Detailed information for compound 427160

Basic information

Technical information
  • TDR Targets ID: 427160
  • Name: 3-chloro-N-[4-chloro-2-[(5-chloropyridin-2-yl )carbamoyl]-6-methoxyphenyl]-4-[[methyl-(4-ox o-1,3-oxazol-2-yl)amino]methyl]thiophene-2-ca rboxamide
  • MW: 582.844 | Formula: C23H18Cl3N5O5S
  • H donors: 2 H acceptors: 4 LogP: 4.64 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(Cl)cc(c1NC(=O)c1scc(c1Cl)CN(C1=NC(=O)CO1)C)C(=O)Nc1ccc(cn1)Cl
  • InChi: 1S/C23H18Cl3N5O5S/c1-31(23-29-17(32)9-36-23)8-11-10-37-20(18(11)26)22(34)30-19-14(5-13(25)6-15(19)35-2)21(33)28-16-4-3-12(24)7-27-16/h3-7,10H,8-9H2,1-2H3,(H,30,34)(H,27,28,33)
  • InChiKey: LNQJTMLSOGSJSG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-N-[4-chloro-2-[(5-chloro-2-pyridyl)carbamoyl]-6-methoxy-phenyl]-4-[[methyl-(4-oxooxazol-2-yl)amino]methyl]thiophene-2-carboxamide
  • 3-chloro-N-[4-chloro-2-[[(5-chloro-2-pyridyl)amino]-oxomethyl]-6-methoxyphenyl]-4-[[methyl-(4-oxo-2-oxazolyl)amino]methyl]-2-thiophenecarboxamide
  • 3-chloro-N-[4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxy-phenyl]-4-[[methyl-(4-oxo-1,3-oxazol-2-yl)amino]methyl]thiophene-2-carboxamide
  • 3-chloro-N-[4-chloro-2-[(5-chloro-2-pyridyl)carbamoyl]-6-methoxy-phenyl]-4-[[(4-keto-2-oxazolin-2-yl)-methyl-amino]methyl]thiophene-2-carboxamide
  • 3-chloro-N-[4-chloro-2-[(5-chloro-2-pyridyl)carbamoyl]-6-methoxy-phenyl]-4-[[(4-ketooxazol-2-yl)-methyl-amino]methyl]thiophene-2-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0335 0.3008 0.3151
Mycobacterium ulcerans oxidoreductase 0.003 0.0161 0.0155
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0392
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.0035
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0161 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0533
Echinococcus granulosus intermediate filament protein 0.0027 0.0135 0.0137
Schistosoma mansoni hypothetical protein 0.0335 0.3008 1
Treponema pallidum phosphoglycolate phosphatase 0.0028 0.0145 0.0533
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.1712
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2609 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Schistosoma mansoni choline dehydrogenase 0.0028 0.0145 0.0462
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0211 0.0205
Onchocerca volvulus 0.0024 0.0104 0.1667
Brugia malayi beta-lactamase family protein 0.0035 0.0211 0.167
Entamoeba histolytica hypothetical protein 0.003 0.0161 0.0226
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0048 0.1745
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0499 0.0519
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0273
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0221 0.0715
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0028 0.0145 0.0162
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0082 0.275
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1155 0.1582
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0039 0.0033
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0034 0.0273
Loa Loa (eye worm) hydrolase 0.003 0.0161 0.1304
Schistosoma mansoni hypothetical protein 0.0034 0.0201 0.0649
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0211 0.0205
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1215 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0034 0.0999
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0499 0.068
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.003 0.0161 0.6409
Plasmodium vivax glutathione reductase, putative 0.0038 0.0238 0.8459
Loa Loa (eye worm) acetyltransferase 0.0145 0.1235 1
Echinococcus granulosus transcription factor Dp 1 0.0038 0.024 0.0247
Mycobacterium ulcerans epoxide hydrolase EphE 0.003 0.0161 0.0155
Mycobacterium tuberculosis Possible phosphatase 0.0028 0.0145 0.0139
Toxoplasma gondii thioredoxin reductase 0.0038 0.0238 0.8459
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2609 1
Leishmania major hydrolase, alpha/beta fold family-like protein 0.003 0.0161 0.314
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0135 0.1045
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0499 0.1575
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0028 0.0145 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0533
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0972 0.7868
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0273
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0028 0.0145 0.0162
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0028 0.0145 0.1129
Loa Loa (eye worm) hypothetical protein 0.0026 0.013 0.1054
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0211 0.0205
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0161 0.0594
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0028 0.0145 0.0193
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.003 0.0161 0.1259
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0533
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.2609 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.1712
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0161 0.314
