TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 204.265 | Formula: C13H16O2
H donors: 1 H acceptors: 2 LogP: 3.33 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccc(cc1)CC1CC1)C(=O)O
InChi: 1S/C13H16O2/c1-9(13(14)15)12-6-4-11(5-7-12)8-10-2-3-10/h4-7,9-10H,2-3,8H2,1H3,(H,14,15)
InChiKey: PJIURQRCQMEQNR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.0658	0.5934
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0097	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0319	0.4846
Brugia malayi	Niemann-Pick C1 protein precursor	0.0195	0.1109	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0075	0.0349	0.1307
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.003	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0407	0.3674
Schistosoma mansoni	microtubule-associated protein tau	0.1412	0.8759	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0024	0.003	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0097	0.0877
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0085	0.1246
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0024	0.003	0.0453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Schistosoma mansoni	hypothetical protein	0.0081	0.0388	0.0443
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0085	0.1246
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0024	0.003	0.0112
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0054	0.0219	0.0219
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0024	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0799	0.7203
Leishmania major	trypanothione reductase	0.0051	0.0198	0.0701
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0159	0.0182
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.0453
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0097	0.4918
Echinococcus multilocularis	protein patched	0.0084	0.0407	0.0407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0319	0.4846
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0046	0.0171	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0124	0.0658	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0046	0.0171	1
Echinococcus multilocularis	muscleblind protein	0.0146	0.0799	0.0799
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0124	0.0658	1
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0024	0.003	0.0106
Brugia malayi	FAT domain containing protein	0.0054	0.0219	0.1978
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0024	0.003	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0799	0.7203
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0169	0.2571
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0101	0.0116
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0024	0.003	0.003
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0024	0.003	0.0453
Brugia malayi	Muscleblind-like protein	0.0146	0.0799	0.7203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0319	0.2875
Schistosoma mansoni	hypothetical protein	0.0081	0.0388	0.0443
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.003	0.0269
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.003	0.0269
Leishmania major	hypothetical protein, unknown function	0.0024	0.003	0.0106
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0024	0.003	0.0112
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0046	0.0171	0.1539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0024	0.003	0.0435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Giardia lamblia	GTOR	0.0124	0.0658	1
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.007	0.0319	0.2875
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0124	0.0658	0.2464
Plasmodium falciparum	thioredoxin reductase	0.0051	0.0198	1
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0171	0.1539
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.0198	1
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.1275	0.79	0.9019
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0349	0.3148
Entamoeba histolytica	protein kinase rad3, putative	0.007	0.0319	0.2875
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0024	0.003	0.0453
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0185	0.1664
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.003	0.0269
Brugia malayi	Thioredoxin reductase	0.0051	0.0198	0.1783
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0097	0.0877
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0024	0.003	0.0034
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0024	0.003	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0159	0.0182
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0219	0.3333
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0024	0.003	0.0453
Echinococcus granulosus	microtubule associated protein 2	0.1412	0.8759	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0024	0.003	0.0269
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0078	0.0369	0.5607
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0124	0.0658	0.5934
Echinococcus multilocularis	Zinc finger, PHD finger	0.0024	0.003	0.003
Echinococcus granulosus	tumor protein p63	0.0741	0.454	0.5183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.003	0.0453
Plasmodium vivax	glutathione reductase, putative	0.0051	0.0198	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.003	0.0269
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0084	0.0407	0.3674
Echinococcus multilocularis	Spectrin alpha actinin	0.0034	0.0097	0.0097
Plasmodium vivax	hypothetical protein	0.0024	0.003	0.1506
Mycobacterium tuberculosis	Probable reductase	0.0115	0.0605	0.8821
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0124	0.0658	0.2334
Schistosoma mansoni	hypothetical protein	0.0034	0.0097	0.0111
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0024	0.003	0.0453
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0024	0.003	0.0112
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0024	0.003	0.0034
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.0198	0.1783
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0024	0.003	0.0453
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.0605	0.8821
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0124	0.0658	0.0751
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.007	0.0319	0.1194
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0024	0.003	0.0034
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0098	0.0499	0.4497
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0024	0.003	0.0034
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0124	0.0658	0.2464
Loa Loa (eye worm)	phosphatidylinositol 3	0.0024	0.003	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0078	0.0369	0.5607
Entamoeba histolytica	hypothetical protein	0.0035	0.0101	0.0914
Schistosoma mansoni	hypothetical protein	0.0081	0.0388	0.0443
Mycobacterium ulcerans	hypothetical protein	0.0046	0.0171	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0024	0.003	0.0453
Entamoeba histolytica	hypothetical protein	0.0024	0.003	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0046	0.0171	0.0605
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.0799	0.0799
Entamoeba histolytica	hypothetical protein	0.0035	0.0101	0.0914
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0046	0.0171	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0024	0.003	0.0034
