Detailed information for compound 458533

Basic information

Technical information
  • TDR Targets ID: 458533
  • Name: (2R)-N-(1-cyanocyclopropyl)-3-(cyclopropylmet hylsulfonyl)-2-[[(1S)-2,2,2-trifluoro-1-(4-fl uorophenyl)ethyl]amino]propanamide
  • MW: 447.447 | Formula: C19H21F4N3O3S
  • H donors: 2 H acceptors: 4 LogP: 2.17 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CC1)NC(=O)[C@H](CS(=O)(=O)CC1CC1)N[C@H](C(F)(F)F)c1ccc(cc1)F
  • InChi: 1S/C19H21F4N3O3S/c20-14-5-3-13(4-6-14)16(19(21,22)23)25-15(10-30(28,29)9-12-1-2-12)17(27)26-18(11-24)7-8-18/h3-6,12,15-16,25H,1-2,7-10H2,(H,26,27)/t15-,16-/m0/s1
  • InChiKey: NOTSCKFHTQJLMM-HOTGVXAUSA-N  


Substructure search Similarity search

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Synonyms

  • (2R)-N-(1-cyanocyclopropyl)-3-(cyclopropylmethylsulfonyl)-2-[[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]amino]propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Mus musculus cathepsin S Starlite/ChEMBL References
Rattus norvegicus Cathepsin L Starlite/ChEMBL References
Mus musculus cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Mus musculus cathepsin L Starlite/ChEMBL References
Mus musculus cathepsin K Starlite/ChEMBL References
Rattus norvegicus Cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis papain family cysteine protease containing protein Get druggable targets OG5_129645 All targets in OG5_129645
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis cysteine protease 2 Get druggable targets OG5_129645 All targets in OG5_129645
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_129645 All targets in OG5_129645
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_129645 All targets in OG5_129645
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Cathepsin L homolog Cathepsin L   334 aa 322 aa 41.6 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 324 aa 34.6 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Dictyostelium discoideum cysteine proteinase 5 precursor Cathepsin B   339 aa 303 aa 22.4 %
Plasmodium berghei dipeptidyl aminopeptidase 1, putative Cathepsin B   339 aa 319 aa 26.6 %
Echinococcus granulosus cathepsin L cysteine protease Cathepsin L   334 aa 323 aa 46.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 23.4 %
Onchocerca volvulus Cathepsin L   334 aa 311 aa 40.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin S   330 aa 319 aa 23.5 %
Plasmodium vivax vivapain-1 Cathepsin L   334 aa 366 aa 28.4 %
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 273 aa 26.0 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 298 aa 28.9 %
Schistosoma mansoni SmCB2 peptidase (C01 family) Cathepsin L   334 aa 288 aa 26.7 %
Plasmodium knowlesi dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 273 aa 27.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 336 aa 25.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 276 aa 26.8 %
Schistosoma japonicum ko:K01275 cathepsin C [EC3.4.14.1], putative Cathepsin B   339 aa 334 aa 29.3 %
Plasmodium berghei dipeptidyl aminopeptidase 2 Cathepsin B   339 aa 314 aa 24.5 %
Babesia bovis preprocathepsin c precursor, putative Cathepsin B   339 aa 282 aa 29.8 %
Plasmodium falciparum cysteine proteinase falcipain 1 Cathepsin L   334 aa 359 aa 29.8 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.9 %
Onchocerca volvulus Cathepsin B-like cysteine proteinase 6 homolog Cathepsin B   339 aa 326 aa 51.2 %
Plasmodium knowlesi knowpain-2 Cathepsin B   339 aa 302 aa 24.8 %
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) Cathepsin L   334 aa 318 aa 48.4 %
Drosophila melanogaster CG6347 gene product from transcript CG6347-RA Cathepsin L   334 aa 311 aa 36.0 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 279 aa 25.8 %
Plasmodium berghei berghepain-1 Cathepsin L   334 aa 353 aa 29.7 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 25.9 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 298 aa 23.8 %
Plasmodium vivax serine-repeat antigen (SERA), putative Cathepsin S   330 aa 293 aa 22.2 %
