Detailed information for compound 435238

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.595 | Formula: C19H30N4O6S2
  • H donors: 3 H acceptors: 6 LogP: -2.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(S1(=O)=O)C[C@H]1NC[C@H](C1)SC1=C(C(=O)O)N2C([C@H]1C)C(C2=O)[C@H](O)C
  • InChi: 1S/C19H30N4O6S2/c1-4-21-5-6-22(31(21,28)29)9-12-7-13(8-20-12)30-17-10(2)15-14(11(3)24)18(25)23(15)16(17)19(26)27/h10-15,20,24H,4-9H2,1-3H3,(H,26,27)/t10-,11-,12+,13+,14?,15?/m1/s1
  • InChiKey: DMRAGSSFKFTFDL-UWAOJUJRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0762
Schistosoma mansoni ap endonuclease 0.0012 0.0077 0.0068
Schistosoma mansoni cpg binding protein 0.0036 0.0522 0.0563
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0036 0.0522 0.0578
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0276 0.0705
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0171 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1785 0.1969
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0485 0.23
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0207 0.7496
Giardia lamblia PHD finger protein 15 0.0019 0.0207 1
Schistosoma mansoni hypothetical protein 0.0079 0.1355 0.149
Echinococcus multilocularis peregrin 0.0019 0.0207 0.0205
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0542 0.0601
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0171 0.0762
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0207 0.0936
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0171 0.0173
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0013 0.0083 0.0091
Brugia malayi mbt repeat family protein 0.0031 0.0439 0.2075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0542 0.2581
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0171 0.0173
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0013 0.0083 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0171 0.0762
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0171 0.0189
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0171 0.017
Loa Loa (eye worm) histone methyltransferase 0.001 0.004 0.0122
Echinococcus granulosus peregrin 0.0019 0.0207 0.0228
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0276 0.0705
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0157 0.0695
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0171 0.0173
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0013 0.0083 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0762
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0171 0.017
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0077 0.2794
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0.0077 0.0301
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0023 0.0276 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0077 0.0076
Onchocerca volvulus Alhambra homolog 0.0019 0.0207 0.1133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0171 0.0762
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0276 0.0705
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0171 0.0762
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0171 0.0189
Echinococcus multilocularis histone acetyltransferase MYST2 0.0036 0.0522 0.052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0522 0.2481
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.1038 0.1036
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0171 0.017
Leishmania major DNA polymerase eta, putative 0.0029 0.0402 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0542 0.2581
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0036 0.0522 0.052
Brugia malayi Bromodomain containing protein 0.0019 0.0207 0.0936
Treponema pallidum exodeoxyribonuclease (exoA) 0.0012 0.0077 0.5
Schistosoma mansoni jumonji domain containing protein 0.005 0.0792 0.0863
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.2056 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0013 0.0083 0.0082
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.0083 0.0331
Echinococcus granulosus SAM and MBT domain containing protein 0.0031 0.0439 0.0486
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0542 0.0541
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0171 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0171 0.0762
Loa Loa (eye worm) hypothetical protein 0.0029 0.0402 0.1896
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.032 0.0339
Echinococcus granulosus Aminotransferase class III 0.0023 0.0276 0.0305
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0171 0.017
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0207 0.1318
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.032 0.0339
Schistosoma mansoni hypothetical protein 0.0037 0.0542 0.0586
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0542 0.2581
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0207 0.1318
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0171 0.0762
Trypanosoma brucei unspecified product 0.0013 0.0083 0.1904
Loa Loa (eye worm) mbt repeat family protein 0.0031 0.0439 0.2075
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0171 0.0762
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0276 0.0705
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0171 0.0173
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0171 0.0762
Mycobacterium ulcerans DNA polymerase IV 0.0013 0.0083 0.0022
Schistosoma mansoni sex comb on midleg homolog 0.0031 0.0439 0.0471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0171 0.0762
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0171 0.0173
Echinococcus multilocularis dnaJ subfamily B 0.0481 0.9005 0.9005
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0276 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0013 0.0083 0.0189
Schistosoma mansoni myelin transcription factor 1 myt1 0.0036 0.0522 0.0563
Schistosoma mansoni hypothetical protein 0.0193 0.3522 0.39
Brugia malayi nuclear hormone receptor 0.0017 0.0171 0.0762
Schistosoma mansoni hypothetical protein 0.0037 0.0542 0.0586
Schistosoma mansoni hypothetical protein 0.0037 0.0542 0.0586
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0276 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0171 0.0762