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.003 0.0161 0.0215
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0408 0.1337
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0211 0.0788
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0211 0.0788
Echinococcus granulosus Tolloid protein 1 0.0016 0.0034 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0104 0.0098
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0034 0.0999
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0499 0.4009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1215 0.1209
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0028 0.0145 0.1174
Plasmodium falciparum alpha/beta hydrolase, putative 0.003 0.0161 0.6409
Onchocerca volvulus 0.0062 0.0457 1
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.003 0.0161 0.0155
Mycobacterium leprae Probable exported protease 0.003 0.0161 0.051
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1215 0.1209
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0018 0.0145
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0039 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0016 0.003 0.0195
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0104 0.0098
Toxoplasma gondii alpha/beta hydrolase, putative 0.003 0.0161 0.5636
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0211 0.4165
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0694 0.0688
Echinococcus multilocularis lamin 0.0027 0.0135 0.0179
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0694 0.0688
Entamoeba histolytica hypothetical protein 0.0028 0.0145 0.0162
Brugia malayi hydrolase, alpha/beta fold family protein 0.003 0.0161 0.1259
Brugia malayi hypothetical protein 0.0104 0.0854 0.6896
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0034 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1155 0.3825
Mycobacterium tuberculosis Conserved protein 0.0035 0.0211 0.0205
Mycobacterium ulcerans proline iminopeptidase PIP 0.003 0.0161 0.0155
Brugia malayi intermediate filament protein 0.0027 0.0135 0.1045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0211 0.1712
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0211 0.4165
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0082 0.1532
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0034 0.0273
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0281 0.1054
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0211 0.0284
Trichomonas vaginalis hydrolase, putative 0.003 0.0161 0.0594
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.003 0.0161 0.051
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.003 0.0161 0.1304
Mycobacterium ulcerans lipase/esterase 0.003 0.0161 0.0155
Echinococcus multilocularis ephrin type A receptor 4 A 0.0062 0.0464 0.0631
Mycobacterium tuberculosis Probable hydrolase 0.0028 0.0145 0.0139
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0028 0.0145 0.0147
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.003 0.0161 0.5636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1155 0.1206
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0408 0.3266
Trypanosoma brucei trypanothione reductase 0.0038 0.0238 0.4713
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0028 0.0145 0.0162
Entamoeba histolytica hypothetical protein 0.0036 0.0221 0.0466
Trichomonas vaginalis valacyclovir hydrolase, putative 0.003 0.0161 0.0594
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0348 0.2782
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0211 0.0788
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1235 0.1692
Brugia malayi ephrin receptor 1 precursor 0.003 0.016 0.1251
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.1155 0.9346
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2609 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0694 0.0688
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0161 0.314
Onchocerca volvulus 0.0035 0.0211 0.4197
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0104 0.0798
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0408 0.0554
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0408 0.0401
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.008
Entamoeba histolytica hypothetical protein 0.0036 0.0221 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0533
Trypanosoma cruzi hydrolase-like protein, putative 0.003 0.0161 0.314
Giardia lamblia Phosphoglycolate phosphatase 0.0028 0.0145 0.0533
Mycobacterium tuberculosis Probable reductase 0.0087 0.0694 0.0688
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.003 0.0161 0.314
Loa Loa (eye worm) hypothetical protein 0.005 0.0348 0.2819
Mycobacterium tuberculosis Conserved protein 0.0035 0.0211 0.0205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0201 0.1628
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0348 0.2782
Mycobacterium ulcerans hydrolase 0.0028 0.0145 0.0139
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0348 0.2819
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0116 0.0966 0.1322
Giardia lamblia Hydrolase, haloacid dehalogenase-like family 0.0028 0.0145 0.0533