Echinococcus granulosus cysteine protease Cathepsin L   334 aa 323 aa 44.3 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Plasmodium falciparum dipeptidyl aminopeptidase 2 Cathepsin L   334 aa 294 aa 23.8 %
Plasmodium vivax serine-repeat antigen 4 (SERA), putative Cathepsin S   330 aa 274 aa 23.4 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 270 aa 25.6 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 337 aa 26.1 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 276 aa 25.4 %
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) Cathepsin B   339 aa 327 aa 30.3 %
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Cathepsin L   334 aa 290 aa 27.6 %
Plasmodium yoelii cysteine proteinase precursor Cathepsin L   334 aa 360 aa 29.2 %
Babesia bovis cathepsin C precursor, putative Cathepsin B   339 aa 304 aa 26.6 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 Cathepsin B   339 aa 367 aa 25.9 %
Toxoplasma gondii cathepsin CPC1 Cathepsin L   334 aa 295 aa 28.1 %
Plasmodium knowlesi dipeptidyl aminopeptidase 1, putative Cathepsin L   334 aa 277 aa 24.5 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 274 aa 48.5 %
Schistosoma mansoni SmCL2-like peptidase (C01 family) Cathepsin L   334 aa 316 aa 30.1 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Cathepsin L   334 aa 309 aa 26.5 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Schistosoma mansoni cathepsin S (C01 family) Cathepsin L   334 aa 311 aa 35.0 %
Theileria parva cathepsin C, putative Cathepsin B   339 aa 295 aa 26.1 %
Echinococcus granulosus cathepsin b Cathepsin S   330 aa 288 aa 30.2 %
Plasmodium knowlesi cysteine protease, putative Cathepsin S   330 aa 291 aa 23.0 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 319 aa 25.7 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 278 aa 26.6 %
Trypanosoma cruzi cysteine protease, putative Cathepsin L   334 aa 323 aa 30.3 %
Dictyostelium discoideum hypothetical protein Cathepsin L   334 aa 325 aa 38.1 %
Echinococcus multilocularis cathepsin b Cathepsin S   330 aa 288 aa 30.2 %
Onchocerca volvulus Cathepsin L   334 aa 325 aa 47.4 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 270 aa 25.6 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 25.0 %
Giardia lamblia Encystation-specific protease Cathepsin B   339 aa 272 aa 23.5 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 302 aa 24.5 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 275 aa 29.1 %
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase Cathepsin B   339 aa 287 aa 22.6 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 274 aa 48.2 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 347 aa 28.8 %
Plasmodium vivax unspecified product Cathepsin L   334 aa 366 aa 28.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 332 aa 23.5 %
Schistosoma japonicum Cathepsin C precursor, putative Cathepsin B   339 aa 332 aa 26.8 %
Plasmodium yoelii cathepsin c precursor Cathepsin L   334 aa 292 aa 22.6 %
Plasmodium falciparum serine repeat antigen 8 Cathepsin B   339 aa 272 aa 25.0 %
Onchocerca volvulus Cathepsin S   330 aa 289 aa 29.4 %
Plasmodium vivax dipeptidyl aminopeptidase 1, putative Cathepsin B   339 aa 304 aa 27.0 %
Schistosoma japonicum ko:K01365 cathepsin L [EC3.4.22.15], putative Cathepsin S   330 aa 309 aa 44.7 %
Echinococcus granulosus cathepsin L Cathepsin L   334 aa 325 aa 29.5 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 27.9 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 303 aa 26.1 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 317 aa 33.8 %
Drosophila melanogaster Cathepsin B1 Cathepsin S   330 aa 305 aa 27.2 %
Onchocerca volvulus Cathepsin L   334 aa 300 aa 24.3 %
Echinococcus multilocularis cathepsin L Cathepsin L   334 aa 309 aa 30.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 346 aa 26.9 %
Brugia malayi cathepsin B-like cysteine proteinase Cathepsin L   334 aa 303 aa 23.4 %
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Cathepsin L   334 aa 277 aa 26.0 %
Onchocerca volvulus Cathepsin B   339 aa 319 aa 38.9 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Neospora caninum hypothetical protein Cathepsin L   334 aa 299 aa 28.4 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 295 aa 25.4 %
