Detailed information for compound 428495

Basic information

Technical information
  • TDR Targets ID: 428495
  • Name: N-cyclopentyl-3-[2-(cyclopentylamino)pyrimidi n-4-yl]-2-[4-(cyclopropylmethoxy)phenyl]imida zo[1,2-a]pyridin-8-amine
  • MW: 508.657 | Formula: C31H36N6O
  • H donors: 2 H acceptors: 3 LogP: 6.96 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: C1CCC(C1)Nc1cccn2c1nc(c2c1ccnc(n1)NC1CCCC1)c1ccc(cc1)OCC1CC1
  • InChi: 1S/C31H36N6O/c1-2-7-23(6-1)33-27-10-5-19-37-29(26-17-18-32-31(35-26)34-24-8-3-4-9-24)28(36-30(27)37)22-13-15-25(16-14-22)38-20-21-11-12-21/h5,10,13-19,21,23-24,33H,1-4,6-9,11-12,20H2,(H,32,34,35)
  • InChiKey: ZVFBUFIJHUDYHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-[4-(cyclopropylmethoxy)phenyl]-8-imidazo[1,2-a]pyridinamine
  • cyclopentyl-[4-[8-(cyclopentylamino)-2-[4-(cyclopropylmethoxy)phenyl]imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-yl]amine
  • cyclopentyl-[3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-[4-(cyclopropylmethoxy)phenyl]imidazo[1,2-a]pyridin-8-yl]amine
  • AIDS298139
  • AIDS-298139

