Detailed information for compound 458518

Basic information

Technical information
  • TDR Targets ID: 458518
  • Name: (2R)-N-(1-cyanocyclopropyl)-3-methylsulfonyl- 2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)et hyl]amino]propanamide
  • MW: 407.383 | Formula: C16H17F4N3O3S
  • H donors: 2 H acceptors: 4 LogP: 1.43 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CC1)NC(=O)[C@H](CS(=O)(=O)C)N[C@H](C(F)(F)F)c1ccc(cc1)F
  • InChi: 1S/C16H17F4N3O3S/c1-27(25,26)8-12(14(24)23-15(9-21)6-7-15)22-13(16(18,19)20)10-2-4-11(17)5-3-10/h2-5,12-13,22H,6-8H2,1H3,(H,23,24)/t12-,13-/m0/s1
  • InChiKey: HBOZUMOKFHNMQI-STQMWFEESA-N  


Substructure search Similarity search

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Synonyms

  • (2R)-N-(1-cyanocyclopropyl)-3-mesyl-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Mus musculus cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Rattus norvegicus Cathepsin S Starlite/ChEMBL References
Mus musculus cathepsin B Starlite/ChEMBL References
Rattus norvegicus Cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Mus musculus cathepsin L Starlite/ChEMBL References
Mus musculus cathepsin K Starlite/ChEMBL References
Rattus norvegicus Cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_129645 All targets in OG5_129645
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis papain family cysteine protease containing protein Get druggable targets OG5_129645 All targets in OG5_129645
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis cysteine protease 2 Get druggable targets OG5_129645 All targets in OG5_129645
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_129645 All targets in OG5_129645
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia Dipeptidyl-peptidase I precursor Cathepsin L   334 aa 304 aa 28.3 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 38.0 %
Plasmodium vivax vivapain-3 Cathepsin L   334 aa 345 aa 30.7 %
Plasmodium yoelii SERA-2 Cathepsin S   330 aa 267 aa 24.3 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 277 aa 26.0 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin L   334 aa 300 aa 41.0 %
Plasmodium knowlesi knowpain-1 Cathepsin L   334 aa 373 aa 27.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 282 aa 26.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 341 aa 375 aa 29.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Onchocerca volvulus Cathepsin L   334 aa 311 aa 40.8 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 334 aa 367 aa 30.0 %
Plasmodium falciparum cysteine proteinase falcipain 2b cathepsin K 329 aa 328 aa 34.5 %
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 273 aa 27.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 341 aa 26.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 24.8 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin L   334 aa 312 aa 42.0 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.2 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 273 aa 25.3 %
Dictyostelium discoideum cysteine protease Cathepsin B   339 aa 283 aa 24.7 %
Echinococcus granulosus cathepsin b Cathepsin S   330 aa 276 aa 26.1 %
Cryptosporidium hominis preprocathepsin c precursor Cathepsin B   339 aa 282 aa 29.4 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 301 aa 23.6 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 36.4 %
Plasmodium berghei dipeptidyl aminopeptidase 1, putative Cathepsin B   339 aa 319 aa 26.6 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 372 aa 23.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 276 aa 26.8 %
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase Cathepsin S   330 aa 266 aa 32.0 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 271 aa 26.9 %
Babesia bovis papain family cysteine protease containing protein Cathepsin L   334 aa 321 aa 32.7 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 333 aa 28.8 %
Cryptosporidium parvum preprocathepsin c precursor, putative Cathepsin B   339 aa 287 aa 30.3 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 28.6 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin L   334 aa 296 aa 31.8 %
Loa Loa (eye worm) hypothetical protein Cathepsin S   330 aa 281 aa 28.5 %
Toxoplasma gondii cathepsin B Cathepsin S   330 aa 265 aa 24.9 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 278 aa 26.6 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 279 aa 28.3 %
Plasmodium berghei serine repeat antigen 1 Cathepsin S   330 aa 287 aa 25.4 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 277 aa 26.0 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin L   334 aa 303 aa 23.4 %