Babesia bovis papain family cysteine protease containing protein Cathepsin L   334 aa 321 aa 32.7 %
Theileria parva cysteine proteinase, putative Cathepsin L   334 aa 333 aa 28.8 %
Cryptosporidium parvum preprocathepsin c precursor, putative Cathepsin B   339 aa 287 aa 30.3 %
Giardia lamblia Cathepsin L precursor Cathepsin L   334 aa 271 aa 26.9 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 347 aa 26.5 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 279 aa 28.3 %
Plasmodium berghei serine repeat antigen 1 Cathepsin S   330 aa 287 aa 25.4 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 280 aa 28.6 %
Toxoplasma gondii cathepsin B Cathepsin S   330 aa 265 aa 24.9 %
Loa Loa (eye worm) hypothetical protein Cathepsin S   330 aa 281 aa 28.5 %
Brugia malayi Papain family cysteine protease containing protein Cathepsin L   334 aa 296 aa 31.8 %
Giardia lamblia Cathepsin L-like protease Cathepsin L   334 aa 273 aa 25.3 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 36.4 %
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin B   339 aa 301 aa 23.6 %
Plasmodium vivax dipeptidyl aminopeptidase 2, putative Cathepsin L   334 aa 271 aa 27.7 %
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase Cathepsin S   330 aa 266 aa 32.0 %
Schistosoma mansoni cathepsin F (C01 family) Cathepsin B   339 aa 273 aa 28.9 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 372 aa 23.7 %
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Cathepsin L   334 aa 329 aa 39.5 %
Trypanosoma cruzi cysteine proteinase, putative Cathepsin L   334 aa 304 aa 33.2 %
Dictyostelium discoideum cysteine protease Cathepsin B   339 aa 283 aa 24.7 %
Cryptosporidium hominis preprocathepsin c precursor Cathepsin B   339 aa 282 aa 29.4 %
Echinococcus granulosus cathepsin b Cathepsin S   330 aa 276 aa 26.1 %
Plasmodium knowlesi knowpain-4 Cathepsin B   339 aa 304 aa 24.3 %
Plasmodium falciparum cysteine proteinase falcipain 2b cathepsin K 329 aa 328 aa 34.5 %
Echinococcus multilocularis cathepsin b Cathepsin S   330 aa 278 aa 28.8 %
Entamoeba histolytica cysteine protease, putative Cathepsin L   334 aa 341 aa 26.7 %
Schistosoma japonicum Disco-interacting protein 2 homolog B, putative Cathepsin L   334 aa 345 aa 35.4 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 334 aa 367 aa 30.0 %
Dictyostelium discoideum cathepsin L-like proteinase Cathepsin L   334 aa 312 aa 42.0 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 274 aa 24.8 %
Plasmodium yoelii SERA-2 Cathepsin S   330 aa 267 aa 24.3 %
Plasmodium vivax vivapain-3 Cathepsin L   334 aa 345 aa 30.7 %
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Cathepsin L   334 aa 277 aa 26.0 %
Plasmodium knowlesi knowpain-1 Cathepsin L   334 aa 373 aa 27.6 %
Onchocerca volvulus Protein MCM10 homolog Cathepsin L   334 aa 300 aa 41.0 %
Trypanosoma congolense cysteine peptidase C (CPC) Cathepsin L   334 aa 282 aa 26.2 %
Giardia lamblia Dipeptidyl-peptidase I precursor Cathepsin L   334 aa 304 aa 28.3 %
Onchocerca volvulus Cathepsin L   334 aa 321 aa 38.0 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 341 aa 375 aa 29.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0218 0.3088 1
Trypanosoma cruzi cruzipain precursor, putative 0.0218 0.3088 0.2225
Echinococcus multilocularis cysteine protease 0.0218 0.3088 0.3088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.3088 0.2225
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0204 0.2795 0.2795
Trypanosoma brucei cysteine peptidase C (CPC) 0.0204 0.2795 0.8519
Leishmania major cysteine peptidase A (CPA) 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Onchocerca volvulus 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Echinococcus granulosus cathepsin b 0.0537 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0204 0.2795 0.8519
Leishmania major cathepsin L-like protease 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Brugia malayi Papain family cysteine protease containing protein 0.0218 0.3088 0.3088
Echinococcus multilocularis cathepsin L 0.0126 0.111 0.111
