TDR Targets

Basic information

Technical information

TDR Targets ID: 501591
Name: 6-(benzylamino)-9-(3-hydroxypropyl)purine-2-c arbonitrile
MW: 308.338 | Formula: C16H16N6O
H donors: 2 H acceptors: 5 LogP: 1.52 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OCCCn1cnc2c1nc(C#N)nc2NCc1ccccc1
InChi: 1S/C16H16N6O/c17-9-13-20-15(18-10-12-5-2-1-3-6-12)14-16(21-13)22(11-19-14)7-4-8-23/h1-3,5-6,11,23H,4,7-8,10H2,(H,18,20,21)
InChiKey: OSKOJPCCSWWEKX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-(benzylamino)-9-(3-hydroxypropyl)-2-purinecarbonitrile
9-(3-hydroxypropyl)-6-(phenylmethylamino)purine-2-carbonitrile
9-(3-hydroxypropyl)-6-(phenylmethylamino)-2-purinecarbonitrile

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative		References
Trypanosoma brucei	cysteine peptidase C (CPC)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 2b	cysteine peptidase C (CPC)	340 aa	321 aa	26.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Schistosoma mansoni	cathepsin F (C01 family)	0.006	0.0026	0.0219
Trypanosoma cruzi	cysteine peptidase, putative	0.0112	0.0075	0.0437
Echinococcus granulosus	heat shock protein 90	0.0117	0.008	0.0677
Schistosoma mansoni	heat shock protein	0.0117	0.008	0.0677
Leishmania major	DNA topoisomerase III, putative	0.0129	0.0091	0.0528
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Loa Loa (eye worm)	hypothetical protein	0.004	0.0006	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.1607	0.1489	0.1484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0091	0.0055	0.0049
Plasmodium vivax	DNA gyrase subunit A, putative	0.0627	0.0562	0.3774
Loa Loa (eye worm)	glutaminase	0.0302	0.0254	0.2158
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	0.0132	0.1121
Brugia malayi	Cathepsin L-like precursor	0.006	0.0026	0.0219
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0091	0.0055	0.0466
Chlamydia trachomatis	DNA gyrase subunit A	0.0254	0.0209	0.1073
Onchocerca volvulus		0.004	0.0006	0.0072
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0045	0.0012	0.0098
Trypanosoma brucei	DNA topoisomerase III, putative	0.0129	0.0091	0.0536
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Toxoplasma gondii	cathepsin CPL	0.006	0.0026	0.0219
Loa Loa (eye worm)	hypothetical protein	0.004	0.0006	0.0053
Mycobacterium ulcerans	integral membrane indolylacetylinositol arabinosyltransferase EmbB	1.0607	1	1
Chlamydia trachomatis	DNA gyrase subunit B	0.1156	0.1062	0.7021
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.1278	0.1177	1
Brugia malayi	Cathepsin L-like precursor	0.006	0.0026	0.0219
Loa Loa (eye worm)	cathepsin B	0.0173	0.0132	0.1121
Schistosoma mansoni	pyruvate dehydrogenase	0.0091	0.0055	0.0466
Loa Loa (eye worm)	ctsf protein	0.006	0.0026	0.0219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0091	0.0055	0.0312
Plasmodium falciparum	DNA topoisomerase 2	0.1278	0.1177	0.7899
Leishmania major	cathepsin L-like protease	0.006	0.0026	0.0122
Mycobacterium ulcerans	DNA gyrase subunit A	0.0627	0.0562	0.0556
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0091	0.0055	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0706	0.0636	0.5405
Trypanosoma brucei	Heat shock protein 83, putative	0.0117	0.008	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0012	0.0098
Entamoeba histolytica	cysteine proteinase, putative	0.006	0.0026	0.0178
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0091	0.0055	0.0049
Trichomonas vaginalis	receptor histidine kinase, putative	0.0091	0.0055	0.0426
Mycobacterium leprae	Probable two-component sensor kinase	0.0091	0.0055	0.0049
Plasmodium vivax	heat shock protein 86, putative	0.0117	0.008	0.0535
Giardia lamblia	DNA topoisomerase III	0.0129	0.0091	0.0345
Toxoplasma gondii	ABC1 family protein	0.004	0.0006	0.0053
Loa Loa (eye worm)	TOPoisomerase family member	0.1278	0.1177	1
Trypanosoma brucei	heat shock protein 90, putative	0.0117	0.008	0.0467
Trichomonas vaginalis	sensor histidine kinase, putative	0.0091	0.0055	0.0426
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.173	0.1604	1
Trichomonas vaginalis	heat shock protein, putative	0.0117	0.008	0.0638
Trypanosoma brucei	DNA topoisomerase ii	0.173	0.1604	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0112	0.0075	0.0437
Onchocerca volvulus		0.006	0.0026	0.0294
Toxoplasma gondii	heat shock protein HSP90	0.0117	0.008	0.0677
Leishmania major	DNA topoisomerase ii	0.1149	0.1055	0.6564
