Detailed information for compound 45962

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 692.749 | Formula: C38H44O12
  • H donors: 2 H acceptors: 4 LogP: 5.99 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(/C=C/C(=O)O[C@@H]2[C@H]3OC4(O[C@@H]3[C@H]([C@@H]3[C@H]2OC2(O3)CCCCC2)OC(=O)/C=C/c2ccc(c(c2)OC)O)CCCCC4)ccc1O
  • InChi: 1S/C38H44O12/c1-43-27-21-23(9-13-25(27)39)11-15-29(41)45-31-33-35(49-37(47-33)17-5-3-6-18-37)32(36-34(31)48-38(50-36)19-7-4-8-20-38)46-30(42)16-12-24-10-14-26(40)28(22-24)44-2/h9-16,21-22,31-36,39-40H,3-8,17-20H2,1-2H3/b15-11+,16-12+/t31-,32-,33-,34-,35-,36+/m1/s1
  • InChiKey: KEVLDHSGDMXFOT-WWNZOKGSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0106 0.018
Schistosoma mansoni chromatin regulatory protein sir2 0.0034 0.0286 0.0583
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0208 0.0817
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0977 0.4203
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0286 0.081
Onchocerca volvulus Netrin receptor homolog 0.0157 0.1776 0.7406
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0068 0.0699 1
Echinococcus multilocularis musashi 0.0028 0.0208 0.019
Giardia lamblia Hypothetical protein 0.0034 0.0286 0.081
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.2324 0.4737
Brugia malayi transcriptional regulator, Sir2 family protein 0.0034 0.0286 0.1231
Schistosoma mansoni chromatin regulatory protein sir2 0.0155 0.1749 0.3565
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0977 0.4152
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0108 0.0465
Brugia malayi Death domain containing protein 0.0157 0.1776 0.7638
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0119 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0038 0.0163
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0034 0.0286 0.0548
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0621 0.1267
Echinococcus granulosus dna polymerase eta 0.002 0.0113 0.0192
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0155 0.1749 0.7407
Brugia malayi CXXC zinc finger family protein 0.0029 0.0225 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0203 0.2324 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0113 0.0104
Echinococcus multilocularis dna polymerase eta 0.002 0.0113 0.0094
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.024 0.2777 0.2764
Giardia lamblia Transcriptional regulator, Sir2 family 0.0068 0.0699 0.267
Trichomonas vaginalis rotamase, putative 0.0066 0.0666 0.2521
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0067 0.0685 0.2884
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0286 0.3908
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0038 0.0163
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0157 0.1776 0.3594
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0113 0.0104
Loa Loa (eye worm) hypothetical protein 0.0155 0.1749 0.7504
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0068 0.0699 0.267
Trypanosoma brucei polo-like protein kinase 0.0203 0.2324 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0068 0.0699 0.267
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0034 0.0286 0.081
Leishmania major sir2-family protein-like protein 0.0034 0.0286 0.081
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.0666 0.2521
Loa Loa (eye worm) transcriptional regulator 0.0034 0.0286 0.1155
Schistosoma mansoni intermediate filament proteins 0.0028 0.0208 0.0425
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0683 0.2876
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Plasmodium vivax NAD-dependent deacetylase, putative 0.0068 0.0699 1
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0068 0.0699 0.3006
Trypanosoma brucei unspecified product 0.002 0.0113 0.0484
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0068 0.0699 0.267
Echinococcus granulosus expressed protein 0.0067 0.0685 0.1363
Mycobacterium ulcerans Sir2-like regulatory protein 0.0034 0.0286 0.3034
Echinococcus multilocularis dna polymerase kappa 0.002 0.0113 0.0094
Schistosoma mansoni chromatin regulatory protein sir2 0.0034 0.0286 0.0583
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0977 0.1961
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0088 0.0179
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.002 0.0119 0.1701
Onchocerca volvulus 0.0029 0.0225 0.0079
Leishmania major silent information regulator 2, putative 0.0034 0.0286 0.081
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0113 0.0028
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.4907 0.4897
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0203 0.2324 0.231
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0157 0.1776 0.3618
Echinococcus granulosus Ankyrin 0.0157 0.1776 0.3594
Giardia lamblia PHD finger protein 15 0.0032 0.0264 0.0712
Brugia malayi Protein kinase domain containing protein 0.0158 0.1784 0.7673
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.002 0.0119 1
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.024 0.2777 0.2764
Schistosoma mansoni ankyrin 23/unc44 0.0157 0.1776 0.3618
Brugia malayi Immunoglobulin I-set domain containing protein 0.0157 0.1776 0.7638
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0068 0.0699 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0264 0.0539
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0203 0.2324 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0034 0.0286 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0113 0.0028
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0066 0.0666 0.2521
Entamoeba histolytica serine/threonine protein kinase, putative 0.0203 0.2324 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0113 0.0028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0113 0.023
Brugia malayi PHD-finger family protein 0.0012 0.002 0.0087
Schistosoma mansoni ap endonuclease 0.0019 0.0106 0.0217
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.024 0.2777 0.5644
Schistosoma mansoni hypothetical protein 0.0416 0.4907 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.1158 0.2332
Trypanosoma brucei unspecified product 0.0014 0.0038 0.0163
Schistosoma mansoni tumor necrosis factor receptor related 0.024 0.2777 0.566
Loa Loa (eye worm) transcriptional regulator 0.0034 0.0286 0.1155
Plasmodium falciparum phd finger protein, putative 0.0032 0.0264 0.3587