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0024	0.003	0.0453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0124	0.0658	0.5934
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0097	0.0875
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0024	0.003	0.0034
Echinococcus multilocularis	Niemann Pick C1 protein	0.0279	0.1636	0.1636
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.0605	0.8821
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0046	0.0171	0.2149
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0024	0.003	0.003
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0024	0.003	0.0453
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0124	0.0658	0.2334
Onchocerca volvulus		0.0046	0.0171	0.2647
Echinococcus granulosus	Protein patched homolog 1	0.0084	0.0407	0.0465
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0046	0.0171	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.0605	0.8821
Brugia malayi	hypothetical protein	0.0035	0.0101	0.0914
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0159	0.1438
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0124	0.0658	0.0751
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0046	0.0171	0.0605
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0046	0.0171	0.2149
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0024	0.003	0.0269
Schistosoma mansoni	fkbp-rapamycin associated protein	0.007	0.0319	0.0364
Plasmodium falciparum	glutathione reductase	0.0051	0.0198	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0024	0.003	0.0453
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0128	0.0685	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.0198	0.0741
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0024	0.003	0.003
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0159	0.0182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.0658	0.5934
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0171	0.1539
Schistosoma mansoni	hypothetical protein	0.0034	0.0097	0.0111
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0279	0.1636	0.1868
Plasmodium vivax	hypothetical protein, conserved	0.0024	0.003	0.1506
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0159	0.0182
Leishmania major	phosphatidylinositol kinase, putative	0.0024	0.003	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0098	0.0499	0.7579
Entamoeba histolytica	hypothetical protein	0.0024	0.003	0.0269
Schistosoma mansoni	hypothetical protein	0.0033	0.0088	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0097	0.0877
Echinococcus granulosus	sterol regulatory element binding protein	0.0084	0.0407	0.0465
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0124	0.0658	0.5934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Brugia malayi	VAB-10A protein	0.0034	0.0097	0.0875
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0124	0.0658	0.2464
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0024	0.003	0.0453
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0097	0.0877
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0078	0.0369	0.5607
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0024	0.003	0.1506
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0088	0.0796
Loa Loa (eye worm)	phosphatidylinositol 3	0.0024	0.003	0.0269
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0124	0.0658	0.0658
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0024	0.003	0.0034
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0024	0.003	0.0453
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0046	0.0171	0.249
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.0106
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0562	0.507
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0124	0.0658	0.0658
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0085	0.1246
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.1275	0.79	0.79
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0124	0.0658	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0024	0.003	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0046	0.0171	0.1539
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0098	0.0499	0.7579
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0124	0.0658	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0195	0.1109	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0128	0.0685	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0085	0.1246
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0159	0.0182
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0024	0.003	0.0453
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0024	0.003	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0171	0.1539
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0088	0.0796
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0159	0.0159
Echinococcus multilocularis		0.0024	0.003	0.003
Echinococcus multilocularis	protein dispatched 1	0.0096	0.0482	0.0482
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0024	0.003	0.0453
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0369	0.5607
Schistosoma mansoni	cellular tumor antigen P53	0.0108	0.0562	0.0642
Loa Loa (eye worm)	glutathione reductase	0.0051	0.0198	0.1783
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0124	0.0658	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.0605	0.8821
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0407	0.6192
Entamoeba histolytica	hypothetical protein	0.0024	0.003	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.003	0.0453
Brugia malayi	Growth-Arrest-Specific Protein 2 Domain containing protein	0.0034	0.0097	0.0875
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0171	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0124	0.0658	0.0751
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.007	0.0319	0.0364
Trypanosoma cruzi	kinetoplast DNA-associated protein, putative	0.0034	0.0097	0.0363
Echinococcus multilocularis	serine protein kinase ATM	0.0098	0.0499	0.0499
Echinococcus multilocularis	sterol regulatory element binding protein	0.0084	0.0407	0.0407
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0097	0.5697
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Trypanosoma brucei	trypanothione reductase	0.0051	0.0198	0.3005
Loa Loa (eye worm)	hypothetical protein	0.0024	0.003	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.1664
Schistosoma mansoni	patched 1	0.0084	0.0407	0.0465
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0319	0.4846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0319	0.4846
Echinococcus multilocularis	tumor protein p63	0.0741	0.454	0.454
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.0198	0.0226
Schistosoma mansoni	hypothetical protein	0.0054	0.0219	0.025
Leishmania major	4-coumarate:coa ligase-like protein	0.0046	0.0171	0.0605
Loa Loa (eye worm)	spectraplakin	0.0034	0.0097	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0195	0.1109	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0024	0.003	0.0034
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0159	0.1438
Echinococcus granulosus	muscleblind protein	0.0146	0.0799	0.0912
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0052	0.021	0.0785
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.0605	0.8821
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0	0.5
