Detailed information for compound 44875

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 191.233 | Formula: C9H13N5
  • H donors: 3 H acceptors: 0 LogP: 0.16 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(c(c1)/C=N/N=C(N)N)C
  • InChi: 1S/C9H13N5/c1-6-2-3-8(10)4-7(6)5-13-14-9(11)12/h2-5H,10H2,1H3,(H4,11,12,14)/b13-5+
  • InChiKey: LGUREDKRFCLZTF-WLRTZDKTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi SNF2 family N-terminal domain containing protein 0.0006 0.0001 0.0001
Echinococcus multilocularis polybromo 1 0.0007 0.0001 0.0019
Brugia malayi nuclear hormone receptor 0.0011 0.0007 0.0009
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.002 0.0343
Schistosoma mansoni importin beta-1 0.0032 0.0033 0.0579
Brugia malayi polybromodomain protein 0.0007 0.0001 0.0002
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0007 0.0006
Plasmodium vivax DEAD/DEAH helicase, putative 0.0012 0.0007 0.0026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0004 0.0066
Schistosoma mansoni hypothetical protein 0.0187 0.0234 0.4064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0154
Schistosoma mansoni hypothetical protein 0.0006 0.0001 0.001
Loa Loa (eye worm) glutaminase 0.0302 0.0382 0.886
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0022 0.002 0.0354
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0015 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0007 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0019 0.0067
Echinococcus granulosus Chromo domain 0.0013 0.0009 0.0153
Echinococcus multilocularis cpg binding protein 0.0071 0.0083 0.1447
Echinococcus multilocularis geminin 0.0187 0.0234 0.4064
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0053 0.0193
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0007 0.0115
Echinococcus granulosus importin subunit beta 1 0.0032 0.0033 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Schistosoma mansoni ap endonuclease 0.0021 0.0019 0.0331
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Schistosoma mansoni polybromo-1 0.0007 0.0001 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0019 0.0067
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0022 0.002 0.0354
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0085
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0014 0.001 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.0431 1
Echinococcus granulosus global transcription activator snf2l2 0.0074 0.0088 0.1529
Echinococcus multilocularis Helicase SANT associated, DNA binding 0.0006 0.0001 0.001
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0029 0.0108
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0334 0.0422 0.1547
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0004 0.0066
Echinococcus multilocularis muscleblind protein 0.0165 0.0205 0.3566
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0033 0.0122
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0162 0.3768
Brugia malayi glutaminase DH11.1 0.0302 0.0382 0.0525
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0115
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0026 0.0669
Schistosoma mansoni DNA polymerase eta 0.0021 0.002 0.0343
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0005
Toxoplasma gondii RNA-directed DNA polymerase 0.2123 0.2726 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Giardia lamblia Telomerase catalytic subunit 0.2123 0.2726 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0019 0.0331
Mycobacterium ulcerans glutaminase 0.0302 0.0382 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0054
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.002 0.0343
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0007 0.0115
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0019 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0011 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0022 0.002 0.0075
Schistosoma mansoni hypothetical protein 0.034 0.0431 0.7492
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0115
Brugia malayi Muscleblind-like protein 0.0165 0.0205 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0113
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0019 0.007
Echinococcus granulosus dna polymerase eta 0.0021 0.002 0.0343
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.002 0.007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0009
Entamoeba histolytica hypothetical protein 0.004 0.0043 0.0892
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0007 0.0115
Plasmodium falciparum flap endonuclease 1 0.0029 0.0029 0.0108
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0022 0.002 0.0075
Brugia malayi Smad1 0.0009 0.0004 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0085
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0043 0.0756
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.002 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.002 0.0244
Onchocerca volvulus 0.0069 0.0081 0.008
Plasmodium falciparum importin beta, putative 0.0032 0.0033 0.0122
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0007 0.0009
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0005
Brugia malayi MH2 domain containing protein 0.0132 0.0162 0.0223
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0026 0.0669
Brugia malayi hypothetical protein 0.004 0.0043 0.006
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0498
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0498
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Giardia lamblia DNA repair protein RAD52 0.0385 0.0487 0.1786
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0019 0.007
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0004 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0015 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0115
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0021
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.002 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0072
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0026 0.0669
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0007 0.0115
Echinococcus granulosus dna polymerase kappa 0.0021 0.002 0.0343
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0019 0.5
Echinococcus granulosus Smad4 0.0009 0.0004 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0015 0.0256
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0066 0.0239
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0043 0.0756
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0002 0.0042
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0001 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0019 0.0498
Brugia malayi polk-prov protein 0.0007 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.0021 0.0019 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0019 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0009
Trypanosoma brucei unspecified product 0.0015 0.0011 0.0041
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0001 0.0003
Echinococcus granulosus polybromo 1 0.0007 0.0001 0.0019
Schistosoma mansoni Smad4 0.0009 0.0004 0.0066
Loa Loa (eye worm) glutaminase 2 0.0302 0.0382 0.886
Brugia malayi nuclear receptor NHR-88 0.0011 0.0007 0.0009
Echinococcus granulosus helicase 0.0006 0.0001 0.001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0158 0.0196 0.0718
