Detailed information for compound 44736

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.421 | Formula: C19H26N2O4
  • H donors: 1 H acceptors: 1 LogP: 2.53 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1cc2c(cc1OC)CCN1[C@H]2C[C@@]2(CC1)CNC(=O)O2
  • InChi: 1S/C19H26N2O4/c1-3-8-24-17-10-14-13(9-16(17)23-2)4-6-21-7-5-19(11-15(14)21)12-20-18(22)25-19/h9-10,15H,3-8,11-12H2,1-2H3,(H,20,22)/t15-,19-/m0/s1
  • InChiKey: OIFJABMYOKZQMC-KXBFYZLASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0115
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0011 0.0009 0.0031
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0011 0.0153
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0023 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0003 0.0042
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0013 0.0012 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0023 0.008
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0235 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.004 0.0147
Brugia malayi polk-prov protein 0.0006 0.0001 0.0001
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0001 0.0003
Echinococcus multilocularis importin subunit beta 1 0.003 0.004 0.0579
Loa Loa (eye worm) hypothetical protein 0.005 0.0074 0.1426
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0023 0.0479
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0023 0.0442
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0115
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0115
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0102 0.016 0.2731
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Leishmania major DNA polymerase kappa, putative 0.0006 0.0001 0.0003
Loa Loa (eye worm) helicase DNA-binding protein 0.0012 0.0011 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0011
Schistosoma mansoni Smad4 0.0008 0.0005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0021
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0066
Giardia lamblia Telomerase catalytic subunit 0.1647 0.2725 1
Loa Loa (eye worm) BRM protein 0.0036 0.005 0.0968
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0011
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0011
Echinococcus granulosus helicase 0.0006 0.0001 0.001
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0458
Mycobacterium ulcerans hypothetical protein 0.0164 0.0263 0.5726
Trichomonas vaginalis lymphoid specific helicase, putative 0.0013 0.0012 0.0253
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0024 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0006 0.0001 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0023 0.0331
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0079 0.0287
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0005 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0063 0.0229
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0001 0.0003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0005 0.0066
Brugia malayi RNA, U transporter 1 0.0084 0.0131 0.018
Echinococcus granulosus importin subunit beta 1 0.003 0.004 0.0579
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0235 0.0862
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.0507 0.1857
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0115
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0035 0.0768
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0018
Echinococcus multilocularis disco interacting protein 2 0.004 0.0057 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.069 1
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0246
Echinococcus granulosus dna polymerase kappa 0.002 0.0024 0.0343
Brugia malayi Smad1 0.0008 0.0005 0.0006
Echinococcus multilocularis Chromo domain 0.0012 0.0011 0.0153
Brugia malayi SNF2 family N-terminal domain containing protein 0.0006 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0115
Plasmodium vivax helicase, putative 0.0006 0.0001 0.0002
Echinococcus multilocularis Smad4 0.0008 0.0005 0.0066
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0005 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0011
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.0507 0.186
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0115
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0024 0.0343
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0001 0.0003
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0018 0.0065
Schistosoma mansoni flap endonuclease-1 0.0024 0.0031 0.0448
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0067 0.1294
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0035 0.0681
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0358 0.0585 1
Echinococcus granulosus Smad4 0.0008 0.0005 0.0066
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0083
Giardia lamblia DINP protein human, muc B family 0.002 0.0024 0.0083
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0129
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0115
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0115
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0024 0.0033
Echinococcus multilocularis dna polymerase kappa 0.002 0.0024 0.0343
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0498
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.0024 0.009
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0011 0.0153
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0024 0.0458
Schistosoma mansoni polybromo-1 0.0006 0.0001 0.0019
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0042
Onchocerca volvulus 0.004 0.0057 0.0056
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0011 0.0153
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Schistosoma mansoni importin beta-1 0.003 0.004 0.0579
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0154
Echinococcus multilocularis muscleblind protein 0.0154 0.0246 0.3566
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0005 0.0066
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0024 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0024 0.0343
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0024 0.0517
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0097 0.1878
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0195 0.3768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0154
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0052 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0115
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0035 0.051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0115
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0024 0.0498
Echinococcus granulosus disco interacting protein 2 0.004 0.0057 0.0819
Trypanosoma brucei telomerase reverse transcriptase 0.1647 0.2725 1
Leishmania major DNA polymerase eta, putative 0.0006 0.0001 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0115
Plasmodium vivax hypothetical protein, conserved 0.0006 0.0001 0.0002
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1647 0.2725 1
Echinococcus granulosus BRK domain containing protein 0.0012 0.0011 0.0153
Echinococcus granulosus dna polymerase eta 0.002 0.0024 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi Importin beta-1 subunit 0.003 0.004 0.0055
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.0517 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0115
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0035 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0154 0.0246 0.476
Brugia malayi MH2 domain containing protein 0.0123 0.0195 0.0268
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.0507 0.186
Onchocerca volvulus 0.001 0.0008 0.0007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0052 0.0756
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0017 0.0328
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0035 0.0129
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0066