Plasmodium vivax	vivapain-1	0.0038	0.0005	0.0033
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.096	0.0877	1
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.096	0.0877	1
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Wolbachia endosymbiont of Brugia malayi	topoisomerase IA, TopA	0.0129	0.0091	0.0249
Loa Loa (eye worm)	fibroinase	0.006	0.0026	0.0219
Loa Loa (eye worm)	DNA topoisomerase III beta-1	0.0129	0.0091	0.077
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.0129	0.0091	0.0536
Brugia malayi	beta-lactamase family protein	0.004	0.0006	0.0053
Leishmania major	cathepsin L-like protease	0.006	0.0026	0.0122
Trypanosoma cruzi	heat shock protein 90, putative	0.0117	0.008	0.0467
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0254	0.0209	0.0203
Plasmodium vivax	endoplasmin, putative	0.0117	0.008	0.0535
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.0005	0.0042
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0012	0.0057
Mycobacterium ulcerans	DNA gyrase subunit B	0.1607	0.1489	0.1484
Echinococcus multilocularis	cathepsin L cysteine protease	0.006	0.0026	0.0219
Echinococcus granulosus	cysteine protease	0.0038	0.0005	0.0042
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0091	0.0055	0.0336
Schistosoma mansoni	endoplasmin	0.0117	0.008	0.0677
Loa Loa (eye worm)	hypothetical protein	0.004	0.0006	0.0053
Onchocerca volvulus		0.006	0.0026	0.0294
Echinococcus granulosus	DNA topoisomerase 3 alpha	0.0129	0.0091	0.077
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.1607	0.1489	1
Echinococcus multilocularis	cysteine protease	0.006	0.0026	0.0219
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0091	0.0055	0.0049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Plasmodium vivax	DNA topoisomerase II, putative	0.1278	0.1177	0.7906
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0096	0.0815
Brugia malayi	Probable DNA topoisomerase II	0.1278	0.1177	1
Plasmodium falciparum	endoplasmin, putative	0.0105	0.0068	0.0422
Toxoplasma gondii	DNA topoisomerase 2, putative	0.1278	0.1177	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Entamoeba histolytica	DNA topoisomerase II, putative	0.1278	0.1177	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0091	0.0055	0.0049
Brugia malayi	DNA topoisomerase III beta-1	0.0129	0.0091	0.077
Mycobacterium tuberculosis	Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase)	1.0607	1	1
Brugia malayi	kinase, mitochondrial precursor	0.0091	0.0055	0.0466
Leishmania major	mitochondrial DNA topoisomerase II	0.173	0.1604	1
Entamoeba histolytica	DNA topoisomerase III, putative	0.0129	0.0091	0.0731
Leishmania major	cathepsin L-like protease	0.006	0.0026	0.0122
Treponema pallidum	DNA topoisomerase I (topA)	0.0129	0.0091	0.0249
Trypanosoma brucei	heat shock protein, putative	0.0117	0.008	0.0467
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0091	0.0055	0.0049
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0091	0.0055	0.0049
Trichomonas vaginalis	heat shock protein, putative	0.0105	0.0068	0.0535
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0006	0.0008
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0091	0.0055	0.0049
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	0.0132	0.1121
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0091	0.0055	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0012	0.0057
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0006	0.0053
Plasmodium falciparum	DNA gyrase subunit A	0.0627	0.0562	0.3754
Mycobacterium tuberculosis	Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase)	1.0607	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0173	0.0132	0.1121
Entamoeba histolytica	DNA topoisomerase III, putative	0.0129	0.0091	0.0731
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.006	0.0026	0.0178
Brugia malayi	beta-lactamase	0.004	0.0006	0.0053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	0.0132	0.1121
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	0.0132	0.1121
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0006	0.0042
Echinococcus granulosus	cathepsin l1	0.0045	0.0012	0.0098
Onchocerca volvulus		0.0263	0.0217	0.2474
Entamoeba histolytica	heat shock protein 90, putative	0.0117	0.008	0.0638
Echinococcus granulosus	cathepsin L cysteine proteinase	0.006	0.0026	0.0219
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.0005	0.0042
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.006	0.0026	0.0219