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax peptide deformylase, putative 0.0233 0.2628 1
Schistosoma mansoni ap endonuclease 0.002 0.0039 0.0048
Schistosoma mansoni smad1 5 8 and 0.0025 0.0101 0.0125
Brugia malayi intermediate filament protein 0.0028 0.0138 0.0327
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0039 0.011
Brugia malayi beta-lactamase family protein 0.0107 0.1094 0.2586
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0085 0.0838 0.0838
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0913 0.2159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0913 0.0913
Mycobacterium tuberculosis Conserved protein 0.0107 0.1094 0.1345
Plasmodium falciparum peptide deformylase 0.0233 0.2628 1
Brugia malayi beta-lactamase family protein 0.0107 0.1094 0.2586
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0434 0.1025
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0264 0.2343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0913 0.1127
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0181 0.1999 0.2467
Loa Loa (eye worm) hypothetical protein 0.0107 0.1094 0.2474
Schistosoma mansoni inositol monophosphatase 0.0038 0.0264 0.0326
Mycobacterium ulcerans lipase LipD 0.0107 0.1094 0.4075
Toxoplasma gondii hypothetical protein 0.0233 0.2628 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0039 0.0266
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0264 0.097
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0264 0.2343
Loa Loa (eye worm) hypothetical protein 0.0107 0.1094 0.2474
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2708 1
Echinococcus granulosus geminin 0.0168 0.1838 0.2269
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0039 0.0266
Mycobacterium tuberculosis Conserved protein 0.0107 0.1094 0.1345
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0114 0.1179 0.1456
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0042
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0572 0.0706
Loa Loa (eye worm) reprolysin 0.0018 0.0019 0.0042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0434 0.0981
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1094 0.4075
Schistosoma mansoni Smad4 0.0025 0.0101 0.0125
Trypanosoma brucei Polypeptide deformylase 1 0.0089 0.0879 0.8015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0264 0.2343
Brugia malayi MH1 domain containing protein 0.0025 0.0101 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0913 0.1127
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0039 0.0266
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1094 0.3953
Schistosoma mansoni smad1 5 8 and 0.0025 0.0101 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0166 0.0205
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1094 0.3642
Schistosoma mansoni hypothetical protein 0.0168 0.1838 0.2269
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0138 0.0327
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0264 0.087
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0039 0.0036
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0264 0.0264
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0101 0.0125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0913 0.1127
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0572 0.5187
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.4231 0.9569
Brugia malayi MH1 domain containing protein 0.0025 0.0101 0.0239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0572 0.206
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0913 0.2066
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0085 0.0838 0.1034
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0085 0.0838 0.1981
Loa Loa (eye worm) hypothetical protein 0.0036 0.0233 0.0527
Schistosoma mansoni hypothetical protein 0.0036 0.0233 0.0288
Onchocerca volvulus 0.0239 0.2708 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1094 0.3953
Loa Loa (eye worm) inositol-1 0.0038 0.0264 0.0597
Echinococcus multilocularis neuropeptide receptor A26 0.0469 0.55 0.55
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0039 0.011
Echinococcus multilocularis smad 0.0025 0.0101 0.0101
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0089 0.0879 0.8015
Brugia malayi isocitrate dehydrogenase 0.0017 0.001 0.0023
Onchocerca volvulus 0.0107 0.1094 0.3718
Echinococcus multilocularis Smad4 0.0025 0.0101 0.0101
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0039 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1094 0.3953
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0264 0.0844
Brugia malayi MH2 domain containing protein 0.0365 0.4231 1
Onchocerca volvulus 0.0107 0.1094 0.3718
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1094 0.1094
Echinococcus granulosus muscleblind protein 0.0146 0.157 0.1938
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0101 0.0125
Mycobacterium ulcerans peptide deformylase 0.0233 0.2628 1
Echinococcus granulosus lamin 0.0028 0.0138 0.0171
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0434 0.1025
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0114 0.1179 0.1179
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0572 0.206
Schistosoma mansoni lamin 0.0028 0.0138 0.0171
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0166 0.0596
Loa Loa (eye worm) hypothetical protein 0.0052 0.0429 0.097
Brugia malayi Inositol-1 0.0038 0.0264 0.0624
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.001 0.001
Echinococcus granulosus disintegrin and metalloproteinase 0.0018 0.0019 0.0023
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0138 0.0313
Brugia malayi Isocitrate dehydrogenase 0.0017 0.001 0.0023
Onchocerca volvulus 0.0052 0.0429 0.113
Loa Loa (eye worm) hypothetical protein 0.0107 0.1094 0.2474
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0166 0.0166
Treponema pallidum polypeptide deformylase (def) 0.0233 0.2628 1
Brugia malayi beta-lactamase 0.0107 0.1094 0.2586
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0039 0.0266
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0101 0.0229
Schistosoma mansoni intermediate filament proteins 0.0028 0.0138 0.0171
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1094 0.135
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0019 0.0023
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0031 0.0182 0.0224
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0572 0.206
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0019 0.0023
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0138 0.0313
Loa Loa (eye worm) beta-lactamase 0.0107 0.1094 0.2474
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1094 0.3953
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0434 0.0981
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0264 0.0844
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.001 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1094 0.1345
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0233 0.2628 1
Echinococcus granulosus smad 0.0025 0.0101 0.0125
Echinococcus multilocularis muscleblind protein 0.0146 0.157 0.157
Echinococcus granulosus lamin dm0 0.0028 0.0138 0.0171
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1094 0.135
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0101 0.0101
Brugia malayi Pre-SET motif family protein 0.003 0.0166 0.0392
Brugia malayi Pre-SET motif family protein 0.021 0.2355 0.5566
Mycobacterium leprae Probable lipase LipE 0.0107 0.1094 0.3642
