Detailed information for compound 444348

Basic information

Technical information
  • TDR Targets ID: 444348
  • Name: 5-butyl-6-chloro-1H-pyrimidine-2,4-dione
  • MW: 202.638 | Formula: C8H11ClN2O2
  • H donors: 2 H acceptors: 2 LogP: 1.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1c(Cl)[nH]c(=O)[nH]c1=O
  • InChi: 1S/C8H11ClN2O2/c1-2-3-4-5-6(9)10-8(13)11-7(5)12/h2-4H2,1H3,(H2,10,11,12,13)
  • InChiKey: CYNWJDGCUODOPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-butyl-6-chloro-uracil

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis two component regulatory system response regulator/ATPase 0.0023 0.0106 0.5
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0075 0.0137
Entamoeba histolytica hypothetical protein 0.0019 0.0075 0.1726
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.1847
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.006 0.0377 0.069
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0068 0.0434 0.2124
Echinococcus multilocularis ras C3 botulinum toxin substrate 2 0.0012 0.0027 0.0049
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0075 0.0716
Loa Loa (eye worm) hypothetical protein 0.1334 0.9564 0.9564
Brugia malayi hypothetical protein 0.0019 0.0075 0.0075
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0068 0.0434 0.7119
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0068 0.0434 0.7119
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0093 0.0609 0.5827
Loa Loa (eye worm) histone methyltransferase 0.001 0.0014 0.0014
Echinococcus granulosus expressed protein 0.0361 0.2542 0.4654
Mycobacterium ulcerans two component response transcriptional regulatory protein PrrA 0.0023 0.0106 0.0016
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0075 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0075 0.1229
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Entamoeba histolytica Rho family GTPase 0.0012 0.0027 0.0615
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0075 0.0716
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0377 0.069
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.1589 0.2909
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0389 0.3724
Mycobacterium ulcerans two component sensory transduction transcriptional regulatory protein MtrA 0.0023 0.0106 0.0016
Giardia lamblia hypothetical protein 0.006 0.0377 0.6191
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0377 0.3607
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0075 0.0716
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Schistosoma mansoni cell polarity protein 0.0135 0.0913 0.873
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0075 0.0716
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0022 0.0098 0.1603
Wolbachia endosymbiont of Brugia malayi response regulator PleD 0.0023 0.0106 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0075 0.0137
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0075 0.1229
Trichomonas vaginalis GTPase_rho, putative 0.0012 0.0027 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0075 0.1229
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0068 0.0434 0.2124
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Loa Loa (eye worm) hypothetical protein 0.0228 0.1589 0.1589
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0093 0.0609 0.2984
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0153 0.1045 0.1914
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0075 0.0137
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0068 0.0434 0.0794
Mycobacterium tuberculosis Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) 0.0023 0.0106 0.0016
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0153 0.1045 0.5121
Mycobacterium ulcerans two component transcriptional regulator TrcR 0.0023 0.0106 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0364 0.0497
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0075
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0153 0.1045 0.1914
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0075 0.0137
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Echinococcus multilocularis thymidine phosphorylase 0.0765 0.5462 1
Echinococcus multilocularis cpg binding protein 0.0035 0.0191 0.035
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0068 0.0434 0.7119
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Mycobacterium ulcerans two-component system transcriptional regulator 0.0023 0.0106 0.0016
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0153 0.1045 0.5121
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0093 0.0609 0.2984
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0075 0.0716
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0093 0.0609 0.1115
Entamoeba histolytica Rho family GTPase 0.0012 0.0027 0.0615
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0075 0.0075
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0075 0.0716
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0153 0.1045 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0066 0.063
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0377 0.1847
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.006 0.0377 0.069
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0153 0.1045 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0291 0.2041 1
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0022 0.0098 0.0934
Mycobacterium tuberculosis Two component DNA binding transcriptional regulatory protein TcrA 0.0023 0.0106 0.0016
Echinococcus multilocularis expressed protein 0.0361 0.2542 0.4654
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.006 0.0377 0.0377
Mycobacterium tuberculosis Two component response transcriptional regulatory protein PrrA 0.0023 0.0106 0.0016
Brugia malayi CXXC zinc finger family protein 0.0033 0.0178 0.0178
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Brugia malayi PXA domain containing protein 0.0019 0.0075 0.0075
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0068 0.0434 0.7119
Giardia lamblia Guanine phosphoribosyltransferase 0.0093 0.0609 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0377 0.0377
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0093 0.0609 0.1115
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0093 0.0609 0.2984
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.006 0.0377 0.1847
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0075 0.0716
Loa Loa (eye worm) PDE1B protein 0.0153 0.1045 0.1045
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0075 0.0137