Onchocerca volvulus Cathepsin L   334 aa 300 aa 24.3 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 309 aa 30.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 295 aa 25.4 %
Neospora caninum hypothetical protein Cathepsin L   334 aa 299 aa 28.4 %
Onchocerca volvulus Cathepsin B   339 aa 319 aa 38.9 %
Plasmodium yoelii cathepsin c precursor Cathepsin L   334 aa 292 aa 22.6 %
Plasmodium falciparum serine repeat antigen 8 Cathepsin B   339 aa 272 aa 25.0 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 332 aa 23.5 %
Plasmodium vivax unspecified product Cathepsin L   334 aa 366 aa 28.4 %
Schistosoma japonicum Cathepsin C precursor, putative Cathepsin B   339 aa 332 aa 26.8 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 298 aa 23.8 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 317 aa 33.8 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 303 aa 26.1 %
Drosophila melanogaster Cathepsin B1 Cathepsin S   330 aa 305 aa 27.2 %
Onchocerca volvulus Cathepsin S   330 aa 289 aa 29.4 %
Schistosoma japonicum ko:K01365 cathepsin L [EC3.4.22.15], putative Cathepsin S   330 aa 309 aa 44.7 %
Plasmodium knowlesi knowpain-2 Cathepsin B   339 aa 302 aa 24.8 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 325 aa 29.5 %
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 271 aa 27.7 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase Cathepsin B   339 aa 287 aa 22.6 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 274 aa 48.2 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 347 aa 28.8 %
Onchocerca volvulus Cathepsin L   334 aa 325 aa 47.4 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 270 aa 25.6 %
Echinococcus multilocularis cathepsin b Cathepsin S   330 aa 288 aa 30.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Giardia lamblia Encystation-specific protease Cathepsin B   339 aa 272 aa 23.5 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 25.0 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 302 aa 24.5 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Echinococcus granulosus cathepsin b Cathepsin S   330 aa 288 aa 30.2 %
Plasmodium knowlesi cysteine protease, putative Cathepsin S   330 aa 291 aa 23.0 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Trypanosoma cruzi cysteine protease, putative Cathepsin L   334 aa 323 aa 30.3 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 325 aa 38.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 319 aa 25.7 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 309 aa 26.5 %
Theileria parva cathepsin C, putative Cathepsin B   339 aa 295 aa 26.1 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin L   334 aa 311 aa 35.0 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin L   334 aa 360 aa 29.2 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Cathepsin B   339 aa 327 aa 30.3 %
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Cathepsin L   334 aa 290 aa 27.6 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 274 aa 48.5 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin L   334 aa 316 aa 30.1 %
Babesia bovis cathepsin C precursor, putative Cathepsin B   339 aa 304 aa 26.6 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 Cathepsin B   339 aa 367 aa 25.9 %
Toxoplasma gondii cathepsin CPC1 Cathepsin L   334 aa 295 aa 28.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin L   334 aa 294 aa 23.8 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 276 aa 25.4 %
Plasmodium vivax serine-repeat antigen 4 (SERA), putative Cathepsin S   330 aa 274 aa 23.4 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 270 aa 25.6 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Echinococcus granulosus cysteine protease Cathepsin L   334 aa 323 aa 44.3 %
Plasmodium vivax serine-repeat antigen (SERA), putative Cathepsin S   330 aa 293 aa 22.2 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 337 aa 26.1 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin L   334 aa 277 aa 24.5 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin L   334 aa 311 aa 36.0 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 279 aa 25.8 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin L   334 aa 318 aa 48.4 %
Plasmodium vivax dipeptidyl aminopeptidase 1, putative Cathepsin B   339 aa 304 aa 27.0 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 25.9 %
Plasmodium berghei berghepain-1 Cathepsin L   334 aa 353 aa 29.7 %
Plasmodium berghei dipeptidyl aminopeptidase 2 Cathepsin B   339 aa 314 aa 24.5 %
