TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.399 | Formula: C15H13NO3S2
H donors: 2 H acceptors: 3 LogP: 1.77 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)Cc1ccc(cc1)C1C(=S)NC2C(C1=O)SC=C2
InChi: 1S/C15H13NO3S2/c17-11(18)7-8-1-3-9(4-2-8)12-13(19)14-10(5-6-21-14)16-15(12)20/h1-6,10,12,14H,7H2,(H,16,20)(H,17,18)
InChiKey: IYRIFOOVYCNVAK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0064	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0028	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0601	0.358	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0028	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0416	0.2453	0.6853
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.014	0.0775	0.4129
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.0317	0.0519
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.0317	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0359	0.2107	0.3778
Loa Loa (eye worm)	acetylcholinesterase 1	0.0069	0.0344	0.0961
Schistosoma mansoni	hypothetical protein	0.0025	0.0076	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0026	0.008	0.0225
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.0317	0.1575
Plasmodium vivax	aspartyl protease, putative	0.0093	0.0487	0.5016
Echinococcus granulosus	Solute carrier family 22 5	0.1016	0.6108	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0154	0.056
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0064	0.0198
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.014	0.0775	1
Brugia malayi	peptidase family M13 containing protein	0.0024	0.0065	0.0159
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0177	0.029
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0028	0.0078
Schistosoma mansoni	ephrin receptor	0.0063	0.0303	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0344	0.0961
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0049	0.0219	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0096	0.051	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0016	0.0046
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.1669	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0317	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0367	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0357	0.0996
Plasmodium falciparum	plasmepsin I	0.0168	0.0943	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0367	0.1025
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.1669	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0299	0.0836
Schistosoma mansoni	hypothetical protein	0.0025	0.0076	0.0107
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0083	0.0233
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0064	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0064	0.0179
Schistosoma mansoni	hypothetical protein	0.0025	0.0076	0.0107
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0009	0.0024
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0071	0.0357	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0357	0.0996
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.1669	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0487	0.0851
Loa Loa (eye worm)	TK/EPH protein kinase	0.008	0.0407	0.1136
Giardia lamblia	Fructose-bisphosphate aldolase	0.0287	0.1669	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0064	0.0179
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.0317	0.0317
Mycobacterium leprae	probable zinc metalloprotease	0.0096	0.051	0.6268
Plasmodium vivax	plasmepsin IV, putative	0.0168	0.0943	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0063	0.0303	0.0497
Treponema pallidum	fructose-bisphosphate aldolase	0.0287	0.1669	0.5
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0093	0.0487	0.4048
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0064	0.0198
Echinococcus granulosus	intermediate filament protein	0.0026	0.0083	0.0137
Brugia malayi	hypothetical protein	0.0038	0.0154	0.0407
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0168	0.0943	1
Onchocerca volvulus	Alkaline ceramidase homolog	0.0405	0.2388	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0016	0.0016
Mycobacterium ulcerans	hydrolase/amidase	0.0315	0.1838	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0156	0.1395
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0083	0.021
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0064	0.0198
Brugia malayi	Carboxylesterase family protein	0.0069	0.0344	0.094
Onchocerca volvulus		0.0026	0.0083	0.0084
Plasmodium vivax	plasmepsin V, putative	0.0093	0.0487	0.5016
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0151	0.0247
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0064	0.0198
Onchocerca volvulus		0.0026	0.0083	0.0084
Onchocerca volvulus		0.0062	0.0299	0.1012
Brugia malayi	ephrin receptor 1 precursor	0.003	0.0104	0.0267
Onchocerca volvulus		0.0048	0.0213	0.0643
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.1669	1
Echinococcus multilocularis	endothelin converting enzyme 1	0.0096	0.051	0.051
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0177	0.1627
Plasmodium falciparum	plasmepsin VII	0.0093	0.0487	0.5016
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0487	0.0851
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0016	0.0027