Loa Loa (eye worm) hypothetical protein 0.0218 0.3088 0.3088
Echinococcus multilocularis cathepsin b 0.0537 1 1
Brugia malayi Cathepsin L-like precursor 0.0146 0.1547 0.1547
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0218 0.3088 0.3088
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 1 1
Toxoplasma gondii cathepsin CPL 0.0218 0.3088 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0537 1 1
Brugia malayi Cathepsin L-like precursor 0.0218 0.3088 0.3088
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0218 0.3088 0.3088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Onchocerca volvulus 0.0218 0.3088 1
Echinococcus granulosus cysteine protease 0.0126 0.111 0.111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.111 0.111
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.3088 1
Onchocerca volvulus 0.0146 0.1547 0.5009
Onchocerca volvulus Cathepsin L homolog 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.1547 0.2208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0218 0.3088 0.3088
Loa Loa (eye worm) fibroinase 0.0218 0.3088 0.3088
Brugia malayi Cathepsin L-like precursor 0.0218 0.3088 0.3088
Leishmania major cathepsin L-like protease 0.0218 0.3088 1
Brugia malayi Cathepsin L-like precursor 0.0218 0.3088 0.3088
Echinococcus multilocularis cysteine protease 0.0218 0.3088 0.3088
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0218 0.3088 0.3088
Echinococcus granulosus cathepsin b 0.0537 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0218 0.3088 0.3088
Loa Loa (eye worm) hypothetical protein 0.0146 0.1547 0.1547
Giardia lamblia Cathepsin B precursor 0.0204 0.2795 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.0126 0.111 0.111
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0218 0.3088 1
Echinococcus granulosus cathepsin l1 0.0146 0.1547 0.1547
Plasmodium falciparum cysteine proteinase falcipain 3 0.0218 0.3088 1
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.3088 0.2225
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.111 0.111
Leishmania major cathepsin L-like protease 0.0218 0.3088 1
Loa Loa (eye worm) cathepsin B 0.0204 0.2795 0.2795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.1547 0.2208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Brugia malayi Cathepsin L-like precursor 0.0218 0.3088 0.3088
Onchocerca volvulus Cathepsin F homolog 0.0218 0.3088 1
Loa Loa (eye worm) ctsf protein 0.0218 0.3088 0.3088
Echinococcus granulosus cathepsin L 0.0126 0.111 0.111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0218 0.3088 0.3088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0204 0.2795 0.1895
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0218 0.3088 0.3088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Brugia malayi Cathepsin L-like precursor 0.0218 0.3088 0.3088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Echinococcus multilocularis cathepsin b 0.0537 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0218 0.3088 0.3088
Loa Loa (eye worm) hypothetical protein 0.0537 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1547 0.1547
Plasmodium vivax vivapain-2 0.0218 0.3088 1
Entamoeba histolytica cysteine protease, putative 0.0218 0.3088 1
Onchocerca volvulus 0.0218 0.3088 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.111 0.111
Onchocerca volvulus 0.0218 0.3088 1
Schistosoma mansoni cathepsin F (C01 family) 0.0146 0.1547 0.1547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Giardia lamblia Cathepsin B precursor 0.0204 0.2795 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0537 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0537 1 1
Brugia malayi Cathepsin L-like precursor 0.0218 0.3088 0.3088
Brugia malayi Cathepsin L-like cysteine proteinase 0.0146 0.1547 0.1547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Loa Loa (eye worm) cysteine protease 0.0218 0.3088 0.3088
Brugia malayi Cathepsin L-like precursor 0.0146 0.1547 0.1547
Onchocerca volvulus 0.0218 0.3088 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1547 0.1547