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0091	0.0055	0.0426
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0129	0.0091	0.0536
Brugia malayi	heat shock protein 90	0.0117	0.008	0.0677
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Trypanosoma cruzi	major cysteine proteinase, putative	0.0075	0.004	0.0218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Echinococcus granulosus	cathepsin b	0.0173	0.0132	0.1121
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0006	0.0008
Mycobacterium ulcerans	putative regultory protein	0.0091	0.0055	0.0049
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.0129	0.0091	0.0731
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0091	0.0055	0.0049
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0173	0.0132	0.0794
Echinococcus granulosus	cathepsin b	0.0173	0.0132	0.1121
Onchocerca volvulus		0.006	0.0026	0.0294
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0091	0.0055	0.0426
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0091	0.0055	0.0049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0091	0.0055	0.0049
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Loa Loa (eye worm)	hypothetical protein	0.004	0.0006	0.0053
Loa Loa (eye worm)	hypothetical protein	0.004	0.0006	0.0053
Leishmania major	cathepsin L-like protease	0.0112	0.0075	0.0429
Mycobacterium leprae	Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase)	1.0607	1	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0117	0.008	0.0467
Schistosoma mansoni	DNA topoisomerase II	0.1278	0.1177	1
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0091	0.0055	0.0466
Schistosoma mansoni	heat shock protein	0.0117	0.008	0.0677
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.173	0.1604	1
Echinococcus multilocularis	cysteine protease	0.006	0.0026	0.0219
Plasmodium vivax	vivapain-2	0.006	0.0026	0.0173
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.1607	0.1489	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.006	0.0026	0.0219
Echinococcus granulosus	geminin	0.0187	0.0146	0.1236
Schistosoma mansoni	cathepsin F (C01 family)	0.006	0.0026	0.0219
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0091	0.0055	0.0426
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0006	0.0053
Schistosoma mansoni	endoplasmin	0.0117	0.008	0.0677
Echinococcus multilocularis	heat shock protein	0.0117	0.008	0.0677
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0091	0.0055	0.0426
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0578	0.0515	0.4375
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0129	0.0091	0.0536
Toxoplasma gondii	DNA topoisomerase family protein	0.0129	0.0091	0.077
Entamoeba histolytica	cysteine proteinase, putative	0.006	0.0026	0.0178
Trypanosoma brucei	heat shock protein, putative	0.0117	0.008	0.0467
Loa Loa (eye worm)	cysteine protease	0.006	0.0026	0.0219
Giardia lamblia	Cathepsin B precursor	0.0173	0.0132	0.0743
Giardia lamblia	DNA topoisomerase II	0.1187	0.1091	1
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0091	0.0055	0.0312
Leishmania major	cathepsin L-like protease	0.0112	0.0075	0.0429
Giardia lamblia	Cathepsin B precursor	0.0173	0.0132	0.0743
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0091	0.0055	0.0049
Brugia malayi	Pre-SET motif family protein	0.0231	0.0187	0.1587
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Loa Loa (eye worm)	hypothetical protein	0.004	0.0006	0.0053
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.1158	0.1064	0.904
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0173	0.0132	0.1083
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Onchocerca volvulus	Cathepsin L homolog	0.006	0.0026	0.0294
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0129	0.0091	0.077
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0012	0.0098
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.006	0.0026	0.014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0895	0.0815	0.6923
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0006	0.0011
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0199	0.0157	0.015
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0091	0.0055	0.0304
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0129	0.0091	0.0536
Onchocerca volvulus		0.004	0.0006	0.0072
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0091	0.0055	0.0312
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0091	0.0055	0.0049