Babesia bovis preprocathepsin c precursor, putative Cathepsin B   339 aa 282 aa 29.8 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin L   334 aa 288 aa 26.7 %
Plasmodium knowlesi knowpain-4 Cathepsin B   339 aa 304 aa 24.3 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 275 aa 29.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 336 aa 25.9 %
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Cathepsin B   339 aa 334 aa 29.3 %
Onchocerca volvulus Cathepsin B-like cysteine proteinase 6 homolog Cathepsin B   339 aa 326 aa 51.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin L   334 aa 359 aa 29.8 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.9 %
Onchocerca volvulus Cathepsin L homolog Cathepsin L   334 aa 322 aa 41.6 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 324 aa 34.6 %
Dictyostelium discoideum cysteine proteinase 5 precursor Cathepsin B   339 aa 303 aa 22.4 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Plasmodium vivax vivapain-1 Cathepsin L   334 aa 366 aa 28.4 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 298 aa 28.9 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 273 aa 26.0 %
Echinococcus multilocularis cathepsin b Cathepsin S   330 aa 278 aa 28.8 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin L   334 aa 323 aa 46.1 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin L   334 aa 345 aa 35.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 23.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin S   330 aa 319 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin L cysteine protease 0.0218 0.2244 0.2231
Plasmodium vivax vivapain-2 0.0218 0.2244 1
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.1173 0.5229
Brugia malayi cathepsin F-like cysteine proteinase 0.0071 0.0533 0.0891
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0204 0.2085 0.3093
Schistosoma mansoni hypothetical protein 0.0039 0.0156 0.0233
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Plasmodium vivax unspecified product 0.0126 0.1173 0.438
Echinococcus multilocularis tar DNA binding protein 0.0131 0.1228 0.1214
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0055 0.0339 0.0541
Leishmania major cathepsin L-like protease 0.0218 0.2244 1
Brugia malayi Cathepsin L-like precursor 0.0218 0.2244 0.3749
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0218 0.2244 1
Entamoeba histolytica cysteine protease, putative 0.0055 0.0339 0.1511
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0 0.5
Echinococcus granulosus cathepsin l1 0.0218 0.2244 0.3732
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0339 0.0567
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.1173 0.1477
Brugia malayi CHE-14 protein 0.0046 0.0236 0.0394
Brugia malayi Muscleblind-like protein 0.0162 0.1596 0.2667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.095 0.1586
Entamoeba histolytica hypothetical protein 0.0039 0.0156 0.0695
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0339 0.0541
Entamoeba histolytica cysteine protease, putative 0.0055 0.0339 0.1511
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.0339 0.0567
Toxoplasma gondii cathepsin CPL 0.0218 0.2244 1
Mycobacterium ulcerans hypothetical protein 0.0026 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1228 0.203
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.1486 0.2462
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.095 0.1563
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0043 0.0201 0.0335
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Entamoeba histolytica cysteine proteinase 2 0.0126 0.1173 0.5229
Loa Loa (eye worm) fibroinase 0.0218 0.2244 0.3749
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0339 0.0516
Onchocerca volvulus Cathepsin L homolog 0.0218 0.2244 1
Entamoeba histolytica hypothetical protein 0.0039 0.0156 0.0695
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0017 0.0028
Brugia malayi Metabotropic glutamate receptor precursor. 0.0167 0.1656 0.2767
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1228 0.203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.0339 0.0541
Brugia malayi Cathepsin L-like precursor 0.0218 0.2244 0.3749
Loa Loa (eye worm) hypothetical protein 0.0046 0.0236 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0204 0.2085 0.9211
Plasmodium falciparum cysteine proteinase falcipain 1 0.0126 0.1173 0.438
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0156 0.0233
Echinococcus granulosus cathepsin L cysteine proteinase 0.0218 0.2244 0.3732
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0339 0.0516