Echinococcus granulosus Smad4 0.0025 0.0101 0.0125
Mycobacterium tuberculosis Conserved protein 0.0107 0.1094 0.1345
Echinococcus multilocularis adam 17 protease 0.0181 0.1999 0.1999
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1094 0.4075
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0572 0.2148
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2355 0.5326
Schistosoma mansoni smad 0.0025 0.0101 0.0125
Loa Loa (eye worm) hypothetical protein 0.0107 0.1094 0.2474
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1094 0.3953
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0166 0.0205
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0146 0.157 0.3551
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.8102 0.8102
Onchocerca volvulus 0.0107 0.1094 0.3718
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1094 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0572 0.0706
Mycobacterium ulcerans beta-lactamase 0.0107 0.1094 0.4075
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1094 0.1345
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0101 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0166 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0913 0.0913
Schistosoma mansoni inositol monophosphatase 0.0038 0.0264 0.0326
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0101 0.0229
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.0012
Loa Loa (eye worm) Smad1 0.0025 0.0101 0.0229
Echinococcus multilocularis neuropeptide s receptor 0.0469 0.55 0.55
Toxoplasma gondii ABC1 family protein 0.0107 0.1094 0.414
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0039 0.0087
Echinococcus granulosus adam 17 protease 0.0199 0.2218 0.2738
Loa Loa (eye worm) hypothetical protein 0.038 0.4421 1
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0018 0.0019 0.0019
Onchocerca volvulus 0.003 0.0166 0.0106
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.001 0.001
Echinococcus multilocularis lamin dm0 0.0028 0.0138 0.0138
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0039 0.5
Trypanosoma cruzi Peptide deformylase 2, putative 0.0089 0.0879 0.8015
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0233 0.2628 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0572 0.0698
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.4231 0.9569
Schistosoma mansoni smad1 5 8 and 0.0025 0.0101 0.0125
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1094 0.2474
Loa Loa (eye worm) hypothetical protein 0.0107 0.1094 0.2474
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0264 0.0844
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0429 0.0529
Echinococcus granulosus adam 0.0031 0.0182 0.0224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0913 0.1127
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0233 0.2628 0.3248
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1094 0.1345
Loa Loa (eye worm) hypothetical protein 0.003 0.0166 0.0375
Brugia malayi Disintegrin family protein 0.0018 0.0019 0.0044
Brugia malayi MH2 domain containing protein 0.0025 0.0101 0.0239
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0572 0.0706
Plasmodium vivax SET domain protein, putative 0.003 0.0166 0.0596
Echinococcus multilocularis geminin 0.0168 0.1838 0.1838
Echinococcus multilocularis adam 0.0031 0.0182 0.0182
Toxoplasma gondii exonuclease III APE 0.002 0.0039 0.011
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0264 0.2343
Echinococcus granulosus neuropeptide receptor A26 0.0469 0.55 0.6788
Echinococcus multilocularis lamin 0.0028 0.0138 0.0138
Schistosoma mansoni ap endonuclease 0.002 0.0039 0.0048
Echinococcus granulosus tumor protein p63 0.0354 0.41 0.5061
Schistosoma mansoni hypothetical protein 0.0168 0.1838 0.2269
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1094 0.1345
Brugia malayi MH2 domain containing protein 0.0025 0.0101 0.0239
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1094 0.135
Chlamydia trachomatis peptide deformylase 0.0233 0.2628 0.5
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.001 0.0012
Schistosoma mansoni lamin 0.0028 0.0138 0.0171
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0039 0.0091
Mycobacterium ulcerans hypothetical protein 0.0107 0.1094 0.4075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0166 0.0205
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0152 0.0188
Loa Loa (eye worm) hypothetical protein 0.0146 0.157 0.3551
Brugia malayi Muscleblind-like protein 0.0146 0.157 0.3711
Trypanosoma brucei Peptide deformylase 2 0.0089 0.0879 0.8015
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1094 0.414
Schistosoma mansoni dihydroceramide desaturase 0.0018 0.0019 0.0023
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0089 0.0879 0.8015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0166 0.0166
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0572 0.0572
Brugia malayi Smad1 0.0025 0.0101 0.0239
Echinococcus multilocularis tumor protein p63 0.0354 0.41 0.41
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0264 1
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1094 1
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0233 0.0551
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1094 0.2586
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0018 0.0019 0.0023
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0264 0.0326
Loa Loa (eye worm) hypothetical protein 0.0107 0.1094 0.2474
Trypanosoma cruzi Peptide deformylase 2, putative 0.0089 0.0879 0.8015
Echinococcus granulosus microtubule associated protein 2 0.0683 0.8102 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0166 0.0205
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1094 0.1345
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0681 0.8071 1
Echinococcus granulosus neuropeptide s receptor 0.0469 0.55 0.6788
Loa Loa (eye worm) hypothetical protein 0.0027 0.0132 0.0299
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0264 0.087
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1094 1
Trichomonas vaginalis esterase, putative 0.0107 0.1094 0.3953
Echinococcus multilocularis muscleblind protein 1 0.0146 0.157 0.157
Leishmania major hypothetical protein, conserved 0.0107 0.1094 1
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1094 0.1345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0913 0.1127
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.8102 1
Echinococcus multilocularis disintegrin and metalloproteinase 0.0018 0.0019 0.0019
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1094 0.1345
Leishmania major polypeptide deformylase-like protein, putative 0.0089 0.0879 0.8015
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0215 0.0255
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0313
Echinococcus granulosus intermediate filament protein 0.0028 0.0138 0.0171
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0085 0.0838 0.1034
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0101 0.0101
Brugia malayi hypothetical protein 0.0031 0.0182 0.0429
Echinococcus multilocularis musashi 0.0028 0.0138 0.0138

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) > 40 uM Cytotoxicity against Vero cells ChEMBL. 17368024
IC50 (functional) = 0.27 uM Antiviral activity against HSV1 SC16 in Vero cells by capture hybrid method ChEMBL. 17368024

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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