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0034 0.0286 0.0548
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0119 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0038 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0034
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0113 0.0028
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0208 0.0817
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0106 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Giardia lamblia DINP protein human, muc B family 0.002 0.0113 0.0028
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0264 0.106
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0113 0.0028
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0052 0.0224
Brugia malayi hypothetical protein 0.0168 0.1908 0.8209
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0106 0.0375
Schistosoma mansoni chromatin regulatory protein sir2 0.0068 0.0699 0.1424
Toxoplasma gondii histone deacetylase SIR2 0.0068 0.0699 1
Toxoplasma gondii histone deacetylase SIR2-like 0.0034 0.0286 0.4096
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0157 0.1776 0.7618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0977 0.1991
Echinococcus multilocularis netrin receptor unc 5 0.0157 0.1776 0.176
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Trypanosoma cruzi polo-like protein kinase, putative 0.0203 0.2324 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0034 0.0286 0.0583
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0155 0.1749 0.1734
Echinococcus multilocularis peregrin 0.0032 0.0264 0.0246
Echinococcus granulosus death domain containing protein 0.0157 0.1776 0.3594
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0061
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0034 0.0286 0.0268
Giardia lamblia Kinase, PLK 0.0203 0.2324 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1086 0.4415
Brugia malayi jmjC domain containing protein 0.0106 0.1158 0.4984
Schistosoma mansoni kinase 0.0103 0.1118 0.2279
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0155 0.1749 0.7407
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0034 0.0284 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0113 0.0028
Brugia malayi transcriptional regulator, Sir2 family protein 0.0034 0.0286 0.1231
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0113 0.0484
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.024 0.2777 0.5644
Loa Loa (eye worm) hypothetical protein 0.0157 0.1776 0.7618
Schistosoma mansoni ap endonuclease 0.0019 0.0106 0.0217
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0066 0.0666 0.2521
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0106 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Echinococcus multilocularis expressed protein 0.0067 0.0685 0.0667
Schistosoma mansoni lamin 0.0028 0.0208 0.0425
Loa Loa (eye worm) hypothetical protein 0.0168 0.1908 0.8193
Schistosoma mansoni cpg binding protein 0.0031 0.0245 0.05
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0113 0.0484
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0894 0.1822
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0106 0.1254
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0066 0.0666 0.2864
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0286 0.081
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0264 0.3785
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0264 0.0246
Trypanosoma brucei unspecified product 0.0014 0.0038 0.0163
Loa Loa (eye worm) hypothetical protein 0.0056 0.0545 0.2279
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0113 0.0028
Onchocerca volvulus 0.0168 0.1908 0.8032
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0264 0.0503
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0155 0.1749 0.7407
Brugia malayi jmjC domain containing protein 0.0041 0.0367 0.158
Loa Loa (eye worm) hypothetical protein 0.0032 0.0264 0.106
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0106 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0977 0.1991
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0155 0.1749 0.7407
Loa Loa (eye worm) hypothetical protein 0.0027 0.0202 0.079
Echinococcus multilocularis Ankyrin 0.0157 0.1776 0.176
Loa Loa (eye worm) hypothetical protein 0.002 0.0113 0.0401
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0034 0.0286 0.1231
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0068 0.0699 0.267
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0113 0.0104
Schistosoma mansoni chromatin regulatory protein sir2 0.0034 0.0286 0.0583
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0067 0.0685 0.2946
Schistosoma mansoni DNA polymerase eta 0.002 0.0113 0.023
Toxoplasma gondii peptidylprolyl isomerase 0.0066 0.0666 0.9526
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0034
Brugia malayi PHD-finger family protein 0.0032 0.0264 0.1138
Brugia malayi transcriptional regulator, Sir2 family protein 0.0034 0.0286 0.1231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0977 0.1961
Brugia malayi intermediate filament protein 0.0028 0.0208 0.0897
Schistosoma mansoni chromatin regulatory protein sir2 0.0034 0.0286 0.0583
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0264 0.3785
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0286 0.081
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0541 0.7748
Brugia malayi Uncoordinated protein 44 0.0157 0.1776 0.7638
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.2324 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0034 0.0286 0.081
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0052 0.0138
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.002 0.0119 0.0056
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0034 0.0286 0.3908
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0367 0.0749
Schistosoma mansoni lamin 0.0028 0.0208 0.0425
Onchocerca volvulus Alhambra homolog 0.0032 0.0264 0.0265
Schistosoma mansoni hypothetical protein 0.0157 0.1776 0.3618
Echinococcus multilocularis lamin dm0 0.0028 0.0208 0.019
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0034 0.0286 0.081
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.2324 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0245 0.0227
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0367 0.0749