Brugia malayi	Papain family cysteine protease containing protein	0.0038	0.0005	0.0042
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0006	0.0053
Mycobacterium ulcerans	glutaminase	0.0302	0.0254	0.0248
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.006	0.0026	0.0219
Trichomonas vaginalis	set domain proteins, putative	0.0263	0.0217	0.1809
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0091	0.0055	0.0049
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0091	0.0055	0.0466
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.0026	0.013
Plasmodium falciparum	DNA gyrase subunit B	0.1607	0.1489	1
Leishmania major	cysteine peptidase A (CPA)	0.006	0.0026	0.0122
Leishmania major	cathepsin L-like protease	0.0112	0.0075	0.0429
Schistosoma mansoni	hypothetical protein	0.0187	0.0146	0.1236
Giardia lamblia	Cathepsin B precursor	0.0173	0.0132	0.0743
Entamoeba histolytica	cysteine protease, putative	0.006	0.0026	0.0178
Trypanosoma brucei	heat shock protein, putative	0.0117	0.008	0.0467
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0117	0.008	0.024
Plasmodium vivax	vivapain-2	0.006	0.0026	0.0173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Trypanosoma cruzi	DNA topoisomerase II, putative	0.1149	0.1055	0.6567
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0012	0.0057
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0129	0.0091	0.077
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.096	0.0877	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0117	0.008	0.0467
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0173	0.0132	0.0786
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Loa Loa (eye worm)	glutaminase 2	0.0302	0.0254	0.2158
Brugia malayi	beta-lactamase family protein	0.004	0.0006	0.0053
Chlamydia trachomatis	DNA topoisomerase I	0.0129	0.0091	0.0249
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Mycobacterium ulcerans	two component sensor kinase MprB	0.0091	0.0055	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0132	0.1121
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Plasmodium vivax	hypothetical protein, conserved	0.0091	0.0055	0.0369
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Trypanosoma cruzi	cysteine peptidase, putative	0.0112	0.0075	0.0437
Onchocerca volvulus	Cathepsin L homolog	0.006	0.0026	0.0294
Onchocerca volvulus		0.0129	0.0091	0.1033
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0038	0.0005	0.0042
Trichomonas vaginalis	receptor histidine kinase, putative	0.0091	0.0055	0.0426
Plasmodium falciparum	cysteine proteinase falcipain 3	0.006	0.0026	0.014
Echinococcus multilocularis	cathepsin L cysteine protease	0.006	0.0026	0.0219
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.006	0.0026	0.014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Onchocerca volvulus		0.006	0.0026	0.0294
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.006	0.0026	0.0219
Trypanosoma brucei	DNA topoisomerase IA, putative	0.0129	0.0091	0.0536
Trichomonas vaginalis	esterase, putative	0.004	0.0006	0.0011
Trypanosoma brucei	heat shock protein, putative	0.0117	0.008	0.0467
Toxoplasma gondii	cathepsin B	0.0173	0.0132	0.1121
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0627	0.0562	0.3536
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.1149	0.1055	0.6567
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Schistosoma mansoni	glutaminase	0.0302	0.0254	0.2158
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0091	0.0055	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Brugia malayi	Cathepsin L-like precursor	0.0045	0.0012	0.0098
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0091	0.0055	0.0049
Chlamydia trachomatis	DNA gyrase subunit A	0.0627	0.0562	0.3536
Plasmodium vivax	unspecified product	0.0038	0.0005	0.0033
Plasmodium vivax	DNA topoisomerase 3, putative	0.0129	0.0091	0.0609
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0627	0.0562	0.4774
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0091	0.0055	0.0049
Plasmodium vivax	vivapain-3	0.0038	0.0005	0.0033
Onchocerca volvulus		0.006	0.0026	0.0294
Brugia malayi	GRF zinc finger family protein	0.0129	0.0091	0.077
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0112	0.0075	0.0437
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Trypanosoma brucei	heat shock protein, putative	0.0117	0.008	0.0467
Onchocerca volvulus		0.0045	0.0012	0.0132