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Loa Loa (eye worm) RNA binding protein 0.0131 0.1228 0.2052
Loa Loa (eye worm) hypothetical protein 0.0071 0.0533 0.0891
Loa Loa (eye worm) glutamate receptor 0.0167 0.1656 0.2767
Echinococcus multilocularis cysteine protease 0.0218 0.2244 0.2231
Loa Loa (eye worm) hypothetical protein 0.0107 0.095 0.1586
Onchocerca volvulus 0.0218 0.2244 1
Schistosoma mansoni cathepsin F (C01 family) 0.0146 0.141 0.2334
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0055 0.0339 0.1511
Brugia malayi fibroinase precursor 0.0055 0.0339 0.0567
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 0.5986 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0156 0.0233
Loa Loa (eye worm) hypothetical protein 0.0055 0.0339 0.0567
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 0.5986 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.141 0.5846
Entamoeba histolytica hypothetical protein 0.0039 0.0156 0.0695
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0218 0.2244 0.2231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0204 0.2085 0.3466
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.1173 0.5229
Schistosoma mansoni hypothetical protein 0.0044 0.0216 0.0335
Onchocerca volvulus 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0339 0.0516
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.2244 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0218 0.2244 0.3732
Loa Loa (eye worm) cathepsin B 0.0204 0.2085 0.3484
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0218 0.2244 0.2231
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0218 0.2244 0.3749
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0339 0.0516
Loa Loa (eye worm) hypothetical protein 0.0162 0.1596 0.2667
Brugia malayi cathepsin Z-like cysteine proteinase 0.0055 0.0339 0.0567
Onchocerca volvulus 0.0218 0.2244 1
Echinococcus multilocularis cathepsin b 0.0537 0.5986 0.5979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0533 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0055 0.0339 0.0516
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.1228 0.2052
Schistosoma mansoni patched 1 0.0046 0.0236 0.0367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0 0.5
Brugia malayi RNA binding protein 0.0131 0.1228 0.2052
Brugia malayi Cathepsin L-like cysteine proteinase 0.0146 0.141 0.2355
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0218 0.2244 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.095 0.0935
Brugia malayi Cathepsin L-like precursor 0.0218 0.2244 0.3749
Giardia lamblia Cathepsin B precursor 0.0204 0.2085 1
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.1173 0.196
Onchocerca volvulus Poor gastrulation protein homolog 0.0027 0.0017 0.0074
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.1173 0.5229
Loa Loa (eye worm) TAR-binding protein 0.0131 0.1228 0.2052
Entamoeba histolytica cysteine protease, putative 0.0055 0.0339 0.1511
Entamoeba histolytica cysteine protease, putative 0.0055 0.0339 0.1511
Echinococcus granulosus cathepsin L cysteine protease 0.0126 0.1173 0.1938
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Echinococcus granulosus cysteine protease 0.0126 0.1173 0.1938
Entamoeba histolytica hypothetical protein 0.0039 0.0156 0.0695
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0126 0.1173 0.1477
Loa Loa (eye worm) hypothetical protein 0.0055 0.0339 0.0567
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0152 0.1472 0.2459
Leishmania major cathepsin L-like protease 0.0218 0.2244 1
Giardia lamblia Cathepsin B precursor 0.0204 0.2085 1
Echinococcus multilocularis tumor protein p63 0.0367 0.3991 0.3981
Brugia malayi Cathepsin L-like precursor 0.0146 0.141 0.2355
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0146 0.141 0.1896
Loa Loa (eye worm) cysteine protease 0.0218 0.2244 0.3749
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0206 0.2108 0.3522
Schistosoma mansoni hypothetical protein 0.0044 0.0216 0.0335
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Leishmania major cathepsin L-like protease 0.0218 0.2244 1
Toxoplasma gondii cathepsin B 0.0204 0.2085 0.9168
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0339 0.0516
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0236 0.0367
Echinococcus granulosus cathepsin L 0.0055 0.0339 0.0541
Loa Loa (eye worm) ctsf protein 0.0218 0.2244 0.3749
Schistosoma mansoni hypothetical protein 0.0044 0.0216 0.0335
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0339 0.1511
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0156 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0339 0.0516
