Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1882 | 0.1882 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.5114 | 0.3693 |
Onchocerca volvulus | Arrow homolog | 0.0079 | 0.1882 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0088 | 0.2253 | 0.2253 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5114 | 0.5114 |
Brugia malayi | Fibulin-1 precursor | 0.0088 | 0.2253 | 1 |
Loa Loa (eye worm) | AStacin protease | 0.017 | 0.5714 | 0.5714 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0079 | 0.1882 | 0.8351 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0079 | 0.1882 | 0.1882 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0272 | 1 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0272 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.3223 | 0.3223 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.5114 | 0.3693 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.9535 | 0.9535 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0156 | 0.5114 | 0.3693 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0272 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1882 | 0.1882 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0088 | 0.2253 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2253 | 0.2253 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.5114 | 0.5114 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0088 | 0.2253 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0088 | 0.2253 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0156 | 0.5114 | 0.3982 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Activity at 5HT1A receptor in Swiss Albino mouse assessed as decrease in 8-OH-DPAT induced body temperature | ChEMBL. | 17321139 | |
Activity (functional) | 0 | Activity at 5HT1A receptor in Swiss Albino mouse assessed as decrease in 8-OH-DPAT induced body temperature | ChEMBL. | 17321139 |
Ki (binding) | = 14.5 nM | Displacement of [3H]8-OH-DPAT from serotonin 5HT1A receptor in rat brain hippocampus | ChEMBL. | 17321139 |
Ki (binding) | = 14.5 nM | Displacement of [3H]8-OH-DPAT from serotonin 5HT1A receptor in rat brain hippocampus | ChEMBL. | 17321139 |
Ki (binding) | = 547 nM | Displacement of [3H]ketanserin from serotonin 5HT2A receptor in rat brain cortex | ChEMBL. | 17321139 |
Ki (binding) | = 547 nM | Displacement of [3H]ketanserin from serotonin 5HT2A receptor in rat brain cortex | ChEMBL. | 17321139 |
Ki (binding) | = 1365 nM | Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatal membrane | ChEMBL. | 17321139 |
Ki (binding) | = 1365 nM | Displacement of [3H]spiperone from dopaminergic D2 receptor in rat striatal membrane | ChEMBL. | 17321139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.