Leishmania major importin beta-1 subunit, putative 0.0026 0.0026 0.0094
Brugia malayi RNA, U transporter 1 0.0091 0.0109 0.015
Loa Loa (eye worm) BRM protein 0.0038 0.0042 0.0968
Leishmania major DNA polymerase eta, putative 0.0007 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0452 0.0575 1
Trichomonas vaginalis glutaminase, putative 0.0302 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0115
Echinococcus granulosus DNA methyltransferase 2, putative 0.0022 0.002 0.0354
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0042
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0029 0.0108
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.002 0.0405
Loa Loa (eye worm) Smad1 0.0009 0.0004 0.0089
Brugia malayi SET domain containing protein 0.0007 0.0002 0.0002
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0005
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2123 0.2726 1
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0154
Mycobacterium tuberculosis Conserved hypothetical protein 0.0176 0.0219 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0004 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0154
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0015 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0009
Brugia malayi ecdysteroid receptor 0.0011 0.0007 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0256
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0115
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0015 0.0256
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0007 0.0154
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0109 0.0133 0.2731
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0007 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0009
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0005
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.0196 0.0718
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.002 0.0343
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0053 0.0191
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0029 0.0105
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0007 0.0009
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0029 0.0768
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0054
Brugia malayi Importin beta-1 subunit 0.0032 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.0165 0.0205 0.476
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0019 0.021
Echinococcus multilocularis muscleblind protein 1 0.0165 0.0205 0.3566
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0007 0.0115
Echinococcus multilocularis global transcription activator snf2l2 0.0074 0.0088 0.1529
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0162 0.3768
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0053 0.0191
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0033 0.0122
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0015 0.0342
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0007 0.0115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0079 0.1374
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0029 0.0602
Onchocerca volvulus 0.0043 0.0047 0.0047
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0007 0.0115
Loa Loa (eye worm) SNF2 family domain-containing protein 0.0006 0.0001 0.0013
Toxoplasma gondii DNA methyltransferase 2, putative 0.0022 0.002 0.0075
Leishmania major modification methylase-like protein 0.0022 0.002 0.0075
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0193
Brugia malayi Flap endonuclease-1 0.0029 0.0029 0.004
Trichomonas vaginalis helicase, putative 0.0007 0.0002 0.0039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0007 0.0115
Brugia malayi Disco-interacting protein 2 homolog 0.0043 0.0047 0.0065
Loa Loa (eye worm) helicase DNA-binding protein 0.0013 0.0009 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0009
Loa Loa (eye worm) BRM protein 0.0047 0.0053 0.1238
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0007 0.0115
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0007 0.0115
Trypanosoma brucei unspecified product 0.0015 0.0011 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Echinococcus granulosus geminin 0.0187 0.0234 0.4064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0007 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0007 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0011 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0019 0.0479
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0022 0.002 0.0075
Onchocerca volvulus 0.0011 0.0007 0.0006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0007 0.0115
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.0054
Echinococcus multilocularis helicase 0.0006 0.0001 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0026 0.0091
Leishmania major DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.0196 0.0716
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0029 0.0108
Toxoplasma gondii hypothetical protein 0.0054 0.0062 0.0226
Brugia malayi BRM protein 0.0074 0.0088 0.0121
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0385 0.0487 1
Mycobacterium ulcerans hypothetical protein 0.0176 0.0219 0.5726
Schistosoma mansoni smad 0.0009 0.0004 0.0066
Plasmodium vivax importin-beta 2, putative 0.0032 0.0033 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.002 0.0072
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0001 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0007 0.0115
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0013 0.0009 0.0153
Echinococcus multilocularis Chromo domain 0.0013 0.0009 0.0153
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0007 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0072
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0019 0.0067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.002 0.0244
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0019 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0007 0.0006
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.002 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0007 0.0154
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0002 0.0042
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.2123 0.2726 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0004 0.0066
Schistosoma mansoni helicase 0.0006 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0007 0.0009
Trichomonas vaginalis lymphoid specific helicase, putative 0.0014 0.001 0.0253
Entamoeba histolytica hypothetical protein 0.004 0.0043 0.0892
Brugia malayi Telomerase reverse transcriptase 0.5649 0.7266 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0047 0.1094
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0019 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0054
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0002 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0005 0.0007
Schistosoma mansoni glutaminase 0.0302 0.0382 0.6638
Plasmodium vivax helicase, putative 0.0006 0.0001 0.0002
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Entamoeba histolytica hypothetical protein 0.004 0.0043 0.0892
Schistosoma mansoni cpg binding protein 0.0071 0.0083 0.1447
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0334 0.0422 0.1547