Entamoeba histolytica cysteine protease, putative 0.0055 0.0339 0.1511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.1173 0.4669
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0055 0.0339 0.0541
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0969 0.1595
Plasmodium vivax vivapain-2 0.0218 0.2244 1
Echinococcus multilocularis cathepsin L 0.0055 0.0339 0.0323
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0028
Brugia malayi cathepsin B-like cysteine proteinase 0.0537 0.5986 1
Trypanosoma cruzi cruzipain precursor, putative 0.0218 0.2244 0.3374
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1228 0.203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0339 0.0516
Loa Loa (eye worm) hypothetical protein 0.0056 0.0356 0.0595
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0071 0.0533 0.0891
Echinococcus granulosus tar DNA binding protein 0.0131 0.1228 0.203
Entamoeba histolytica cysteine proteinase 1, putative 0.0126 0.1173 0.5229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.2244 0.3374
Onchocerca volvulus Cathepsin F homolog 0.0218 0.2244 1
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0055 0.0339 0.0516
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.141 0.6282
Loa Loa (eye worm) hypothetical protein 0.0162 0.1596 0.2667
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0533 0.0343
Entamoeba histolytica cysteine proteinase, putative 0.0126 0.1173 0.5229
Trypanosoma brucei cysteine peptidase C (CPC) 0.0204 0.2085 0.8519
Schistosoma mansoni cathepsin F (C01 family) 0.0218 0.2244 0.3732
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0339 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0126 0.1173 0.4669
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0339 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0236 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0339 0.0516
Loa Loa (eye worm) hypothetical protein 0.0043 0.0201 0.0335
Echinococcus multilocularis cathepsin L cysteine protease 0.0218 0.2244 0.2231
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Schistosoma mansoni cathepsin s 0.0071 0.0533 0.0865
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0339 0.0516
Plasmodium vivax unspecified product 0.0071 0.0533 0.1018
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.019 0.1924 0.3196
Echinococcus granulosus muscleblind protein 0.0162 0.1596 0.2647
Onchocerca volvulus 0.0054 0.0327 0.1458
Schistosoma mansoni cathepsin S (C01 family) 0.0055 0.0339 0.0541
Leishmania major cathepsin L-like protease 0.0218 0.2244 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0055 0.0339 0.0567
Onchocerca volvulus 0.0218 0.2244 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0218 0.2244 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0218 0.2244 0.3749
Leishmania major cathepsin L-like protease 0.0218 0.2244 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0055 0.0339 0.0516
Schistosoma mansoni metabotropic glutamate receptor 0.0082 0.0653 0.1066
Onchocerca volvulus 0.0218 0.2244 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.1173 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0055 0.0339 0.1511
Loa Loa (eye worm) hypothetical protein 0.0218 0.2244 0.3749
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.1173 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Echinococcus multilocularis muscleblind protein 0.0162 0.1596 0.1583
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Brugia malayi cathepsin L-like precursor 0.0146 0.141 0.2355
Schistosoma mansoni metabotropic glutamate receptor 0.014 0.1338 0.2215
Loa Loa (eye worm) glutamate receptor 0.0066 0.0469 0.0783
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Leishmania major cathepsin L-like protease 0.0218 0.2244 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.095 0.4231
Brugia malayi Cathepsin L-like precursor 0.0218 0.2244 0.3749
Brugia malayi hypothetical protein 0.0039 0.0156 0.026
Echinococcus multilocularis cathepsin L 0.0126 0.1173 0.1159
Trypanosoma cruzi cysteine protease, putative 0.0126 0.1173 0.1477
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0055 0.0339 0.0567
Echinococcus multilocularis protein dispatched 1 0.0052 0.0311 0.0295
Echinococcus multilocularis cathepsin b 0.0537 0.5986 0.5979
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Onchocerca volvulus 0.0218 0.2244 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0537 0.5986 1
Brugia malayi Cathepsin L-like precursor 0.0071 0.0533 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0339 0.0516
Onchocerca volvulus 0.0146 0.141 0.6282