Mycobacterium ulcerans two component transcriptional regulator 0.0023 0.0106 0.0016
Mycobacterium ulcerans two component response transcriptional regulatory protein MprA 0.0023 0.0106 0.0016
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0075 0.0716
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0377 0.6191
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.006 0.0377 0.0377
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Onchocerca volvulus 0.0093 0.0609 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0153 0.1045 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein KdpE 0.0023 0.0106 0.0016
Leishmania major eukaryotic translation initiation factor-like 0.0068 0.0434 0.2124
Brugia malayi Kringle domain containing protein 0.0017 0.0066 0.0066
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0066 0.0121
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.3607
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0093 0.0609 0.2984
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0075 0.0137
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0178 0.0178
Loa Loa (eye worm) GTP-binding protein 0.0135 0.0913 0.0913
Echinococcus granulosus cpg binding protein 0.0035 0.0191 0.035
Entamoeba histolytica hypothetical protein 0.0019 0.0075 0.1726
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0083 0.0542 0.8901
Schistosoma mansoni cpg binding protein 0.0035 0.0191 0.1829
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0075 0.0716
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0075 0.0716
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0377 0.1847
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0377 0.3607
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0075
Giardia lamblia Adenine phosphoribosyltransferase 0.0022 0.0098 0.1603
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0153 0.1045 0.1914
Leishmania major eukaryotic translation initiation factor-like protein 0.0068 0.0434 0.2124
Entamoeba histolytica hypothetical protein 0.0019 0.0075 0.1726
Onchocerca volvulus 0.0033 0.0178 0.2918
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0277 0.0277
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0066 0.063
Mycobacterium tuberculosis Probable two component transcriptional regulatory protein TcrX 0.0023 0.0106 0.0016
Schistosoma mansoni gtpase_rho 0.0012 0.0027 0.0255
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0075 0.0716
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0075 0.0137
Treponema pallidum protein-glutamate methylesterase (cheB) 0.0023 0.0106 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0153 0.1045 1
Plasmodium vivax phosphodiesterase gamma, putative 0.006 0.0377 0.3607
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.006 0.0377 0.069
Leishmania major hypothetical protein, conserved 0.0017 0.0066 0.0323
Brugia malayi Ras-related protein Rac1 0.0012 0.0027 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0756 0.1228
Leishmania major xanthine phosphoribosyltransferase 0.0093 0.0609 0.2984
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0068 0.0434 0.2124
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0068 0.0434 0.2124
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0291 0.2041 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0023 0.0106 0.1747
Treponema pallidum chemotaxis response regulator (cheY) 0.0023 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0075
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0765 0.5462 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0364 0.3485
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.1589 0.2909
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0093 0.0609 0.2984
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0377 0.3607
Echinococcus granulosus adenine phosphoribosyltransferase 0.0022 0.0098 0.0179
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.006 0.0377 0.6191
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0377 0.6191
Giardia lamblia Rac/Rho-like protein 0.0012 0.0027 0.0438
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Brugia malayi hypothetical protein 0.0228 0.1589 0.1589
Trichomonas vaginalis rho4, putative 0.0012 0.0027 0.0438
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.006 0.0377 0.3607
Brugia malayi PXA domain containing protein 0.0019 0.0075 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0377 0.1847
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0364 0.0667
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0066 0.0066
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0075 0.0137
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0075 0.0075
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Plasmodium falciparum orotate phosphoribosyltransferase 0.0022 0.0098 0.1603
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Onchocerca volvulus 0.0017 0.0066 0.1081
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.3607
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0022 0.0098 0.0098
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.006 0.0377 0.069
Schistosoma mansoni hypothetical protein 0.0047 0.0277 0.2653
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0075 0.0137
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0066 0.012
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0093 0.0609 0.5827
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0075 0.0075
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0075 0.0137
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0364 0.0667
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0023 0.0106 0.1747
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Loa Loa (eye worm) hypothetical protein 0.006 0.0377 0.0377
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0153 0.1045 0.5121
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0075 0.0137
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0023 0.0106 0.0016
Mycobacterium ulcerans two component transcriptional regulatory protein TcrX 0.0023 0.0106 0.0016
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0075 0.0137
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0153 0.1045 0.1914
Onchocerca volvulus 0.0012 0.0027 0.0438
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0377 0.069
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0068 0.0434 0.4149
Echinococcus multilocularis Ras C3 botulinum toxin substrate 1 0.0012 0.0027 0.0049
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0153 0.1045 0.5121