Leishmania major hydrolase-like protein 0.003 0.0161 0.314
Treponema pallidum phosphoglycolate phosphatase 0.0028 0.0145 0.0533
Entamoeba histolytica hypothetical protein 0.0036 0.0221 0.0466
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0161 0.0594
Mycobacterium tuberculosis Conserved hypothetical protein 0.0028 0.0145 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0104 0.0098
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0104 0.0098
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0028 0.0145 0.0162
Loa Loa (eye worm) hypothetical protein 0.0028 0.0145 0.1174
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0028 0.0145 0.0193
Leishmania major hydrolase, alpha/beta fold family, putative 0.003 0.0161 0.314
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.003 0.0161 0.314
Mycobacterium ulcerans exported protease 0.003 0.0161 0.0155
Brugia malayi beta-lactamase 0.0035 0.0211 0.167
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0533
Mycobacterium ulcerans haloalkane dehalogenase 0.003 0.0161 0.0155
Mycobacterium tuberculosis Conserved protein 0.003 0.0161 0.0155
Echinococcus granulosus laminin 0.0016 0.0034 0.0031
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0448
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0034 0.0196 0.019
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0372 0.3015
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0104 0.0098
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0006 0.0002
Plasmodium falciparum thioredoxin reductase 0.0038 0.0238 0.962
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.003 0.0161 0.0515
Mycobacterium ulcerans hypothetical protein 0.003 0.0161 0.0155
Mycobacterium ulcerans lipase LipD 0.0035 0.0211 0.0205
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0048 0.1535
Mycobacterium ulcerans hydrolase 0.0028 0.0145 0.0139
Trypanosoma cruzi hydrolase-like protein, putative 0.003 0.0161 0.314
Mycobacterium ulcerans epoxide hydrolase EphF 0.003 0.0161 0.0155
Echinococcus multilocularis fibrillin 1 0.0016 0.0034 0.004
Entamoeba histolytica hypothetical protein 0.0028 0.0145 0.0162
Brugia malayi UPF0017 protein CG3488 0.003 0.0161 0.1259
Schistosoma mansoni hypothetical protein 0.0036 0.0221 0.0715
Loa Loa (eye worm) beta-lactamase 0.0035 0.0211 0.1712
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0028 0.0145 0.1129
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0533
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0408 0.0423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0039 0.0033
Echinococcus multilocularis geminin 0.0335 0.3008 0.4131
Brugia malayi Alpha/beta hydrolase 0.003 0.0161 0.1259
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.003 0.0161 0.314
Entamoeba histolytica hypothetical protein 0.0036 0.0221 0.0466
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0104 0.0098
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0161 0.0594
Onchocerca volvulus Lipase homolog 0.003 0.0161 0.3005
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0018 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0104 0.0798
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0006 0.0002
Leishmania major hydrolase-like protein,esterase-like protein 0.003 0.0161 0.314
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0211 0.0205
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.1712
Onchocerca volvulus 0.0027 0.0135 0.2385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1155 0.3825
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0392
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.0027
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0211 0.0205
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0028 0.0145 0.1129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2609 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0161 0.5636
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Echinococcus multilocularis abhydrolase domain containing protein 0.003 0.0161 0.0215
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0048 0.3036
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0499 1
Plasmodium falciparum glutathione reductase 0.0038 0.0238 0.962
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0392
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0694 0.0688
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0211 0.0788
Giardia lamblia Hydrolase, putative 0.0028 0.0145 0.0533
Loa Loa (eye worm) hypothetical protein 0.0024 0.0104 0.0845
Loa Loa (eye worm) hypothetical protein 0.0024 0.0104 0.0845
Onchocerca volvulus 0.0028 0.0145 0.2628
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0273
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0104 0.0098
Mycobacterium ulcerans hypothetical protein 0.0035 0.0211 0.0205
Onchocerca volvulus 0.0028 0.0145 0.2628
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.1155 0.9349
Brugia malayi Kringle domain containing protein 0.0021 0.0082 0.0614
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0135 0.1091
Plasmodium falciparum haloacid dehalogenase-like hydrolase, putative 0.0028 0.0145 0.5748
Echinococcus granulosus GPCR family 2 0.0016 0.003 0.0027
