Detailed information for compound 501370

Basic information

Technical information
  • TDR Targets ID: 501370
  • Name: 2-diethylaminoethyl 2-cyclohexyl-2-phenylacet ate
  • MW: 317.466 | Formula: C20H31NO2
  • H donors: 0 H acceptors: 1 LogP: 5.26 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCOC(=O)C(c1ccccc1)C1CCCCC1)CC
  • InChi: 1S/C20H31NO2/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5,7-8,11-12,18-19H,3-4,6,9-10,13-16H2,1-2H3
  • InChiKey: AGJBLWCLQCKRJP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-diethylaminoethyl 2-cyclohexyl-2-phenyl-acetate
  • 2-cyclohexyl-2-phenylacetic acid 2-diethylaminoethyl ester
  • 2-diethylaminoethyl 2-cyclohexyl-2-phenyl-ethanoate
  • 2-cyclohexyl-2-phenyl-acetic acid 2-diethylaminoethyl ester
  • cycloadiphenine
  • SPBio_002837
  • Prestwick2_000789
  • SPBio_001009
  • KBioGR_000670
  • KBioSS_001696
  • Spectrum_001216
  • Spectrum4_000405
  • KBio2_001696
  • DivK1c_000135
  • KBio2_004264
  • NINDS_000135
  • KBio2_006832
  • BSPBio_000898
  • BPBio1_000988
  • Spectrum2_000975
  • KBio3_002348
  • Spectrum5_001574
  • KBio1_000135
  • Spectrum3_001424
  • Prestwick3_000789
  • Prestwick1_000789
  • Prestwick0_000789
  • 2-(Diethylamino)ethyl alpha-phenylcyclohexaneacetate
  • 2-(Diethylamino)ethyl cyclohexylphenylacetate
  • 4-09-00-02145 (Beilstein Handbook Reference)
  • Adiphenine H
  • BRN 2059173
  • Benzeneacetic acid, alpha-cyclohexyl-, 2-(diethylamino)ethyl ester (9CI)
  • Cycloadiphene
  • Cyclohexaneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl ester
  • Drofenina [INN-Spanish]
  • Drofenine
  • Drofenine [INN-French]
  • Drofenine [INN]
  • Drofeninum [INN-Latin]
  • Trasentine 6H
  • Trasentine-6H
  • alpha-Cyclohexylbenzeneacetic acid 2-(diethylamino)ethyl ester
  • alpha-Phenyl-2-(diethylamino)ethylcyclohexaneacetic acid
  • alpha-Phenylcyclohexaneacetic acid 2-(diethylamino)ethyl ester
  • BSPBio_003128
  • IDI1_000135