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0762
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0171 0.0189
Schistosoma mansoni coup transcription factor 0.0017 0.0171 0.0173
Mycobacterium tuberculosis Conserved hypothetical protein 0.0013 0.0083 0.0022
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0126 0.2244 0.2243
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0276 0.202
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0171 0.0173
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0171 0.017
Echinococcus granulosus PHD finger protein rhinoceros 0.0019 0.0207 0.0228
Schistosoma mansoni hypothetical protein 0.0019 0.0207 0.0213
Leishmania major DNA polymerase eta, putative 0.0021 0.0236 0.4874
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0171 0.017
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0077 0.2794
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0762
Schistosoma mansoni terminal deoxycytidyl transferase 0.0013 0.0083 0.0075
Echinococcus multilocularis dna polymerase kappa 0.0013 0.0083 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0596 0.2843
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0012 0.0077 0.1747
Brugia malayi steroid hormone receptor 0.0017 0.0171 0.0762
Brugia malayi ImpB/MucB/SamB family protein 0.0029 0.0402 0.1896
Echinococcus granulosus polycomb protein SCMH1 0.0031 0.0439 0.0486
Schistosoma mansoni hypothetical protein 0.0481 0.9005 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0077 0.0084
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0276 0.0305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0762
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0083 0.0189
Echinococcus multilocularis GPCR, family 2 0.0037 0.0542 0.0541
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0031 0.0439 0.8538
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0171 0.0173
Loa Loa (eye worm) hypothetical protein 0.0031 0.0439 0.2075
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0171 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0542 0.2581
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0171 0.017
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0171 0.0173
Schistosoma mansoni cpg binding protein 0.0036 0.0522 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0171 0.0762
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Giardia lamblia DINP protein human, muc B family 0.0013 0.0083 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Echinococcus multilocularis dna polymerase eta 0.0029 0.0402 0.0401
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.1785 0.1981
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0171 0.0762
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0542 0.0541
Loa Loa (eye worm) hypothetical protein 0.0033 0.0468 0.2215
Loa Loa (eye worm) hypothetical protein 0.0019 0.0207 0.0936
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0171 0.0173
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.1785 0.8674
Brugia malayi PHD-finger family protein 0.0019 0.0207 0.0936
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0021 0.0236 0.1612
Echinococcus granulosus cpg binding protein 0.0036 0.0522 0.0578
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.2056 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0013 0.0083 1
Mycobacterium tuberculosis Probable aminotransferase 0.016 0.2896 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0013 0.0083 0.0075
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.016 0.2896 1
Echinococcus granulosus jumonji domain containing protein 0.0027 0.035 0.0387
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0762
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0031 0.0439 0.0471
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0171 0.0762
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0083 0.0189
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0171 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0171 0.0762
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0126 0.2244 0.2491
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0276 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.032 0.1493
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0236 0.4874
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0171 0.0762
Echinococcus multilocularis lysine specific demethylase 5A 0.0023 0.0283 0.0282
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0276 0.0274
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0083 0.1904
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0276 0.0705
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0171 0.0173
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0013 0.0083 0.0022
Echinococcus granulosus lysine specific demethylase 5A 0.0025 0.032 0.0354
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0016 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.1785 0.1981
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0019 0.0207 0.0213
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0171 0.017
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0083 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Onchocerca volvulus 0.0034 0.0485 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0083 0.0189
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0121 0.0117
Leishmania major DNA polymerase kappa, putative 0.0013 0.0083 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1785 0.1969
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0276 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.1785 0.1784
Echinococcus multilocularis polycomb protein SCMH1 0.0031 0.0439 0.0438
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0276 0.0705
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.1206 0.1324
Schistosoma mansoni sex comb on midleg homolog 0.0031 0.0439 0.0471
Brugia malayi mbt repeat family protein 0.0031 0.0439 0.2075
Echinococcus granulosus dnaJ subfamily B 0.0481 0.9005 1
Brugia malayi jmjC domain containing protein 0.0025 0.032 0.1493
Echinococcus granulosus dna polymerase eta 0.0029 0.0402 0.0445