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0211 0.0965
Mycobacterium ulcerans beta-lactamase 0.0035 0.0211 0.0205
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0211 0.7475
Onchocerca volvulus 0.0035 0.0211 0.4197
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0082 0.275
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0018 0.0051 0.0148
Mycobacterium leprae Probable lipase LipE 0.0035 0.0211 0.0965
Giardia lamblia Phosphoglycolate phosphatase 0.0028 0.0145 0.0533
Brugia malayi Thioredoxin reductase 0.0038 0.0238 0.1889
Mycobacterium ulcerans hydrolase 0.003 0.0161 0.0155
Echinococcus multilocularis abhydrolase domain containing protein 11 0.003 0.0161 0.0215
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0028 0.0145 0.1174
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0784 0.6121
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0104 0.0798
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0408 0.0401
Mycobacterium ulcerans hypothetical protein 0.0024 0.0104 0.0098
Onchocerca volvulus 0.0035 0.0211 0.4197
Echinococcus multilocularis abhydrolase domain containing 3 0.003 0.0161 0.0215
Mycobacterium ulcerans lipase/esterase 0.003 0.0161 0.0155
Leishmania major hypothetical protein, conserved 0.0021 0.0082 0.1532
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0211 0.0683
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0784 0.0778
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0104 0.0098
Toxoplasma gondii ABC1 family protein 0.0035 0.0211 0.7475
Mycobacterium ulcerans lignin peroxidase LipJ 0.003 0.0161 0.0155
Mycobacterium ulcerans epoxide hydrolase EphA 0.1084 1 1
Mycobacterium ulcerans hypothetical protein 0.003 0.0161 0.0155
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0028 0.0145 0.1129
Mycobacterium tuberculosis Probable exported protease 0.003 0.0161 0.0155
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0135 0.1091
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0211 0.0217
Echinococcus granulosus lamin dm0 0.0027 0.0135 0.0137
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0211 0.0205
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.003 0.0161 0.0155
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.003 0.0161 0.051
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.024 0.0323
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1235 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.1712
Brugia malayi alpha/beta hydrolase 0.003 0.0161 0.1259
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0221 0.0298
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.003 0.0161 0.0164
Plasmodium vivax hypothetical protein, conserved 0.003 0.0161 0.5636
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.003 0.0161 0.3005
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0238 0.4713
Mycobacterium ulcerans hypothetical protein 0.0028 0.0145 0.0139
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.003 0.0161 0.0155
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.003 0.0161 0.0155
Giardia lamblia ENC6 protein 0.003 0.0161 0.0594
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0028 0.0145 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0533
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0161 0.0594
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0034 0.0223
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.1712
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1197 0.1251
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0211 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0533
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0028 0.0145 0.1129
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0034 0.0273
Plasmodium vivax alpha/beta hydrolase, putative 0.003 0.0161 0.5636
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0161 0.314
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2609 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0116 0.0966 0.782
Onchocerca volvulus Lipase homolog 0.003 0.0161 0.3005
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0281 1
Brugia malayi Protein kinase domain containing protein 0.0022 0.0088 0.0666
Leishmania major hydrolase-like protein,esterase-like protein 0.003 0.0161 0.314
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.003 0.0246
Brugia malayi hypothetical protein 0.0036 0.0221 0.1748
Mycobacterium ulcerans epoxide hydrolase EphB 0.003 0.0161 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0145 0.2816
Mycobacterium ulcerans acyl-CoA synthetase 0.0031 0.017 0.0164
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0211 0.4165
Echinococcus granulosus abhydrolase domain containing protein 11 0.003 0.0161 0.0164
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0499 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0201 0.1585
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1235 0.4093
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0034 0.0091
Schistosoma mansoni hydrolase 0.003 0.0161 0.0515
Mycobacterium ulcerans haloalkane dehalogenase 0.003 0.0161 0.0155
Mycobacterium ulcerans exported protease 0.003 0.0161 0.0155