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0377 0.3607
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0216 0.15 0.2613
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0377 0.1847
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0022 0.0098 0.0934
Loa Loa (eye worm) rac GTPase 0.0012 0.0027 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0377 0.1847
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0022 0.0098 0.0934
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0075
Brugia malayi hypothetical protein 0.0019 0.0075 0.0075
Leishmania major hypothetical protein, conserved 0.006 0.0377 0.1847
Loa Loa (eye worm) small GTPase 0.0012 0.0027 0.0027
Onchocerca volvulus 0.0047 0.0277 0.4553
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0071 0.0453 0.0662
Leishmania major hypothetical protein, conserved 0.006 0.0377 0.1847
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0756 0.4697
Schistosoma mansoni cell polarity protein 0.0135 0.0913 0.873
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0075 0.0075
Echinococcus granulosus thymidine phosphorylase 0.0765 0.5462 1
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0075
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0023 0.0106 0.0016
Schistosoma mansoni cpg binding protein 0.0035 0.0191 0.1829
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0093 0.0609 1
Giardia lamblia Hypothetical protein 0.006 0.0377 0.6191
Mycobacterium ulcerans thymidine phosphorylase 0.0765 0.5462 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0075 0.0075
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.006 0.0377 0.3607
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0071 0.0453 0.2533
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0000033918 0.0000062098
Schistosoma mansoni survival motor neuron protein 0.0047 0.0277 0.2653
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.006 0.0377 0.069
Mycobacterium ulcerans hypothetical protein 0.0023 0.0106 0.0016
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0093 0.0609 0.5827
Brugia malayi GTP-binding protein, identical 0.0135 0.0913 0.0913
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0023 0.0106 0.0016
Mycobacterium tuberculosis Possible two component system response transcriptional positive regulator PhoP 0.0023 0.0106 0.0016
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0377 0.1847
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0075 0.0137
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0364 0.3486
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.0377 0.6191
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0075 0.0075
Brugia malayi Adenine phosphoribosyltransferase 0.0022 0.0098 0.0098
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0377 0.6191
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0377 0.1847
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0075 0.1229
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0022 0.0098 0.0179
Loa Loa (eye worm) hypothetical protein 0.006 0.0377 0.0377
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0377 0.1847
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0377 0.6191
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0291 0.2041 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0023 0.0106 0.1747
Treponema pallidum response regulatory protein (atoC) 0.0023 0.0106 1
Wolbachia endosymbiont of Brugia malayi response regulator 0.0023 0.0106 1
Brugia malayi orotate phosphoribosyltransferase family protein 0.0022 0.0098 0.0098
Echinococcus granulosus ras C3 botulinum toxin substrate 2 0.0012 0.0027 0.0049
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0364 0.0497
Trypanosoma brucei hypothetical protein, conserved 0.006 0.0377 0.1847
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0022 0.0098 0.0934
Trichomonas vaginalis sensor histidine kinase, putative 0.0023 0.0106 0.1747
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0093 0.0609 0.0609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0364 0.1785
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0022 0.0098 0.0934
Trypanosoma cruzi rho-like GTP binding protein, putative 0.0012 0.0027 0.0131
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0377 0.3607
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0075 0.0137
Mycobacterium leprae TWO COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN PRRA 0.0023 0.0106 0.0062
Loa Loa (eye worm) hypothetical protein 0.1395 1 1
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0022 0.0098 0.1603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0443 0.4236
Entamoeba histolytica Rho family GTPase 0.0012 0.0027 0.0615
Schistosoma mansoni sensor histidine kinase/response regulator 0.0023 0.0106 0.1018
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0068 0.0434 0.0794
Toxoplasma gondii orotate phosphoribosyltransferase 0.0022 0.0098 0.0934
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.1847
Mycobacterium ulcerans two component sensory transduction protein RegX3 0.0023 0.0106 0.0016
Brugia malayi GTP-binding protein 0.0135 0.0913 0.0913
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0022 0.0098 0.0934
Mycobacterium tuberculosis Probable two-component system transcriptional regulator 0.0023 0.0106 0.0016
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.063
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0068 0.0434 1
Trichomonas vaginalis rho4, putative 0.0012 0.0027 0.0438
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.0066 0.1081
Schistosoma mansoni uracil phosphoribosyltransferase 0.0022 0.0098 0.0934
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0153 0.1045 0.1045
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0377 0.6191
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.15 1
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0093 0.0609 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0377 0.1847
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0075 0.1229
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0014 0.0026
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0075 0.0075
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0093 0.0609 0.2984
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0093 0.0609 0.2984
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0364 0.3485
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0014 0.0014
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0075 0.0075