Echinococcus granulosus	heat shock protein	0.0117	0.008	0.0677
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0006	0.0011
Entamoeba histolytica	heat shock protein 90, putative	0.0117	0.008	0.0638
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.0129	0.0091	0.0731
Trypanosoma cruzi	cysteine peptidase, putative	0.0112	0.0075	0.0437
Trypanosoma brucei	heat shock protein 90, putative	0.0117	0.008	0.0467
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.1278	0.1177	1
Schistosoma mansoni	hypothetical protein	0.0187	0.0146	0.1236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Plasmodium falciparum	heat shock protein 90	0.0117	0.008	0.0504
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0006	0.0011
Trypanosoma cruzi	Heat shock protein 83, putative	0.0117	0.008	0.0467
Echinococcus granulosus	cathepsin l1	0.006	0.0026	0.0219
Trypanosoma brucei	heat shock protein, putative	0.0117	0.008	0.0467
Mycobacterium ulcerans	integral membrane indolylacetylinositol arabinosyltransferase EmbA	1.0607	1	1
Loa Loa (eye worm)	beta-lactamase	0.004	0.0006	0.0053
Trichomonas vaginalis	DNA topoisomerase II, putative	0.1278	0.1177	1
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.0129	0.0091	0.0536
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0006	0.0053
Loa Loa (eye worm)	heat shock protein 90	0.0117	0.008	0.0677
Chlamydia trachomatis	DNA gyrase subunit B	0.1607	0.1489	1
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0091	0.0055	0.0049
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Mycobacterium tuberculosis	Conserved protein	0.0091	0.0055	0.0049
Trichomonas vaginalis	glutaminase, putative	0.0302	0.0254	0.2124
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0627	0.0562	0.0556
Trypanosoma cruzi	heat shock protein 90, putative	0.0104	0.0067	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0096	0.0815
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.006	0.0026	0.0219
Mycobacterium leprae	Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (	0.0129	0.0091	0.0084
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0006	0.0011
Leishmania major	DNA topoisomerase III, putative	0.0129	0.0091	0.0528
Brugia malayi	Cathepsin L-like precursor	0.006	0.0026	0.0219
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0006	0.0053
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Leishmania major	cathepsin L-like protease	0.006	0.0026	0.0122
Brugia malayi	cathepsin B-like cysteine proteinase	0.0173	0.0132	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0706	0.0636	0.5405
Echinococcus multilocularis	cathepsin b	0.0173	0.0132	0.1121
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0173	0.0132	0.0794
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0231	0.0187	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0096	0.0815
Giardia lamblia	DNA topoisomerase III	0.0129	0.0091	0.0345
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.1149	0.1055	0.6567
Echinococcus multilocularis	geminin	0.0187	0.0146	0.1236
Brugia malayi	Papain family cysteine protease containing protein	0.006	0.0026	0.0219
Echinococcus multilocularis	rho GTPase activating protein 20	0.0129	0.0091	0.077
Trypanosoma brucei	heat shock protein, putative	0.0117	0.008	0.0467
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Toxoplasma gondii	heat shock protein 90, putative	0.0117	0.008	0.0677
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0173	0.0132	0.0794
Echinococcus granulosus	cathepsin L	0.0038	0.0005	0.0042
Leishmania major	cathepsin L-like protease	0.006	0.0026	0.0122
Loa Loa (eye worm)	DNA topoisomerase III	0.0129	0.0091	0.077
Brugia malayi	Cathepsin L-like precursor	0.006	0.0026	0.0219
Trypanosoma brucei	heat shock protein, putative	0.0117	0.008	0.0467
Trypanosoma brucei	DNA topoisomerase III, putative	0.0129	0.0091	0.0536
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0091	0.0055	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Onchocerca volvulus		0.006	0.0026	0.0294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Echinococcus granulosus	DNA topoisomerase 3 beta 1	0.0129	0.0091	0.077
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0578	0.0515	0.4375
Trypanosoma cruzi	heat shock protein 85, putative	0.0117	0.008	0.0467
Brugia malayi	Cathepsin L-like precursor	0.0045	0.0012	0.0098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0006	0.0011
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0129	0.0091	0.077