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0024	0.003	0.0453
Trypanosoma cruzi	target of rapamycin kinase 3	0.0124	0.0658	0.2464
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0124	0.0658	0.0751
Toxoplasma gondii	FATC domain-containing protein	0.0098	0.0499	0.7579
Mycobacterium tuberculosis	Probable oxidoreductase	0.0128	0.0685	1
Onchocerca volvulus		0.0108	0.0562	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0124	0.0658	0.2334
Entamoeba histolytica	hypothetical protein	0.0098	0.0499	0.4497
Loa Loa (eye worm)	hypothetical protein	0.0024	0.003	0.0269
Brugia malayi	CHE-14 protein	0.0084	0.0407	0.3674
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0024	0.003	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0097	0.0877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.0269
Loa Loa (eye worm)	phosphatidylinositol 3	0.0024	0.003	0.0269
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0024	0.003	0.0112
Entamoeba histolytica	hypothetical protein	0.0035	0.0101	0.0914
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.007	0.0319	0.2875
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0024	0.003	0.0453
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0024	0.003	0.0034
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0024	0.003	0.1506
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0124	0.0658	0.2334
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0024	0.003	0.0112
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.007	0.0319	0.0319
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0024	0.003	0.1506
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0052	0.021	0.0743
Echinococcus multilocularis	microtubule associated protein 2	0.1412	0.8759	0.8759
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0024	0.003	0.0112
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0171	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.003	0.0269
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0054	0.0219	0.025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0024	0.003	0.0269
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0024	0.003	0.0269
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0024	0.003	0.0034
Loa Loa (eye worm)	phosphatidylinositol 3	0.0024	0.003	0.0269
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0185	0.1664
Echinococcus granulosus	Spectrin alpha actinin	0.0034	0.0097	0.0111
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0098	0.0499	0.1868
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0024	0.003	0.1506
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0319	0.4846
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0198	0.1128	0.1288
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.0269
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.003	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0024	0.003	0.0034
Schistosoma mansoni	hypothetical protein	0.0035	0.0101	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0219	0.1978
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.0112
Schistosoma mansoni	hypothetical protein	0.0024	0.003	0.0034
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.0269
Echinococcus granulosus	serine protein kinase ATM	0.0098	0.0499	0.0569
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0101	0.0101
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0046	0.0171	0.249
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0097	0.1419
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.0198	0.2885
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0024	0.003	0.0112
Leishmania major	hypothetical protein, conserved	0.0468	0.282	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0024	0.003	0.0453
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0024	0.003	0.0112
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0098	0.0499	0.0569
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Giardia lamblia	Hypothetical protein	0.0024	0.003	0.0453
Entamoeba histolytica	acyl-coA synthetase, putative	0.0046	0.0171	0.1539
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0171	0.1539
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0171	0.1539
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0124	0.0658	0.2334
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0024	0.003	0.1506
Schistosoma mansoni	hypothetical protein	0.0081	0.0388	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0369	0.3327
Brugia malayi	glutathione reductase	0.0051	0.0198	0.1783
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0169	0.2571
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0024	0.003	0.0269
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0024	0.003	0.1506
Echinococcus granulosus	Niemann Pick C1 protein	0.0195	0.1109	0.1266
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0024	0.003	0.0034
Trypanosoma cruzi	hypothetical protein, conserved	0.0444	0.267	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0101	0.0116
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0024	0.003	0.0453
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0171	0.1539
Echinococcus multilocularis	expressed conserved protein	0.0184	0.1034	0.1034
Entamoeba histolytica	hypothetical protein	0.0035	0.0101	0.0914
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0124	0.0658	1
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0024	0.003	0.0453
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0024	0.003	0.003
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0024	0.003	0.0453
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0128	0.0685	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0159	0.0159
Entamoeba histolytica	hypothetical protein	0.0024	0.003	0.0269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0319	0.4846
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0115	0.0605	0.8767
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0024	0.003	0.0453
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0319	0.4846
Echinococcus multilocularis	Niemann Pick C1 protein	0.0195	0.1109	0.1109
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0185	0.1664
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0124	0.0658	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0124	0.0658	0.5934
Toxoplasma gondii	thioredoxin reductase	0.0051	0.0198	0.3005
Loa Loa (eye worm)	phosphatidylinositol 3	0.0024	0.003	0.0269
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0097	0.4918
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0024	0.003	0.1506
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0024	0.003	0.0453
Echinococcus granulosus	expressed conserved protein	0.0184	0.1034	0.1181
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0124	0.0658	0.2464
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0526	0.4744
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0171	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0024	0.003	0.0453

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 24 %	Inhibition of CXCL8-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay	ChEMBL.	17665889
Inhibition (functional)	= 30 %	Inhibition of CXCL1-induced cell migration in human PMN cells at 0.01 uM by chemotaxis assay	ChEMBL.	17665889

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 433092