Mycobacterium tuberculosis Probable oxidoreductase 0.003 0.0161 0.0155
Loa Loa (eye worm) hypothetical protein 0.003 0.0161 0.1304
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Leishmania major hypothetical protein, conserved 0.003 0.0161 0.314
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0028 0.0145 0.0162
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0243 0.025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.1712
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.003 0.0161 0.0155
Loa Loa (eye worm) hypothetical protein 0.0062 0.0457 0.3702
Echinococcus granulosus ephrin type A receptor 4 A 0.0062 0.0464 0.0481
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0211 0.0788
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.008
Echinococcus granulosus leukotriene A 4 hydrolase 0.0116 0.0966 0.1008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0104 0.0845
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0034 0.0196 0.0828
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0104 0.199
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0408 0.8147
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0248 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2609 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.2609 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0281 0.029
Mycobacterium ulcerans hypothetical protein 0.003 0.0161 0.0155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0175 0.142
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0238 0.0232
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0273
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0082 0.0106
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.198 0.1975
Brugia malayi glutathione reductase 0.0038 0.0238 0.1889
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.003 0.0195
Brugia malayi MH2 domain containing protein 0.0117 0.0972 0.7857
Leishmania major hypothetical protein, conserved 0.0035 0.0211 0.4165
Onchocerca volvulus 0.0027 0.0135 0.2385
Echinococcus multilocularis musashi 0.0027 0.0135 0.0179
Echinococcus granulosus lamin 0.0027 0.0135 0.0137
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0972 0.7868
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.003 0.0161 0.0215
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Leishmania major hypothetical protein, conserved 0.003 0.0161 0.314
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Mycobacterium ulcerans bromoperoxidase BpoC 0.003 0.0161 0.0155
Wolbachia endosymbiont of Brugia malayi phosphatase 0.0028 0.0145 1
Mycobacterium ulcerans hypothetical protein 0.003 0.0161 0.0155
Trichomonas vaginalis esterase, putative 0.0035 0.0211 0.0788
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.003 0.0161 0.0226
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0408 0.0401
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.003 0.0161 0.0215
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0392
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.003 0.0161 0.0226
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0694 0.5306
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Echinococcus granulosus Solute carrier family 22 5 0.1034 0.9537 1
Mycobacterium leprae Probable exported protease 0.003 0.0161 0.051
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Schistosoma mansoni ephrin receptor 0.0062 0.0464 0.1523
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.003 0.0161 0.0155
Schistosoma mansoni hypothetical protein 0.0021 0.0082 0.0251
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0028 0.0145 0.5054
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0028 0.0145 0.1174
Mycobacterium ulcerans short chain dehydrogenase 0.0034 0.0196 0.019
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.003 0.0161 0.0155
Mycobacterium ulcerans homoserine O-acetyltransferase 0.003 0.0161 0.0155
Mycobacterium leprae Probable hydrolase 0.0028 0.0145 0.0366
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2609 1
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.003 0.0161 0.314
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Schistosoma mansoni hypothetical protein 0.0335 0.3008 1
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0028 0.0145 0.0162
Onchocerca volvulus 0.0021 0.0082 0.1134
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0248 0.0572
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.003 0.0161 0.0155
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0082 0.3127
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.2609 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0246
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0028 0.0145 0.0162
Mycobacterium tuberculosis Conserved protein 0.0035 0.0211 0.0205
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0238 0.1931
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0784 0.0778
Brugia malayi hydrolase, alpha/beta fold family protein 0.003 0.0161 0.1259
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0221 0.0227
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0238 0.8459