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0064	0.0198
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0487	0.0851
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.1669	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.1669	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.022	0.0615
Toxoplasma gondii	aspartyl protease ASP1	0.0168	0.0943	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0487	0.0851
Onchocerca volvulus		0.0093	0.0487	0.1821
Schistosoma mansoni	hypothetical protein	0.0033	0.0126	0.0198
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0487	0.0851
Toxoplasma gondii	aspartyl protease	0.0093	0.0487	0.4048
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0096	0.051	0.1404
Brugia malayi	cancer related gene-liver 1	0.0405	0.2388	0.6663
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0287	0.1669	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0638	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0213	0.0596
Plasmodium falciparum	plasmepsin X	0.0093	0.0487	0.5016
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0049	0.0219	0.0366
Plasmodium falciparum	plasmepsin IV	0.0168	0.0943	1
Plasmodium falciparum	plasmepsin IX	0.0093	0.0487	0.5016
Echinococcus multilocularis	lamin	0.0026	0.0083	0.0083
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0024	0.0065	0.0088
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.0788	0.0788
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0156	0.0572
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0064	0.0552
Toxoplasma gondii	aspartyl protease ASP3	0.0093	0.0487	0.4048
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0317	0.5
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0168	0.0943	0.1675
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0049	0.0219	0.0366
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.1669	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0357	0.0996
Echinococcus multilocularis	lamin dm0	0.0026	0.0083	0.0083
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.022	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0028	0.0078
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0064	0.0155
Plasmodium vivax	aspartyl proteinase, putative	0.0168	0.0943	1
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0016	0.0016
Schistosoma mansoni	lamin	0.0026	0.0083	0.0121
Echinococcus granulosus	acetylcholinesterase	0.0069	0.0344	0.0563
Onchocerca volvulus		0.0093	0.0487	0.1821
Echinococcus granulosus	lamin dm0	0.0026	0.0083	0.0137
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0024	0.0065	0.0088
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0064	0.0155
Schistosoma mansoni	hypothetical protein	0.0025	0.0076	0.0107
Echinococcus granulosus	acetylcholinesterase	0.0069	0.0344	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0028	0.0078
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0024	0.0065	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0487	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0367	0.1025
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0168	0.0943	0.0943
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0093	0.0487	0.1361
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.0317	0.0885
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0287	0.1669	1
Schistosoma mansoni	memapsin-2 (A01 family)	0.0924	0.555	1
Brugia malayi	hypothetical protein	0.0093	0.0487	0.134
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.0764	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0344	0.0961
Echinococcus multilocularis	geminin	0.0345	0.2025	0.2025
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0638	0.1781
Plasmodium falciparum	plasmepsin VI	0.0168	0.0943	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0487	0.1361
Loa Loa (eye worm)	aspartyl protease 6	0.0093	0.0487	0.1361
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0487	0.0851
Brugia malayi	MH2 domain containing protein	0.0117	0.0638	0.1762
Echinococcus multilocularis	acetylcholinesterase	0.0069	0.0344	0.0344
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0016	0.0022
Echinococcus granulosus	geminin	0.0345	0.2025	0.3316
Echinococcus multilocularis	musashi	0.0026	0.0083	0.0083
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0049	0.0219	0.0366
Schistosoma mansoni	lamin	0.0026	0.0083	0.0121
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0064	0.0198
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0093	0.0487	0.134
Echinococcus granulosus	lamin	0.0026	0.0083	0.0137
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0016	0.0016
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.0788	0.1395
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0487	0.0851
Brugia malayi	Pepsin A precursor	0.0093	0.0487	0.134
Loa Loa (eye worm)	hypothetical protein	0.0405	0.2388	0.6671
Schistosoma mansoni	hypothetical protein	0.0025	0.0076	0.0107
Plasmodium vivax	aspartyl protease, putative	0.0093	0.0487	0.5016
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0016	0.0046
Echinococcus multilocularis	carboxylesterase 5A	0.0069	0.0344	0.0344
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0063	0.0303	0.0303
Schistosoma mansoni	hypothetical protein	0.0345	0.2025	0.363