Echinococcus multilocularis	DNA topoisomerase 3 beta 1	0.0129	0.0091	0.077
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0586	0.0523	0.0517
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0091	0.0055	0.0049
Onchocerca volvulus		0.004	0.0006	0.0072
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0026	0.0178
Onchocerca volvulus	Cathepsin F homolog	0.006	0.0026	0.0294
Schistosoma mansoni	cathepsin F (C01 family)	0.0045	0.0012	0.0098
Brugia malayi	Cathepsin L-like precursor	0.006	0.0026	0.0219
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0097	0.0061	0.0348
Trichomonas vaginalis	endoplasmin, putative	0.0105	0.0068	0.0535
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.1278	0.1177	1
Echinococcus multilocularis	heat shock protein 90	0.0117	0.008	0.0677
Brugia malayi	DNA topoisomerase III	0.0129	0.0091	0.077
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0091	0.0055	0.0312
Leishmania major	DNA topoisomerase 1A	0.0129	0.0091	0.0528
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0091	0.0055	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.006	0.0026	0.0178
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Brugia malayi	glutaminase DH11.1	0.0302	0.0254	0.2158
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.1278	0.1177	1
Mycobacterium ulcerans	DNA topoisomerase I	0.0129	0.0091	0.0084
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Onchocerca volvulus		0.006	0.0026	0.0294
Plasmodium vivax	DNA gyrase subunit B, putative	0.1607	0.1489	1
Mycobacterium tuberculosis	Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase)	1.0607	1	1
Brugia malayi	Endoplasmin precursor	0.0117	0.008	0.0677
Brugia malayi	Cathepsin L-like precursor	0.006	0.0026	0.0219
Loa Loa (eye worm)	hypothetical protein	0.006	0.0026	0.0219
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0091	0.0055	0.0049
Echinococcus multilocularis	cathepsin L	0.0038	0.0005	0.0042
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0006	0.0008
Brugia malayi	cathepsin L-like precursor	0.0045	0.0012	0.0098
Mycobacterium ulcerans	integral membrane indolylacetylinositol arabinosyltransferase EmbC	1.0607	1	1
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0091	0.0055	0.0049
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0006	0.0053
Mycobacterium leprae	Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase)	1.0607	1	1
Leishmania major	heat shock protein 83-1	0.0117	0.008	0.0459
Loa Loa (eye worm)	endoplasmin	0.0117	0.008	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0012	0.0098
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0091	0.0055	0.0466
Trypanosoma cruzi	DNA topoisomerase II, putative	0.1149	0.1055	0.6567
Plasmodium falciparum	DNA topoisomerase 3, putative	0.0129	0.0091	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0055	0.0466
Leishmania major	hypothetical protein, conserved	0.0091	0.0055	0.0304
Echinococcus granulosus	cathepsin L cysteine protease	0.0038	0.0005	0.0042
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0091	0.0055	0.0049
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0627	0.0562	0.3536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0026	0.0178
Brugia malayi	Papain family cysteine protease containing protein	0.0038	0.0005	0.0042
Echinococcus multilocularis	cathepsin b	0.0173	0.0132	0.1121
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0091	0.0055	0.0049

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 2.9 uM	Antitrypanosomal activity against Trypanosoma brucei	ChEMBL.	18173229
EC50 (functional)	= 2.9 uM	Antitrypanosomal activity against Trypanosoma brucei	ChEMBL.	18173229
IC50 (binding)	= 2.27 uM	Inhibition of human liver cathepsin L	ChEMBL.	18173229
IC50 (binding)	= 2.27 uM	Inhibition of human liver cathepsin L	ChEMBL.	18173229
IC50 (binding)	= 12 uM	Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease	ChEMBL.	18173229
IC50 (binding)	= 12 uM	Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease	ChEMBL.	18173229
IC50 (binding)	> 30 uM	Inhibition of human liver cathepsin B	ChEMBL.	18173229
IC50 (binding)	> 30 uM	Inhibition of human liver cathepsin B	ChEMBL.	18173229

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei	ChEMBL23	18173229
Trypanosoma brucei gambiense		18173229

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL400097
PubChem: 24778320

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 501591