Plasmodium vivax vivapain-1 0.0126 0.1173 0.438
Echinococcus multilocularis metabotropic glutamate receptor 2 0.014 0.1338 0.1324
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0339 0.0567
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0339 0.0567
Loa Loa (eye worm) hypothetical protein 0.0055 0.0339 0.0567
Brugia malayi Cathepsin L-like precursor 0.0146 0.141 0.2355
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.1486 0.1472
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1228 0.203
Schistosoma mansoni cathepsin C 0.0055 0.0339 0.0541
Loa Loa (eye worm) hypothetical protein 0.0054 0.0327 0.0546
Giardia lamblia Cathepsin B precursor 0.0204 0.2085 1
Brugia malayi metabotropic glutamate receptor type 2 0.0082 0.0653 0.1091
Echinococcus multilocularis muscleblind protein 1 0.0162 0.1596 0.1583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Brugia malayi TAR-binding protein 0.0131 0.1228 0.2052
Brugia malayi Cathepsin L-like precursor 0.0218 0.2244 0.3749
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0055 0.0339 0.0516
Loa Loa (eye worm) hypothetical protein 0.0537 0.5986 1
Schistosoma mansoni cathepsin F (C01 family) 0.0218 0.2244 0.3732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0339 0.0516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.2244 0.3374
Echinococcus granulosus expressed conserved protein 0.01 0.0874 0.1436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0055 0.0339 0.0541
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0055 0.0339 0.0516
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Trypanosoma cruzi cysteine proteinase, putative 0.0126 0.1173 0.1477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.2244 0.3374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0339 0.0516
Echinococcus multilocularis cysteine protease 0.0218 0.2244 0.2231
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0339 0.0516
Loa Loa (eye worm) hypothetical protein 0.0071 0.0533 0.0891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Brugia malayi Papain family cysteine protease containing protein 0.0218 0.2244 0.3749
Echinococcus granulosus tumor protein p63 0.0367 0.3991 0.6659
Onchocerca volvulus Cathepsin L homolog 0.0218 0.2244 1
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0339 0.0567
Echinococcus multilocularis protein patched 0.0046 0.0236 0.0219
Echinococcus granulosus metabotropic glutamate receptor 5 0.0206 0.2108 0.3505
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0339 0.0567
Schistosoma mansoni cathepsin B (C01 family) 0.0055 0.0339 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0236 0.0219
Loa Loa (eye worm) hypothetical protein 0.0071 0.0533 0.0891
Leishmania major cysteine peptidase A (CPA) 0.0218 0.2244 1
Echinococcus granulosus cathepsin l1 0.0146 0.141 0.2334
Entamoeba histolytica hypothetical protein 0.0055 0.0339 0.1511
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0206 0.2108 0.2095
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.1173 0.1938
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0339 0.0541
Echinococcus multilocularis expressed conserved protein 0.01 0.0874 0.0859
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.2244 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Schistosoma mansoni hypothetical protein 0.0044 0.0216 0.0335
Loa Loa (eye worm) hypothetical protein 0.0055 0.0339 0.0567
Loa Loa (eye worm) hypothetical protein 0.0146 0.141 0.2355
Entamoeba histolytica cysteine protease, putative 0.0055 0.0339 0.1511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Entamoeba histolytica cysteine protease, putative 0.0126 0.1173 0.5229
Leishmania major cathepsin L-like protease 0.0218 0.2244 1
Brugia malayi cathepsin L precursor 0.0055 0.0339 0.0567
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Brugia malayi Cathepsin L-like precursor 0.0218 0.2244 0.3749
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.0533 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0218 0.2244 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.014 0.1338 0.2215
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0027 0.0017 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.2244 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0218 0.2244 1
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0327 0.052
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0537 0.5986 1
Entamoeba histolytica cysteine protease, putative 0.0218 0.2244 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.2244 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.141 0.2355
Onchocerca volvulus 0.0055 0.0339 0.1511