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis starch branching enzyme II, putative 0.0057 0.0022 0.0163
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0203 0.0119 0.1599
Entamoeba histolytica hypothetical protein 0.0595 0.0378 0.5465
Echinococcus multilocularis raf serine:threonine protein kinase 0.0504 0.0317 0.0317
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0203 0.0119 0.0309
Entamoeba histolytica alpha-amylase family protein 0.0129 0.007 0.087
Trichomonas vaginalis alpha-amylase, putative 0.0129 0.007 0.087
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0079
Onchocerca volvulus 0.0033 0.0006 0.0488
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0203 0.0119 0.1738
Echinococcus granulosus ubiquitin specific protease 41 0.0083 0.0039 0.0039
Leishmania major hypothetical protein, unknown function 0.0203 0.0119 0.0297
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.046 0.0289 0.0289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1056 0.0682 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0595 0.0378 0.5465
Leishmania major phosphatidylinositol kinase related protein, putative 0.0203 0.0119 0.0297
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0083 0.0039 0.0259
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0203 0.0119 0.0309
Entamoeba histolytica hypothetical protein 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0378 0.5465
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0203 0.0119 0.146
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203 0.0119 0.1599
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1056 0.0682 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1056 0.0682 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0203 0.0119 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203 0.0119 0.1599
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1056 0.0682 1
Echinococcus multilocularis serine protein kinase ATM 0.0595 0.0378 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1056 0.0682 1
Trichomonas vaginalis alpha-amylase, putative 0.0129 0.007 0.087
Schistosoma mansoni fkbp-rapamycin associated protein 0.0595 0.0378 0.5539
Loa Loa (eye worm) phosphatidylinositol 3 0.0203 0.0119 0.1738
Brugia malayi follicle stimulating hormone receptor 0.0291 0.0177 0.2591
Plasmodium vivax hypothetical protein 0.0203 0.0119 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0203 0.0119 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0595 0.0378 0.5539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0378 0.5465
Echinococcus granulosus lamin 0.0033 0.0006 0.0006
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0203 0.0119 0.1738
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Loa Loa (eye worm) hypothetical protein 0.0513 0.0324 0.4745
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0203 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0203 0.0119 0.0119
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0203 0.0119 0.0119
Plasmodium vivax hypothetical protein, conserved 0.0203 0.0119 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0203 0.0119 0.1599
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0203 0.0119 0.1738
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0057 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0663 0.0423 0.6135
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trichomonas vaginalis alpha-amylase, putative 0.0115 0.006 0.0731
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0203 0.0119 0.1599
Echinococcus multilocularis ubiquitin specific protease 41 0.0083 0.0039 0.0039
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0286 0.0173 0.2537
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0057 0.0022 0.0325
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0057 0.0022 0.0163
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0203 0.0119 0.1599
Loa Loa (eye worm) hypothetical protein 0.0392 0.0244 0.3571
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0119 0.1738
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1056 0.0682 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0203 0.0119 0.1599
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0083 0.0039 0.0575
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.5152 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0119 0.1599
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0011 0.0948
Onchocerca volvulus 0.0203 0.0119 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0006 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0203 0.0119 0.0119
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0057 0.0022 0.0163
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0083 0.0039 0.0575
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0203 0.0119 0.1599
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1056 0.0682 0.193
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0203 0.0119 0.1599
Giardia lamblia GTOR 0.1056 0.0682 1
Trichomonas vaginalis conserved hypothetical protein 0.0663 0.0423 0.6135
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0203 0.0119 0.0309
Trichomonas vaginalis amylase, putative 0.0129 0.007 0.087
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0203 0.0119 0.1599
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203 0.0119 0.1599
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0057 0.0022 0.0163
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1056 0.0682 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203 0.0119 0.1599
Toxoplasma gondii FATC domain-containing protein 0.0595 0.0378 0.5465
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0378 0.5465
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1056 0.0682 0.0682
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0057 0.0022 0.0163
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0203 0.0119 0.1599
Giardia lamblia Phosphatidylinositol 4-kinase 0.0203 0.0119 0.146
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0203 0.0119 0.0119
Onchocerca volvulus 0.0033 0.0006 0.0488
Toxoplasma gondii glycosyltransferase 0.0057 0.0022 0.0163
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0203 0.0119 0.0309
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0039 0.0081
Toxoplasma gondii target of rapamycin (TOR), putative 0.1056 0.0682 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1056 0.0682 1
Loa Loa (eye worm) hypothetical protein 0.0203 0.0119 0.1738
Loa Loa (eye worm) hypothetical protein 0.0033 0.0006 0.0085
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1056 0.0682 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0203 0.0119 0.1599
Loa Loa (eye worm) hypothetical protein 0.0595 0.0378 0.5539
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0006 0.0085
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0203 0.0119 0.0119
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0011 0.0948
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0203 0.0119 0.1738
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0203 0.0119 0.1738
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0378 0.5465
Mycobacterium tuberculosis Conserved hypothetical protein 0.0203 0.0119 1
Schistosoma mansoni transcription factor btf3 0.0041 0.0011 0.0165
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1056 0.0682 0.1858
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0203 0.0119 0.1738
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0039 0.0081
Leishmania major phosphatidylinositol 4-kinase, putative 0.0203 0.0119 0.0297
Echinococcus multilocularis 0.0203 0.0119 0.0119
Leishmania major phosphatidylinositol 3-kinase, putative 0.1056 0.0682 0.1858
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0203 0.0119 0.1738
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0203 0.0119 1
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0057 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.53 0.3487 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1056 0.0682 1
Echinococcus multilocularis transcription factor btf3 0.0041 0.0011 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0083 0.0039 0.0575
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0203 0.0119 0.1599
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1056 0.0682 0.193
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0203 0.0119 0.0119
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0011 0.0165
Leishmania major hypothetical protein, conserved 0.5503 0.3622 1
Echinococcus multilocularis lamin 0.0033 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0119 0.1599
Trichomonas vaginalis amylase, putative 0.0057 0.0022 0.0163
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0946 0.061 0.061