Echinococcus granulosus geminin 0.0344 0.0562 0.8156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.008
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.0507 0.1857
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0024 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0023 0.0498
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0115
Echinococcus granulosus GPCR family 2 0.0016 0.0017 0.0246
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0074 0.1426
Loa Loa (eye worm) glutaminase 2 0.0281 0.0458 0.886
Loa Loa (eye worm) hypothetical protein 0.004 0.0057 0.1094
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0011 0.0153
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0011
Brugia malayi MH2 domain containing protein 0.0008 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0025
Echinococcus granulosus cpg binding protein 0.0066 0.01 0.1447
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0017 0.0246
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0023 0.0084
Schistosoma mansoni hypothetical protein 0.0344 0.0562 0.8156
Schistosoma mansoni helicase 0.0069 0.0105 0.1529
Echinococcus granulosus flap endonuclease 1 0.0027 0.0035 0.051
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0018 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0115
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0331
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0023 0.5
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0005 0.0066
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.0024 0.009
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi MH1 domain containing protein 0.0008 0.0005 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0052 0.0756
Echinococcus granulosus smad 0.0008 0.0005 0.0066
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0024 0.0343
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0031 0.0109
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.0084
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0085
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0001 0.0003
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0011
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0006 0.0001 0.0013
Trichomonas vaginalis glutaminase, putative 0.0281 0.0458 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0129
Echinococcus multilocularis smad 0.0008 0.0005 0.0066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0115
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0023 0.0084
Brugia malayi polybromodomain protein 0.0006 0.0001 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0256
Brugia malayi MH2 domain containing protein 0.0008 0.0005 0.0006
Echinococcus multilocularis polybromo 1 0.0006 0.0001 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0018 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0115
Loa Loa (eye worm) glutaminase 0.0281 0.0458 0.886
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0011
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0113
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0018 0.0065
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0001 0.0013
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.0024 0.0354
Mycobacterium ulcerans glutaminase 0.0281 0.0458 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0047 0.0065
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0003 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0067 0.0969
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0115
Plasmodium vivax telomerase reverse transcriptase, putative 0.1647 0.2725 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0005 0.0089
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0115
Echinococcus granulosus global transcription activator snf2l2 0.0069 0.0105 0.1529
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0018 0.0256
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.0024 0.0418
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0344 0.0562 0.8156
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0023 0.0031
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0115
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0087 0.0318
Echinococcus granulosus Chromo domain 0.0012 0.0011 0.0153
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0003 0.0042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0018 0.0062
Leishmania major DNA polymerase kappa, putative 0.002 0.0024 0.0087
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.0024 0.009
Trichomonas vaginalis helicase, putative 0.0007 0.0002 0.0039
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0087 0.0135 0.0496
Schistosoma mansoni hypothetical protein 0.0014 0.0013 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0067 0.0969
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0067 0.0969
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0001 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0115
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0154
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0024 0.0244
Toxoplasma gondii RNA-directed DNA polymerase 0.1647 0.2725 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0024 0.0343
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0892
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0024 0.0405
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0017 0.0246
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0024 0.0244
Leishmania major modification methylase-like protein 0.002 0.0024 0.009
Schistosoma mansoni hypothetical protein 0.0421 0.069 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0017 0.0246
Schistosoma mansoni cpg binding protein 0.0066 0.01 0.1447
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0017 0.0246
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0006 0.0008
Echinococcus multilocularis snurportin 1 0.0317 0.0517 0.7492
Trypanosoma brucei unspecified product 0.0014 0.0013 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0024 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Onchocerca volvulus 0.0064 0.0097 0.0096
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0154
Plasmodium falciparum flap endonuclease 1 0.0027 0.0035 0.0129
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0246
Plasmodium falciparum telomerase reverse transcriptase 0.1647 0.2725 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0246
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Echinococcus multilocularis cpg binding protein 0.0066 0.01 0.1447
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0031 0.0669
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0001 0.0003
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.0007
Leishmania major telomerase reverse transcriptase, putative 0.1647 0.2725 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0154 0.0246 0.476
Brugia malayi Muscleblind-like protein 0.0154 0.0246 0.0338
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0918
Schistosoma mansoni ap endonuclease 0.0019 0.0023 0.0331
Schistosoma mansoni cpg binding protein 0.0064 0.0097 0.1407
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.0024 0.009
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0011 0.0015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0085
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0246
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0892
Entamoeba histolytica hypothetical protein 0.0102 0.016 0.2731
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0063 0.0232
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0011 0.0153
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0024 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0154
Plasmodium vivax importin-beta 2, putative 0.003 0.004 0.0147
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0018 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Leishmania major importin beta-1 subunit, putative 0.0024 0.0031 0.0112