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.0788	0.2184
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0367	0.1025
Echinococcus granulosus	GPCR family 2	0.0015	0.0016	0.0027
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0016	0.0027
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0287	0.1669	1
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0083	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0357	0.0996
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0154	0.0248
Loa Loa (eye worm)	carboxylesterase	0.0069	0.0344	0.0961
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0083	0.0233
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0096	0.051	0.6475
Mycobacterium ulcerans	zinc metalloprotease	0.0096	0.051	0.2662
Schistosoma mansoni	hypothetical protein	0.0025	0.0076	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0096	0.051	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0114	0.0319
Brugia malayi	aspartic protease BmAsp-2, identical	0.0093	0.0487	0.134
Entamoeba histolytica	hypothetical protein	0.0038	0.0154	0.056
Brugia malayi	intermediate filament protein	0.0026	0.0083	0.021
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0024	0.0065	0.0183
Entamoeba histolytica	hypothetical protein	0.0038	0.0154	0.056
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0367	0.1025
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0069	0.0344	0.0592
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.0317	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0367	0.1025
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0317	0.5
Echinococcus multilocularis	acetylcholinesterase	0.0069	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0083	0.0233
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0024	0.0065	0.0088
Brugia malayi	Carboxylesterase family protein	0.0069	0.0344	0.094
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0064	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0416	0.2453	0.6853
Brugia malayi	hypothetical protein	0.0093	0.0487	0.134
Plasmodium vivax	aspartyl protease, putative	0.0093	0.0487	0.5016
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0028	0.5
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0025	0.0076	0.0107
Entamoeba histolytica	hypothetical protein	0.0038	0.0154	0.056
Schistosoma mansoni	hypothetical protein	0.0038	0.0154	0.0248
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0016	0.0022
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0093	0.0487	0.0851
Plasmodium falciparum	plasmepsin II	0.0168	0.0943	1
Brugia malayi	hypothetical protein	0.0601	0.358	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0024	0.0065	0.0088
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0168	0.0943	0.5136
Schistosoma mansoni	hypothetical protein	0.0345	0.2025	0.363
Echinococcus granulosus	endothelin converting enzyme 1	0.0096	0.051	0.0835
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.022	0.0615
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0168	0.0943	0.2635
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.014	0.0775	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0064	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0028	0.0078
Plasmodium falciparum	plasmepsin III	0.0093	0.0487	0.5016
Toxoplasma gondii	peptidase family M13 protein	0.0096	0.051	0.4345
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0096	0.051	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0064	0.0179
Loa Loa (eye worm)	acetyltransferase	0.0142	0.0788	0.2202
Loa Loa (eye worm)	hypothetical protein	0.0096	0.051	0.1424
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.022	0.0592
Schistosoma mansoni	cathepsin D (A01 family)	0.0359	0.2107	0.3778
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0943	0.2635
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0071	0.0357	0.0996
Brugia malayi	aspartic protease BmAsp-1, identical	0.0093	0.0487	0.134
Plasmodium vivax	aspartyl proteinase, putative	0.0093	0.0487	0.5016
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0049	0.0219	0.0366
Echinococcus granulosus	carboxylesterase 5A	0.0069	0.0344	0.0563
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0151	0.0151
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0168	0.0943	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0126	0.0352
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0126	0.0329
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0154	0.0252
Brugia malayi	Peptidase family M13 containing protein	0.0096	0.051	0.1404
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0154	0.0154
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.0317	0.0543
Plasmodium falciparum	plasmepsin V	0.0093	0.0487	0.5016
Schistosoma mansoni	neprilysin	0.0025	0.0076	0.0107
Plasmodium falciparum	plasmepsin VIII, putative	0.0093	0.0487	0.5016
Schistosoma mansoni	endothelin-converting enzyme-related	0.0024	0.0065	0.0088

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 880 uM	Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells	ChEMBL.	17367895
Ki (binding)	= 880 uM	Inhibition of bovine low molecular weight PTP expressed in Escherichia coli BL21(D3) cells	ChEMBL.	17367895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 435111