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.2609 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0161 0.5636
Chlamydia trachomatis phosphoglycolate phosphatase 0.0028 0.0145 1
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.003 0.0161 0.0155
Loa Loa (eye worm) TK/EPH protein kinase 0.0079 0.0621 0.5028
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0694 0.0688
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0028 0.0145 0.1174
Brugia malayi beta-lactamase family protein 0.0035 0.0211 0.167
Trypanosoma cruzi glycosyl hydrolase, putative 0.0028 0.0145 0.2816
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0499 0.1641
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0028 0.0145 0.1174
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0211 0.167
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0211 0.0205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0392
Leishmania major trypanothione reductase 0.0038 0.0238 0.4713
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0028 0.0145 0.0462
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.003 0.0161 0.0594
Mycobacterium ulcerans hydrolase 0.003 0.0161 0.0155
Mycobacterium ulcerans hypothetical protein 0.0028 0.0145 0.0139
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0104 0.0098
Loa Loa (eye worm) hypothetical protein 0.003 0.0161 0.1304
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0281 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0248 0.0927
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0048 0.0042
Echinococcus multilocularis GPCR, family 2 0.0016 0.003 0.0035
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0028 0.0145 0.1174
Echinococcus granulosus abhydrolase domain containing protein 0.003 0.0161 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.1155 0.3825
Mycobacterium tuberculosis Protein tyrosine kinase transcriptional regulatory protein PtkA 0.0028 0.0145 0.0139
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.7276 1
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.003 0.0161 0.1304
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.003 0.0161 0.051
Echinococcus granulosus abhydrolase domain containing protein 3 0.003 0.0161 0.0164
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0499 0.404
Schistosoma mansoni intermediate filament proteins 0.0027 0.0135 0.0428
Trypanosoma cruzi hydrolase-like protein 0.003 0.0161 0.314
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0784 0.0778
Plasmodium falciparum epoxide hydrolase 1 0.003 0.0161 0.6409
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.1091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.1155 0.1582
Mycobacterium ulcerans peroxidase BpoB 0.003 0.0161 0.0155
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0104 0.199
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0028 0.0145 0.1129
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.003 0.0161 0.0155
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0499 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.1155 0.1206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.2609 1
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0082 0.0081
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0048 0.0042
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0028 0.0145 0.0533
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0116 0.0966 0.3196
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0211 0.0205
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0281 1
Loa Loa (eye worm) glutathione reductase 0.0038 0.0238 0.1931
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0281 0.1054
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0211 0.0683
Schistosoma mansoni egf-like domain protein 0.0016 0.0034 0.0091
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0499 1
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0028 0.0145 0.0147
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0104 0.199
Echinococcus multilocularis laminin 0.0016 0.0034 0.004
Brugia malayi Fibulin-1 precursor 0.0016 0.0034 0.0223
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0088 0.0714
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0034 0.004
Schistosoma mansoni lamin 0.0027 0.0135 0.0428
Schistosoma mansoni lamin 0.0027 0.0135 0.0428
Echinococcus multilocularis abhydrolase domain containing protein 3 0.003 0.0161 0.0215
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0243 0.0328
Echinococcus multilocularis lamin dm0 0.0027 0.0135 0.0179

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 2.2 uM Anticoagulant potency in human plasma assessed as concentration for doubling of prothrombin time ChEMBL. 17536795
Ki (binding) = 0.026 nM Inhibition of human F10a ChEMBL. 17536795
Ki (binding) = 90 nM Inhibition of human F2a ChEMBL. 17536795
Ki app (binding) = 0.026 nM Inhibition of human F10a ChEMBL. 17536795
Ki app (binding) = 90 nM Inhibition of human F2a ChEMBL. 17536795
Ki app (binding) > 5000 nM Inhibition of bovine trypsin ChEMBL. 17536795

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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