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0126 0.111 0.111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0218 0.3088 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Leishmania major cathepsin L-like protease 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0218 0.3088 1
Giardia lamblia Cathepsin B precursor 0.0204 0.2795 0.5
Leishmania major cathepsin L-like protease 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Echinococcus granulosus cathepsin l1 0.0218 0.3088 0.3088
Leishmania major cathepsin L-like protease 0.0218 0.3088 1
Brugia malayi cathepsin L-like precursor 0.0146 0.1547 0.1547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.1547 0.2208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Leishmania major cathepsin L-like protease 0.0218 0.3088 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0146 0.1547 0.0491
Entamoeba histolytica cysteine proteinase, putative 0.0218 0.3088 1
Onchocerca volvulus 0.0218 0.3088 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0218 0.3088 1
Onchocerca volvulus 0.0218 0.3088 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0218 0.3088 1
Leishmania major cathepsin L-like protease 0.0218 0.3088 1
Brugia malayi Papain family cysteine protease containing protein 0.0126 0.111 0.111
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.3088 0.2225
Plasmodium vivax vivapain-2 0.0218 0.3088 1
Onchocerca volvulus Cathepsin L homolog 0.0218 0.3088 1
Schistosoma mansoni cathepsin F (C01 family) 0.0218 0.3088 0.3088
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.3088 0.2225
Schistosoma mansoni cathepsin F (C01 family) 0.0218 0.3088 0.3088

Activities

Activity type Activity value Assay description Source Reference
Cmax (ADMET) = 2.8 uM Cmax in Sprague-Dawley rat ChEMBL. 17590332
F (ADMET) = 40 mg kg-1 Bioavailability in Sprague-Dawley rat ChEMBL. 17590332
IC50 (binding) = 0.4 nM Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence assay ChEMBL. 23084902
IC50 (binding) = 0.5 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 0.5 nM Inhibition of human cathepsin S ChEMBL. 17590332
IC50 (binding) = 0.9 nM Inhibition of mouse recombinant cathepsin S ChEMBL. 17590332
IC50 (binding) = 0.9 nM Inhibition of mouse recombinant cathepsin S ChEMBL. 17590332
IC50 (binding) = 33 nM Inhibition of cathepsin S-mediated antigen presentation in B/T hybridoma cells assessed as IL-2 level ChEMBL. 23084902
IC50 (binding) = 62 nM Inhibition of cathepsin L using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence assay ChEMBL. 23084902
IC50 (binding) = 188 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 188 nM Inhibition of human cathepsin L ChEMBL. 17590332
IC50 (binding) = 253 nM Inhibition of mouse recombinant cathepsin B ChEMBL. 17590332
IC50 (binding) = 253 nM Inhibition of mouse recombinant cathepsin B ChEMBL. 17590332
IC50 (binding) = 272 nM Inhibition of rat liver lysosomal cathepsin B ChEMBL. 17590332
IC50 (binding) = 272 nM Inhibition of rat liver lysosomal cathepsin B ChEMBL. 17590332
IC50 (binding) = 332 nM Inhibition of mouse recombinant cathepsin L ChEMBL. 17590332
IC50 (binding) = 332 nM Inhibition of mouse recombinant cathepsin L ChEMBL. 17590332
IC50 (binding) = 738 nM Inhibition of rat liver lysosomal cathepsin L ChEMBL. 17590332
IC50 (binding) = 738 nM Inhibition of rat liver lysosomal cathepsin L ChEMBL. 17590332
IC50 (binding) = 759 nM Inhibition of rat spleen cathepsin S ChEMBL. 17590332
IC50 (binding) = 759 nM Inhibition of rat spleen cathepsin S ChEMBL. 17590332
IC50 (binding) = 1000 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 1000 nM Inhibition of human cathepsin B ChEMBL. 17590332
IC50 (binding) = 2003 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) = 2003 nM Inhibition of human cathepsin K ChEMBL. 17590332
IC50 (binding) > 10000 nM Inhibition of mouse recombinant cathepsin K ChEMBL. 17590332
IC50 (binding) > 10000 nM Inhibition of mouse recombinant cathepsin K ChEMBL. 17590332
t1/2 (ADMET) = 3.8 hr Half life in Sprague-Dawley rat ChEMBL. 17590332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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