
Onchocerca volvulus		0.0011	0.0023	0.0448
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0013	0.0031	0.0519
Brugia malayi	photoreceptor-specific nuclear receptor	0.0013	0.0031	0.003
Schistosoma mansoni	aspartate carbamoyltransferase	0.0018	0.0061	0.1044
Trichomonas vaginalis	protein phosphatase 2C delta isoform, putative	0.0068	0.0334	0.1436
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0013	0.0031	0.003
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.003
Schistosoma mansoni	sterol O-acyltransferase 1	0.0113	0.0584	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0013	0.0031	0.0519
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0011	0.0021	0.0346
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0013	0.0031	0.003
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0011	0.0023	0.039
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0013	0.0031	0.0519
Onchocerca volvulus	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog	0.0048	0.0226	0.4445
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0011	0.0021	0.0346
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0013	0.0031	0.0519
Echinococcus granulosus	sterol O acyltransferase 1	0.0113	0.0584	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0013	0.0031	0.003
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0011	0.0021	0.0346
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0011	0.0021	0.0346
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0011	0.0021	0.0346
Schistosoma mansoni	lipoxygenase	0.0032	0.0137	0.235
Echinococcus granulosus	ecdysone induced protein 78C	0.0013	0.0031	0.0519
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0013	0.0031	0.0596
Schistosoma mansoni	hypothetical protein	0.0011	0.0021	0.0346
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.004	0.0184	0.0767
Mycobacterium ulcerans	NADH dehydrogenase I subunit F	0.009	0.0457	0.6161
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0011	0.0023	0.039
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.002
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.003
Loa Loa (eye worm)	MBOAT family protein	0.0011	0.0021	0.002
Mycobacterium tuberculosis	Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo	0.0141	0.0741	1
Brugia malayi	steroid hormone receptor	0.0013	0.0031	0.003
Entamoeba histolytica	rodhanase-like domain containing protein	0.004	0.0184	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0465	0.0464
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0033	0.0144	0.2469
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0008	0.0002	0.0023
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.004	0.0184	0.3147
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0033	0.0144	0.1949
Brugia malayi	ecdysteroid receptor	0.0013	0.0031	0.003
Onchocerca volvulus		0.0011	0.0023	0.0448
Onchocerca volvulus		0.004	0.0184	0.3615
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0071	0.0951
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0011	0.0021	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.003
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0013	0.0031	0.0519
Echinococcus multilocularis	ecdysone induced protein 78C	0.0013	0.0031	0.0519
Schistosoma mansoni	polycystin 1-related	0.0011	0.0023	0.039
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0013	0.0031	0.0519
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0013	0.0031	0.0519
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0013	0.0031	0.003
Brugia malayi	MBOAT family protein	0.0011	0.0021	0.002
Trichomonas vaginalis	porcupine, putative	0.0011	0.0021	0.0039
Loa Loa (eye worm)	MBOAT family protein	0.0011	0.0021	0.002
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0038	0.0172	0.3477
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0035	0.0155	0.3086
Brugia malayi	hypothetical protein	0.0011	0.0023	0.0023
Schistosoma mansoni	coup transcription factor	0.0013	0.0031	0.0519
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0013	0.0031	0.0519
Echinococcus multilocularis	RUN	0.0011	0.0023	0.039
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0166	0.0166
Trichomonas vaginalis	cdc25c, putative	0.004	0.0184	0.0767
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0013	0.0031	0.0519
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0035	0.0155	0.2654
Brugia malayi	Steroid receptor seven-up type 2	0.0013	0.0031	0.003
Schistosoma mansoni	rab6-interacting	0.0011	0.0023	0.039
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0011	0.0021	0.0346
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.009	0.0457	0.1982
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0008	0.0002	0.0023
Loa Loa (eye worm)	hypothetical protein	0.1812	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0013	0.0031	0.0519
Trichomonas vaginalis	NADH-ubiquinone oxidoreductase flavoprotein, putative	0.009	0.0457	0.1982
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0038	0.0172	0.0678
Loa Loa (eye worm)	hypothetical protein	0.004	0.0184	0.0184
Brugia malayi	Hhat protein	0.0011	0.0021	0.002
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0011	0.0021	0.0346
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0038	0.0172	0.3477
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0013	0.0031	0.003
Schistosoma mansoni	retinoic acid receptor RXR	0.0013	0.0031	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0013	0.0031	0.003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	0	Antiproliferative activity against ID8 cells	ChEMBL.	17123821
IC50 (functional)	= 13 uM	Antiproliferative activity against MCF7 cells	ChEMBL.	17123821
IC50 (functional)	= 13 uM	Antiproliferative activity against MCF7 cells	ChEMBL.	17123821
IC50 (binding)	= 339 uM	Inhibition of CDK2/Cyclin A	ChEMBL.	17123821
IC50 (binding)	= 339 uM	Inhibition of CDK2/Cyclin A	ChEMBL.	17123821

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	17123821

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 420366