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0 0.5
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0204 0.2085 0.9293
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0236 0.0394
Loa Loa (eye worm) hypothetical protein 0.0055 0.0339 0.0567
Echinococcus granulosus cathepsin b 0.0537 0.5986 1
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.1173 0.196
Loa Loa (eye worm) hypothetical protein 0.0055 0.0339 0.0567
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1228 0.203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.141 0.5846
Onchocerca volvulus 0.0218 0.2244 1
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0043 0.0201 0.0335
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.1228 0.2052
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0055 0.0339 0.0567
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.2244 0.3374
Loa Loa (eye worm) hypothetical protein 0.0146 0.141 0.2355
Echinococcus granulosus cathepsin b 0.0537 0.5986 1
Brugia malayi Receptor family ligand binding region containing protein 0.0043 0.0201 0.0335
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0 0.5
Brugia malayi cathepsin L-like cysteine proteinase 0.0055 0.0339 0.0567
Echinococcus granulosus cathepsin L 0.0126 0.1173 0.1938
Plasmodium vivax vivapain-3 0.0126 0.1173 0.438
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0339 0.0541
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 0.5986 1
Trypanosoma cruzi cysteine proteinase, putative 0.0126 0.1173 0.1477
Leishmania major cathepsin L-like protease 0.0218 0.2244 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0055 0.0339 0.0541

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 43 uM AUC (0 to 24 hrs) in C57BL/6 mouse at 5 mg/kg, po ChEMBL. 17590332
AUC (ADMET) = 43 uM AUC (0 to 24 hrs) in C57BL/6 mouse at 5 mg/kg, po ChEMBL. 17590332
AUC (ADMET) = 111 uM AUC (0 to 24 hrs) in C57BL/6 mouse at 50 mg/kg, po ChEMBL. 17590332
AUC (ADMET) = 111 uM AUC (0 to 24 hrs) in C57BL/6 mouse at 50 mg/kg, po ChEMBL. 17590332
Cmax (ADMET) = 6.3 uM Cmax in Sprague-Dawley rat ChEMBL. 17590332
F (ADMET) = 48 mg kg-1 Bioavailability in Sprague-Dawley rat ChEMBL. 17590332
IC50 (binding) = 0.6 nM Inhibition of mouse recombinant cathepsin S ChEMBL. 17590332
IC50 (binding) = 0.6 nM Inhibition of mouse recombinant cathepsin S ChEMBL. 17590332
IC50 (binding) = 1.8 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 1.8 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 2.5 nM Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence assay ChEMBL. 23084902
IC50 (binding) = 5 nM Inhibition of cathepsin S-mediated antigen presentation in B/T hybridoma cells assessed as IL-2 level ChEMBL. 23084902
IC50 (functional) = 44 nM Inhibition of antigen presentation in mouse B cells ChEMBL. 17590332
IC50 (binding) = 230 nM Inhibition of cathepsin L using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence assay ChEMBL. 23084902
IC50 (binding) = 233 nM Inhibition of mouse recombinant cathepsin B ChEMBL. 17590332
IC50 (binding) = 233 nM Inhibition of mouse recombinant cathepsin B ChEMBL. 17590332
IC50 (binding) = 319 nM Inhibition of rat liver lysosomal cathepsin B ChEMBL. 17590332
IC50 (binding) = 319 nM Inhibition of rat liver lysosomal cathepsin B ChEMBL. 17590332
IC50 (binding) = 405 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 405 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 426 nM Inhibition of rat spleen cathepsin S ChEMBL. 17590332
IC50 (binding) = 426 nM Inhibition of rat spleen cathepsin S ChEMBL. 17590332
IC50 (binding) = 1013 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 1013 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 1104 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 1104 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 1646 nM Inhibition of mouse recombinant cathepsin K ChEMBL. 17590332
IC50 (binding) = 1646 nM Inhibition of mouse recombinant cathepsin K ChEMBL. 17590332
IC50 (binding) = 3037 nM Inhibition of mouse recombinant cathepsin L ChEMBL. 17590332
IC50 (binding) = 3037 nM Inhibition of mouse recombinant cathepsin L ChEMBL. 17590332
IC50 (binding) = 3159 nM Inhibition of rat liver lysosomal cathepsin L ChEMBL. 17590332
IC50 (binding) = 3159 nM Inhibition of rat liver lysosomal cathepsin L ChEMBL. 17590332
Stabilty (ADMET) 0 Metabolic stability in rat hepatocytes after 2 hrs ChEMBL. 17590332
t1/2 (ADMET) = 5.2 hr Half life in Sprague-Dawley rat ChEMBL. 17590332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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