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0203 0.0119 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0203 0.0119 0.1599
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1056 0.0682 0.0682
Loa Loa (eye worm) phosphatidylinositol 3 0.0203 0.0119 0.1738
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0039 0.0417
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0203 0.0119 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0663 0.0423 0.6135
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0083 0.0039 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trichomonas vaginalis conserved hypothetical protein 0.046 0.0289 0.4133
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0203 0.0119 1
Echinococcus multilocularis musashi 0.0033 0.0006 0.0006
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0203 0.0119 0.146
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0203 0.0119 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0392 0.0244 0.0668
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0203 0.0119 0.1599
Schistosoma mansoni lipoxygenase 0.0142 0.0078 0.115
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.046 0.0289 0.0289
Echinococcus granulosus intermediate filament protein 0.0033 0.0006 0.0006
Echinococcus granulosus lamin dm0 0.0033 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0203 0.0119 0.1738
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0378 0.5465
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0203 0.0119 0.0119
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0203 0.0119 0.0119
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0203 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0663 0.0423 0.6198
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0006 0.0085
Loa Loa (eye worm) phosphatidylinositol 3 0.0203 0.0119 0.1738
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0203 0.0119 0.0309
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0203 0.0119 0.0309
Mycobacterium ulcerans glycogen branching protein 0.0057 0.0022 0.5
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0203 0.0119 0.0119
Giardia lamblia Hypothetical protein 0.0203 0.0119 0.146
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0022 0.0325
Schistosoma mansoni starch branching enzyme II 0.0057 0.0022 0.0325
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0595 0.0378 0.1055
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0203 0.0119 0.1738
Trichomonas vaginalis amylase, putative 0.0129 0.007 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0595 0.0378 0.5539
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0203 0.0119 0.1599
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1056 0.0682 0.193
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0119 0.1738
Loa Loa (eye worm) phosphatidylinositol 3 0.0203 0.0119 0.1738
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1056 0.0682 0.0682
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Leishmania major phosphatidylinositol kinase, putative 0.0203 0.0119 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0039 0.0417
Entamoeba histolytica hypothetical protein 0.0203 0.0119 0.1599
Brugia malayi Raf kinase 0.0486 0.0306 0.4481
Entamoeba histolytica protein kinase rad3, putative 0.0595 0.0378 0.5465
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0083 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0378 0.5465
Trypanosoma cruzi target of rapamycin kinase 3 0.1056 0.0682 0.193
Schistosoma mansoni lipoxygenase 0.01 0.005 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0595 0.0378 0.0378
Brugia malayi beta-NAC-like protein 0.0041 0.0011 0.0165
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0203 0.0119 0.0309
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0203 0.0119 0.1599
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0203 0.0119 0.0297
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0083 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0039 0.0417
Echinococcus granulosus transcription factor btf3 0.0041 0.0011 0.0011
Echinococcus granulosus raf serine:threonine protein kinase 0.0504 0.0317 0.0317
Schistosoma mansoni intermediate filament proteins 0.0033 0.0006 0.0085
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0203 0.0119 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0378 0.5465
Entamoeba histolytica hypothetical protein 0.0203 0.0119 0.1599
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1056 0.0682 0.1858
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0083 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0378 0.5465
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0039 0.0417
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1056 0.0682 0.193
Loa Loa (eye worm) phosphatidylinositol 3 0.1056 0.0682 1
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.0244 0.3463
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0595 0.0378 0.5465
Chlamydia trachomatis 1,4-alpha-glucan branching enzyme 0.0057 0.0022 0.5
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0203 0.0119 0.1738
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0083 0.0039 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0119 0.1738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0392 0.0244 0.3463
Loa Loa (eye worm) hypothetical protein 0.0083 0.0039 0.0575
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203 0.0119 0.1599
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0291 0.0177 0.2591
Schistosoma mansoni serine/threonine protein kinase 0.0504 0.0317 0.4651
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0203 0.0119 0.1599
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Loa Loa (eye worm) hypothetical protein 0.0513 0.0324 0.4745
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0203 0.0119 0.0309
Schistosoma mansoni hypothetical protein 0.046 0.0289 0.423
Trichomonas vaginalis alpha-amylase, putative 0.0129 0.007 0.087
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1056 0.0682 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0203 0.0119 0.1738
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0119 0.1738
Entamoeba histolytica alpha-amylase family protein 0.0129 0.007 0.087
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1056 0.0682 0.1858
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0203 0.0119 0.0309
Onchocerca volvulus 0.0203 0.0119 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0203 0.0119 0.1599
Loa Loa (eye worm) phosphatidylinositol 3 0.0203 0.0119 0.1738
Trichomonas vaginalis alpha-amylase, putative 0.0129 0.007 0.087
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0203 0.0119 0.1599
Mycobacterium leprae conserved hypothetical protein 0.0203 0.0119 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0203 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0119 0.1738
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0203 0.0119 0.0297
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0595 0.0378 0.1055
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1056 0.0682 0.0682
Echinococcus multilocularis Zinc finger, PHD finger 0.0203 0.0119 0.0119
Entamoeba histolytica hypothetical protein 0.0203 0.0119 0.1599
Loa Loa (eye worm) hypothetical protein 0.046 0.0289 0.423
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.0682 1
Loa Loa (eye worm) phosphatidylinositol 3 0.1056 0.0682 1
Echinococcus granulosus serine protein kinase ATM 0.0595 0.0378 0.0378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0119 0.1738
Schistosoma mansoni hypothetical protein 0.0203 0.0119 0.1738
Schistosoma mansoni lamin 0.0033 0.0006 0.0085
Loa Loa (eye worm) raf kinase 0.0501 0.0316 0.4627
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0083 0.0039 0.0417
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0595 0.0378 0.5539
Brugia malayi FAT domain containing protein 0.046 0.0289 0.423
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0078 0.0078
Brugia malayi intermediate filament protein 0.0033 0.0006 0.0085
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1056 0.0682 0.1858
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0663 0.0423 0.6135
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0203 0.0119 0.1599
Echinococcus multilocularis lamin dm0 0.0033 0.0006 0.0006
Schistosoma mansoni lamin 0.0033 0.0006 0.0085
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0595 0.0378 0.0378

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 48.2 % Inhibition of ASM in human H4 cells assessed as residual activity at 10 uM ChEMBL. 18027916
Activity (binding) = 48.2 % Inhibition of ASM in human H4 cells assessed as residual activity at 10 uM ChEMBL. 18027916

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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