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0019 0.039
Giardia lamblia DINP protein human, muc B family 0.0021 0.002 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0022 0.002 0.0418
Leishmania major DNA damage repair protein, putative 0.0007 0.0001 0.0003
Brugia malayi isocitrate dehydrogenase 0.0017 0.0015 0.002
Echinococcus granulosus disco interacting protein 2 0.0043 0.0047 0.0819
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0007 0.0009
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0029 0.051
Echinococcus granulosus Helicase SANT associated DNA binding 0.0006 0.0001 0.001
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0007 0.0115
Echinococcus multilocularis dna polymerase eta 0.0021 0.002 0.0343
Brugia malayi steroid hormone receptor 0.0011 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Echinococcus granulosus BRK domain containing protein 0.0013 0.0009 0.0153
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0053 0.0191
Echinococcus multilocularis BRK domain 0.0013 0.0009 0.0153
Toxoplasma gondii exonuclease III APE 0.0021 0.0019 0.007
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0029 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0004 0.0089
Leishmania major mitochondrial DNA polymerase beta 0.0334 0.0422 0.155
Schistosoma mansoni hypothetical protein 0.004 0.0043 0.0756
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0256
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0007 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0773
Echinococcus granulosus dnaJ subfamily B 0.0452 0.0575 1
Leishmania major DNA polymerase kappa, putative 0.0021 0.002 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0094 0.0113 0.0414
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0015 0.0256
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0029 0.0108
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0043 0.0756
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0009 0.0012
Schistosoma mansoni coup transcription factor 0.0011 0.0007 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0033 0.0122
Schistosoma mansoni cpg binding protein 0.0069 0.0081 0.1407
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Leishmania major DNA polymerase eta, putative 0.0021 0.002 0.0072
Entamoeba histolytica hypothetical protein 0.0109 0.0133 0.2731
Plasmodium vivax telomerase reverse transcriptase, putative 0.2123 0.2726 1
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0007 0.0115
Echinococcus granulosus muscleblind protein 0.0165 0.0205 0.3566
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0007 0.0115
Loa Loa (eye worm) hypothetical protein 0.0165 0.0205 0.476
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0015 0.0054
Echinococcus granulosus snurportin 1 0.034 0.0431 0.7492
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0019 0.0442
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0002 0.0039
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0022 0.002 0.0075
Brugia malayi CXXC zinc finger family protein 0.0069 0.0081 0.0111
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0007 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trypanosoma brucei unspecified product 0.0021 0.002 0.0072
Schistosoma mansoni flap endonuclease-1 0.0026 0.0026 0.0448
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0452 0.0575 1
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.0027
Echinococcus multilocularis smad 0.0009 0.0004 0.0066
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0002 0.0042
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0012 0.0007 0.0026
Echinococcus granulosus cpg binding protein 0.0071 0.0083 0.1447
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0007 0.0115
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0019 0.007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0007 0.0009
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0007 0.0115
Echinococcus multilocularis dna polymerase kappa 0.0021 0.002 0.0343
Trypanosoma brucei telomerase reverse transcriptase 0.2123 0.2726 1
Echinococcus granulosus flap endonuclease 1 0.0029 0.0029 0.051
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.007
Leishmania major telomerase reverse transcriptase, putative 0.2123 0.2726 1
Schistosoma mansoni cpg binding protein 0.0071 0.0083 0.1447
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.002 0.0343
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0154
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0019 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0002 0.0039
Loa Loa (eye worm) CXXC zinc finger family protein 0.0069 0.0081 0.1878
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0334 0.0422 0.155
Schistosoma mansoni hypothetical protein 0.0013 0.0009 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0007 0.0009
Entamoeba histolytica hypothetical protein 0.0026 0.0026 0.0524
Echinococcus multilocularis Smad4 0.0009 0.0004 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0007 0.0154
Plasmodium falciparum telomerase reverse transcriptase 0.2123 0.2726 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0002 0.0039
Plasmodium falciparum Snf2-related CBP activator, putative 0.0006 0.0001 0.0002
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0043 0.0047 0.0819
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0029 0.0105
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0004 0.0089
Schistosoma mansoni helicase 0.0074 0.0088 0.1529
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0011 0.0041
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0033 0.0579
Echinococcus granulosus smad 0.0009 0.0004 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Schistosoma mansoni hypothetical protein 0.0187 0.0234 0.4064
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0001 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.0027
Toxoplasma gondii hypothetical protein 0.0094 0.0113 0.0414
Entamoeba histolytica hypothetical protein 0.004 0.0043 0.0892
Plasmodium vivax hypothetical protein, conserved 0.0006 0.0001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0007 0.0154
Echinococcus multilocularis disco interacting protein 2 0.0043 0.0047 0.0819
Echinococcus multilocularis snurportin 1 0.034 0.0431 0.7492
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0256
Echinococcus multilocularis BRK domain containing protein 0.0013 0.0009 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0072
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0018
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0007 0.0026
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0007 0.0154
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.002 0.0517
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0072 0.0265
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0007 0.0115

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) 0 mg kg-1 Inhibition of cholera toxin induced intestinal fluid secretion in rat; I= Inactive ChEMBL. 2891854
Inhibition (functional) 0 Inhibition of increase in intestine potential difference caused by diarrhea-inducing secretagogues in rabbits using 'Ussing chamber'; NT is not tested ChEMBL. 2891854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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