Loa Loa (eye worm) hypothetical protein 0.0121 0.1335 0.5705
Toxoplasma gondii exonuclease III APE 0.0019 0.0106 0.1524
Echinococcus granulosus cpg binding protein 0.0031 0.0245 0.0464
Loa Loa (eye worm) hypothetical protein 0.0028 0.0208 0.0817
Brugia malayi serine/threonine-protein kinase plk-2 0.0203 0.2324 1
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.2324 1
Trichomonas vaginalis rotamase, putative 0.0067 0.0685 0.2607
Trypanosoma cruzi polo-like protein kinase, putative 0.0203 0.2324 1
Schistosoma mansoni rotamase 0.0067 0.0685 0.1396
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0418 0.0818
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0157 0.1776 0.176
Schistosoma mansoni cpg binding protein 0.0031 0.0245 0.05
Schistosoma mansoni cpg binding protein 0.0029 0.0225 0.0459
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.002 0.0119 0.0056
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0155 0.1749 0.3541
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0113 0.0028
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0418 0.0401
Echinococcus granulosus lamin dm0 0.0028 0.0208 0.0388
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0068 0.0699 0.267
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0106 0.1254
Brugia malayi NAD-dependent deacetylase SIRT1 0.0155 0.1749 0.7526
Echinococcus granulosus peregrin 0.0032 0.0264 0.0503
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0068 0.0699 0.267
Echinococcus granulosus lamin 0.0028 0.0208 0.0388
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0066 0.0666 0.2521
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.1158 0.1142
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Loa Loa (eye worm) transcriptional regulator 0.0034 0.0286 0.1155
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0347 0.0329
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0034 0.0286 0.0548
Schistosoma mansoni hypothetical protein 0.0032 0.0264 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0113 0.0484
Echinococcus multilocularis lamin 0.0028 0.0208 0.019
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0113 0.0192
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0113 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0685 0.2607
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0113 0.0484
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0155 0.1749 0.7407
Brugia malayi Bromodomain containing protein 0.0032 0.0264 0.1138
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0264 0.3587
Echinococcus granulosus intermediate filament protein 0.0028 0.0208 0.0388
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0203 0.2324 0.4717
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.2324 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0286 0.081
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0113 0.0094
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.2324 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0113 0.023
Loa Loa (eye worm) hypothetical protein 0.0157 0.1776 0.7618
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0034 0.0286 0.081
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0034 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.2324 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0113 0.0484
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0034 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0203 0.2324 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0106 0.0458
Echinococcus granulosus chromatin regulatory protein sir2 0.0034 0.0286 0.0548
Echinococcus granulosus dnaJ subfamily B 0.0416 0.4907 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0977 0.1991
Onchocerca volvulus Serine\/threonine kinase homolog 0.0203 0.2324 1
Echinococcus granulosus netrin receptor unc 5 0.0157 0.1776 0.3594
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0113 0.0401
Echinococcus granulosus dna polymerase kappa 0.002 0.0113 0.0192
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1086 0.4415
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0034 0.0286 0.081
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0225 0.0889
Echinococcus multilocularis chromatin regulatory protein sir2 0.0034 0.0286 0.0268
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0034 0.0286 0.081
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0034 0.0286 0.0268
Leishmania major DNA polymerase eta, putative 0.002 0.0113 0.0028
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0113 0.0484
Giardia lamblia Sirtuin type 2 0.0034 0.0286 0.081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0977 0.096
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0113 0.0484
Mycobacterium ulcerans NAD-dependent deacetylase 0.0068 0.0699 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0113 0.0028
Loa Loa (eye worm) sirtuin 4 0.0034 0.0286 0.1155
Trypanosoma brucei SIR2-like protein 4, putative 0.0034 0.0286 0.1231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0977 0.096
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0208 0.0897
Schistosoma mansoni netrin receptor unc5 0.0157 0.1776 0.3618
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0367 0.0713
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0068 0.0699 0.267
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0367 0.1507
Leishmania major DNA polymerase kappa, putative 0.002 0.0113 0.0028

Activities

Activity type Activity value Assay description Source Reference
Cell viability (functional) ~ 60 % Cell viability in TPA-induced superoxide (O2-) generation in human promyelocytic leukemia HL-60 cells, at 100 uM concentration ChEMBL. 10888327
Cell viability (functional) ~ 60 % Cell viability in TPA-induced superoxide (O2-) generation in human promyelocytic leukemia HL-60 cells, at 100 uM concentration ChEMBL. 10888327
Inhibition (functional) ~ 30 % Inhibitory activity against TPA-induced superoxide (O2-) generation in human promyelocytic leukemia HL-60 cells, at 100 uM concentration ChEMBL. 10888327
Inhibition (functional) ~ 30 % Inhibitory activity against TPA-induced superoxide (O2-) generation in human promyelocytic leukemia HL-60 cells, at 100 uM concentration ChEMBL. 10888327

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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