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0276 0.0705
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0762
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0171 0.0173
Brugia malayi nuclear receptor NHR-88 0.0017 0.0171 0.0762
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0276 0.0705
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.004 0.0044
Echinococcus multilocularis jumonji domain containing protein 0.0027 0.035 0.0348
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.2056 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0171 0.0762
Plasmodium falciparum phd finger protein, putative 0.0019 0.0207 0.7496
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0276 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0171 0.0762
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.016 0.2896 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.004 0.0039
Brugia malayi CXXC zinc finger family protein 0.0034 0.0485 0.23
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Schistosoma mansoni hypothetical protein 0.0037 0.0542 0.0586
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.016 0.2896 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0083 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0171 0.017
Brugia malayi jmjC domain containing protein 0.0063 0.1038 0.5009
Trichomonas vaginalis DNA polymerase eta, putative 0.0013 0.0083 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0.0077 0.0301
Echinococcus granulosus dna polymerase kappa 0.0013 0.0083 0.0091
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.1785 0.8674
Onchocerca volvulus 0.0031 0.0439 0.8538
Echinococcus granulosus histone acetyltransferase MYST2 0.0036 0.0522 0.0578
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.1038 0.1151
Loa Loa (eye worm) hypothetical protein 0.0116 0.2056 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0171 0.0762
Trypanosoma brucei DNA polymerase eta, putative 0.0029 0.0402 1
Loa Loa (eye worm) MBCTL1 0.0036 0.0522 0.2481
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0036 0.0522 0.2481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.1785 0.1784
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0276 0.1275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0171 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0171 0.0762
Schistosoma mansoni DNA polymerase eta 0.0029 0.0402 0.043
Mycobacterium ulcerans DNA polymerase IV 0.0013 0.0083 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0083 0.1904
Loa Loa (eye worm) hypothetical protein 0.0079 0.1355 0.6566
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.016 0.2896 1
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0276 0.0705
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0171 0.0189
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0171 0.0762
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.1785 0.1969
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0171 0.0762
Echinococcus granulosus GPCR family 2 0.0037 0.0542 0.0601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0171 0.0762
Schistosoma mansoni cpg binding protein 0.0034 0.0485 0.0522
Brugia malayi ecdysteroid receptor 0.0017 0.0171 0.0762
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0276 0.0289
Echinococcus multilocularis cpg binding protein 0.0036 0.0522 0.052
Echinococcus multilocularis SAM and MBT domain containing protein 0.0031 0.0439 0.0438
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0171 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0083 0.1904
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0171 0.0189
Echinococcus multilocularis PHD finger protein rhinoceros 0.0019 0.0207 0.0205
Mycobacterium ulcerans hypothetical protein 0.016 0.2896 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0029 0.0402 1
Schistosoma mansoni ap endonuclease 0.0012 0.0077 0.0068
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0542 0.0601
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.106 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0171 0.0189
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0276 0.0705
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0016 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.1355 0.6566

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.02 ug ml-1 Antibacterial activity against Streptococcus pyogenes 9889 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.04 ug ml-1 Antibacterial activity against Streptococcus agalactiae 32 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.04 ug ml-1 Antibacterial activity against Streptococcus pneumoniae 0025 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Escherichia coli 04 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Citrobacter freundii 323 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Enterobacter cloacae 34 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Serratia marcescens 3349 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.098 ug ml-1 Antibacterial activity against Escherichia coli 04 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.198 ug ml-1 Antibacterial activity against coagulase negative Staphylococcus after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 0.198 ug ml-1 Antibacterial activity against Klebsiella pneumoniae 523 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 6.25 ug ml-1 Antibacterial activity against Enterococcus faecalis 2347 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 12.5 ug ml-1 Antibacterial activity against Haemophilus influenzae 1210 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 12.5 ug ml-1 Antibacterial activity against Pseudomonas aeruginosa 5455 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 25 ug ml-1 Antibacterial activity against Staphylococcus aureus 1218 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453
MIC (functional) = 25 ug ml-1 Antibacterial activity against Acinetobacter baumannii 2289 after 18 to 24 hrs by agar dilution method ChEMBL. 17418453

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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