Brugia malayi CXXC zinc finger family protein 0.0064 0.0097 0.0134
Echinococcus multilocularis geminin 0.0344 0.0562 0.8156
Echinococcus multilocularis dna polymerase eta 0.002 0.0024 0.0343
Brugia malayi isocitrate dehydrogenase 0.0016 0.0018 0.0024
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0115
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.0024 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0773
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0074 0.0101
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0018 0.0342
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0256
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0067 0.0092
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0031 0.0669
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0154
Plasmodium falciparum importin beta, putative 0.003 0.004 0.0147
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0001 0.0003
Toxoplasma gondii hypothetical protein 0.0087 0.0135 0.0496
Echinococcus multilocularis BRK domain containing protein 0.0012 0.0011 0.0153
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0024 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus granulosus snurportin 1 0.0317 0.0517 0.7492
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0018 0.0256
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0063 0.0229
Echinococcus granulosus dnaJ subfamily B 0.0421 0.069 1
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.004 0.0057 0.0819
Trypanosoma brucei unspecified product 0.002 0.0024 0.0087
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0018 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Schistosoma mansoni cpg binding protein 0.0066 0.01 0.1447
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0001 0.0003
Loa Loa (eye worm) BRM protein 0.0044 0.0064 0.1238
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0023 0.0084
Brugia malayi glutaminase DH11.1 0.0281 0.0458 0.063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0011
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0035 0.0126
Schistosoma mansoni hypothetical protein 0.0317 0.0517 0.7492
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0023 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0024 0.0498
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0012 0.0011 0.0153
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0049
Plasmodium falciparum Snf2-related CBP activator, putative 0.0006 0.0001 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0115
Echinococcus granulosus Helicase SANT associated DNA binding 0.0006 0.0001 0.001
Entamoeba histolytica hypothetical protein 0.0024 0.0031 0.0524
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.0024 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Echinococcus multilocularis helicase 0.0006 0.0001 0.001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0018 0.0256
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1647 0.2725 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0154
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0063 0.0229
Brugia malayi Telomerase reverse transcriptase 0.4382 0.7266 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0067 0.0969
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0018 0.0065
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.004 0.0147
Toxoplasma gondii hypothetical protein 0.005 0.0074 0.0271
Giardia lamblia DNA repair protein RAD52 0.0358 0.0585 0.2143
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.0263 1
Echinococcus multilocularis global transcription activator snf2l2 0.0069 0.0105 0.1529
Brugia malayi Flap endonuclease-1 0.0027 0.0035 0.0048
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0031 0.0669
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.0024 0.0354
Schistosoma mansoni hypothetical protein 0.0006 0.0001 0.001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0256
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0235 0.0862
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.004 0.0147
Brugia malayi SET domain containing protein 0.0007 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0153
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0023 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0001 0.0003
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0011 0.0009 0.0031
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0018 0.0065
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0018 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0087
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0024 0.0087
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0115
Schistosoma mansoni hypothetical protein 0.0037 0.0052 0.0756
Loa Loa (eye worm) Smad1 0.0008 0.0005 0.0089
Entamoeba histolytica hypothetical protein 0.0037 0.0052 0.0892
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0195 0.3768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0067 0.0969
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0067 0.0969
Schistosoma mansoni hypothetical protein 0.0034 0.0047 0.0688
Toxoplasma gondii exonuclease III APE 0.0019 0.0023 0.0084
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0095 0.1374
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0023 0.5
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.0057 0.0078
Echinococcus granulosus muscleblind protein 0.0154 0.0246 0.3566
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0023 0.0331
Echinococcus multilocularis BRK domain 0.0012 0.0011 0.0153
Brugia malayi BRM protein 0.0069 0.0105 0.0145
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0246 0.3566
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0013 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0074 0.0101
Brugia malayi MH1 domain containing protein 0.0008 0.0005 0.0006
Leishmania major DNA polymerase eta, putative 0.002 0.0024 0.0087
Schistosoma mansoni glutaminase 0.0281 0.0458 0.6638
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0115
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0017 0.0246
Plasmodium vivax DEAD/DEAH helicase, putative 0.0011 0.0009 0.0031
Schistosoma mansoni smad1 5 8 and 0.0008 0.0005 0.0066
Schistosoma mansoni smad 0.0008 0.0005 0.0066
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0017 0.0023
Leishmania major DNA damage repair protein, putative 0.0006 0.0001 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0115
Echinococcus granulosus polybromo 1 0.0006 0.0001 0.0019
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0035 0.0126
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0035 0.0602
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0018 0.0256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0067 0.0969
Brugia malayi hypothetical protein 0.0037 0.0052 0.0072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0328
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0005 0.0066

Activities

Activity type Activity value Assay description Source Reference
Fall (functional) NA 0 % Percentage fall in systolic blood pressure in spontaneously hypertensive rats 1 hr after 50 mg/kg p.o. administration; Not significant. ChEMBL. 6312043
Fall (functional) NA 0 % Percentage fall in systolic blood pressure in spontaneously hypertensive rats 2 hr after 50 mg/kg p.o. administration; Not significant. ChEMBL. 6312043
Fall (functional) NA 0 % Percentage fall in systolic blood pressure in spontaneously hypertensive rats 3h after 50 mg/kg p.o. administration; Not significant. ChEMBL. 6312043
Fall (functional) NA 0 % Antihypertensive activity as percentage fall in systolic blood pressure in spontaneously hypertensive rats 4 hr after 50 mg/kg po administration; NS means nonsignificant difference between treated and control group ChEMBL. 6312043

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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