Mycobacterium tuberculosis Two component sensory transduction transcriptional regulatory protein MtrA 0.0023 0.0106 0.0016
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0377 0.6191
Trichomonas vaginalis rho5 protein, putative 0.0012 0.0027 0.0438
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0000033918 0.0000062098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0075
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0075 0.1229
Trypanosoma cruzi rho-like GTP binding protein, putative 0.0012 0.0027 0.0131
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0377 0.3607
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.006 0.0377 0.069
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0075 0.0137
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0093 0.0609 0.2984
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0066 0.0323
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.006 0.0377 0.069
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0075 0.0137
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0022 0.0098 0.0478
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.006 0.0377 0.3607
Entamoeba histolytica Rho family GTPase 0.0012 0.0027 0.0615
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Mycobacterium leprae TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY) 0.0023 0.0106 0.0062
Mycobacterium ulcerans two component transcriptional regulator 0.0023 0.0106 0.0016
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0023 0.0106 0.1747
Plasmodium falciparum phosphodiesterase gamma, putative 0.006 0.0377 0.6191
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0756 0.4697
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0068 0.0434 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0377 0.1847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0364 0.0497
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0377 0.1847
Plasmodium falciparum cGMP-specific phosphodiesterase 0.006 0.0377 0.6191
Brugia malayi Protein kinase domain containing protein 0.0017 0.0066 0.0066
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0075 0.0137
Loa Loa (eye worm) hypothetical protein 0.006 0.0377 0.0377
Mycobacterium leprae Probable two-component system transcriptional regulator 0.0023 0.0106 0.0062
Mycobacterium ulcerans two component system response phosphate regulon transcriptional regulator, PhoP 0.0023 0.0106 0.0016
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0023 0.0106 0.1747
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0022 0.0098 0.0098
Mycobacterium ulcerans two component regulator receiver domain-containing protein 0.0023 0.0106 0.0016
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.006 0.0377 0.069
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0022 0.0098 0.0179
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0023 0.0106 0.1747
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0023 0.0106 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Brugia malayi small GTPase 0.0012 0.0027 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0075 0.0716
Loa Loa (eye worm) translation initiation factor 4E 0.0068 0.0434 0.0434
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Echinococcus multilocularis ras gtpase 0.0135 0.0913 0.1671
Echinococcus granulosus uridine 5' monophosphate synthase 0.0022 0.0098 0.0179
Schistosoma mansoni cpg binding protein 0.0033 0.0178 0.17
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0093 0.0609 0.0954
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0093 0.0609 0.5827
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.006 0.0377 0.0377
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.006 0.0377 0.3607
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Entamoeba histolytica Rho family GTPase 0.0012 0.0027 0.0615
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0014 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0756 0.1228
Brugia malayi translation initiation factor 4E 0.0068 0.0434 0.0434
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0364 0.0497
Trichomonas vaginalis sensor histidine kinase, putative 0.0023 0.0106 0.1747
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0075 0.0716
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0075 0.0137
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.15 0.2613
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0023 0.0106 0.0016
Mycobacterium tuberculosis Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family) 0.0023 0.0106 0.0016
Echinococcus granulosus ras gtpase 0.0135 0.0913 0.1671
Mycobacterium tuberculosis Two component transcriptional regulator TrcR 0.0023 0.0106 0.0016
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.006 0.0377 0.0377
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0022 0.0098 0.1603
Leishmania major adenine phosphoribosyltransferase 0.0022 0.0098 0.0478
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0093 0.0609 0.1115
Entamoeba histolytica Rho family GTPase 0.0012 0.0027 0.0615
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0093 0.0609 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0075 0.1229
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0075 0.0716
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.006 0.0377 0.6191
Schistosoma mansoni rac gtpase 0.0012 0.0027 0.0255
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.006 0.0377 0.069
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0377 0.6191
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.006 0.0377 0.069
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.006 0.0377 0.3607
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0075 0.0075
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0022 0.0098 0.0478
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0068 0.0434 0.4148
Plasmodium falciparum phosphodiesterase delta, putative 0.006 0.0377 0.6191
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0377 0.1847

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.03 uM Inhibition of human recombinant thymidine phosphorylase expressed in V79 cells ChEMBL. 17963370
Ki (binding) = 1.03 uM Inhibition of human recombinant thymidine phosphorylase expressed in V79 cells ChEMBL. 17963370
Ki (binding) = 1.65 uM Inhibition of human placental thymidine phosphorylase ChEMBL. 17963370
Ki (binding) = 1.65 uM Inhibition of human placental thymidine phosphorylase ChEMBL. 17963370

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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